EGFR-Directed Therapy in Lung Cancer (Paperback)

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

General

Imprint:	Cambridge UniversityPress
Country of origin:	United Kingdom
Series:	Elements in Molecular Oncology
Release date:	2023
Authors:	Soyeon Kim • Daniel B. Costa • Daisuke Shibahara • Susumu Kobayashi • Balazs Halmos
Dimensions:	228 x 153 x 7mm (L x W x T)
Format:	Paperback - Trade
Pages:	75
ISBN-13:	978-1-00-934230-8
Categories:	Books > Medicine > Clinical & internal medicine > Respiratory medicine Books > Medicine > Clinical & internal medicine > Medical diagnosis > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-00-934230-4
Barcode:	9781009342308

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