As the title suggests this book has been written to assist manual therapists to understand and hone the palpatory skills which are essential to their effectiveness as practitioners. Skilful palpation is the foundation stone of all effective manual therapy assessments and treatments. The ability to use subtle and sensitive touch to examine and assess patients is essential for an accurate interpretation of the underlying problems of fascial and muscle function. The accurate interpretation of palpatory findings is difficult and comes with experience. This book aims to increase awareness of how to palpate and understanding of what is being felt. In this fourth edition of his now well-established and much loved book Leon Chaitow has introduced references to the latest research findings relating to fascia and its role in health and disease, so that practitioners can apply this knowledge in interpreting what they palpate. In addition to the author, six notable contributors from Europe and North America enhance the work's range and authority. All manual therapists, whatever their professional background, will benefit from the wealth of experience- and research-based information presented in this book.

The diagnosis and treatment of benign prostatic hyperplasia (BPH) is considered to be one of the most important topics in urology and afflicts millions of older men world-wide. Although it is not life threatening, its clinical manifestation as lower urinary tract symptoms (LUTS) reduces the patient's quality of life over many years. Patients often suffer from LUTS due to BPH for a long time. If left untreated, the patients are at significant risk of potentially severe complications. Over the last decade, new diagnostic approaches and treatment options such as prostate lasers have become more accepted in the urological community. This pocketbook provides an update of several aspects related with BPH / LUTS and covers the entire background, diagnostic process and treatment options available to patients suffering from LUTS due to BPH. It will give trainees in urology and general physicians a quick, concise but complete overview of diagnostic processes and recommended treatment options.

Today most of immunochemistry methods for the determination of proteins, peptides, drugs, and many small molecules are fully automated, with good precision, excellent sensitivity and short reaction time. However, inaccuracy due to poor standardization and the presence of interfering substances in biological samples is still a serious and life-threatening issue. Proper validation of methods and quality assurance have little effect on frequency of occurrence of false positive or false negative results, which, if unrecognized, may lead to patient's misdiagnosis, unnecessary treatment or even unnecessary surgery. Deep knowledge of basic principles of immunochemical methods (antigen-antibody reaction, standardization, matrix effect, limit of detection, cross-reactivity, etc.), sources of analyte-independent interferences (preanalitycal errors, the presence of binding proteins, the presence of autoantibodies) and analyte-dependent interferences (presence of heterophilic antibodies, high-dose effect) are very important to understand, detect, reduce and/or eliminate the interferences. This book helps to reduce false results and, at the same time, improve patient's care and patient's safety.

This groundbreaking book explains prognosis from the perspective of doctors, examining why physicians are reluctant to predict the future, how doctors use prognosis, the symbolism it contains, and the emotional difficulties it involves. Drawing on his experiences as a doctor and sociologist, Nicholas Christakis interviewed scores of physicians and searched dozens of medical textbooks and medical school curricula for discussions of prognosis in an attempt to get to the core of this nebulous medical issue that, despite its importance, is only partially understood and rarely discussed.
"Highly recommended for everyone from patients wrestling with their personal prognosis to any medical practitioner touched by this bioethical dilemma."--"Library Journal, " starred review
" T]he first full general discussion of prognosis ever written. . . . A] manifesto for a form of prognosis that's equal parts prediction-an assessment of likely outcomes based on statistical averages-and prophecy, an intuition of what lies ahead."--Jeff Sharlet, "Chicago Reader"
" S]ophisticated, extraordinarily well supported, and compelling. . . . Christakis] argues forcefully that the profession must take responsibility for the current widespread avoidance of prognosis and change the present culture. This prophet is one whose advice we would do well to heed."--James Tulsky, M.D., "New England Journal of Medicine"

The lymphatic system has been one of the most misunderstood systems in our bodies. Until now. Cardiothoracic surgeon Dr. Gerald M. Lemole explains why a healthy lymphatic flow aids our bodies in reducing toxins that contribute to disease and injury. In ten short chapters, Dr. Lemole demystifies the lymphatic system, describes how powerful it is and shows how to maintain a healthy lymph system to combat specific diseases and health problems - from heart disease to cognitive function to weight management. Featuring sidebars with charts and graphs that illustrate basic principles, Lymph & Longevity also includes menus, recipes and information on supplements, as well as basic yoga and meditation guides. Illuminating, informative, and practical this essential guide is timelier now than ever as we continue to work to protect ourselves and our communities against COVID-19 and other viruses.

Musculoskeletal Examination is a user-friendly textbook on the techniques of physical examination. Written by a physiatrist, orthopedic surgeon, and physical therapist, it has a uniquely multidisciplinary approach. Musculoskeletal Examination covers the complete basic examination and basic principles of normal and abnormal musculoskeletal function are fully explained, leading you to the correct differential diagnosis. The new fourth edition is now in full colour throughout and includes over 750 detailed illustrations, X-rays and MRIs, and more than 100 photographs showing examination techniques. It also includes a companion website at www.wiley.com/go/musculoskeletalexam featuring 107 MCQs and links to videos demonstrating key examination methods. Musculoskeletal Examination is perfect as a quick reference guide, while the detailed descriptions and clinically relevant examples of frequently encountered conditions will help even the most novice practitioner gain the understanding necessary to make a correct diagnosis and determine a successful treatment plan. It is ideal for physical therapists, physiatrists, orthopedists, medical students, practitioners, and all those involved in sports medicine and clinical massage.

Urgent Care Dermatology: Symptom-Based Diagnosis, by Drs. James E. Fitzpatrick, Whitney A. High, and Lamar Kyle, helps you quickly identify skin conditions and provide necessary treatment at the point of care. Concise, to-the-point text is highlighted by more than 1,000 high-quality photographs - all conveniently organized by lesion appearance - making this resource ideal for first-line clinicians to quickly identify and treat dermatologic conditions. Appearance-based format designed for non-specialists who diagnose and treat skin conditions, such as family practice physicians, urgent care providers, nurse practitioners, and physician assistants Organized by presentation (scaly lesions, blisters, etc.), with a full chapter on treatment pearls that offers expert advice pertaining to diagnosis and treatment Richly illustrated with more than 1,000 full-color clinical examples of lesions you're likely to see Each topic is covered in a two-page spread for quick reference - text on the left and images on the right Up-to-date coverage of morbilliform eruptions, scaly papular lesions, dermatitis (eczematoid reactions), and abscesses, as well as a timely chapter on cutaneous diseases of travelers organized by global region Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices Appearance-based format designed for non-specialists who diagnose and treat skin conditions, such as family practice physicians, urgent care providers, nurse practitioners, and physician assistants. Organized by presentation (scaly lesions, blisters, etc.), with a full chapter on treatment pearls that offers expert advice pertaining to diagnosis and treatment. Richly illustrated with more than 1,000 full-color clinical examples of lesions you're likely to see. Each topic is covered in a two-page spread for quick reference - text on the left and images on the right. Up-to-date coverage of morbilliform eruptions, scaly papular lesions, dermatitis (eczematoid reactions), and abscesses, as well as a timely chapter on cutaneous diseases of travelers organized by global region. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

Selected as a Doody's Core Title for 2022! Concise, portable, and user-friendly, The Washington Manual (R) Rheumatology Subspecialty Consult, Third Edition, provides essential information on inpatient and outpatient management of rheumatologic diseases and disorders. This edition offers state-of-the-art content on how to perform the musculoskeletal exam and arthrocentesis, what laboratory testing may prove useful, and which medications are appropriate, including dosages and recommended monitoring. Ideal for residents, fellows, and practicing physicians who need quick access to current scientific and clinical information in rheumatology, the manual is also useful as a first-line resource for internists and other primary care providers. Thoroughly revised content from cover to cover, including new chapters on current topics such as mosquito-transmitted viral arthritis and arthralgias, IgG4-related disease, interstitial lung disease, and cutting-edge technologies in rheumatology. Text covers all aspects of rheumatology, including hereditary periodic fever syndromes, recently approved drugs and biologic agents used in the treatment of rheumatic disease, and much more. Utilizes a highly templated, bulleted format ensuring that you can find what you need quickly and easily. Content is written by residents, fellows, and clinical faculty of the distinguished Washington University School of Medicine in St. Louis. Enrich Your Ebook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech. The Washington Manual (R) is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University.

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

The Handbook of Electrogastrography is the first textbook dedicated to reviewing the physiology of gastric myelectrical activity and the measurement of this electrical activity with electrodes placed on the abdominal surface - the electrogastrogram. The Handbook is divided into three major sections. The first section (Chapters 1-3) focuses on the history of electrogastrography, electrical activity of the interstitial cells of Cajal, the cells from which gastric electrical rhythmicity emanates. The cellular level of gastric electrical rhythmicity provides an understanding of the physiological basis of the electrogastrogram signal.

The second major section of the book (Chapters 4-6) incorporates the practical aspects of recording a high quality electrogastrogram and approaches to the analysis of the electrogastrogram using visual inspection and computer techniques. This section focuses on the authors' combined experience of examining EGG recordings for more than sixty years. From this rich research and clinical experience, the clinical application of EGG recordings in an approach to patients with unexplained nausea and vomiting is described. Neuromuscular disorders of the stomach involving gastric dysrhythmias are reviewed.

The third major section of the book (Chapters 7-9) comprises many examples of gastric dysrythmias ranging from bradygastrias to tachygastrias and mixed dysrythmias. Current understanding of the mechanisms of gastric dysrhythmias is reviewed. Artifacts in the EGG signal, which may be confused with gastric dysrhythmias, are also presented.

The Handbook of Electrogastrography will be a valuable reference for physicians interested in recording gastric electrical activity in clinical practices or in clinical research. Gastroenterologists, internists, psychologists and others with an interest in gastric myoelectrical events will also find extensive and relevant information for recording and interpreting EGGs in the Handbook.

This book disseminates information on paper-based diagnostics devices and describes novel paper materials, fabrication techniques, and Basic Paper-based microfluidics/electronics theory. The section on sample preparation, paper-based electronics/sensors for developing paper-based point-of-care (POC) systems also contains detailed descriptions. In the application sections this book covers sensing technique for DNA/RNA, bacteria/virus and integration of lateral flow assay. The book provides deep understanding and knowledge of paper-based diagnostic device development in terms of concept, materials, fabrication and applications.

The majority of tropical diseases manifest themselves through the skin, and while many can be diagnosed on physical examination, dermatopathologic results are often of critical importance to the diagnostic process. However, general dermatopathology texts lack images of diseases endemic in the developing world; they also lack clinical correlates linking the pathology to the clinical entity. This is a problem, because greater movement between countries where tropical diseases are prevalent and Europe, North America and other developed nations makes it essential for physicians to be able to recognize, diagnose and treat these diseases. Dermatopathology of Tropical Diseases covers the pathology and clinical correlations of the most important tropical diseases. Each entity is described using brief text that summarises its epidemiology, pathogenesis and clinical features. The diagnostic process is then described and illustrated using both clinical and histopathologic images. Wherever possible, different examples are shown of the same disease, in order to illustrate as wide a variety of presentations as possible. Extensively illustrated with almost 600 photographs, Dermatopathology of Tropical Diseases is an invaluable resource for dermatopathologists, pathologists and dermatologists based in the developing world as well as those in developed countries who see tropical diseases in returned travellers and immigrant populations. Key features Includes chapters on all major tropical diseases, with both clinical and histopathological images provided for each entity, allowing the reader to correlate pathological characteristics with the clinical presentation of each disease Wherever possible, different examples of the same disease are shown, to illustrate the variety of presentations Lavishly illustrated with almost 600 colour photographs

Written by a team of medical experts, this market-leading dictionary offers clear and authoritative definitions for all aspects of medical science. It features up-to-date coverage of public health medicine, medical research and general practice, drugs and pharmacology, endocrinology, cardiology and radiology, among other specialist areas. This new edition has been revised and updated to reflect advancements in medical research and practice, while over 250 new entries have been added, including American Medical Association, burden of treatment, gaming disorder, MERS, person-centred care, and Zika virus. Recommended web links and detailed illustrations complement the text, and extensive appendices offer useful lists and tables on areas such as inherited medical conditions, units of alcohol, and abbreviations and symbols. Selling over a million copies in previous editions, this is an essential A-Z for students and those working in the medical and allied professions, including nurses, pharmacists, physiotherapists, social workers, hospital administrators, and medical secretaries. It is also an invaluable home reference guide for the general reader.

This is the second edition of a full colour reference atlas published first to excellent reviews in 1994. Every renal unit needs to have a reference text of this kind and urine microscopy is an important diagnostic aid in nephrology. After the 'Historical Introduction' by J Stewart Cameron, chapter 1 descibes the methods used to prepare and analyse the urine samples. Chapter 2, which is the most important section of the book, describes with the help of 249 illustrations (over 200 in full colour) the elements of the urinary sediment. Chapter 3 deals with the urinary sediment of the normal subject, while chapter 4 deals with the urinary changes which are observed in the main diseases of the kidney and urinary tract. Chapter 5 describes the changes of the urinary sediment caused by drugs. Chapter 6 is about the interpretation of the urinary findings shown in the previous chapters. Chapter 7 covers the new systems to analyse the urinary sediments. An appendix shows how to adjust the microscope to analyse the urine specimens. The primary audience is practising nephrologists and nephrologists in training, and also those in internal medicine rotating through the renal unit who perform routinely the analysis of the urinary sediment. Clinical pathologists would also find this an attractive and useful book. The illustrations are outstanding and additional clinical information has been added in this new edition. From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet

Magnetic Resonance Procedures: Health Effects and Safety is the first authoritative text on MR procedures and its associated health and safety concerns written by noted radiologists, physicists, and scientists with expertise in the field. It contains both theoretical and practical information.

This timely text discusses emergent issues related to MR imaging and concerns such as shielding, the safe use of contrast agents, and management of patients with claustrophobia, anxiety, and emotional stress. It also contains a sample pre-MR screening form; comprehensive safety information for over 700 implants, devices, and materials; a list of medical devices and products for interventional MR procedures; and a summary of peer-reviewed MR safety studies.

In the wake of recent government demands for increased patient safety in hospitals, along with the rapidly expanding use of MRI, this book is particularly important. It is the definitive resource for information on the safety aspects of magnetic resonance procedures.

The last ten years have seen an increase in travel to tropical countries and, as a consequence, infections such as malaria and schistosomiasis are more common. It is therefore essential that physicians, microbiologists, and scientists are familiar with the diagnosis of these parasitic diseases. There is a growing recognition of the importance of "temperate" parasites, and this has been emphasized by the HIV epidemic.
This book is a practical manual for use in both routine diagnostic microbiology laboratories and more specialists laboratories diagnosing human parasites. All of the major groups of parasites are dealt with in individual chapters which include detailed protocols and recommendation for the diagnosis of infections caused by those parasites, together with color and black and white illustrations. The authors provide information and practical guidance appropriate for both the developed and developing world. This informative new book will be of great use to clinical pathologists, laboratory technicians, and students and researchers in tropical medicine.

Selected as a Doody's Core Title for 2022! Now in a fully revised 4th Edition, Modern Epidemiology remains the gold standard text in this complex and evolving field, offering unparalleled, comprehensive coverage of the principles and methods of epidemiologic research. Featuring a new, full-color design, updated models, and a new format allowing space for margin notes, this edition continues to provide authoritative information on the methodologic issues crucial to the wide range of epidemiologic applications in public health and medicine. Reflects both the conceptual development of this evolving science and the increasing role that epidemiology plays in both public health and medicine. Features a new full-color design, new coverage of marginal structural models, new instrumental variable analysis, updated structural nested models, and more. Covers a broad range of concepts and methods, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, field methods, and causal diagrams. Includes data analysis topics such as Bayesian analysis, sensitivity analysis, and bias analysis, with an extensive overview of modern regression methods including logistic and survival regression, splines, hierarchical (multilevel) regression, propensity scores and other scoring methods, and g-estimation. Discusses special topics such as disease surveillance, ecologic studies, social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, nutritional epidemiology, environmental epidemiology, reproductive epidemiology, clinical epidemiology, and meta-analysis. Coauthored by three leading epidemiologists, with contributions from experts in a variety of epidemiologic sub-disciplines.

This unique book presents a framework for the strategy and methodology of diagnostic research, in relation to its relevance for practice. Now in its second edition The "Evidence Base of Clinical Diagnosis" has been fully revised and extended with new chapters covering the STARD guidelines (STAndards for the Reporting of Diagnostic accuracy studies) and the multivariable analysis of diagnostic data.

With contributions from leading international experts in evidence-based medicine, this book is an indispensable guide on how to conduct and interpret studies in clinical diagnosis. It will serve as a valuable resource for all investigators who want to embark on diagnostic research and for clinicians, practitioners and students who want to learn more about its principles and the relevant methodological options available.

Acute Medical Algorithms is an original and compact text designed to aid the clinician in dealing with acute medical conditions. The book includes 70 algorithms - either problem-orientated or related to specific conditions - together with complementary notes and references. It will therefore be relevant to all grades of hospital doctor, and to medical students and general practitioners also.

This newly updated, step-by-step guide to the key points of conducting the GYN exam addresses everything both busy nurse practitioners and NP students need to know, from basic procedures to high-level challenges. Part I breaks down the GYN exam into clinical parts, emphasizing strategies to decrease anxiety and minimize discomfort at every stage of the exam. Part II walks the caregiver through the exam for women at every stage of the life span, sexually abused women, obese women, and women who have undergone genital mutilation. This second edition delivers an all-new chapter on providing care to transgender and LGBT women and also includes new information on intimate partner violence and working with adolescents and menopausal and older women. Comprehensive and organized for easy access to information, the book features prominently displayed key points, learning objectives, and ""Fast Facts in a Nutshell"" boxes based on the authors' more than 40 years of teaching experience. Along with the most up-to-date information on STIs, Pap guidelines across the life span, and recommendations on the well-woman exam, this concise guide comes with a wealth of essential resources, including links to instructional videos and free apps for patient and practitioner education, adding to the book's value as an indispensable, quick-access guide to delivering excellent holistic care to women. New to the Second Edition: New chapter on examining the transgender and LGBT woman Latest information on intimate partner violence Updates on examining adolescents and menopausal and older women New information on female genital mutilation New CDC STD, PAP, and ACOG Guidelines Links to instructional videos Free apps for patient and practitioner education Key Features: Delivers easy-to-read, bulleted information in a convenient pocket size Provides learning objectives, key points, and Fast Facts in a Nutshell Includes tips on examining special populations including obese, anxious, multiparous, pediatric, menopausal, and older patients and transgender/LGBTQ Serves as a refresher for those studying for the WHNP Exam This book was originally published under the Fast Facts series by Springer Publishing Company.

A practical guide to the diagnosis and treatment of acute symptoms and conditions, the "ABC of Emergency Differential Diagnosis" provides a step-by-step guide to emergency differential diagnosis for non-specialists in a hospital or primary care setting.

This new title in the "ABC" series covers the assessment, diagnosis, treatment, and management of the most common symptoms with 'walk through' diagnosis, clear learning outcomes, and easy to find treatment options.

Using the familiar problem-based teaching approach for rapid assimilation of information, case studies in each chapter allow the reader to be sure that they have synthesised the information given and can apply it to clinical cases.

This book presents different experimental results as evidence of the good results obtained compared with respect to conventional approaches and literature references based on fuzzy logic. Nowadays, the evolution of intelligence systems for decision making has been reached considerable levels of success, as these systems are getting more intelligent and can be of great help to experts in decision making. One of the more important realms in decision making is the area of medical diagnosis, and many kinds of intelligence systems provide the expert good assistance to perform diagnosis; some of these methods are, for example, artificial neural networks (can be very powerful to find tendencies), support vector machines, that avoid overfitting problems, and statistical approaches (e.g., Bayesian). However, the present research is focused on one of the most relevant kinds of intelligent systems, which are the fuzzy systems. The main objective of the present work is the generation of fuzzy diagnosis systems that offer competitive classifiers to be applied in diagnosis systems. To generate these systems, we have proposed a methodology for the automatic design of classifiers and is focused in the Generalized Type-2 Fuzzy Logic, because the uncertainty handling can provide us with the robustness necessary to be competitive with other kinds of methods. In addition, different alternatives to the uncertainty modeling, rules-selection, and optimization have been explored. Besides, different experimental results are presented as evidence of the good results obtained when compared with respect to conventional approaches and literature references based on Fuzzy Logic.

Sexual problems are a major cause of personal distress and marital breakdown, affecting as many as one in ten of the general population. The author, who has had extensive clinical, research, and teaching experience in the field of sexual dysfunction, has written a very practical account of the nature, causes, assessment, and treatment of sexual problems. The various stages of treatment are described in sufficient detail for therapists who are about to start sex therapy. Experienced therapists will also find this book a source of useful advice. The treatment approach includes behavioural, psychotherapeutic, and educational techniques. In addition to the treatment of couples, the management of sexual problems of individuals without partners, and of the phsyically disabled, are also described. Practical guidance is backed up by research findings. This book is an up-to-date, straightforward, and practical account which should be of considerable interest to anyone involved in the management of sexual problems.

This book will enable practitioners to understand the many complex intricacies of immunohistochemistry (IHC) and make best use of this powerful analytical tool. Providing a thorough grounding in the fundamentals of immunohistochemistry, the book includes several chapters on robotics and automation technology, giving key information on the design of machines and tips to maximise workflow efficiencies. The relationship between IHC and molecular pathology is explained clearly, demonstrating the increasing impact on personalized medicine and targeted therapies for cancer patients. The staining protocol is deconstructed, allowing the reader to adapt it for a variety of diagnostic and research applications. Written by experts at the forefront of hospital immunohistochemistry, there is a strong emphasis on practical guidance on a range of techniques as well as troubleshooting of common problems driven by the authors' experiences. Extensively illustrated with high-quality colour images, this is an invaluable resource to all pathology practitioners utilising the technique.