MicroRNA research and development is the billion-dollar baby and most lucrative option for drug discovery in gene therapy industries worldwide. Personalized microRNA treatments are in many cases the only remedy for viral diseases that have no cure in conventional drugs and offer to bring us closer than ever to "personalized medicine." They also counteract cancer and other infectious and neuro-diseases. Early diagnosis, prognosis, staging, and sub-classification of various cancers can easily be facilitated by microRNA-based biomarkers. MicroRNA surveys recent advances in RNA and RNA-protein components that highlight RNA delivery, its stability, and applications of RNA-based drugs for the modulation of gene/protein expression and gene editing. The book not only focuses on the modern medicines of microRNA-based early diagnostic and therapy development, but also works as a hidden treasure for drug discovery of multiple rare diseases worldwide. It offers indispensable learning materials for academic researchers, graduate, and medical students, and offers a powerful practical guide for RNA-Pharma and gene therapy industries.

Demonstrating the role of nuclear medicine as a complementary technique to mammography and other imaging modalities for the diagnosis of breast cancer, Radionuclide Imaging of the Breast provides a comprehensive overview of scintimammography-an accurate, safe, and noninvasive imaging method for the evaluation of breast lesions and malignancies. Reveals the encouraging results of multicenter clinical trials in the U.S. and Canada using 99mTc sestamibi breast imaging for the diagnosis of primary breast carcinoma! Addressing nonsurgical sampling of nonpalpable breast lesions as an effective means of providing diagnostic and prognostic information, Radionuclide Imaging of the Breast -discusses increasing the diagnostic value of mammography and its widespread use -examines the reliability of FDG-PET and FDG-SPECT in detecting lymph node involvement and distant metastases -reviews breast cancer imaging with monoclonal antibodies, including murine and bioengineered antibodies -compares the benefits and limitations of Thallium-20l to 99mTc-sestamibi breast imaging in evaluating suspected malignancy -assesses the clinical impact of scintimammography as an adjunctive test to mammography to improve the dependability of diagnoses -considers the possibility of replacing axillary lymph node dissection in patients with small breast cancers with the sentinel node approach -clarifies the importance of surgery in the multimodality treatment of breast cancer -elucidates pathologic difficulties for breast cancer diagnosis -and more! Radionuclide Imaging of the Breast serves as an essential reference for nuclear medicine physicians, radiologists, breast surgeons, medical and surgical oncologists, gynecologists, pathologists, internists, and primary care physicians.

This is a comprehensive, large-format review text with complete answers for the American national examination of the Registry of Diagnostic Medical Sonographers (RDMS). It contains 600 questions divided evenly between sections on physics, the abdomen and small parts, and obstetrics and gynecology. The authors combine many years of experience teaching diagnostic ultrasound and provide illustrative scans and drawings for added comprehension.

A physician with thirty-five years of experience treating people with brain injuries shares the latest research on concussions and best practices for care. The explosion of attention to sports concussions has many of us thinking about the addled brains of our football and hockey heroes. But concussions happen to everyone, not just elite athletes. Children fall from high chairs, drivers and cyclists get into accidents, and workers encounter unexpected obstacles on the job. Concussions are prevalent, occurring even during everyday activities. In fact, in less time than it takes to read this sentence, three Americans will experience a concussion. The global statistics are no less staggering. Shaken Brain offers expert advice and urgently needed answers. Elizabeth Sandel, MD, is a board-certified physician who has spent more than three decades treating patients with traumatic brain injuries, training clinicians, and conducting research. Here she explains the scientific evidence for what happens to the brain and body after a concussion. And she shares stories from a diverse group of patients, educating readers on prevention, diagnosis, and treatment. Few people understand that what they do in the aftermath of their injury will make a dramatic difference to their future well-being; patient experiences testify to the best practices for concussion sufferers and their caregivers. Dr. Sandel also shows how to evaluate risks before participating in activities and how to use proven safety strategies to mitigate these risks. Today concussions aren't just injuries-they're big news. And, like anything in the news, they're the subject of much misinformation. Shaken Brain is the resource patients and their families, friends, and caregivers need to understand how concussions occur, what to expect from healthcare providers, and what the long-term consequences may be.

This unique workbook can be used as a stand-alone text or supplemental text for any course designed to enhance the work of radiologic technology students. It will also serve the needs of graduate radiographers as well as the physician in learning specific areas of the Fluoroscopic Image Intensifier such as:

This is a complete, medically reliable dictionary of congenital malformations and disorders. As the authors explain, "Down syndrome is the only common congenital disorder; the other defects and disorders are rare or very rare, some having been reported fewer than 20 times worldwide." This dictionary covers them all. Examples: Aagenaes syndrome is due to congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant-cell hepatitis with fibrosis of the portal tracts. Acrocallosal syndrome is characterized by total or partial absence of the corpus callosum, craniofacial dysmorphism, polydactyly, and severe mental retardation. Other features can be retinal pigmentation anomalies, optic atrophy, strabismus, nystagmus, cleft lip and palate, cardiovascular anomalies, hernia, abnormal nipples, and fits. Acrodysostosis is characterized by prenatal growth deficiency, brachycephaly, deformities of the humerus, radius and ulna, short and broad hands, hypoplastic maxilla, and mental retardation.

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease.

BORB provides a set of standardised procedures for assessing neuropsychological disorders of visual object recognition, based on tests developed in the cognitive neuropsychological literature. The tests are introduced in terms of cognitive neuropsychological analyses of object recognition, and guidance is given concerning test use and interpretation.
The tests assess low-level aspects of visual perception (using same-different matching of basic perceptual features, such as orientation, length, position and object size), intermediate visual processes (e.g., matching objects different in viewpoint), access to stored perceptual knowledge about objects (object decision), access to semantic knowledge (function and associative matches) and access to names from object (picture naming). BORB will serve as an invaluable companion test battery to the PALPA test of language ability.

Not sure how to interpret the wealth of data in front of you?

Do you lack confidence in applying the results of investigations to your clinical decision making?

Then this pocket-sized, quick reference guide to data interpretation may be just right for you.

"The Hands-on Guide to Data Interpretation" is the perfect companion for students, doctors, nurses and other health care professionals who need a reference guide on the ward or when preparing for exams. It focuses on the most common investigations and tests encountered in clinical practice, providing concise summaries of how to confidently interpret investigative findings and, most importantly, how to apply this to clinical decision making.

The benefits of this book include: An overview of the normal ranges of test results, followed by a consideration of the differential diagnoses suggested by variance from these valuesArranged by system to allow quick access to the key investigations encountered in different specialtiesA summary 'patient data' chapter to bring the different specialties together, providing an overview to completing investigation documentation and chartsSummary table and bullet point format, with a full index, to aid rapid retrieval of informationEach chapter reviewed by a specialist to ensure an accurate, practical approach to data interpretation

Take the stress out of data interpretation with "The Hands-on Guide"

Volume 66 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of Clinical Chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Volume65 in the internationally acclaimed "Advances in Clinical Chemistry" contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists.The serialprovides the latest and most up-to-date technologies related to the field of Clinical Chemistry andis the benchmark for novel analytical approaches in the clinical laboratory.
Expertise of international contributorsLatest cutting-edge technologiesComprehensive in scope"

This volume presents several machine intelligence technologies, developed over recent decades, and illustrates how they can be combined in application. One application, the detection of dementia from patterns in speech, is used throughout to illustrate these combinations. This application is a classic stationary pattern detection task, so readers may easily see how these combinations can be applied to other similar tasks. The expositions of the methods are supported by the basic theory they rest upon, and their application is clearly illustrated. The book's goal is to allow readers to select one or more of these methods to quickly apply to their own tasks. Includes a variety of machine intelligent technologies and illustrates how they can work together Shows evolutionary feature subset selection combined with support vector machines and multiple classifiers combined Includes a running case study on intelligent processing relating to Alzheimer's / dementia detection, in addition to several applications of the machine hybrid algorithms

This book is a comprehensive reference on both the structure and content of the clinical interview and its authors present the strategies and fundamental knowledge required to conduct the clinical interview with different kinds of patients and for specific psychopathologies. It provides a thorough overview on clinical and diagnostic interviewing with state-of-the-art presentations of significant theoretical orientations (psychoanalytic, behavioral, humanistic/existential, and family systems) as well as information on frequently encountered psychopathologies. The book stresses the idea that the clinical interview is controlled by the therapist and develops in a phase-sequenced progression along predictable lines. Clinical interviews flow from a theoretical stance on the part of the clinician, are usually semi-structured to the extent that areas are probed consistent with official diagnostic criteria and with know aspects of suspected psychopathologies, including co-morbidities, and include an understanding of the patient's personality and possible personality disorders that may complicate treatment of Axis I disorders or which may be the focus of treatment itself. This book elucidates this process and may serves as a primary source for practitioners who want to know more about the process of clinical interviewing as well as a useful text for those students who are in the process of learning clinical interviewing.

Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual Clinical Trials Methodology Workshop for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.

Over the past 20 years, diagnostic tests for pediatric pulmonologists have revolutionized care of children afflicted with respiratory disorders. These tests have been used to not only help in diagnosis, but also in the management and treatment of these children. Bronchoscopic, imaging and physiologic advances have improved clinical care of these children and have been used as outcome measures in research trials. Diagnostic Tests in Pediatric Pulmonology: Applications and Interpretation describes the various diagnostic modalities (especially the newer ones) that are available for the evaluation of pediatric respiratory disorders. It also provides an understanding of the advantages and limitations of each test so that the clinician may choose the most appropriate ones. An internationally renowned group of authors describe how best to interpret the key findings in a variety of tests as well as the possible pitfalls in incorrect interpretation. This volume focuses on the main diagnostic modalities used in the evaluation of pediatric patients with respiratory disorders and presents up-to-date information on the advantages and limitations of each test for a variety of conditions encountered in the practice of pediatric pulmonology. Clinical utility of these tests is also highlighted. This valuable resource is well suited to practicing clinicians, including pediatric pulmonologists, pediatricians and primary care practitioners, as well as trainees, respiratory therapists and clinical researchers.

In October 2016 Jo Watson hosted the very first `A Disorder for Everyone!' event in Birmingham, with psychologist Dr Lucy Johnstone, to explore (and explode) the culture of psychiatric diagnosis in mental health. To provide a space to continue the debate after the event, Jo also set up the now hugely popular and active Facebook group `Drop the Disorder!'.; Since then, they have delivered events in towns and cities across the UK, bringing together activists, survivors and professionals to debate psychiatric diagnosis. How and why does psychiatric diagnosis hold such power? What harm it can do? What are the alternatives to diagnosis, and how it can be positively challenged?; This book takes the themes, energy and passions of the AD4E events - bringing together many of the event speakers with others who have stories to tell and messages to share in the struggle to challenge diagnosis.; This is an essential book for everyone of us who looks beyond the labels.

Modern practical medicine requires high tech in diagnostics and therapy and in consequence in education. All disciplines use computers to handle large data bases allowing individual therapy, to interpret large data bases in form of neuronal signals, help visualization of organs during surgery. This book contains chapters on personalised therapy, advanced diagnostics in neurology, modern techniques like robotic surgery (da Vinci robots), 3D-printing and 3D-bioprinting, augmented reality applied in medical diagnostics and therapy. It is impossible without fast large scale data mining in both: clinical data interpretation as well as in hospital organization including hybrid surgery rooms and personal data flow. The book is based on a course for medical students organized in the editor's department. Every year, around 300 international undergraduate medical students take the course.

Examining children presents unique challenges for trainees and new doctors in paediatrics. Paediatric patients vary greatly in age and development, often find it difficult to describe their symptoms, and can behave unpredictably in clinical settings. Clinical Examination Skills in Paediatrics helps MRCPCH candidates and other practitioners learn effective history taking and fundamental examination techniques. Clear and concise chapters-with contributions from a team of paediatric specialists-demonstrate the clinical examination and questioning techniques used in daily practice. Emphasis on the intellectual processes involved in decision making assists both trainees preparing for a formal examination as well as new clinicians faced with a difficult diagnostic problem. Topics include cardiovascular and respiratory examination, examining a child with a neuromuscular disorder, musculoskeletal examination, and taking history from a child with diabetes and a rheumatological condition. Includes access to a companion website containing high-quality videos that demonstrate techniques, procedures and approaches Features commentary by experienced practitioners which offer observations and deductions at each stage of the examination process Offers tips for communicating effectively with the patients using appropriate lay terms Helps translate the symptoms and signs experienced by patients into medical-speak Covers all the skills tested in the MRCPCH Clinical exam Clinical Examination Skills in Paediatrics is the perfect study and reference guide for paediatrics trainees, MRCPCH candidates, foundation doctors, allied healthcare professionals, and anyone looking to improve their clinical and communication skills in paediatrics.

The book discusses novel visualization techniques driven by the needs in medicine and life sciences as well as new application areas and challenges for visualization within these fields. It presents ideas and concepts for visual analysis of data from scientific studies of living organs or to the delivery of healthcare. Target scientific domains include the entire field of biology at all scales - from genes and proteins to organs and populations - as well as interdisciplinary research based on technological advances such as bioinformatics, biomedicine, biochemistry, or biophysics. Moreover, they comprise the field of medicine and the application of science and technology to healthcare problems. This book does not only present basic research pushing the state of the art in the field of visualization, but it also documents the impact in the fields of medicine and life sciences.

Diagnosis is central to medical practice, medical knowledge and research, medicalization dynamics, and health and illness experience. Embedded in social relations, diagnoses reflect and shape social dynamics and cultural concerns. Diagnoses are integral to resource allocation, form the basis for identities, and may become a focal point of turf battles and contested authority. Some diagnoses are willingly embraced, whereas others are strenuously resisted. Some diagnoses come and go as fashions; others persist. A sociological approach to diagnosis therefore occupies a complex intersection of diverse subfields including medical sociology, sociology of knowledge, mental health, deviance, social control, sociology of science, social movements, the body, sexualities, gender, and health and illness. This volume explores the breadth of diagnosis and diagnoses through empirical reports, conceptual work, and theoretical statements from diverse perspectives. Reflecting the multi-faceted nature of the emerging field, the book is arranged in five sections: Frameworks, Context, Contestation, Identity, and Social Control. Sociology of Diagnosis thus provides both a starting point for discussion and means with which to organize the nascent conceptual landscape.

The Study Guide to DSM-5 is an indispensable instructional supplement to DSM-5 to help teachers and students of psychiatry, psychology, social work, medical schools, and residency programs understand and apply diagnostic criteria and key clinical concepts through a variety of learning tools. The Study Guide can stand alone as a training supplement to DSM-5 or be paired with DSM-5 Clinical Cases as comprehensive instruction for understanding and applying DSM-5. The Study Guide possesses a multitude of features that will benefit both learner and instructor: * Foundational concepts of diagnosis are amplified with case vignettes, discussion questions, and recommended reading to enrich knowledge and practice. * Content and features are consistent across the chapters for diagnostic classes. These chapters include an introduction, diagnostic pearls, summary discussion, and self-assessment questions and answers. In-depth discussions of key diagnoses within each class cover approach to the diagnosis, getting the history, diagnostic tips, clinical vignettes, and differential diagnosis.* Key clinical vignettes exemplify diagnostic criteria while reflecting the complexity of real-life scenarios. In addition, examples are offered to help readers appreciate diagnostic variations and ambiguities. * Discussion points and questions for self-assessment are provided for each diagnostic class throughout the guide, allowing readers to test their understanding of DSM-5 and helping teachers to focus on the most critical issues.* A special section dedicated to an overview of diagnostic questions that cover material across the Study Guide and DSM-5 provides additional testing of knowledge, along with an answer key. Engagingly written, the Study Guide to DSM-5 introduces learners to DSM-5 and provides them with the tools they need to fully understand and deftly apply DSM-5 concepts and criteria.

Medical Short Cases for Medical Students is intended to help medical s tudents with their preparations for medical short case examinations an d through this process to enhance the depth and breadth of their knowl edge of clinical medicine as well as their clinical skills. Though par ticularly useful to students during their final clinical exams, it wil l also be of interest to more junior students, particularly those who face medical short case clinical exams in their early clinical years. It aims to be useful whether the exam format is of the traditional sty le or more modern variations such as the Object, Structured, Clinical Examination (OSCE).

The definitive resource to the signs, symptoms, and patterns of medical diseases that CAN present as psychological problems This invaluable reference enables clinicians, as well as patients and their families, to become more familiar with these medical conditions and how they may masquerade as mental disorders.Part One of this book is organized so that it corresponds to the sections of the Standard Mental Status Exam. It is composed of clinical presentation descriptions that direct the reader to the medical diseases described inPart Two that may be contributing to the patient's discomfort. Without medical jargon, Barbara Schildkrout lucidly explains how patients with each medical condition may end up seeking help from a mental health professional. The conditions explored in this book include: * Alzheimer's disease * Brain tumors * Carbon monoxide poisoning * Diseases of the thyroid * Endocrine disorders * Hepatic encephalopathy * HIV/AIDS * Hyperventilation syndrome * Hypoglycemia * Limbic encephalitis * Lyme disease * Syphilis * Thiamine deficiency * Traumatic brain injury The book also describes a proven process for working with patients during and after the referral process, and integrating medical findings into ongoing therapeutic work. All mental health professionals need access to this information, and Masquerading Symptoms puts it all in a single, easily navigated reference. BARBARA SCHILDKROUT, MD,is an Assistant Clinical Professor of Psychiatry at Harvard Medical School. She has taught for many years at the Beth Israel Deaconess Medical Center. She has a Subspecialty Board Certification through the United Council for Neurological Subspecialties in behavioral neurology and neuropsychiatry and has maintained a private clinical practice in the Boston area for over 25 years.

Drawing on the author's wealth of experience in health care communications and backed up by solid research, Communicating with Today's Patient is filled with proven techniques and time-tested strategies physicians and other clinicians can immediately put into action.
This activity has been reviewed and is acceptable for up to 6 Prescribed credit hours by the American Academy of Family Physicians. Term of approval is for one year from beginning distribution date of October 1, 2000 with option to request yearly renewal.

To read Ten Reasons You Need to Read This Book, an excerpt from this book, click here.