This book is for all those entering general surgical training. It explains the reasoning involved in recognizing and dealing with general surgical conditions and pays special attention to managing surgical emergencies and trauma patients. It is also intended to serve as a practical guide to safe and effective day-to-day surgical practice. The content is laid out logically so that a patient can be followed from a working diagnosis, through investigation and assessment, preparation for surgery, care in the operating theatre and afterwards, including the prevention and treatment of complications. Throughout, factors are identified which affect surgical outcome and which are important in surgical audit and quality control. It is not meant as a textbook of diagnosis, or an atlas of operative surgery; however, it does cover the principles of both, as well as details of the common operations trainees are likely to have to perform. Each chapter concludes with a few key references to classic papers, books and review articles. Philip Deakin, a medical artist and GP, has illustrated tha book throughout. Clive Quick and Paul Thomas are recent past members of the Court of Examiners for the Royal College of Surgeons of England and have planned the book to meet the requirements of the new syllabus for the higher general surgical qualification. Their team of contributing authors is made ip of senior trainees and recently appointed consultants who provide a clear and focused perspective, reflecting their recent experience or the training process.

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

There is a widespread view that modern medicine is primarily a scientific enterprise and that the decisions of clinicians follow from evidence-based science. In terms of this view the need for clinical judgement is minimal. The aims of this book are to make a case for the centrality and irreplaceability of clinical judgement, to identify the elements of good clinical judgement, and to suggest how these might be developed by using the humanities in medical undergraduate and postgraduate education. The authors argue that good clinical judgement requires both technical evidence and a humane attitude. But technical evidence is not always quantifiable or even scientific; it can be like that of the detective or the literary scholar. A humane attitude involves ethical sensitivity, but also a broad educated perspective which can be derived from the arts. The authors illustrate their argument by examining decisions made by doctors in clinical situations, in public health, and (in a chapter contributed by a hospital consultant) in resource management. About the authors: Robert S. Downie is Professor of Moral Philosophy at Glasgow University since 1969. He is a member of the BMA Ethics Committee and co-editor of the Journal of Medical Ethics. He has published extensively in the field of medical ethics. Jane MacNaughton has recently taken the position of Director of Centre for Arts, Humanities, Health and Medicine at the University of Durham. Previously she was Clinical Lecturer in General Practice at Glasgow University and a part-time GP.

Magnetic Resonance Procedures: Health Effects and Safety is the first authoritative text on MR procedures and its associated health and safety concerns written by noted radiologists, physicists, and scientists with expertise in the field. It contains both theoretical and practical information.

This timely text discusses emergent issues related to MR imaging and concerns such as shielding, the safe use of contrast agents, and management of patients with claustrophobia, anxiety, and emotional stress. It also contains a sample pre-MR screening form; comprehensive safety information for over 700 implants, devices, and materials; a list of medical devices and products for interventional MR procedures; and a summary of peer-reviewed MR safety studies.

In the wake of recent government demands for increased patient safety in hospitals, along with the rapidly expanding use of MRI, this book is particularly important. It is the definitive resource for information on the safety aspects of magnetic resonance procedures.

Diagnostic radiology plays a vital role in patient management and all clinicians need to be able to recognize the radiological appearances of many medical conditions. Not only are traditional imaging techniques important, but newer techniques such as interventional radiology, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine and ultrasound are increasingly important in clinical practice and also, the interpretation of radiological images is an integral part of professional examinations for MRCP (part II): there are five compulsory questions based on printed photographic material, with additional radiographs or other diagnostic images being shown occasionally throughout. This book covers all modalities in radiology, providing a guide to the principles of plain radiographic film interpretation and an understanding of the roles and limitations of more complex imaging across general medicine. The material is presented through the discussion of a hundred fully-illustrated cases in question and answer format.

Rapidly Progressive Glomerulonephritis is one of the most exciting areas in renal medicine. However, appropriate immunosuppressive therapy can dramatically improve the prognosis in many cases, such that renal failure is avoided. It is clear now that various immunopathological processes are involved, and that an accurate diagnosis is of value in guiding management. This volume aims to bring together current knowledge of both scientific and clinical aspects of RPN. Recent advances in the immunology, inflammatory mechanisms and pathology of RPGN are discussed. This is followed by consideration of the major causes of RPGN, which include Goodpasture's disease, primary systematic vasculitis and systematic lupus erythematosus. RPGN secondary to other renal and systemic diseases, and RPGN in children are also described. Finally, new approaches to treatment are reviewed. Although certain of these areas are covered in the larger textbooks of renal medicine, our aim is to provide a current overview of RPGN, in a concise volume. This should be of particular interest to nephrologists and general physicians, including those in training, but may also be of value to pathologists, immunologists, and other studying the mechanisms of renal disease. We hope that this volume will help them in the management of patients with RPNG, or in planning their research into this condition.

'...approaches the consultation intuitively ... The book oozes with patience for the patient and for the reader. What better prescription for the clinic could the practitioner need?' Glycosmedia (of the Fifth Edition) '... this is a book worth having available at the point of care for health professionals, including doctors, nurses, undergraduates and postgraduates, to help them make sense of common symptoms. With the help of the authors' opinions in combination with our own experience we should then be able to make better clinical decisions.' Sultan Qaboos University Medical Journal (of the Fourth Edition) Across its six editions, Symptom Sorter has excelled in redressing the balance between symptoms and diagnoses to become the essential handbook to accompany the consultation in primary care. Presenting a multitude of symptoms commonly encountered in primary care, these are meticulously explored using the red flags, top tips and ready reckoner format for sorting symptoms that have made previous editions so popular and respected. This revised and updated sixth edition includes several new chapters and features expanded coverage of paediatric symptoms. Key features: * Fully updated, with 'investigations' sections amended in line with latest guidelines and significant revisions throughout * Brand new chapters on acute abdominal pain in childhood, hand and wrist swellings, diarrhoea in children, loin pain, rectal bleeding in children, vomiting in babies, skinfold rash and dysuria * Consistent and logical presentation enables speedy access * Replicates accurately the experience in the consultation or clinic An invaluable reference for all general practitioners, especially GP trainers and registrars, this new edition of Symptom Sorter is also highly recommended for advanced nurse practitioners, A&E nurses and pharmacists requiring a concise, easy-to-use guide. The authors: Keith Hopcroft is a GP in Basildon, Essex, UK, an associate trainer, an editorial adviser to Pulse, and a medical writer and columnist. Vincent Forte is a former GP based in Norfolk, UK

Many inherited diseases and non-herediatry disorders have in common the development of renal cyctic disease. The most common, autosonal dominant polycystic kidney disease, is responsible for 5-10% of end-stage renal failure treated by dialysis or transplantation.
Since the publication six years ago of the last book on polycystic kidney disease, a number of genes causing the disease have been identified, mapped, or sequenced; new experimental models and the application of molecular biology techniques have provided new insights into the pathogenesis of polycystic kidney disease; novel clinical studies have provided valuable information for the prevention, evaluation, and treatment of the complications of this disease. This book provides an updated, state-of-the-art review of the genetics, pathophysiology, evaluation, and management of these diseases and will be of interest to both basic researchers and clinicians in nephrology.

Dialysis amyloidosis is a syndrome observed in dialysis patients characterized initially by joint pain, followed later by joint destruction. It is at present one of the few compliations in these patients. The factors involved in the genesis of this syndrome are not yet known with certainty and there is as yet no proven efficacious treatment otehr then renal transplantation. As a result, the interest in this topic among nephrologists remains very high. Dialysis amyloid gives general information on the pathophysiology, and the clinical aspects of all types of amyloidosis. It then goes on to discuss recently discovered B2, type of dialysis amyloidosis, from clinical and pathological features to physiological and pathophysiological aspects of this serious complication which effects patients suffering from chronic renal failure. This book will give nephrologists and rheumatologists a clear understanding of the dialysis amyloidosis syndrome as well as making a valuable contribution to identifying strategies for treatment and prevention. This book is intended for consultant nephrologists, trainee nephrologists.

This book introduces the reader to the basic skills necessary for good communication between doctors (and other health professionals) and patients. The practical importance of such skills is outlined, making the doctor much more effective in all fields of medicine. This is not a book for the specialist reader, but aimed at all those who need to talk with patients.

The last ten years have seen an increase in travel to tropical countries and, as a consequence, infections such as malaria and schistosomiasis are more common. It is therefore essential that physicians, microbiologists, and scientists are familiar with the diagnosis of these parasitic diseases. There is a growing recognition of the importance of "temperate" parasites, and this has been emphasized by the HIV epidemic.
This book is a practical manual for use in both routine diagnostic microbiology laboratories and more specialists laboratories diagnosing human parasites. All of the major groups of parasites are dealt with in individual chapters which include detailed protocols and recommendation for the diagnosis of infections caused by those parasites, together with color and black and white illustrations. The authors provide information and practical guidance appropriate for both the developed and developing world. This informative new book will be of great use to clinical pathologists, laboratory technicians, and students and researchers in tropical medicine.

Volatile biomarkers play a significant signalling role in communication between biological cells living as individual entities or as mini-societies that sense, respond and adapt to changes in their environment. In this process, volatile biomarkers can leak into the blood, from which they can be secreted into most body fluids (blood, breath, skin, urine, saliva, feces, etc.), from which sensing devices can capture and interpret their chemical fingerprint to reflect any association with health disorders in a fast, easy, and minimally non-invasive manner. This book introduces the concept of biomarkers within the body in terms of basic and translational sciences. It starts with a comprehensive review of the expression and mechanistic pathways involving volatile biomarkers at single cell and (micro)organism levels, cell-to-cell and cell-to-organism communications, and their secretion into body fluids. It discusses several ways for discovering and detecting the secreted biomarkers using mass spectrometry and other spectroscopic techniques. This is followed by an appraisal and translation of the accumulating knowledge from the laboratory to the Point-of-Care phase, using selective sensors as well as desktop and wearable artificial sensing devices, e.g., electronic noses and electronic skins, in conjugation with AI-assisted data processing and healthcare decision-making in diagnostics. The book offers an outlook into the challenges in the continuing development of volatile biomarkers and their wider availability to healthcare, which can be substantially improved. It should appeal to research groups in universities, start-up and large-scale industries associated in all aspects of biomedicine.

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The "Evidence Base of Clinical Diagnosis" has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.

With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

There is currently a great deal of interest in patients with functional somatic symptoms--physical complaints which are not explained by organic findings--but until now there has been little information available on the principles and practical methods of their treatment. This book covers all the key topics in the management of somatic disorders, and will be invaluable both as a comprehensive reference and as a practical clinical guide. The authors have included material on the problems specific to children and the elderly, the organization of service provision, as well as the clinical syndromes characteristic of somatic disorders such as hypochondriasis, chronic pain, chronic fatigue, and low back pain.
Treatment of Functional Somatic Symptoms is the first comprehensive, authoritative and practical guide on the management of a wide variety of medically unexplained symptoms encountered frequently in all areas of primary and hospital care. The book will be useful to clinicians and to research workers as a source book and a clinical manual.

Acute Medical Algorithms is an original and compact text designed to aid the clinician in dealing with acute medical conditions. The book includes 70 algorithms - either problem-orientated or related to specific conditions - together with complementary notes and references. It will therefore be relevant to all grades of hospital doctor, and to medical students and general practitioners also.

This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.

Clinical Skills, Second Edition, is a practical and comprehensive guide to history taking, examination, and interpretation of results for medical students, junior doctors, and nurse practitioners. Written with wit and clarity, and packed with illustrations, this book will teach you how to join the dots between signs, symptoms, and diagnoses. This textbook sets out invaluable routines for the examination of each system, and includes chapters on interpreting chest x-rays and spot diagnosis. Over 500 line drawings and colour photographs give practical examples of core and advanced examination skills. Throughout the text, key points and tips dispense essential wisdom, while case studies help you to put theory into practice. This new edition of Clinical Skills is now more useful than ever in your preparation for finals. Each chapter ends with a short set of assesment questions and a section on how the system in question is tested in OSCEs. Even better, the chapter on finals has been expanded and updated to give more practical advice than ever before. Written in plain English and designed to demystify even the most daunting procedures, Clinical Skills, Second Edition is the ultimate all-round textbook to help you hone your skills and prepare for finals.

A practical guide to the diagnosis and treatment of acute symptoms and conditions, the "ABC of Emergency Differential Diagnosis" provides a step-by-step guide to emergency differential diagnosis for non-specialists in a hospital or primary care setting.

This new title in the "ABC" series covers the assessment, diagnosis, treatment, and management of the most common symptoms with 'walk through' diagnosis, clear learning outcomes, and easy to find treatment options.

Using the familiar problem-based teaching approach for rapid assimilation of information, case studies in each chapter allow the reader to be sure that they have synthesised the information given and can apply it to clinical cases.

This newly updated, step-by-step guide to the key points of conducting the GYN exam addresses everything both busy nurse practitioners and NP students need to know, from basic procedures to high-level challenges. Part I breaks down the GYN exam into clinical parts, emphasizing strategies to decrease anxiety and minimize discomfort at every stage of the exam. Part II walks the caregiver through the exam for women at every stage of the life span, sexually abused women, obese women, and women who have undergone genital mutilation. This second edition delivers an all-new chapter on providing care to transgender and LGBT women and also includes new information on intimate partner violence and working with adolescents and menopausal and older women. Comprehensive and organized for easy access to information, the book features prominently displayed key points, learning objectives, and ""Fast Facts in a Nutshell"" boxes based on the authors' more than 40 years of teaching experience. Along with the most up-to-date information on STIs, Pap guidelines across the life span, and recommendations on the well-woman exam, this concise guide comes with a wealth of essential resources, including links to instructional videos and free apps for patient and practitioner education, adding to the book's value as an indispensable, quick-access guide to delivering excellent holistic care to women. New to the Second Edition: New chapter on examining the transgender and LGBT woman Latest information on intimate partner violence Updates on examining adolescents and menopausal and older women New information on female genital mutilation New CDC STD, PAP, and ACOG Guidelines Links to instructional videos Free apps for patient and practitioner education Key Features: Delivers easy-to-read, bulleted information in a convenient pocket size Provides learning objectives, key points, and Fast Facts in a Nutshell Includes tips on examining special populations including obese, anxious, multiparous, pediatric, menopausal, and older patients and transgender/LGBTQ Serves as a refresher for those studying for the WHNP Exam This book was originally published under the Fast Facts series by Springer Publishing Company.

Five Stars. "Best book available if you want to learn about molecular techniques applied to clinical pathology." - Ruben A., Amazon Reviewer Five Stars. "Easy read. helped me to pass ASCP molecular bio certification exam." - Amazon Reviewer The only book you need to become certified. "Excellent book, full of details and clinical information. In addition, it describes very complexed concepts in a very easy way to understand including comprehensive diagrams." - Ruben G., Amazon Reviewer MB(ASCP) must read. "This is a must read for those laboratory professionals trying to advance their knowledge in molecular diagnostics especially for those people taking the MB(ASCP) exam. Sure it helped me pass the exam." - JR, Amazon Reviewer Meet the challenges of this rapidly expanding field: Molecular diagnostics continues to grow in importance in the clinical laboratory. This respected text will prepare your students with a grounding in the fundamental principles of molecular biology. current methods, and their clinical applications. With a focus on the application of molecular concepts to diagnostic purposes, the text explains and illustrate the use and interpretation of molecular-based assays in patient care. Now with an expanded discussion of nucleic acid sequencing, with added emphasis on next generation sequencing (NGS), and updated coverage of proteomics and mass spectrometry applications, your students will have the most current information available today.

Best of Five MCQs for the MRCP Part 1 volumes 1-3 offers a comprehensive and trustworthy solution to anybody wishing to sit, pass, and excel at the Membership of the Royal College of Physicians Part 1 examination. Presented as a unique three-volume set, each volume features 375 high-quality practice questions on each of the medical systems and specialties in alphabetical order. Volume 1 features 375 Best of Five questions on clinical sciences, clinical haematology and oncology, cardiology, and clinical pharmacology, therapeutics and toxicology. All 375 questions contain questions written and reviewed by successful candidates and previous examiners, and are accompanied by detailed explanations and further reading, ensuring complete and successful revision for this challenging exam. Matched to the latest Royal College curricula in coverage and format, this dedicated resource provides readers with an accurate, authoritative and evidence-based companion to the MRCP Part 1.

This book disseminates information on paper-based diagnostics devices and describes novel paper materials, fabrication techniques, and Basic Paper-based microfluidics/electronics theory. The section on sample preparation, paper-based electronics/sensors for developing paper-based point-of-care (POC) systems also contains detailed descriptions. In the application sections this book covers sensing technique for DNA/RNA, bacteria/virus and integration of lateral flow assay. The book provides deep understanding and knowledge of paper-based diagnostic device development in terms of concept, materials, fabrication and applications.

Sexual problems are a major cause of personal distress and marital breakdown, affecting as many as one in ten of the general population. The author, who has had extensive clinical, research, and teaching experience in the field of sexual dysfunction, has written a very practical account of the nature, causes, assessment, and treatment of sexual problems. The various stages of treatment are described in sufficient detail for therapists who are about to start sex therapy. Experienced therapists will also find this book a source of useful advice. The treatment approach includes behavioural, psychotherapeutic, and educational techniques. In addition to the treatment of couples, the management of sexual problems of individuals without partners, and of the phsyically disabled, are also described. Practical guidance is backed up by research findings. This book is an up-to-date, straightforward, and practical account which should be of considerable interest to anyone involved in the management of sexual problems.

Thousands of high-quality clinical photographs paired with authoritative clinical content make Zitelli and Davis' Atlas of Pediatric Physical Diagnosis the trusted, go-to resource for residents and physicians alike. In this thoroughly revised 8th Edition, Drs. Basil J. Zitelli, Sara C. McIntire, Andrew J. Nowalk, and Jessica Garrison, provide a much-needed visual perspective on pediatric illness, helping you hone your visual examination skills and improve your diagnostic accuracy. Features more than 3,000 color photographs supplemented by clear explanatory text, laboratory tests, tables, algorithms, imaging, and approximately 25 clinical videos. Emphasizes pertinent historical factors, examination techniques, visual findings, and diagnostic methods. Provides meticulously updated content throughout, including an extensively revised ophthalmology chapter. Discusses key topics in pediatrics such as development, child abuse, and adolescent gynecology. Covers both common and uncommon disorders, making it an excellent resource not only for clinical diagnosis, but also for studying for the pediatric boards. Lists actionable and practical references, bibliographies, and resources at the end of each chapter. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.