Today, as hundreds of genomes have been sequenced and thousands of proteins and more than ten thousand metabolites have been identi?ed, navigating safely through this wealth of information without getting completely lost has become crucial for research in, and teaching of, molecular biology. Consequently, a considerable number of tools have been developed and put on the market in the last two decades that describe the multitude of potential/putative interactions between genes, proteins, metabolites, and other biologically relevant compounds in terms of metabolic, genetic, signaling, and other networks, their aim being to support all sorts of explorations through bio-data bases currently called Systems Biology. As a result, navigating safely through this wealth of information-processing tools has become equally crucial for successful work in molecular biology. To help perform such navigation tasks successfully, this book starts by providing an extremely useful overview of existing tools for ?nding (or designing) and inv- tigating metabolic, genetic, signaling, and other network databases, addressing also user-relevant practical questions like • Is the database viewable through a web browser? • Is there a licensing fee? • What is the data type (metabolic, gene regulatory, signaling, etc. )? • Is the database developed/maintained by a curator or a computer? • Is there any software for editing pathways? • Is it possible to simulate the pathway? It then goes on to introduce a speci?c such tool, that is, the fabulous “Cell - lustrator 3. 0� tool developed by the authors.

“We live in the age of data. In the last few years, the methodology of extracting insights from data or "data science" has emerged as a discipline in its own right. The R programming language has become one-stop solution for all types of data analysis. The growing popularity of R is due its statistical roots and a vast open source package library. The goal of “Beginning Data Science with R� is to introduce the readers to some of the useful data science techniques and their implementation with the R programming language. The book attempts to strike a balance between the how: specific processes and methodologies, and understanding the why: going over the intuition behind how a particular technique works, so that the reader can apply it to the problem at hand. This book will be useful for readers who are not familiar with statistics and the R programming language.

The 6th International Conference in Methodologies and intelligent Systems for Technology Enhanced Learning held in Seville (Spain) is host by the University of Seville from 1st to 3rd June, 2016. The 6th edition of this conference expands the topics of the evidence-based TEL workshops series in order to provide an open forum for discussing intelligent systems for TEL, their roots in novel learning theories, empirical methodologies for their design or evaluation, stand-alone solutions or web-based ones. It intends to bring together researchers and developers from industry, the education field and the academic world to report on the latest scientific research, technical advances and methodologies.

Now you can master investments by both learning and doing with Adair/Nofsinger's unique FOUNDATIONS OF INVESTMENTS. From theory to practice to implementation, the authors use clear descriptions, real examples, interactive learning features and MindTap and Excel digital resources to strengthen your understanding and skills to confidently implement investment ideas. You learn trusted places on the internet to obtain information and data as you work with data from companies such as Tesla, Apple and Walmart. You then use that data in spreadsheets to create investment solutions that lead to good decision making. Even if you have limited Excel experience, Excel Expert example boxes guide you through how to analyze investment spreadsheets. Applications from today's headlines highlight examples such as Bitcoin and GameStop. With this edition, you develop your own personal investment strategies to use in your personal portfolio or in your professional job.

Peer to Peer Accommodation networks presents a new conceptual framework which offers an initial explanation for the continuing and rapid success of 'disruptive innovators’ and their effects on the international hospitality industry, with a specific focus on Airbnb, in the international context. Using her first-hand experience as a host on both traditional holiday accommodation webpages and a peer-to-peer accommodation network, respected tourism academic Sara Dolnicar examines possible reasons for the explosive success of peer to peer accommodation networks, investigates related topics which are less frequently discussed – such as charitable activities and social activism – and offers a future research agenda. Using first hand empirical results, this text provides much needed insight into this ‘disruptive innovator’ for those studying and working within the tourism and hospitality industries. This book discusses a wealth of issues including: * The disruptive innovation model - the criteria for identifying and understanding new disruptive innovators, and how peer-to-peer accommodation networks comply with these; * The factors postulated to drive the success of these networks and the celebration of variation; * Who are genuine networks members, tourist motivators and the chance of the ‘perfect match’; * Pricing, discrimination and stimulation of the creation of new businesses.

This is the first book to present field studies on the application of subject-oriented business process management (S-BPM). Each case presents a specific story and focuses on an essential modeling or implementation issue, and most end with implications or suggestions for further studies. Significant variables and success factors are identified that were discovered during the respective study and lead to suggesting S-BPM novelties. For each case, the authors explain step-by-step how the story develops, and provide readers guidance by detailing the respective rationale. The studies covered are clustered according to three main S-BPM themes: Part I “Business Operation Support� documents approaches to the practical development of S-BPM solutions in various application domains and organizational settings, while Part II “Consultancy and Education Support� highlights cases that can help to train readers in S-BPM modeling and knowledge acquisition for S-BPM lifecycle iterations. It also refers to architecting S-BPM solutions for application cases based on hands-on experience. Part III “Technical Execution Support� focuses on concepts for utilizing specific theories and technologies to execute S-BPM models. It also addresses how to create reference models for certain settings in the field. Lastly, the appendix covers all relevant aspects needed to grasp S-BPM modeling and apply it based on fundamental examples. Its format reconciles semantic precision with syntactic rigor.>Addressing the needs of developers, educators and practitioners, this book will help companies to learn from the experiences of first-time users and to develop systems that fit their business processes, explaining the latest key methodological and technological S-BPM developments in the fields of training, research and application.

This book presents a collection of computational intelligence algorithms that addresses issues in visual pattern recognition such as high computational complexity, abundance of pattern features, sensitivity to size and shape variations and poor performance against complex backgrounds. The book has 3 parts. Part 1 describes various research issues in the field with a survey of the related literature. Part 2 presents computational intelligence based algorithms for feature selection and classification. The algorithms are discriminative and fast. The main application area considered is hand posture recognition. The book also discusses utility of these algorithms in other visual as well as non-visual pattern recognition tasks including face recognition, general object recognition and cancer / tumor classification. Part 3 presents biologically inspired algorithms for feature extraction. The visual cortex model based features discussed have invariance with respect to appearance and size of the hand, and provide good inter class discrimination. A Bayesian model of visual attention is described which is effective in handling complex background problem in hand posture recognition. The book provides qualitative and quantitative performance comparisons for the algorithms outlined, with other standard methods in machine learning and computer vision. The book is self-contained with several figures, charts, tables and equations helping the reader to understand the material presented without instruction.

An emerging trend in the automobile industry is its convergence with information technology (IT). Indeed, it has been estimated that almost 90% of new automobile technologies involve IT in some form. Smart driving technologies that improve safety as well as green fuel technologies are quite representative of the convergence between IT and automobiles. The smart driving technologies include three key elements: sensing of driving environments, detection of objects and potential hazards and the generation of driving control signals including warning signals. Although radar-based systems are primarily used for sensing the driving environments, the camera has gained importance in advanced driver assistance systems (ADAS). This book covers system-on-a-chip (SoC) designs—including both algorithms and hardware—related with image sensing and object detection by using the camera for smart driving systems. It introduces a variety of algorithms such as lens correction, super resolution, image enhancement and object detections from the images captured by low-cost vehicle camera. This is followed by implementation issues such as SoC architecture, hardware accelerator, software development environment and reliability techniques for automobile vision systems. This book is aimed for the new and practicing engineers in automotive and chip-design industries to provide some overall guidelines for the development of automotive vision systems. It will also help graduate students understand and get started for the research work in this field.

This book describes how evolutionary algorithms (EA), including genetic algorithms (GA) and particle swarm optimization (PSO) can be utilized for solving multi-objective optimization problems in the area of embedded and VLSI system design. Many complex engineering optimization problems can be modelled as multi-objective formulations. This book provides an introduction to multi-objective optimization using meta-heuristic algorithms, GA and PSO and how they can be applied to problems like hardware/software partitioning in embedded systems, circuit partitioning in VLSI, design of operational amplifiers in analog VLSI, design space exploration in high-level synthesis, delay fault testing in VLSI testing and scheduling in heterogeneous distributed systems. It is shown how, in each case, the various aspects of the EA, namely its representation and operators like crossover, mutation, etc, can be separately formulated to solve these problems. This book is intended for design engineers and researchers in the field of VLSI and embedded system design. The book introduces the multi-objective GA and PSO in a simple and easily understandable way that will appeal to introductory readers.

This book analyzes the philosophical foundations of sensorimotor theory and discusses the most recent applications of sensorimotor theory to human computer interaction, child’s play, virtual reality, robotics, and linguistics. Why does a circle look curved and not angular? Why does red not sound like a bell? Why, as I interact with the world, is there something it is like to be me? An analytic philosopher might suggest: ``if we ponder the concept of circle we find that it is the essence of a circle to be round’’. However, where does this definition come from? Was it set in stone by the Gods, in other words by divine arbiters of circleness, redness and consciousness? Particularly, with regard to visual consciousness, a first attempt to explain why our conscious experience of the world appears as it does has been attributed to Kevin O’Regan and Alva Noe, who published their sensorimotor account of vision and visual consciousness in 2001. Starting with a chapter by Kevin O’Regan, Contemporary Sensorimotor Theory continues by presenting fifteen additional essays on as many developments achieved in recent years in this field. It provides readers with a critical review of the sensorimotor theory and in so doing introduces them to a radically new enactive approach in cognitive science.

Nowadays embedded and real-time systems contain complex software. The complexity of embedded systems is increasing, and the amount and variety of software in the embedded products are growing. This creates a big challenge for embedded and real-time software development processes and there is a need to develop separate metrics and benchmarks. “Embedded and Real Time System Development: A Software Engineering Perspective: Concepts, Methods and Principles� presents practical as well as conceptual knowledge of the latest tools, techniques and methodologies of embedded software engineering and real-time systems. Each chapter includes an in-depth investigation regarding the actual or potential role of software engineering tools in the context of the embedded system and real-time system. The book presents state-of-the art and future perspectives with industry experts, researchers, and academicians sharing ideas and experiences including surrounding frontier technologies, breakthroughs, innovative solutions and applications. The book is organized into four parts “Embedded Software Development Process�, “Design Patterns and Development Methodology�, “Modelling Framework� and “Performance Analysis, Power Management and Deployment� with altogether 12 chapters. The book is aiming at (i) undergraduate students and postgraduate students conducting research in the areas of embedded software engineering and real-time systems; (ii) researchers at universities and other institutions working in these fields; and (iii) practitioners in the R&D departments of embedded system. It can be used as an advanced reference for a course taught at the postgraduate level in embedded software engineering and real-time systems.

The proceedings from the  eighth KMO conference represent the findings of this international meeting which brought together researchers and developers from industry and the academic world to report on the latest scientific and technical advances on knowledge management in organizations. This conference provided an international forum for authors to present and discuss research focused on the role of knowledge management for innovative services in industries, to shed light on recent advances in social and big data computing for KM as well as to identify future directions for researching the role of knowledge management in service innovation and how cloud computing can be used to address many of the issues currently facing KM in academia and industrial sectors.

This book is about running modern industrial enterprises with the help of information systems. Enterprise resource planning (ERP) is the core of business informa­tion processing. An ERP system is the backbone of most companies' information systems landscape. All major business pro­cesses are han­dled with the help of this system. Supply chain management (SCM) looks beyond the individual company, taking into account that enterprises are increasingly concen­trating on their core com­petencies, leaving other activities to suppliers. With the growing dependency on the partners, effective supply chains have become as important for a com­pany's suc­cess as efficient in-house processes. This book covers typical business processes and shows how these processes are implemented. Examples are presented using the leading systems on the market – SAP ERP and SAP SCM. In this way, the reader can understand how business processes are actually carried out "in the real world".

This book describes recent theoretical findings relevant to bilevel programming in general, and in mixed-integer bilevel programming in particular. It describes recent applications in energy problems, such as the stochastic bilevel optimization approaches used in the natural gas industry. New algorithms for solving linear and mixed-integer bilevel programming problems are presented and explained.

This book addresses topics of mobile multi-agent systems, pattern formation, biological modelling, artificial life, unconventional computation, and robotics. The behaviour of a simple organism which is capable of remarkable biological and computational feats that seem to transcend its simple component parts is examined and modelled. In this book the following question is asked: How can something as simple as Physarum polycephalum - a giant amoeboid single-celled organism which does not possess any neural tissue, fixed skeleton or organised musculature - can approximate complex computational behaviour during its foraging, growth and adaptation of its amorphous body plan, and with such limited resources? To answer this question the same apparent limitations as faced by the organism are applied: using only simple components with local interactions. A synthesis approach is adopted and a mobile multi-agent system with very simple individual behaviours is employed. It is shown their interactions yield emergent behaviour showing complex self-organised pattern formation with material-like evolution. The presented model reproduces the biological behaviour of Physarum; the formation, growth and minimisation of transport networks. In its conclusion the book moves beyond Physarum and provides results of scoping experiments approximating other complex systems using the multi-agent approach. The results of this book demonstrate the power and range of harnessing emergent phenomena arising in simple multi-agent systems for biological modelling, computation and soft-robotics applications. It methodically describes the necessary components and their interactions, showing how deceptively simple components can create powerful mechanisms, aided by abundant illustrations, supplementary recordings and interactive models. It will be of interest to those in biological sciences, physics, computer science and robotics who wish to understand how simple components can result in complex and useful behaviours and who wish explore the potential of guided pattern formation themselves.

This textbook provides an introduction to the concept of sustainability in the context of transportation planning, management, and decision-making. The book is divided into two parts. In the first part, indicators and frameworks for measuring sustainable development in the transportation sector are developed. In the second, the authors analyze actual planning and decision-making in transportation agencies in a variety of governance settings. This analysis of real-world case studies demonstrates the benefits and limitations of current approaches to sustainable development in transportation. The book concludes with a discussion on how to make sustainability count in transportation decision-making and practice.

How long does it take for your website to load? Web performance is just as critical for small and medium-sized websites as it is for massive websites that receive tons of hits. Before you pour money and time into rewriting your code or replacing your infrastructure, first consider a reverse-caching proxy server like Varnish. With this practical book, you'll learn how Varnish can give your website or API an immediate performance boost. Varnish mimicks the behavior of your webserver, caches its output in memory, and serves the result directly to clients without having to access your webserver. If you're a web developer familiar with HTTP, this book helps you master Varnish basics, so you can get up and running in no time. You'll learn how to use the Varnish Configuration Language and HTTP best practices to achieve faster performance and a higher hit rate.Understand how Varnish helps you gain optimum web performance Use HTTP to improve the cache-ability of your websites, web applications, and APIs Properly invalidate your cache when the origin data changes Optimize access to your backend servers Avoid common mistakes when using Varnish in the wild Use logging and debugging tools to examine the behavior of Varnish

This textbook teaches crucial statistical methods to answer research questions using a unique range of statistical software programs, including MINITAB and R. This textbook is developed for undergraduate students in agriculture, nursing, biology and biomedical research. Graduate students will also find it to be a useful way to refresh their statistics skills and to reference software options. The unique combination of examples is approached using MINITAB and R for their individual strengths. Subjects covered include among others data description, probability distributions, experimental design, regression analysis, randomized design and biological assay. Unlike other biostatistics textbooks, this text also includes outliers, influential observations in regression and an introduction to survival analysis. Material is taken from the author's extensive teaching and research in Africa, USA and the UK. Sample problems, references and electronic supplementary material accompany each chapter.

This volume is the first systematic and thorough attempt to investigate the relation and the possible applications of mereology to contemporary science. It gathers contributions from leading scholars in the field and covers a wide range of scientific theories and practices such as physics, mathematics, chemistry, biology, computer science and engineering. Throughout the volume, a variety of foundational issues are investigated both from the formal and the empirical point of view. The first section looks at the topic as it applies to physics. The section addresses questions of persistence and composition within quantum and relativistic physics and concludes by scrutinizing the possibility to capture continuity of motion as described by our best physical theories within gunky space times. The second part tackles mathematics and shows how to provide a foundation for point-free geometry of space switching to fuzzy-logic. The relation between mereological sums and set-theoretic suprema is investigated and issues about different mereological perspectives such as classical and natural Mereology are thoroughly discussed. The third section in the volume looks at natural science. Several questions from biology, medicine and chemistry are investigated. From the perspective of biology, there is an attempt to provide axioms for inferring statements about part hood between two biological entities from statements about their spatial relation. From the perspective of chemistry, it is argued that classical mereological frameworks are not adequate to capture the practices of chemistry in that they consider neither temporal nor modal parameters. The final part introduces computer science and engineering. A new formal mereological framework in which an indeterminate relation of part hood is taken as a primitive notion is constructed and then applied to a wide variety of disciplines from robotics to knowledge engineering. A formal framework for discrete mereotopology and its applications is developed and finally, the importance of mereology for the relatively new science of domain engineering is also discussed.

This book brings together research on numerical methods adapted for Graphics Processing Units (GPUs). It explains recent efforts to adapt classic numerical methods, including solution of linear equations and FFT, for massively parallel GPU architectures. This volume consolidates recent research and adaptations, covering widely used methods that are at the core of many scientific and engineering computations. Each chapter is written by authors working on a specific group of methods; these leading experts provide mathematical background, parallel algorithms and implementation details leading to reusable, adaptable and scalable code fragments. This book also serves as a GPU implementation manual for many numerical algorithms, sharing tips on GPUs that can increase application efficiency. The valuable insights into parallelization strategies for GPUs are supplemented by ready-to-use code fragments. Numerical Computations with GPUs targets professionals and researchers working in high performance computing and GPU programming. Advanced-level students focused on computer science and mathematics will also find this book useful as secondary text book or reference.

From 9/11 to Charlie Hebdo along with Sony-pocalypse and DARPA's $2 million Cyber Grand Challenge, this book examines counterterrorism and cyber security history, strategies and technologies from a thought-provoking approach that encompasses personal experiences, investigative journalism, historical and current events, ideas from thought leaders and the make-believe of Hollywood such as 24, Homeland and The Americans. President Barack Obama also said in his 2015 State of the Union address, "We are making sure our government integrates intelligence to combat cyber threats, just as we have done to combat terrorism. In this new edition, there are seven completely new chapters, including three new contributed chapters by healthcare chief information security officer Ray Balut and Jean C. Stanford, DEF CON speaker Philip Polstra and security engineer and Black Hat speaker Darren Manners, as well as new commentaries by communications expert Andy Marken and DEF CON speaker Emily Peed. The book offers practical advice for businesses, governments and individuals to better secure the world and protect cyberspace.

This book is intended as an introduction to fuzzy algebraic hyperstructures. As the first in its genre, it includes a number of topics, most of which reflect the authors’ past research and thus provides a starting point for future research directions. The book is organized in five chapters. The first chapter introduces readers to the basic notions of algebraic structures and hyperstructures. The second covers fuzzy sets, fuzzy groups and fuzzy polygroups. The following two chapters are concerned with the theory of fuzzy Hv-structures: while the third chapter presents the concept of fuzzy Hv-subgroup of Hv-groups, the fourth covers the theory of fuzzy Hv-ideals of Hv-rings. The final chapter discusses several connections between hypergroups and fuzzy sets, and includes a study on the association between hypergroupoids and fuzzy sets endowed with two membership functions. In addition to providing a reference guide to researchers, the book is also intended as textbook for undergraduate and graduate students.

Data Preprocessing for Data Mining addresses one of the most important issues within the well-known Knowledge Discovery from Data process. Data directly taken from the source will likely have inconsistencies, errors or most importantly, it is not ready to be considered for a data mining process. Furthermore, the increasing amount of data in recent science, industry and business applications, calls to the requirement of more complex tools to analyze it. Thanks to data preprocessing, it is possible to convert the impossible into possible, adapting the data to fulfill the input demands of each data mining algorithm. Data preprocessing includes the data reduction techniques, which aim at reducing the complexity of the data, detecting or removing irrelevant and noisy elements from the data. This book is intended to review the tasks that fill the gap between the data acquisition from the source and the data mining process. A comprehensive look from a practical point of view, including basic concepts and surveying the techniques proposed in the specialized literature, is given.Each chapter is a stand-alone guide to a particular data preprocessing topic, from basic concepts and detailed descriptions of classical algorithms, to an incursion of an exhaustive catalog of recent developments. The in-depth technical descriptions make this book suitable for technical professionals, researchers, senior undergraduate and graduate students in data science, computer science and engineering.

This book presents perspectives for and by teachers, school and university administrators and educational researchers regarding the great impact pen and tablet technology can have on classrooms and education. presents three distinctly valuable threads of research: Emerging technologies and cutting-edge software invented by researchers and evaluated through real classroom deployments. First-hand perspectives of instructors and administrators who actively implement pen or tablet technologies in their classrooms. Up-and-coming systems that provide insight into the future of pen, touch, and sketch recognition technologies in the classrooms and the curriculums of tomorrow. The Impact of Pen and Touch Technology on Education is an essential read for educators who wish get to grips with ink-based computing and bring their teaching methods into the twenty-first century, as well as for researchers in the areas of education, human-computer interaction and intelligent systems for pedagogical advancement.

This volume provides updated, in-depth material on the application of intelligent optimization in biology and medicine. The aim of the book is to present solutions to the challenges and problems facing biology and medicine applications. This Volume comprises of 13 chapters, including an overview chapter, providing an up-to-date and state-of-the research on the application of intelligent optimization for bioinformatics applications, DNA based Steganography, a modified Particle Swarm Optimization Algorithm for Solving Capacitated Maximal Covering Location Problem in Healthcare Systems, Optimization Methods for Medical Image Super Resolution Reconstruction and breast cancer classification. Moreover, some chapters that describe several bio-inspired approaches in MEDLINE Text Mining, DNA-Binding Proteins and Classes, Optimized Tumor Breast Cancer Classification using Combining Random Subspace and Static Classifiers Selection Paradigms, and Dental Image Registration. The book will be a useful compendium for a broad range of readers—from students of undergraduate to postgraduate levels and also for researchers, professionals, etc.—who wish to enrich their knowledge on Intelligent Optimization in Biology and Medicine and applications with one single book.