Tools, techniques, and progress in cancer biomarkers discovery
The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers. This book provides a comprehensive overview of current methodologies and technologies. It discusses biomarker discovery as a whole, rather than focusing on one specific marker or cancer. With information on both existing and potential biomarkers, Cancer Biomarkers: Analytical Techniques for Discovery:
* Provides insights into the current technological platforms for biomarker discovery, including mass spectrometry combined with multidimensional chromatography, DIGE, and various chip technologies
* Includes a detailed discussion of protein networks and protein phosphorylation in cancer
* Details the use of imaging mass spectrometry, laser capture microdissection, serial analysis of gene expression, enzyme-linked immunosorbent assays, protein microarrays, antibody-based microarrays, and bioinformatics
* Covers the emerging role of surface-enhanced laser desorption ionization (SELDI) and various tagging and labeling strategies
* Discusses related regulatory and ethical issues
With a wealth of information that can be applied to a broad spectrum of biomarker research projects, this is a core reference for biomarker researchers, scientists working in proteomics and bioinformatics, pharmaceutical scientists, oncologists, biochemists, biologists, and chemists.

Fully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers the basics of x-rays, ECGs and other key areas. A new chapter on the eyes is included along with the sections on body language and non-verbal communication, and the section on practical procedures has been expanded. This handbook will help to ensure you have the confidence and skill to carry out an 'A' grade examination every time.

Volume 1 of the Child Maltreatment Assessment focuses on supplying the reader with the skills to identify and respond to the physical indicators of child maltreatment. With its inclusion of 17 case studies and dozens of high-quality images, this assessment serves to help readers differentiate between abusive and nonabusive injuries. Chapters include topics pertaining to different forms of physical abuse, such as skeletal injuries, abusive head trauma, and how to respond to pediatric poisoning cases. By seeing examples of abusive scenarios and injuries they may encounter in the field, professionals and students alike will be better prepared to respond to cases of maltreatment in the future. Each workbook in the Child Maltreatment Assessment series will also feature both a test section and photographic atlas at the back of the book. Using this assessment, the reader can review and apply the knowledge they have gained from the chapters within, making this text ideal for self-study or classroom settings. The photographic atlas will contain an additional 80 high-quality images with accompanying case histories.

Volume 2 of the Child Maltreatment Assessment serves to help readers identify and interpret sexual, emotional, and psychological forms of abuse in children by providing chapters on the topics of sexual abuse, neglect and abandonment, torture, and more. While sexual abuse typically has some physical indicators, many cases of emotional and psychological abuse do not. By providing detailed examples and descriptions of abusive scenarios and injuries that readers may encounter in the field, this workbook aims to better prepare experienced professionals and students alike. This assessment is supplemented with 16 case studies and dozens of full-color clinical images, guiding readers through the potential indicators of sexual, emotional, or psychological abuse, better preparing them to respond to cases of maltreatment in the future. Each workbook in the Child Maltreatment Assessment series will also feature both a test section and photographic atlas at the back of the book. Using this assessment, the reader can review and apply the knowledge they have gained from the chapters within, making this text ideal for self-study or classroom settings. The photographic atlas will contain an additional 80 high-quality images with accompanying case histories.

With major advances in technology there are thousands of clinical and laboratory tests available, forming a key part of the diagnostic process in the highly complex field of modern medicine. This handbook provides a patient-orientated approach to investigation, with a comprehensive review of specialty-related tests. Written in the Oxford Handbook style, this book features references and up-to-date website links for extra clinical detail. This new edition has been revised to include the most recent developments in investigatory tests, with clear step-by-step instructions and updated illustrations to provide greater clarifying background to the text. Written by an experienced team of active clinicians, this is invaluable for junior doctors as a quick reference, as well as senior medical students preparing for examinations.

Gout has become increasingly prevalent in recent years, and is now the most common form of inflammatory arthritis. There have been significant developments in our understanding of the basic biology of gout over the last decade, and major advances in therapeutics have provided successful treatments for acute attacks and long-term prevention, offering clinicians effective treatment options for their patients. Part of the Oxford Rheumatology Library series, Gout provides an up-to-date summary of the pathogenesis, clinical features, and treatment approaches to this condition. The main focus is on key aspects of the biology of the disease, relevant diagnostic tools, and principles of gout management. Practical information is included to guide safe and effective prescribing of gout medications. Chapters on imaging and the future of gout management are also included. The three authors are experts in the basic biology and therapeutics of gout, and have summarized key practice points in a concise and readable manner, making this comprehensive yet practical volume an essential resource for all rheumatologists and general practitioners.