1 Methoden.- 1.1 Elektroenzephalographie (EEG).- 1.1.1 Einfuhrung.- 1.1.2 Entstehungsmechanismen des EEG.- 1.1.3 Methodik der EEG-Ableitung.- 1.1.4 Das normale EEG.- 1.1.5 Pathologische EEG-Veranderungen.- 1.1.6 Diagnostisch relevante EEG-Befunde.- 1.1.7 EEG-Indikationen im Intensivbereich.- 1.2 Ultraschalldiagnostik.- 1.2.1 Physikalische und apparative Voraussetzungen.- 1.2.2 Anatomische und physiologische Voraussetzungen.- 1.2.3 Untersuchungsgang.- 1.2.4 Indikationen der Ultraschalldiagnostik in der Intensivmedizin.- 1.3 Somatosensibel evozierte Potentiale (SEP).- 1.3.1 Einfuhrung.- 1.3.2 Methodik.- 1.3.3 Ursprungsorte der SEP-Komponenten.- 1.3.4 Auswertung und Normwerte.- 1.3.5 Ausfallsmuster bei typischen Schadigungsorten.- 1.3.6 Indikationen zur Ableitung von SEP.- 1.4 Fruhe akustisch evozierte Potentiale (FAEP).- 1.4.1 Einfuhrung.- 1.4.2 Methodik.- 1.4.3 Generatoren des FAEP.- 1.4.4 Auswertung und Normwerte.- 1.4.5 Lokalisationsdiagnostische Bedeutung der FAEP.- 1.4.6 Indikationen zur Ableitung von FAEP.- 1.5 Motorisch evozierte Potentiale (MEP).- 1.5.1 Einfuhrung.- 1.5.2 Wirkungsweise der Magnetstimulation.- 1.5.3 Methodik.- 1.5.4 Auswertung.- 1.5.5 Kontraindikationen.- 1.5.6 Besonderheiten der MEP-Untersuchung auf der Intensivstation.- 1.5.7 Einsatz der MEP auf der neurologischen Intensivstation und im Neuromonitoring.- 1.6 Visuell evozierte Potentiale (VEP).- 1.6.1 Einfuhrung.- 1.6.2 Anatomische und physiologische Grundlagen.- 1.6.3 Technische Durchfuhrung.- 1.6.4 Auswertung.- 1.6.5 Beeinflussung der VEP.- 1.6.6 Indikationen fur VEP-Ableitung in der Intensivmedizin.- 1.7 Elektromyographie (EMG) und Neurographie.- 1.7.1 Einfuhrung.- 1.7.2 Elektromyographie.- 1.7.3 Motorische Neurographie.- 1.7.4 Sensible Neurographie.- 1.7.5 Prufung der neuromuskularen UEberleitung.- 1.7.6 F-Antworten.- 1.7.7 Reflexmessungen.- 1.8 Untersuchung des autonomen Nervensystems.- 1.8.1 Anatomie.- 1.8.2 Physiologie.- 1.8.3 Methodik: Grundlagen.- 1.8.4 Pathophysiologie.- 1.8.5 Methodik: Analyse der Herzfrequenzvariabilitat.- 1.8.6 Allgemeine Befunde.- 1.8.7 Blutdruckmonitoring.- 1.8.8 Methodik: Sympathische Hautreaktion.- 1.9 Exogene und endogene Einflusse auf neurophysiologische Parameter.- 1.9.1 Einfuhrung.- 1.9.2 Exogene Einflusse.- 1.9.3 Endogene Einflusse.- 2 Neuromonitoring bei Intensivtherapiepflichtigen Erkrankungen.- 2.1 Schadel-Hirn-Trauma.- 2.1.1 Einfuhrung.- 2.1.2 Pathophysiologie.- 2.1.3 Klinische Diagnostik.- 2.1.4 Radiologische Diagnostik.- 2.1.5 Neurophysiologische Diagnostik.- 2.2 Hypoxisch-ischamische Hirnschadigung.- 2.2.1 Einfuhrung.- 2.2.2 Ursachen und Pathophysiologie.- 2.2.3 Klinisches Erscheinungsbild.- 2.2.4 Prognose aufgrund der klinischen Untersuchung.- 2.2.5 Bedeutung neurophysiologischer Methoden fur Diagnostik, Verlauf und Prognose.- 2.2.6 Andere Untersuchungen.- 2.3 Intrakranielle Blutungen.- 2.3.1 Einfuhrung.- 2.3.2 Infratentorielle intrazerebrale Blutungen.- 2.3.3 Supratentorielle intrazerebrale Blutungen.- 2.3.4 Subarachnoidalblutungen.- 2.4 Hirninfarkt.- 2.4.1 Einfuhrung.- 2.4.2 Klinische und radiologische Klassifikation der Hirninfarkte.- 2.4.3 Ultraschalldiagnostik.- 2.4.4 Elektroenzephalographie (EEG).- 2.4.5 Fruhe akustisch evozierte Potentiale (FAEP).- 2.4.6 Motorisch evozierte Potentiale (MEP).- 2.4.7 Somatosensibel evozierte Potentiale (SEP).- 2.5 Meningoenzephalitis.- 2.5.1 Einfuhrung.- 2.5.2 Bedeutung neurophysiologischer Methoden fur Verlauf und Prognose.- 2.6 Metabolische und septische Enzephalopathien.- 2.6.1 Einfuhrung.- 2.6.2 Hepatische Enzephalopathie.- 2.6.3 Uramische Enzephalopathie und Dysequilibrium-Syndrom.- 2.6.4 Hypoglykamie.- 2.6.5 Hyperglykamie und hyperosmolares Koma.- 2.6.6 Elektrolytstoerungen.- 2.6.7 Schilddrusenfunktionsstoerungen.- 2.6.8 Weitere metabolische Enzephalopathien.- 2.6.9 Septische Enzephalopathie.- 2.7 Toxische Enzephalopathien.- 2.7.1 Einfuhrung.- 2.7.2 Intoxikation mit Barbituraten und Benzodiazepinen.- 2.7.3 Intoxikation mit Neurol

Family doctors, pediatricians and other professionals who deal with children are regularly consulted because of febrile children. During the past few years remarkable advances on this subject of fever have been made. Among others, this book covers: - Different types of fever with possible complications, - Hyperthermia and their management, - Management of fever with guidelines on antipyretics and their side effects, - Complimentary medicine and fever, - Differential diagnosis of fever, with problem-setting and solving as a case presentation. This reader-friendly reference on the disorders of body temperature in children covers the entire spectrum of subjects related to fever. It gives an overview of the best treatment options in order to achieve the best results.

The ACMT National Case Conference (NCC) is a monthly discussion of novel or interesting cases in medical toxicology. Participation is through online webinar, and the conferences are recorded to allow for review at any time. The cases in this book are taken from recordings of NCC with edits and revisions by contributors and editors to demonstrate educational points. The majority of the case information is from the original recording and represents actual patient presentations. However, some of the details have been changed and fictional information added to enhance the educational value. This volume covers a broad range of toxicological topics, and specialty guidance is offered at the end of every case to aid non-toxicologists. The dilemmas are applicable to both academic and clinical medicine. A list of relevant questions is also provided for each case. Subjects include common toxicological problems, rare presentations of common problems, common problems with controversial treatments or difficult diagnoses, and rare problems. Case Studies in Medical Toxicology from the American College of Medical Toxicology is a detailed reference text on specific toxicological issues and also serves as a practical review for those taking board exams. As a result, this volume is an important and necessary resource for medical students, residents, and fellows, as well as primary-care physicians, intensivists, and toxicologistsCase Studies in Medical Toxicology from the American College of Medical Toxicology is a detailed reference text on specific toxicological issues and also serves as a practical review for those taking board exams. As a result, this volume is an important and necessary resource for medical students, residents, and fellows, as well as primary-care physicians, intensivists, and toxicologists. All proceeds from this book will be donated to the Medical Toxicology Foundation.

A comprehensive, state-of-the-art contribution to a field that is rapidly developing, "The Behavioral Consequences of Stroke" provides a broad overview of the cognitive and neurobehavioral effects of stroke. As attention to paralysis and the more obvious physical disabilities stroke patients incur expands, greater attention is being paid today to the cognitive and neurobehavioral complications that impact stroke morbidity and even functional neurological recovery in patients. Written by an international panel of experts and edited by a neurosurgeon and by a cognitive neuroscientist, this unique title addresses the full range of issues relevant to the field, including epidemiology, general treatment, sensorimotor control after stroke, post-stroke aphasia, memory loss after stroke, post-stroke depression, the role of imaging after a stroke, and an update on some stroke clinical trials, to name just some of the areas covered.

Illuminative and an influential addition to the literature, "The Behavioral Consequences of Stroke" will serve as an invaluable resource for neurologsits, neurosurgeons, physiatrists and other physicians, as well as physical, speech and occupational therapists, nurses, psychologists, and other professionals. "

The OSCEs have become a part of most examinations in Critical Care Medicine. This book will be of great help to the examinees. The contents have been divided into two sections one is Questions and the second is Answers. It contains chapters on Respiratory Medicine, Neurology, Nephrology, Microbiology and Infection Control, Hemodynamics, Drugs, Biochemistry, Miscellaneous, and Case Scenarios. Contains nearly 330 questions with model answers. Questions range from the old tests, new techniques and devices, and results of laboratory and other investigations. Also covers questions on all organ systems and different ways these systems may be affected by the disease. The answers are structured from examination point-of-view. These will help the examinees in developing the skills to face the objective structured clinical examinations (OSCEs) in their examination.

Decision making regarding fluid volume loading, fluid restriction, or administration of vasoactive drugs may vary among physicians, depending solely upon their clinical experience in the absence of evidence-based measurement. The initial distribution volume of glucose (IDVG) is believed to be clinically relevant as a marker of cardiovascular and fluid management in critically ill patients without a significant modification of glucose metabolism. This book covers all aspects of IDVG measurement, including the basic concept, its relationship with other fluid volumes, and the clinical application of this technique in the intensive care unit based on both the authors studies and their clinical experience with more than 4000 IDVG determinations. When the concept of IDVG is properly understood and its measurement is then performed routinely, daily fluid and cardiovascular management in critically ill patients can be improved based on evidence-based measurement."

This text has been prepared with a view to be simple, practical, concise and easy-to-read for pediatricians, pediatric intensive care unit (PICU) and neonatal intensive care unit (NICU) residents and fellows using conventional mechanical ventilation for commonly seen conditions such as respiratory distress syndrome (RDS), meconium aspiration syndrome (MAS), persistent pulmonary hypertension (PPHN), pneumonia, acute respiratory distress syndrome (ARDS), asthma, and various cardiovascular and neurological conditions. This book is intended to be a practical resource for pediatric residents, pediatricians, and physicians involved in the care of neonatal and pediatric intensive care patients needing mechanical ventilation. Ventilation technique specifically applicable to neonate or an older child has been indicated wherever necessary Easy-to-read flow diagrams (algorithms) have been used for management of respiratory distress, rapid sequence intubation (RSI), basic mechanical ventilation, and weaning. Noninvasive ventilation modalities such as continuous positive airway pressure (CPAP), biphasic positive airway pressure (BIPAP), and high flow nasal oxygen have also been included. Newer modes such as high frequency ventilation and common ventilator graphics interpretation have also been included for the reader aspiring to learn the newer and advanced modes of ventilation. A chapter on extracorporeal membrane oxygenation has been added to make the reader familiar with technology beyond mechanical ventilation to support patients with refractory hypoxemia. A chapter on how to choose a ventilator has also been included as a guide to new units providing care to neonates and children. This book would be helpful to the user in management of common conditions requiring CPAP, invasive and non-invasive mechanical ventilation in neonates and older children.

Intensive Care Medicine compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Although its roots date back to the early decades of the 20th century, critical care medicine did not emerge as a specialty in medicine until the 1970 s. Over the last 30 years or so, the field of critical care medicine has grown tremendously and there is now a solid body of scientific information that forms the foundation for the practice of critical care medicine. But, now as physicians and hospitals around the world focus to an ever greater extend on providing high quality care, the practice of critical care medicine will continue to grow in visibility and importance among clinicians and the general public as well.

This book seeks to identify the trends in critical care medicine that will form the basis for practice over the next ten years. Predicting the future is always risky. Nevertheless, the ideas articulated in this book are likely to serve as a road map for intensivists, hospital administrators and governmental leaders interested in healthcare, as they seek to improve the quality and efficiency of hospital-based services."

This textbook encompasses the essential topics on the subject that all clinicians need to know for the effective management of their patients. It has four sections each for ventilation, fluids and electrolytes, blood gases, and miscellaneous. Each section starts with applied physiology and then covers routine as well as advance topics related to ventilation, fluids, and electrolytes in critically ill adult patients. The miscellaneous section covers enteral and parenteral nutrition, immunonutrition, blood product transfusion, and care of potential organ donor in the intensive care unit (ICU). There are also chapters on common problems such as the approach to the patient with hypoxemia, hypercapnia, hypovolemia, electrolyte abnormalities, and acid-base disturbances. Covers all essential aspects, from applied physiology to advanced care, related to ventilation, fluids, and electrolytes in critically ill adult patients. Based on common problems like the approach to the patient with hypoxemia, hypercapnia, hypovolemia, electrolyte abnormalities, and acid-base disturbances. Chapters start with a case scenario, followed by structured description of the problem, and in the end discussion about the index case. Figures, tables, and flowcharts have been used throughout the chapters. At the end of each chapter, a few salient points are given to emphasis on the important area of the particular topic. Useful for trainees as well as consultants of various clinical specialties who manage critically ill adult patients, including critical care medicine, emergency medicine, pulmonary medicine, and anesthesiology.

This atlas is a comprehensive guide to critical care for intensivists. Divided into eight sections, the book begins with discussion on airway management. The following sections describe critical care for different sub specialties - respiratory system, cardiology, gastroenterology and neurology. The final sections cover trauma cases, microbiology and miscellaneous topics which provide an overview of rheumatology, nephrology, haematology, ultrasound and more. The book is highly illustrated with more than 1100 clinical photographs, diagrams, radiological images and tables. Key points Comprehensive guide to critical care for intensivists Covers key sub specialties Includes trauma cases Highly illustrated with more than 1100 photographs, diagrams and radiological images

This book has been organized and sponsored by the Asia Pacific Association of Critical Care Medicine (APACCM) to assist dissemination of the available evidence in the field. The book has been exclusively written by 85 authors, who practice in the Asia Pacific regions intensive care environment, thus provides a contemporary overview of the practice intensive care medicine in our region. In addition to the sections on general assessment and organ support in critically ill, over the half of the book is dedicated to organ dysfunction and specific critical illness syndromes (including the infectious diseases) that are prevalent in areas of the region.

Management of Musculoskeletal Injuries in the Trauma Patient summarizes the most current concepts and clinical practices for the management of the patient with musculoskeletal traumatic injuries. The text covers optimal time frames for stabilization of orthopedic injuries and strategies to mitigate systemic injury while minimizing damage due to pelvic, spine and long bone trauma. The volume covers the gamut of traumatic axial and extremity injuries, including cervico-lumbar-thoracic spine injuries, spinal cord injuries, long bone fractures with special emphasis on the femoral shaft, pelvic and acetabular injuries, open fractures, mangled extremities, upper extremity injuries, combination and severe soft tissues injuries and periarticular fractures. These are discussed in the context of isolated injury and combined with orthopedic injuries of the brain, abdomen, chest and other musculoskeletal injuries. Written by internationally recognized experts, Management of Musculoskeletal Injuries in the Trauma Patient is a valuable resource for orthopedic surgeons.

'...provides an excellent introduction to the management of acute illness for all clinical staff, and a solid foundation for those who choose to make ICM a fulfilling life-long career.' From the Foreword by Julian Bion, Professor of Intensive Care Medicine, University of Birmingham Ideal for any medic or health professional embarking upon an intensive care rotation or specialism, this simple bedside handbook provides handy, pragmatic guidance to the day-to-day fundamentals of working in an intensive care unit, often a daunting prospect for the junior doctor, nurse and allied health professional encountering this challenging environment for the first time. Thoroughly updated, the second edition addresses recent and future developments in a variety of areas and is now organised into easy-to-read sections with clearly outlined learning goals. New topics added include sepsis, ARDS, refractory hypoxia, the role of allied health professionals, post ICU syndrome and follow up, and consent and capacity including new DOLS guidance. The book is authored by world-renowned contributors and edited by established consultants in the field of intensive care medicine.

This book presents pulmonary outcomes of prematurity, from their emergence in infancy through to their consequences in adulthood. With an increasing number of preterm births and more infants surviving, there is now a larger population of adults with lung disease originating in infancy requiring specialized care. Looking at the whole group of preterm infants, not just those with bronchopulmonary dysplasia, this text covers a wide spectrum of pulmonary outcomes, including: pulmonary hypertension, wheezing, and alterations in sleep. The chapter authors focus on critically appraising what is and is not known about each outcome and suggest key questions that still need to be answered. Respiratory Outcomes in Preterm Infants: Sequelae from Infancy through Adulthood is an ideal reference for the multidisciplinary group that cares for these preterm infants and the adults they become, including: neonatologists, pediatric pulmonologists, pediatricians, adult pulmonologists, primary care physicians, nurses, and fellows.

As the number of people aged 65 years and above rises, physicians are increasingly confronted by elderly patients with impaired renal function, altered drug metabolism and multiple comorbidities. This book examines in detail the nature of renal injury in the elderly and its optimal management. A wide range of key topics are covered, including end-stage renal disease, diabetic nephropathy, acute kidney injury, drug metabolism and renal toxicity, dialysis and its complications and the use of renal transplantation. In addition, the assessment of glomerular filtration rate in the elderly and the role of novel renal biomarkers are carefully examined. Quality of life issues, the significance of other age-related medical problems and end of life care are also discussed. This book will be of value not only to nephrologists but also to general practitioners, medical students, intensivists, cardiologists, pharmacologists and those working in related specialties. "

Therapeutic hypothermia has emerged as a very important treatment option for patients with cardiac arrest as it provides significant protection from developing neurologic injury once the patient has been successfully resuscitated. Studies have demonstrated over 15% absolute risk reduction in death and neurologic injury using this therapy. Although hospitals and medical centers have become familiar with this important intervention it still remains greatly under utilized due to an experience and lack of resources to safely and effectively deploy such a program. The objective of this book is to educate and familiarize both providers and institutions as to how to develop and deploy and provide therapeutic hypothermia to their patients. The current knowledge for this is provided by speakers and national experts and also by literature review. There are several courses being provided on this as well throughout the US. These are good venues for people to come and see and get hands on experience, but there still needs to be a concrete book with references on how to go about getting this program started.

This volume explores how the scarce resources of intensive care units should be distributed. Three hypothetical patients, each with a different chance of survival, desire intensive care. A multinational panel of experienced critical care physicians offers assessments of the patients' conditions and outlines approaches to treatment. These approaches are then examined by academic medical experts and a medical ethicist, as well as from a legal perspective. The result is a well-rounded and introspective look at care for critically ill patients at or near the end of life.

This volume provides a comprehensive overview of critical care of the pediatric immunocompromised hematology-oncology patient. The text focuses on unique aspects of the pediatric immunocompromised patient that predisposes the child to significant illness, and presents critical care management strategies specific to the patient population. In addition to chapters on oncology, primary immune deficiency, immunocompromised hematology, and hematopoietic cell transplant patients, the book covers the changing landscape of ICU care, pharmacologic considerations, and psychological and social aspects of the critical care of hematology-oncology patients. Written by experts from a range of disciplines, Critical Care of the Pediatric Immunocompromised Hematology/Oncology Patient: An Evidence-Based Guide is a valuable resource for clinicians and practitioners who treat this patient population.

Infectious Complications in Transplant Patients has been uniquely designed and formatted to address issues and trends pertaining to pathogens deemed important in critically ill transplant patients. The chapters have been carefully selected so as to direct the focus of the book towards current approaches to controversial, emerging or topical problems in these patients. Each chapter has been authored by a North American and a European specialist. This format serves to impart an added dimension reflective of the diversity of opinions and practices pertaining to unresolved or controversial issues. The authors are recognized experts in their respective fields.

In recent years much enthusiasm and energy has been directed toward the development of human gene therapies, especially for inherited conditions and cancers. However, current gene transfer technology is limited in its transduction efficiency and ability to permanently and safely correct genomic defects. Thus the promise of gene therapy for these conditions is as yet unrealized. The progression of gene transfer technology will eventually surmount these limitations. Gene Therapy for Acute and Acquired Diseases includes selected examples of ongoing studies in molecular genetics that have the potential to evolve into human therapies for acute illnesses. These chapters are intended to highlight lesser known applications of gene therapy for acquired disorders. It is expected that human gene therapy trials for these conditions will be forthcoming in the near future, leading to previously unimaginable therapies. Thus, this first-ever book about gene therapy for acute and acquired diseases is intended to serve as a glimpse into the future.

The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Single Subject Designs in Biomedicine draws upon the rich history of single case research within the educational and behavioral research settings and extends the application to the field of biomedicine. Biomedical illustrations are used to demonstrate the processes of designing, implementing, and evaluating a single subject design. Strengths and limitations of various methodologies are presented, along with specific clinical areas of application in which these applications would be appropriate. Statistical and visual techniques for data analysis are also discussed. The breadth and depth of information provided is suitable for medical students in research oriented courses, primary care practitioners and medical specialists seeking to apply methods of evidence practice to improve patient care, and medical researchers who are expanding their methodological expertise to include single subject designs. Increasing awareness of the utility in the single subject design could enhance treatment approach and evaluation both in biomedical research and medical care settings.

Surviving critical illness is not always the happy ending we imagine for patients. Many ICU survivors suffer from a range of long-lasting physical and psychological issues such end stage renal disease, congestive heart failure, cognitive impairment, neuromuscular weakness, and depression or anxiety, which affect their overall quality of life and ability to lead productive lives. This lingering burden or 'legacy' of critical illness is now recognized as a major public health issue, with major efforts underway to understand how it can be prevented, mitigated, or treated. The Textbook of Post-ICU Medicine: The Legacy of Critical Care discusses the science of the recovery process and the innovative treatment regimens which are helping ICU survivors regain function as they heal following trauma or disease. Describing the major clinical syndromes affecting ICU survivors, the book delineates established or postulated biological mechanisms of the post-acute recovery process, and discusses strategies for treatment and rehabilitation to promote recovery in the ICU and in the long term. The chapters are written by an interdisciplinary panel of leading clinicians and researchers working in the field. The book serves as a unique reference for general practitioners, internists and nurses caring for long term ICU survivors as well as specialists in intensive care medicine, neurology, psychiatry, and rehabilitation medicine.