Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.

A practical approach to the early detection and management of breast cancer This atlas provides radiologists with essential information for the differential diagnosis of breast diseases on the basis of clinical presentation, mammography, and ultrasound. It begins with chapters on tumor biology, prognostic factors, and histology. The authors then provide a thorough evaluation of various methods for early detection and accurate diagnosis, including analog and digital mammography, ultrasound, MR imaging, PET/CT, and interventional procedures. They discuss in detail the strengths and limitations of each imaging modality, aspects of quality control, test intervals, peri- and postoperative management principles, and follow-up care. Highlights: Presentation of difficult cases that effectively demonstrate the diagnostic hurdles and forensic pitfalls in breast diagnosis Special sections on breast cancer in men and young women, with discussion of women who are pregnant or lactating Color-coded practical tips and clinical notes for optimal comprehension of the material Extensive Q&A sections for self-testing in two major chapters More than 1,700 high-quality illustrations, including clinical color photographs, ultrasound images, and mammograms

Now in a greatly expanded and updated new edition: The essential pocketbook for rapid and correct differentiation and interpretation of signs and symptoms of neurological and neurosurgical diseases and conditions. Key Features: Exhaustive range of neurologic and neurosurgical disease and conditions covered Vital information presented in short texts, high-yield lists, and concise tables, for maximum efficiency in diagnostic work-ups Clinical and neuroimaging findings, guidelines and classifications, summarized in readily accessible tabular form Statistic overviews (common vs. rare, etc.) help guide diagnostic thought processes Special chapters highlight epidemiology, pediatric disorders, neuroradiology Differential Diagnosis in Neurology and Neurosurgery is ideal as a quick reference in your daily practice, or as an exam preparation guide. This wealth of easily accessed information makes it invaluable to experienced practitioners (especially ER physicians) and to novices alike. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Written by physicians skilled at coaching colleagues in physician-patient communication, this pocket guide presents practical strategies for handling a wide variety of difficult patient interviews. Each chapter presents a hypothetical scenario, describes effective communication techniques for each phase of the interaction, and identifies pitfalls to avoid. The presentation includes examples of physician-patient dialogue, illustrations showing body language, and key references.

This edition includes new chapters on caring for physician-patients, communicating with colleagues, disclosing unexpected outcomes and medical errors, shared decision making and informed consent, and teaching communication skills. Other new chapters describe clinical attitudes such as patience, curiosity, and hope.

Mosby's Pocket Guide to Pediatric Assessment offers a concise but comprehensive approach to health assessment for the pediatric client. It begins with a general description of history taking and includes approaches to children at various ages, nutritional assessment, and measurement and evaluation of vital signs. Emphasis is on "how to" information, including how and what to assess in each body system. Psychosocial, anatomical, and physiological development variations are incorporated as appropriate, as well as normal and abnormal findings. Given the extensive information provided, this reference is ideal for a broad range of nurses and students dealing with pediatric patients. Concise, portable size makes this book very handy for use in clinical settings. Presents content in an outline format for clinical practicality. Includes both psychosocial and physical aspects of assessment within a developmental framework. Body system organization facilitates retrieval of information. Highlighted clinical alerts call attention to potentially serious findings. Up-to-date growth charts are provided for birth through age 18. Extensively revised to reflect trends in pediatric nursing, up-to-date techniques, and current literature. A new chapter on assessment of mental health addresses growing areas of concern including school phobia, ADHD, depression, suicide, anxiety, and schizophrenia. New tables provide quick reference to common childhood symptoms (i.e., fever, diarrhea, vomiting). Updated coverage of immunizations (U.S. and Canada) includes information regarding relevance and normal timing of immunizations as well as most current published tables. Nursing diagnoses have been updated throughout.

Formal training in clinical neuropsychology introduces trainees to diverse patient populations with a variety of conditions and disorders. Learning to competently apply a structured, fact-finding approach to case conceptualization, differential diagnosis, and treatment planning is an essential goal at all levels of training. This approach provides a valuable exercise and method of examining practitioner competence. The structured approach to case analysis promotes good clinical decision making, and exercises based on such an approach can help prepare clinicians for the oral exams that are a part of board certification. The Neuropsychology Fact-Finding Casebook is a resource for both supervisors and trainees in clinical neuropsychology, as well as for clinicians preparing for board certification. The volume provides 24 compelling and diverse fact-finding cases, one for each month of a two-year residency. Each case is presented in a stepwise fashion: presenting problem and referral question, background information and patient report, behavioral observations, and test findings. At the end of each case, a summary, diagnostic impression, recommendations, and questions are provided to assess, reinforce, and teach core competencies; an outcome section describes what occurred after the full case evaluation is completed; and critical teaching points are discussed. This Casebook is a standardized approach to fact-finding that training programs at various levels can use to help trainees develop such evaluation skills.

This practical and highly accessible workbook allows students and practitioners-in-training to gain the skills and knowledge needed in order to conduct a comprehensive psychiatric mental status examination. This rich selection of pedagogical content, which includes case studies, activities, chapter glossaries, and study questions, reinforces the terms and concepts that are related to key assessment areas. Each chapter functions as a distinct unit and allows readers to pick and choose relevant material, and lays the groundwork to help clinicians effectively assess patients for potential psychopathology, suicidal or homicidal ideation, and psychosis. Written at an introductory level, the Fundamentals of the Psychiatric Mental Status Examination is an essential tool for students in health, nursing, occupational therapy, and social work programs, as well as any specialist employed in the areas of mental health and addiction.

Choosing wisely for better patient care. Lab Literacy for Doctors helps you make quick and efficient decisions about the right tests for typical clinical situations, thereby improving patient care. In a study published by the Journal of the American Board of Family Medicine (2014-03-01), primary care physicians reported that 15% of the time they are unsure about ordering lab tests and 8% of the time they are unsure about interpreting the results. This raises concerns about the need for more efficient and cost-effective lab test utilization. Lab Literacy for Doctors addresses these concerns in a practical, up-to-date, and easy-to-use format. Refer to this essential guide for: Diagnostic algorithms. A quick index summarizing the clinical utility of common tests. Advice and information on lab errors, false positives and negatives, and blood and tissue collection. Sections on dermatology, ENT and respiratory system, endocrine system, fatigue, GI and hepatic system, gynecology and pregnancy, routine screening, and more.

The opening chapter of The Essential Guide to Magnetic Resonance presents applications of Fluorine-19 Magnetic Resonance Imaging (19F MRI) in cancer research, tissue metabolomics, quantification of drug delivery, cellular tracking, tissue pH measurements and detection of 19F labeled cells. The authors review in vitro research applying 19F MRI and Magnetic Resonance Spectroscopy (MRS) to facilitate the synthesis, tracking and visualization of new fluorinated drug conjugates. 19F MRI also provides high contrast in vivo images due to the absence of an endogenous 19F signal, 100% natural abundance of 19F, and a chemical shift range of over 400 ppm. Afterwards, examples of current methods of magnetic resonance imaging (MRI) guided photodynamic therapy are presented. Recent development of MRI detectable nanoparticle constructs, magnetic resonance spectroscopy (MRS) sensors, gadolinium based photosensitizers and europium singlet oxygen probes are discussed. In addition, applications of Functional MRI using a blood oxygen dependent level (BOLD) MRI in monitoring photodynamic action are addressed, with the goal of informing researchers about the potential for using MRI guided photodynamic therapy and oxygen dosimetry. The applications of MRI within the sphere of pharmacy are analyzed; in particular, the use of MRI to track pharmaceuticals in vitro and in vivo noninvasively and monitoring their controlled-release. Functional MRI for noninvasive clinical brain imaging is explored as it is applied to studies of autism, schizophrenia, epilepsy Alzheimers disease, Parkinson's disease, traumatic brain injury and blood oxygenation-level dependent (BOLD) imaging of brain function. An overview of the scope of MRI as a diagnostic technique in neurology and in neurosurgery is also provided.

The knowledge of the morphofunctional features from the coronary microcirculation is essential for understanding its role in cardiac physiological work and in the pathogenesis of coronary microvascular dysfunction (CMD). The cardiovascular system comprises the heart and blood vessels, including arteries, veins, and capillaries, both systemic and pulmonary. Arterioles are the primary site of vascular resistance and have only one to two layers of smooth muscular walls. Chapter One will provide an overview of the coronary microcirculation, its functions and regulatory mechanisms. The importance of CMD will be summarised in the context of diverse clinic scenarios, considering its pathogenesis, assessment and therapeutic management. The purpose of Chapter Two is to understand the role of arteriolar endothelial dysfunction in CVDs and its underlying mechanisms. Chapter Three will explore the physiopathology, epidemiology, and the diagnosis and treatment of hypertensive retinopathy. Chapter Four reports on angiogenesis, a critical process for reproduction in mammals, which consists of arterioles and blood vessels formation from the existing ones.

This book is written for the primary care clinician to help update knowledge of pediatric endocrinology (with an emphasis on diabetes) from both ancient and modern times. The current and future shortage of pediatric endocrinologists necessitates steady, rejuvenated information on diabetes and other endocrine disorders for primary care clinicians as they care for the child and adolescent with complex endocrine dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric diabetes as well as understanding indications for referral to pediatric endocrinologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important.

The single-best guide to learning how to perform the diagnostic neurologic examination - enhanced by more than 80 online videos Presented in full color, DeMyer's provides neurologists and psychiatrists in training with a proven, didactic way to learn the complicated technique of using the physical examination to diagnose neurologic illness. This trusted classic also reviews the anatomy and physiology necessary to interpret the examination, and it details the laboratory tests and neuroimaging best suited for a particular clinical problem. You will also find complete, up-to-date coverage of the latest imaging modalities for assessing disease. Utilizing a learn at your own pace teaching approach, DeMyer's The Neurologic Examination features valuable learning aids such as: * Full-color illustrations that clearly explain neuroanatomy and physiology * Detailed tables and mnemonics to help you remember important steps and signs to look for during the examination * Learning Objectives to help you organize and retain important takeaways from each chapter * Questions and answers within the text to reinforce key points * Clear algorithms that reveal the differential diagnoses of common neurologic symptoms * NEW! More than 80 online clinical vignette videos If you are looking for authoritative, step-by-step guidance from experienced teachers/clinicians on how to perform an accomplished neurologic examination, your search ends with DeMyer's. Authors Jose Biller, MD is Chair of the Department of Neurology at Loyola University's Stritch School of Medicine, Maywood, Illinois Gregory Gruener, MD, MBA is Professor in the Department of Neurology and Director, Ralph P. Leischner, Jr. MD Institute for Medical Education at Loyola University's Stritch School of Medicine, Maywood, Illinois Paul W. Brazis, MD is Professor of Neurology in the Department of Neurology and Ophthalmology at the Mayo Medical School, and Consultant in Neurology and Neuro-Ophthalmology at the Mayo Clinic-Jacksonville, Florida.

A revision and reference text for pre-registration and postgraduate optometrists, covering procedures for investigating heterophoria, heterotropia, vergence and accommodative anomalies. The text covers the diagnosis of disorders of voluntary eye movement, nystagmus and supranuclear defects, paresis and non-paralytic incomitancy. Both motor and sensory anomalies are discussed together with syndromes involving oculomotor anomalies. Clinical management is outlined in protocols in an easily assimilable form. The second edition has additional information for final year undergraduates. Amblyopia treatment has been extended to cover new American optometric methods. Strabismus surgical techniques are now included. There are two new chapters on vision training and case management which will interest optometrists and orthoptists involved in sports vision and in developmental vision therapy. Pre-registration optometrists will find the chapters on routine orthoptic assessment and the PQE examination of particular interest.

Accurately identify complex geometrical distortions of cardiac anatomy and make more informed decisions regarding diagnosis and treatment with Atlas of 3D Echocardiography. This new cardiology reference presents the authoritative, case-based, expert guidance you need to enhance your utilization and interpretation of this cutting-edge, dimensional diagnostic tool. Master the application of techniques to specific clinical situations with detailed case studies and discussions of challenging issues. See imaging findings as they appear in practice and discern subtle nuances with the aid of high-quality still images plus online videos. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of images and figures that facilitate visual learning. Take it with you anywhere! Access the full text, downloadable image library, videos, and more at www.expertconsult.com. Sharpen your interpretive and diagnostic skills in 3-D echo!

This book presents topical research in the study of the procedures, types and complications of biopsies. Topics included in this compilation are the historical evolution of the sentinel node biopsy; temporal artery biopsy; the value of FDG PET/CT in guiding bone marrow biopsy procedures in the initial evaluation of lymphoma patients; biopsy procedures in the diagnosis of IgG4-related sclerosing cholangitis; the options and techniques in the biopsy of musculoskeletal tumours; computed-tomography guided percutaneous biopsy; and lymphatic mapping and sentinel lymph node biopsy in early-stage cervical cancer.

Hearing the patient's story, asking the right questions, and doing a careful, thorough and informed physical examination are intrinsic to good medicine. It is easy to rely and become dependent on technology to diagnose and to treat our patients. Yet, no machine will ever be a match for a listening ear and the laying on of hands. These skills are core to the art of medicine and require practice. It is only by becoming familiar with the norm that we can appreciate the norm. This book is a clinical skills textbook with a third dimension -- the human factor. We read about real people, real symptoms and real diagnostic problems. It doesn't waste time on rare physical signs that will never be encountered but instead, focuses on common, important clinical skills and symptom patterns.

Stroke is the leading cause of permanent disability, including post-stroke dementia, pain, depression, and personality changes. While large clinical trials reflect information about large stroke populations, the presentation of each and every stroke patient is individual and special. More Case Studies in Stroke presents a new selection of stroke cases from seven countries prepared by practising stroke physicians. The book includes both common and unusual cases, as well as misleading cases of diseases mimicking stroke. The aim is to reinforce diagnostic skills through careful analysis of individual presenting patterns, and to guide treatment decisions. Each case consists of a clinical history, examination findings and special investigations, followed by diagnosis and discussion. The outline of the actual diagnostic process, including the use of modern diagnostic tools, decision making and course, challenge the reader at all stages of their career from medical students to neurologists and stroke physicians.

Predictive, preventive and personalised medicine offers great promise for the future practice of medicine. Essential components of this approach include well-organised population screening protocols utilising novel diagnostic biomarkers of disease states, targeted prevention of common human pathologies, optimal treatment planning and personalised medicine thereby resulting in substantial improvement of the quality of life. This approach also offers the advantage of delivering care at potentially reduced costs to the population at large thereby addressing social and ethical issues related to access to and affordability of health care. Consequently, conventional medicine and new branches of biomedicine are currently challenging many issue-related questions: Should molecular diagnostic approaches be considered complementary or substitutive measures to conventional approaches? How reliable are biomarkers for any given pathology? How to distinguish between the highly predictive power of innovation and quackery in diagnostics? How to overcome currently well-recognisable (inter)national barriers in knowledge transfer? How to correctly educate the new generation of experts in bio- and predictive medicine? The book addresses these highly relevant issues and provides some clues for plausible solutions. The information presented in this book emphasises the necessity of individualised patient treatment and provides compelling reasons as to why "across-the-board" treatment is not warranted. Application of nutritional proteomics results in individualised optimal diet and may potentially restrict the epidemic scale of type 2 Diabetes mellitus. A broad distribution and a routine clinical utilisation of these advanced technological approaches could enable a significant portion of the population to reach the 100-year age limit yet remaining vibrant in excellent physical and mental health and as actively contributing members of society. The examples given in the book are based on well-recognised expertise, scientific publications and international patents. A panel of leading world experts and authorities of the international issue-related associations have contributed to the book by addressing relevant issues and topics such as model-based patient-care and individualised therapy-planning, reproductive medicine and postnatal diagnostics, early/predictive diagnosis and optimised treatment of cancer as well as the most frequent neurodegenerative disorders.

Psychiatric diagnosis is one of the most important topics within the broad field of psychiatry. Clear, accurate definitions of the various disorders are essential for clinicians around the world to be confident that they are classifying patients in the same way, thereby enabling comparisons of treatment regimens and their outcomes. There are two major classification systems in use, one produced by the World Health Organization, the WHO International Classification of Diseases, Mental Disorders Chapter, and one by the American Psychiatric Association, the well known Diagnostic and Statistical Manual of Mental Disorders. Both of these are being revised so this book from the prestigious World Psychiatric Association is especially timely.

In this book, leading experts in the field provide a broad and integrated coverage of the concepts, structure and context of psychiatric diagnosis. It begins by addressing mental health and illness around the world from historical, philosophical and cultural perspectives. Health is approached comprehensively, to include such aspects as resilience, resources and quality of life. The book then covers major specific psychopathology topics in Section II, including new categorizations and dimensional approaches. Section III concentrates on the complex problem of comorbidity, a primary challenge for modern diagnostic classifications in psychiatry. Finally, Section IV reviews emerging international diagnostic systems in psychiatry, considering innovative models and adaptations.

This book will be essential reading for anyone involved in the diagnosis of psychiatric disorders.

The increasing pressure upon clinicians to see more and more patients generates great concern as to how to offer a comprehensive and thorough diagnostic approach and yet maintain efficiency. Neurologic Differential Diagnosis is the answer. Unlike other texts which are divided into disease entities, this book uses a case study approach to focus on the patients' symptoms. Each chapter is dedicated to a specific presenting symptom or sign and includes a comprehensive, yet succinct table of clinical features to aid clarification of the broad list of diagnostic possibilities. This allows the clinician to quickly reference specific symptoms such as dizziness, mental status change or diplopia; or signs such as foot drop or psychotic behavior, and then immediately generate diagnostic possibilities. Written from the authors' extensive clinical experience, Neurologic Differential Diagnosis is an invaluable text for neurologists and psychiatrists at all stages of training.

The third updated and revised edition of Differential Diagnosis in Conventional Radiology provides essential information to make conventional x-ray an effective tool in diagnosing disorders affecting the bones and joints and the thoracic and abdominal body segments. The book is organized according to classifications of radiologic findings rather than disease, enabling the reader to approach diagnosis in a way that reflects the actual clinical situation. Concise and comprehensive tables outline key information on diagnosis and differential diagnosis. Highlights: The unique organization of chapters based on radiologic findings mirrors the situations encountered in daily clinical practice Easy-to-reference tables classifying findings, diagnosis, and differential diagnosis and providing important clinical data are perfect for an at-a-glance review More than 2000 radiographs and schematic diagrams help to guide the reader toward the most likely diagnoses The third edition of Differential Diagnosis in Conventional Radiology contains an updated and revised section on radiology of the abdomen combined with the complete text from the recently published books Bone and Joint Disorders and The Chest X-Ray by the same authors. An exceptional reference work to have on hand, Differential Diagnosis in Conventional Radiology will benefit radiologists and specialists seeking to improve their skills in diagnostic imaging and will also be of great interest to residents preparing for their specialist examinations.

Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications. This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.

Medical Response to Adult Sexual Assault, Second Edition provides evidence-based research on diagnosis, treatment, and examination in cases of sexual violence and assault. Survivors of sexual assault face any number of unique challenges both on the path to physical and psychological recovery and in navigating the investigative and judicial processes related to their traumatic experiences. Medical practitioners who work with these survivors require informed expertise in order to support their patients' safety and personal well-being. The authors and contributors, a team of expert physicians, nurses, attorneys, and other multidisciplinary practitioners, have fully revised and updated Medical Response to Child Sexual Abuse to reflect contemporary best practices in the investigation and treatment of sexual violence. Any professionals who work with victims of sexual assault will find this latest edition essential to their responsibilities and to the renewed well-being of those in their care.

Manual of Therapeutics for Addictions

Edited by Norman S. Miller, MD, Mark S. Gold,MD, and David E. Smith, MD

Here is a much-needed practical guide to the effective diagnosis and treatment of alcohol and drug addictive disorders. Designed to meet the diverse needs of family and primary care physicians, psychiatrists and mental health professionals, and medical students and residents, this authoritative text offers clear, step-by-step recommendations on the selection and application of both pharmacological and psychosocial therapies. Arranged in an easy-to-use outline format, Manual of Therapeutics for Addictions:

• Covers the pharmacology, neurochemistry, and treatment options for alcohol and such drugs as marijuana, cocaine, and opiates
• Includes material on eating, sexual, and gambling addictions
• Contains age-, cultural-, and gender-specific information for diagnosis and treatment
• Addresses relevant medical complications and psychiatric interactions
• Features contemporary topics such as managed care, minority concerns, and forensic issues