The simple reason for creating this book was my impression that the law is having an increasing impact on the practice of medicine. There is hardly a physician I know who has not been deeply troubled by legal problems professionally, economically, and most important of all, psychologically. The past decade has seen medical practice premiums steadily rising. Multimillion dollar verdicts have not been unusual. Having disregarded these vital issues for many years, physicians have suddenly become very aware of litigation-related problems. Having been interested for a long time in the logic ofthe law and the romance of legal research, I thought it would be useful to create a book that would result in the blending of great minds in law and medicine. It has been my long standing observation and belief that the approach of professors of medicine, and that of learned members of the bar and bench, when put together, produce unique results. Putting these views together has been the real challenge in editing this book."

This issue of Critical Care Clinics, guest edited by Drs. John Kellum and Dana Fuhrman, focuses on Acute Kidney Injury. This is one of four issues each year selected by the series consulting editor, Dr. John Kellum. Articles in this issue include, but are not limited to: Acute Kidney Injury and Disease, AKI in Cardiac Surgery, AKI in Sepsis, Hepatorenal Disease, Cardiorenal Syndrome, Onconephrology, Renal Functional Reserve and more.

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

The surge in COVID-19 cases leading to hospitalizations around the world quickly depleted hospital resources and reserves, forcing physicians to make extremely difficult life-or-death decisions on ventilator allocation between patients. Leaders in academia and industry have developed numerous ventilator support systems using both consumer- and industry-grade hardware to sustain life and to provide intermediate respiratory relief for hospitalized patients. This book is the first of its kind to discuss the respiratory pathophysiology underlying COVID-19, explain ventilator mechanics, provide and evaluate a repository of innovative ventilator support devices conceived amid the pandemic, and explain both hardware and software components necessary to develop an inexpensive ventilator support device. This book serves both as a historical record of the collaborative and innovative response to the anticipated ventilator shortage during the COVID-19 pandemic and as a guide for physicians, engineers, and DIY'ers interested in developing inexpensive transitory ventilator support devices.

Now, 25 years into our country's most recent "women's movement" for equality, it is appropriate to reexamine the social and cultural experiences of women. Thanks to the media, researchers, clinicians, and the general public, all are aware that women have been unable to realize many of their goals. At times, distress rather than satisfaction and rejection and disap pointment rather than contentment have been the result of the ongoing struggle of women to achieve change-the change in attitudes, behavior, and values necessary to broaden the personal choices and work options open to women. Nationally recognized authorities on several of the sociocultural issues addressed in this volume, the editors invited noted scholars and clinicians to study some of those issues particularly relevant to women. These include frequently neglected topics, such as the multiplicity of responsibilities of single women and the spectrum of mothering roles, and those more commonly discussed, such as the various roles and patterns in the family, work options and burdens, and interpersonal relationships. The volume provides insightful detail on two prominent and poignant problems of the 1980s-the causes and repercussions of homelessness and sexual life-styles. Such material may facilitate under standing and serve as a catalyst for positive action."

Infection Control in the ICU Environment provides the details of the most common infection control problems facing intensive care units. Authors include noted scientists, intensivists and epidemiologists from the United States and Europe as well as infection control experts from the Centers for Disease Control and Prevention. Acinetobacter, methicillin resistant staphylococcus aureus and vancomycin resistant enterococci are examined in detail. This volume also includes cutting edge information regarding the potential for prophylactic and pre-emptive therapy of fungal infections in intensive care units. Innovations in vascular catheter care and prevention of bloodstream infections are discussed in this volume as well as the newest information in mathematical modeling to understand the epidemiology and control of infections in intensive care units.

Designed specifically for the revised Final FRCA examination, this book contains four mock exams, combining the new single best answer format with the traditional true/false format MCQs. A further fifth chapter contains only single best answer questions allowing candidates extra practice on this new and more difficult format. Uniquely the book includes answers with explanations and cross-references to key textbooks, allowing the candidate to read around on more difficult areas. The editor team balances extensive exam experience with recent exam success. Each question has also been expertly reviewed to ensure the highest quality and relevance to the Final FRCA. This is a must buy when preparing for this key exam.

Critical Care Neurology, Part II: Neurology of Critical Illness focuses on the care specialists and general neurologists that consult in the ICU and their work with patients in acute, life-threatening situations who are dealing with neurologic or neurosurgical crises emanating from either a preexisting neurologic syndrome or from a new neurologic complication appearing as a result of another medical or surgical critical illness. These two separate clinical situations form the pillars of neurocritical care, hence these practices are addressed via two separate, but closely related, HCN volumes. Chapters in both focus on pathophysiology and management, and are tailored for both general neurologists and active neurocritical specialists, with a specific focus on management over diagnostics. Part I addresses the principles of neurocritical care and the management of various neurologic diseases. Part II addresses the interplay between neurologic complications and the surgical, medical, cardiac, and trauma of critical illnesses that most typically present in the ICU.

One in three people will develop some kind of cancer in their lifetime. The overall cancer incidence has increased by 25% since 1975. Anaesthetic involvement in hospital interactions has been estimated at around 75%, and so anaesthetists are likely to have major input into the care of the cancer patient. This input may start with the preoperative assessment, but often extends to the intensive care unit and the management of both acute and chronic disease, or procedural related pain.
This book is comprised of five main sections dealing with cancer, anaesthesia for cancer surgery, intensive care, pain management and supportive and palliative care. The chapters are authored by acknowledged specialists in their field of cancer patient management. The anaesthesia section discusses not just major surgery but includes the specific and subtle differences that exist in the diverse types of specialist cancer surgery. The pain section deals with the current status of several specific cancer pain problems with contemporary evidence and recent developments in management. This book also introduces novel ways of looking at conventional treatments such as the genetic aspects of opioid use. For a complete understanding of the cancer patient, other aspects of care are also considered, including psychological care and complementary medicines.

The Oxford Desk Reference: Major Trauma is the missing link between basic trauma management and advanced specialist care. Advanced Trauma Life Support courses have revolutionised trauma care in the last 3 decades, but there is little advice for the key decision makers in trauma care once the primary and secondary surveys are complete. This volume is a practical and evidence-based desk reference, giving a comprehensive walk-through from the initial phases of injury, through key decision-making in the resuscitation room, to surgical principles and rehabilitation. Including chapters on damage control, ballistic and blast injuries, and bariatric trauma, this text covers all the main areas of trauma care necessary for the trauma specialist in the 21st Century.
The Oxford Desk Reference emphasises practical help but also covers the evidence and science behind trauma management. It includes the most up-to-date guidance from national bodies making recommendations for trauma care, using an international team of contributing authors. This book will become an essential tool for everyday use in the management of trauma.

This book covers several areas, such as immunology, infectious diseases, physiology, general nursing, and medicine as well as measurement accuracy and the history of our understanding of fever. This book employs an interdisciplinary approach to exploring our concept of body temperature and specifically fever. The present volume revolves around thermometry, taking the reader on a journey from the past to the present. Yet while the emphasis is on the clinical importance of obtaining accurate, quantitative measurements of body temperature, the reader is also introduced to the most recent clinical work on the subject. This book represents a truly cross-disciplinary collaboration, using evidence-based practice to integrate physiological and immunological knowledge. The authors' intention with this volume is to help readers gain better insight into the importance of using knowledge from different disciplines to develop an appreciation of the different aspects of body temperature. In addition, the reader will come to understand the concept of fever in a broader perspective than is traditionally adopted.

The Comatose Patient is a single authored entirely new work written by a practicing critical care neurologist. It includes a critical historical overview of the concepts of consciousness and unconsciousness, principles of neurologic examination of the comatose patients including instruction of a new coma scale, the 'FOUR Score', a new practical multistep approach to the diagnosis of the comatose patient, extensive coverage of interpretation of neuroimaging and its role in daily practice and decision making, management in the emergency room and ICU and long-term supportive care and approach to communication with family members and end-of-life decision. It also discusses landmark legal cases and ethical problems and a chapter on the public perception of coma. The book is lavishly illustrated with 200 illustrations throughout the book.
Unprecedented, this book includes 75 comprehensive case vignettes covering the entire spectrum of causes leading to coma. In each case a specific cause is presented. Every example is fully discussed and explained with an emphasis on the mechanism of coma in that particular case and followed by a section on management and expected outcome.
This monograph additionally includes a 45-minute DVD with 5 narrated chapters and an easy to use navigation menu. Included are 40 patient examples showing the instructions of the FOUR score Coma Scale, common neurological findings in coma, breathing patterns in coma, different types of prolonged comatose states including a persistent vegetative state and a minimally conscious state. Using 3D animation, the DVD includes a comprehensive description of the determination of Brain Death and how to safely do the apneatest. There is an emphasis on pitfalls and common concerns. The DVD can also be used for neurology and neurosurgery residency programs, medical and nursing school curricula and physical therapy programs.

In this issue of Critical Care Clinics, guest editors Drs. Lauren R. Sorce and Joy D. Howell bring their considerable expertise to the topic of Pediatric Critical Care. Top experts in the field cover key topics such as point-of-care ultrasound for pediatric critical care providers; transfusion strategies in the 21st century; global pediatric critical care; workforce diversity; and more. Contains 13 relevant, practice-oriented topics including pediatric redeployment: unique challenges created by COVID-19; ECMO then and now; PCCM in 21st century and beyond; pediatric critical care outcomes; cardiac output monitoring; and more. Provides in-depth clinical reviews on pediatric critical care, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic 'storm', that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.

Trauma has been recognized in recent years as one of the most important health care issues still to be fully addressed. A new awareness of deficiencies in the clinical management of injured patients has led to an urgent reappraisal of procedures and training in many hospitals. Parallel to this, there has been a revolution in the field of radiology and diagnostic imaging. Imaging in Trauma provides guidance on the safe and effective application of imaging techniques to patients who have been injured - recommending appropriate techniques wherever they are known to be effective and highlighting cases where their use would be inappropriate. The use of basic conventional radiology is most comprehensively covered, recognising that some of the newer modalities, such as magnetic resonance imaging, will not be generally available for some years. . It is important to consider not only the production of good images, but also how to help clinicians to order them appropriately and to interpret them. A full report from a trained radiologist may not be immediately available to junior medical staff trying to manage the patient in the A&E department. Therefore, advice about viewing images systematically is offered, together with hints on the pitfalls which might be faced. This advice is patient- centred rather than image centred - an emphasis which makes the text different from others. Each chapter offers a summary of the key points it contains. The book will be of assistance to all medical and nursing staff working in the speciality of Accident and Emergency Medicine and also to those working in specialities which offer definitive care to injured patients. The contents of the book may also assist those wishing to study for higher examinations in Accident and Emergency, Surgery and Radiology, especially where the interpretation of images forms part of the examination.

This book is designed to provide a comprehensive and state-of-the-art resource for clinicians who care for patients with sepsis and research scientist alike, . Patients with severe sepsis requiring ICU admission have very high rates of ICU and overall hospital mortality, with estimates ranging from 18 to 50%. Risk factors for death from sepsis include underlying illness, increased age, and multi-system organ failure. This is compounded by the significant variation in the management of early severe sepsis. Care of these patients and clinical conditions can be quite complex, and materials are collected from the most current, evidence-based resources. Book sections have been structured to review the overall definitions and epidemiology of sepsis as well as current insights into the pathophysiology of sepsis. This review summarizes the evidence for the international consensus guidelines for the identification and management of sepsis. The latter part of this book reviews emerging concepts and approaches in the diagnosis and management of sepsis that may significantly reduce mortality in the future. Sepsis: Pathophysiology, Definitions and the Challenge of Bedside Management represents a collaboration between authors drawn from a variety of disciplines and contributions from basic scientists and highly recognized clinical opinion leaders with expertise in clinical trials.

This book provides insights into the care of cancer patients in the intensive care unit in a comprehensive manner. It provides an evidence-based approach to practitioners and postgraduate students to understand about the critical care needs of the patients suffering from malignancies. It helps the readers to develop critical thinking and encourage discussion towards improving the overall care of the patients and their families as their optimal management requires expertise in oncology, critical care, and palliative medicine and there is a dearth of books explaining about the special requirements and critical care needs of cancer patients. Each chapter is prepared by an expert in the field and contains well-prepared illustrations, flowcharts and relevant images. Chapters include latest evidence-based information which is useful for the readers. The book is useful for residents, fellows and trainees in the field of onco-anaesthesia, onco-critical care, onco-surgery, critical care and anaesthesia; practitioners and consultants in anaesthesia and onco-anaesthesia as well as intensivist, critical care experts and postgraduates in nursing.

Part of the Mount Sinai Expert Guide series, this outstanding book provides rapid-access, clinical information on all aspects of Critical Care with a focus on clinical diagnosis and effective patient management. With strong focus on the very best in multidisciplinary patient care, it is the ideal point of care consultation tool for the busy physician.

This text presents a basic guide of the principles and applications of ultrasound in the critical care setting. The text also addresses the basic and clinical uses of ultrasound, including clinical cases at the end of each of the 7 sections of the clinical subdivisions. The final chapters focus on the issues of training, certification, credentialing and billing. These discussions make the text unique, as literature regarding monetary and training issues for ultrasound in the ICU is sparse. Each chapter is written by experts in the field, and supplemented with illustrations and links to videos of actual ultrasound examinations in patients. Ultrasonography in the ICU: Practical Applications will be of great utility to critical care specialists in the disciplines of surgery, medicine, anesthesiology and emergency medicine. In addition this book can be used as a teaching tool for critical care fellows and residents interested in further training in ultrasound for the critically ill patient.

The critical care unit is an intense clinical environment with huge responsibilities on the professionals caring for these patients. Imaging is a key source of diagnostic information, but the conditions in which diagnostic imaging has to be performed are often extremely challenging and significantly different to imaging in the non acute setting. Imaging the ICU Patient reviews imaging procedures on the ICU in a highly practical and memorable manner. Swift and efficient clinical decision-making is rewarded on the ICU and this book serves as a practical handbook.

Because of his international prominence, Professor Khan has been able to gather an enviable list of experts in the field to contribute their experience with airway management in a multitude of clinical settings. The critical appraisal of the airway authored by the editor, Professor Khan, sets the stage for the important preoperative tests that may alert the clinician of the potential for a difficult airway so that appropriate plans can be made. The formidable "guest list" of authors spans the world and encompasses clinicians from Malaysia, the United States, Pakistan, India, Denmark, Singapore, Germany, Canada and Iran. What is equally remarkable is the list of topics discussed in the textbook and the varied clinical settings in which airway management is likely to pose particular and unique challenges: pediatrics; patients with cervical spine injury and those with traumatic brain injury; ambulatory surgery; patients with obstructive sleep apnea and obstetric patients. The book also addresses the latest in technological advances that can aid the clinician in diagnosing and managing the difficult airway, such as ultrasonography and also describes surgical approaches to managing the difficult airway, such as cricothyrotomy. Finally, underscoring the truly international appeal of the textbook and acknowledging the potential technological limitations of the developing world, a chapter is dedicated to the use of indigenous devices in managing the difficult airway.

The management of critically ill patients not only involves a bedside clinical assessment, but also a thorough daily review of investigations and monitoring. A detailed knowledge and understanding of data are an important part of training and practice in the day-to-day management of patients in intensive care. This book will play a useful role in the education of trainees, providing a source of real clinical data, with questions and answers, enabling them to test and develop their interpretation skills. Answers with explanations follow each question, providing instant access to the correct interpretation and additional information to enhance the readers understanding. Important review for anesthesia and critical care personnel who need to know this information for practice or for exams.

This book is an up-to-date, comprehensive review of the neuropsychiatry of multiple sclerosis and related diseases, by active authorities in the field, with an emphasis on diagnosis and management. Critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of demyelinating diseases is included, and unanswered questions are highlighted. Pharmacological aspects of management are discussed. Neuropsychiatric Symptoms of Inflammatory Demyelinating Diseases is aimed at neurologists, multiple sclerosis specialists and psychiatrists, and will also be of interest to intensive care doctors, psychologists ad neuropsychologists, research and specialist nurses, clinical researchers and methodologists.