This book will enable practitioners to understand the many complex intricacies of immunohistochemistry (IHC) and make best use of this powerful analytical tool. Providing a thorough grounding in the fundamentals of immunohistochemistry, the book includes several chapters on robotics and automation technology, giving key information on the design of machines and tips to maximise workflow efficiencies. The relationship between IHC and molecular pathology is explained clearly, demonstrating the increasing impact on personalized medicine and targeted therapies for cancer patients. The staining protocol is deconstructed, allowing the reader to adapt it for a variety of diagnostic and research applications. Written by experts at the forefront of hospital immunohistochemistry, there is a strong emphasis on practical guidance on a range of techniques as well as troubleshooting of common problems driven by the authors' experiences. Extensively illustrated with high-quality colour images, this is an invaluable resource to all pathology practitioners utilising the technique.

Acutely unwell patients can deteriorate dangerously without timely recognition and intervention. Emergencies in Clinical Medicine provides an easy-to-use guide to the prompt management of common medical emergencies. Designed for rapid use, it explains how to arrive at a differential diagnosis and how to prevent, manage, or treat an emergency. The second edition has been fully updated to reflect current clinical guidelines and includes several new topics, from pulmonary oedemas to the overdose patient. Revised to cover the curricula for core medical training (CMT) and acute care common stem (ACS), this text addresses exactly what the trainee doctor needs to know. The text covers emergencies from both a problem-based and disease-based approach. Cross-referencing between these two sections enables quick reference under pressure, with clear, step-by-step instructions and advice on when and who to call for help. With key algorithms for quick reference and easy to follow symbols indicating clinical severity, from life-threatening to minor, this text will help clinical staff managing acutely ill patients in an easy-to-read and portable format.

This work presents an unflinching look inside the detective story that marks nearly every illness - the diagnosis - revealing the combination of uncertainty and intrigue that doctors face when confronting patients who are sick or dying.

Multiple sclerosis (MS) is a progressive neurological disease that affects millions of people worldwide. Currently, the causes of MS are still unclear and the cure remains symptomatic, while the effectiveness of treatment varies widely among individuals. The clinical features and neurological defects derived from this progressive neurological disease are diverse since MS may affect the human central nervous system (CNS)) at all levels from the brain to the end of the spinal cord. Immunopathogenesis of MS involves many steps, including activation of peripheral leucocytes against putative CNS antigens, activated leucocytes with inflamed cerebral endothelial cells, the migration of activated lymphocytes and macrophages through the endothelium to the CNS environment, and further propagation of a massive immune response within the CNS. Such large-scale immune activation leads to loss of the myelin-oligodendrocyte complex. Various types of immune cells and mediators of the immune-inflammatory response actively contribute to MS pathogenesis. Genetic factors are also thought to play a central role in the development of most forms of MS. Axonal degeneration and neuronal loss are the core components of irreversible and permanent CNS atrophy and disability in MS. This book provides a comprehensive overview of the current MS situation as researchers try to understand the process and develop treatments that can slow or stop the disease, possibly repair the damage, alleviate specified symptoms, and improve the abilities of MS patients to function in everyday life. Various biological holistic approaches have been shown to slow disease progression in some patients, and the recovery rate of cellular mechanisms in the brain and spinal cord has been accelerated, increasing the possibility of achieving complete balance of the disease state. The panel reviews the background, focusing on novel strategies that are most likely to understand the biological mechanisms of recovery and translate findings into alternative comprehensive approach to the MS management. The modality of such complementary therapies adds a new dimension, geared to further improvement in the management and sustain the acquired long-term results of MS. This book will be necessary to researchers, research funders, healthcare advocates of MS research and treatment, and interested patients and their families.

A practical, real-world approach-focus on what's normal to identify abnormal. Here are all of the how-tos, what-tos, when-tos, and why-tos you need to master in a well-organized, well-illustrated text that makes the material easier to learn now... and reference later. First, it focuses on the normal and the normal variants of the adult, child, elderly, and pregnant patients seem most frequently in practice. Then, when a finding falls outside of those parameters, you'll be able to identify it as abnormal. Second, assessment is presented as a linear and consistent process, so you will always do the same steps in the same order, assuring that you don't miss anything. An access code inside new, printed texts unlocks resources online at FADavis.com, including Advanced Assessment Techniques, an Audio Library with sample auscultation and percussion sounds, Case Studies featuring real-life scenarios, and Performance Checklists that document the steps of each technique.

The announcement of a serious diagnosis is a solemn moment when directions shift, priorities change, and life appears in sharper focus. It is also a moment when a story takes shape. It is a story we are able to imagine, even if we haven't experienced it firsthand, because the moment of diagnosis is as pervasive in popular media as it is in medicine. Diagnosis: Truths and Tales shares stories told from the perspectives of those who receive diagnoses and those who deliver them. Confronting how we address illness in our personal lives and in popular culture, this compelling book explores narratives of diagnosis while pondering the impact they have on how we experience health and disease.

A classic text, Chamberlain's Symptoms and Signs in Clinical Medicine has been providing students and professionals with a detailed and well-illustrated account of the symptoms and signs of diseases affecting all the body systems since the first edition published in 1936. Now completely rewritten by a new team of authors selected for their experience and reputation in writing quality publications in their specialist fields, the 13th edition brings the title into line with current teaching and practice. One of the key challenges of writing a textbook of diagnostic medicine is to balance the "bottom up" approach of constructing a differential diagnosis from individual clinical findings, and the "top down" approach of learning the key features pertaining to a particular diagnosis. The 13th edition of Chamberlain's Symptoms and Signs in Clinical Medicine integrates both approaches into a coherent working framework that will assist the reader in preparing for academic and professional examinations, and in everyday practice. Presented in full colour and illustrated with relevant images, this book provides a thorough lesson in diagnostic medicine, ensuring the reader is fully prepared to deal with the challenging process of differential diagnosis through a thorough knowledge of the central features of the conditions that they are likely to encounter. Key features: Teaches the reader how to diagnose correctly through assessment of symptoms and signs while simultaneously recalling all key features of a given condition Full colour and generously illustrated Conforms with the core competencies required for the foundation years Includes bullet point lists and tip boxes Chapters conclude with a summary of key points for easy revision Written and edited by a highly experienced team of specialists Companion website

Renowned for its holistic perspective and "see and do" approach, Nurses' Handbook of Health Assessment, 10th Edition delivers streamlined, step-by-step guidance at every phase of nursing assessment to help students ensure accurate and effective assessments across all patient populations. This full-color handbook - updated to reflect the latest clinical insights in Health Assessment for Nursing, 7th Edition - details everything students need to interview clients and conduct thorough physical assessments with ease, including up-to-date assessment guidelines, full-color anatomy and physiology illustrations, images of normal and abnormal findings, and more - all in a convenient format ideal for today's on-the-go learning.

From the potent properties of X rays evoked in Thomas Mann's Magic Mountain to the miniaturized surgical team of the classic science fiction film Fantastic Voyage, the possibility of peering into the inner reaches of the body has engaged the twentieth-century popular and scientific imagination. Drawing on examples that are international in scope, The Transparent Body examines the dissemination of medical images to a popular audience, advancing the argument that medical imaging technologies are the material embodiment of collective desires and fantasies--the most pervasive of which is the ideal of transparency itself. The Transparent Body traces the cultural context and wider social impact of such medical imaging practices as X ray and endoscopy, ultrasound imaging of fetuses, the filming and broadcasting of surgical operations, the creation of plastinated corpses for display as art objects, and the use of digitized cadavers in anatomical study. In the early twenty-first century, the interior of the body has become a pervasive cultural presence - as accessible to the public eye as to the physician's gaze. Jose van Dijck explores the multifaceted interactions between medical images and cultural ideologies that have brought about this situation. The Transparent Body unfolds the complexities involved in medical images and their making, illuminating their uses and meanings both within and outside of medicine. Van Dijck demonstrates the ways in which the ability to render the inner regions of the human body visible - and the proliferation of images of the body's interior in popular media - affect our view of corporeality and our understanding of health and disease. Written in an engaging style that brings thought-provoking cultural intersections vividly to life, The Transparent Body will be of special interest to those in media studies, cultural studies, science and technology studies, medical humanities, and the history of medicine.

Pocket Nephrology is a practical, high-yield reference offering current, evidence-based practices and expert guidance from physicians at the world-renowned Columbia University Medical Center. Featuring an easy-to-use loose-leaf format, it can be used as a portable diagnosis and treatment reference, as a quick dosage check, as a review for complex glomerular diseases and acid-base physiology, and for board preparation. Mirrors the thought process of nephrologists in day-to-day practice. Contains the latest clinical guidelines and new therapeutic recommendations. Follows the popular Pocket Notebook format, featuring bulleted lists, tables, diagrams, and algorithms that make essential facts easy to find and retain. Covers all topics encountered in nephrology practice, categorized by subspecialties, making it ideal for trainees in nephrology as well as practicing nephrology consultants with years of experience. Written by current and former faculty members and fellows from Columbia University Medical Center. Enrich Your Ebook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

In this book, a new approach for diagnosis and risk evaluation of ar-terial hypertension is introduced. The new approach was implement-ed as a hybrid intelligent system combining modular neural net-works and fuzzy systems. The different responses of the hybrid system are combined using fuzzy logic. Finally, two genetic algo-rithms are used to perform the optimization of the modular neural networks parameters and fuzzy inference system parameters. The experimental results obtained using the proposed method on real pa-tient data show that when the optimization is used, the results can be better than without optimization. This book is intended to be a refer-ence for scientists and physicians interested in applying soft compu-ting techniques, such as neural networks, fuzzy logic and genetic algorithms, in medical diagnosis, but also in general to classification and pattern recognition and similar problems.

This concise reference clarifies the gray areas between traumatic brain injury and PTSD while providing an empirically sound framework for neuropsychological evaluation and differential diagnosis. Its extended research review summarizes findings on key topics including the neuroanatomy of brain injury, test battery design and selection, and the salience of accurate diagnosis to ensuring appropriate specialized treatment. The authors offer the possibility of combined diagnosis as well as injuries that may fall through the diagnostic cracks, and consider possible relationships between TBI, PTSD, and the dementias, including Alzheimer's disease. This knowledge base and the practical guidelines it informs are presented so that readers can better: * Understand the clinical distinctions between TBI and PTSD, and among forms of TBI. * Recognize cognitive, behavioral, emotional, and social components of the disorders. * Identify skill areas for neuropsychological evaluation of patients. * Select appropriate instruments for individualized assessment.* Address test administration and interpretation concerns. * Make an accurate differential diagnosis between PTSD and TBI. With its sharp focus on the nuances of trauma and recovery, The Intercorrelation of Traumatic Brain Injury and PTSD in Neuropsychological Evaluations will find a wide, interested audience among psychologists, neuropsychologists, neurologists, psychiatrists, social workers, mental health counselors, undergraduate and graduate level students, and researchers. In addition, this text may be useful for those interested in psychology and neurology. <

Following the highly successful model of the first edition, "Pocket Guide to ECG Diagnosis, 2e" describes every known common ECG abnormality and cardiac arrhythmia with a practical and clinical approach. On the left page of the book, each abnormality is described precisely and concisely, including definition, diagnostic criteria, and diagnostic pearls. On the right page, a crystal clear reproduction of a given ECG abnormality is shown. This at-a-glance format makes this Pocket Guide effective for quick interpretation of ECGs. Dr. Ching has updated and revised the entire book and included over 20 new ECGs in this edition.

Serge Tixa presents in this highly popular book a method of palpatory anatomy called Manual Exploration of Surface Anatomy (MESA). MESA locates anatomical structures important to clinical examination allowing careful selection of the most appropriate manual therapy technique or manoeuvre. The new edition presents precisely and visually the various anatomical structures with the help of more than 130 colour illustrations and close to 900 black and white photographs. For every photograph showing an anatomical structure accessible to palpation, a model whose physique shows the structure clearly has been chosen. Each chapter has up to four subsections, treating the various aspects of each body region. These cover osteology, myology (musculotendinous structures), arthrology (joints and ligaments) and lastly nerves and blood vessels. Each photograph is carefully presented and accompanied by a section of text describing the method of approach to finding the structure concerned. Whenever necessary, reminders, essential for the proper use of the methods of approach (attachments, actions and innervations) are included. Clinical notes highlight the link between palpation and clinical diagnoses. Atlas of Surface Palpation: Anatomy of the Neck, Trunk, Upper and Lower Limbs is aimed at students and practitioners who need a method of applied anatomy in their practice. All new artwork programme enhances accessibility and learning Useful template approach aids ready understanding and allows the reader to go at his or her own speed Presents almost 600 photographs and line artworks to render the learning experience as easy as possible Contains over 160 pull out boxes to act as useful aide memoires Clinical Hints and Tips boxes indicate points of relevance for the clinic Methods of approach illustrated with many new photographs Anatomical drawings have been completely redesigned to improve clarity Clinical Notes boxes Glossary Inclusion of Dermatomes

Immunoassays Edited by R. Edwards Immunoassays are among the most widely used of analytical techniques and have been applied successfully to an extensive range of substances, from single molecules to whole cells. This book provides key data on all types of immunoassay, including RIA, ELISA and dry surface immunoassays, and on the use of photoluminescent and chemiluminescent labels in immunoassays. Essential information is also given on assay design and data processing. The Essential Data series provides rapid access to the core data required by researchers on a daily basis, in convenient pocket-sized volumes.

The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.

In this thesis, a tracking system was developed by modifying an add-on collimator, the Siemens Moduleaf, for realtime applications in radiotherapy. As the add-on collimator works almost completely autonomously of the linear accelerator (LinAc), no modifications to the latter were necessary. The adaptations to the Moduleaf were mainly software-based. In order to reduce the complexity of the system, outdated electronic parts were replaced with newer components where practical. Verification was performed by measuring the latency of the system as well as the impact on applied dose to a predefined target volume, moving in the leaf's travel direction. Latency measurements in software were accomplished by comparing the target and current positions of the leaves. For dose measurements, a Gafchromic EBT2 film was placed beneath the target 4D phantom, in between solid water plates, and moved alongside with it. Based on the results, a tracking-capable add-on collimator seems to be a useful tool for reducing the margins for the treatment of small, slow-moving targets. Radiotherapy is one of the most important methods used for the treatment of cancer. Irradiating a moving target is also one of the most challenging tasks to accomplish in modern radiotherapy.

Volume 3 of the Child Maltreatment Assessment aims to help readers recognize and comprehend the procedures for the investigation, care, and prevention of child maltreatment. This workbook features topics such as the role of law enforcement officials and medical examiners in child abuse cases, mental health treatment for children who have experienced maltreatment, and methods for preventing abuse in the future. With guides to reporting, testifying, and intervening in cases of abuse, this workbook is a necessity for better preparing professionals and students alike for working with victims of maltreatment. Featuring in-depth descriptions of abusive scenarios along with informational tables and diagrams, this workbook is ideal for professionals who are preparing to investigate and prosecute child maltreatment cases. Each workbook in the Child Maltreatment Assessment series will feature both a test section and photographic atlas at the back of the book. Using this assessment, the reader can review and apply the knowledge they have gained from the chapters within, making this text ideal for self-study or classroom settings. The photographic atlas will contain an additional 80 high-quality images with accompanying case histories.

Urological disease affects huge numbers of patients at some point in their lives. Diagnostic techniques are critical to ensure the correct diagnosis is made in a timely manner. A huge number of new technologies have been introduced in recent years to aid in this diagnostic pathway in the form of urine tests, blood tests and imaging modalities. Both urologists and other clinicians interested in urology have struggled to keep up with the rapid evolution of these techniques. This book contains up to date and state of the art contributions from major names in the field. It describes the diagnostic pathways for the key aspects of urological disease. Readers will be able to equate symptoms and signs with the relevant investigations. The book focuses on the diagnostic pathways involved, bringing together international leaders in the field who describe the current status of urological investigation.

Despite public perception, osteoporosis remains a widespread, devastating disease, and a very serious and costly public health threat. Early detection and treatment must be a priority for primary health care providers. Dual-energy X-ray absorptiometry (DXA) is the principal x-ray technology used to diagnose osteoporosis in its early, asymptomatic stages, to assess treatment efficacy, and to guide treatment decisions. It remains the gold standard today." ""A DXA Primer for the Practicing Clinician: A Case-Based Manual for Understanding and Interpreting Bone Densitometry" is developed around real cases of patients DXA measurements. The content is derived from presentations given by the authors at a national society training course and exemplifies not only the complete body of education provided through these lectures but the full range of previously undiscussed nuances as well. This practical, easy-to-read title provides the day to day problems of DXA usage that new users may encounter and that training courses do not have time to provide in detail. The central focus of the book is the presentation of what is normal and what is problematic in the use of DXA, depicting various scenarios with real case histories of patients, their corresponding DXA images and the data that explain the problems. Unique in approach and presentation, this case-based manual will be of immense value to all practitioners -- and students interested in providing optimal diagnosis and treatment of osteoporosis. "

In 2013, the American Psychiatric Association published the 5thedition of its"Diagnostic and Statistical Manual of Mental Disorders"(DSM-5). Often referred to as the "bible" of psychiatry, the manual only classifies mental disorders and does not explain them or guide their treatment. While science should be the basis of any diagnostic system, to date, there is no knowledge on whether most conditions listed in the manual are true diseases. Moreover, in DSM-5 the overall definition of mental disorder is weak, failing to distinguish psychopathology from normality. In spite of all the progress that has been made in neuroscience over the last few decades, the psychiatric community is no closer to understanding the etiology and pathogenesis of mental disorders than it was fifty years ago.

In"Making the DSM-5," prominent experts delve into the debate about psychiatric nosology and examine the conceptual and pragmatic issues underlying the new manual. While retracing the historic controversy over DSM, considering the political context and economic impact of the manual, and focusing on what was revised or left unchanged in the new edition, this timely volume addresses the main concerns of the future of psychiatry and questions whether the DSM legacy can truly improve the specialty and advance its goals.

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Our yesterdays have determined who we are today, and knowledge of our past has the potential to enhance both our understanding of the present and our predictions of the future. Diagnosing Giants traces the history of medicine through the illnesses of some of the most influential figures of the past. Standard biographies all too often pay scant attention to the health issues that affected their subjects. Yet, the diseases suffered by these figures had profound effects on their lives and their legacies. Each chapter opens with a detailed medical history of the patient. Facts relevant to the historical figure's life and legacy are woven into the case summary, and the mystery patient's identity is revealed at the conclusion of the case summary. The author then analyzes the medical history, offers a differential diagnosis and a final diagnosis. Where relevant, the potential effects of the subject's medical problems on his or her life and legacy are discussed. Diagnosing Giants is a must-own volume for medical professionals and history buffs alike.

This book will prove an invaluable resource for all those working in the field of primary healthcare and family medicine. Through case histories the reader will be introduced to adolescents who are depressed, to those who have been failed by the system, to those who cannot communicate their needs, and to those for whom issues of confidentiality have become critical.