Examining children presents unique challenges for trainees and new doctors in paediatrics. Paediatric patients vary greatly in age and development, often find it difficult to describe their symptoms, and can behave unpredictably in clinical settings. Clinical Examination Skills in Paediatrics helps MRCPCH candidates and other practitioners learn effective history taking and fundamental examination techniques. Clear and concise chapters-with contributions from a team of paediatric specialists-demonstrate the clinical examination and questioning techniques used in daily practice. Emphasis on the intellectual processes involved in decision making assists both trainees preparing for a formal examination as well as new clinicians faced with a difficult diagnostic problem. Topics include cardiovascular and respiratory examination, examining a child with a neuromuscular disorder, musculoskeletal examination, and taking history from a child with diabetes and a rheumatological condition. Includes access to a companion website containing high-quality videos that demonstrate techniques, procedures and approaches Features commentary by experienced practitioners which offer observations and deductions at each stage of the examination process Offers tips for communicating effectively with the patients using appropriate lay terms Helps translate the symptoms and signs experienced by patients into medical-speak Covers all the skills tested in the MRCPCH Clinical exam Clinical Examination Skills in Paediatrics is the perfect study and reference guide for paediatrics trainees, MRCPCH candidates, foundation doctors, allied healthcare professionals, and anyone looking to improve their clinical and communication skills in paediatrics.

This new volume in the Toolkit series is designed for clinicians and junior researchers who need to interpret the evidence for the effectiveness of the many diagnostic tests now available. Exceptionally user-friendly, this pocket-sized textbook realizes readers are not experts in diagnostic test interpretation. The authors cover a variety of issues, from how to design diagnostic test studies to understanding the results of diagnostic tests and interpreting the findings for clinical practice and health care policy.

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. "Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine" includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.

- Appeals to a multidisciplinary audience, including scientists, researchers, and clinicians with an interest in breath analysis

- Features the latest scientific research and technical breakthroughs in the diagnostic and therapeutic aspects of volatile organic compounds

- Includes case presentations documenting applications in multiple areas of human health and safety

As healthcare costs rise, so too do the costs of assessment instruments, critical tools for mental health professionals. While some traditional assessment instruments have become prohibitively expensive, as with many other fields, the Internet offers a host of more affordable and equitable alternative assessment tools at little or no cost. The pitfall of this alternative, thus far, has been the lack of vetting and quality assessment. "Assessing Common Mental Health and Addiction Issues With Free-Access Instruments" fills this gap by providing the first analysis and assessment of these tools, provided by some of the leading names in mental health assessment instruments. This resource identifies the most efficient free access instruments and provides summary information about administration, scoring, interpretation, psychometric integrity, and strengths and weaknesses. The book is organized around the most common broad range issues encountered by helping professionals, and whenever possible, a link to the instrument itself is provided. This is an essential text for all mental health professionals looking to expand the scope and range of their assessment instruments.

As healthcare costs rise, so too do the costs of assessment instruments, critical tools for mental health professionals. While some traditional assessment instruments have become prohibitively expensive, as with many other fields, the Internet offers a host of more affordable and equitable alternative assessment tools at little or no cost. The pitfall of this alternative, thus far, has been the lack of vetting and quality assessment. Assessing Common Mental Health and Addiction Issues With Free-Access Instruments fills this gap by providing the first analysis and assessment of these tools, provided by some of the leading names in mental health assessment instruments. This resource identifies the most efficient free access instruments and provides summary information about administration, scoring, interpretation, psychometric integrity, and strengths and weaknesses. The book is organized around the most common broad range issues encountered by helping professionals, and whenever possible, a link to the instrument itself is provided. This is an essential text for all mental health professionals looking to expand the scope and range of their assessment instruments.

Immunocytochemistry and in situ hybridization are widely used biomedical sciences. They are essential in medical diagnosis and in cell biology research. Affinity labeling is the central goal of the experimental strategy involving a series of techniques in a logical order; from the effects of specimen fixation, through specimen preparation to expose the antigen, to optimizing immunolabeling, to assessing the result and finally to safety considerations. Numerous examples of these techniques in biomedical sciences are included, as well as experimental assays and practical tips. This survey of methods will serve as an invaluable reference source in any laboratory setting (academic, industrial or clinical) involved in research in almost every branch of biology or medicine, as well as in pharmaceutical, biotechnological and clinical applications.

Accurately identify complex geometrical distortions of cardiac anatomy and make more informed decisions regarding diagnosis and treatment with Atlas of 3D Echocardiography. This new cardiology reference presents the authoritative, case-based, expert guidance you need to enhance your utilization and interpretation of this cutting-edge, dimensional diagnostic tool. Master the application of techniques to specific clinical situations with detailed case studies and discussions of challenging issues. See imaging findings as they appear in practice and discern subtle nuances with the aid of high-quality still images plus online videos. Reference the information you need quickly thanks to easy-to-follow, templated chapters, with an abundance of images and figures that facilitate visual learning. Take it with you anywhere! Access the full text, downloadable image library, videos, and more at www.expertconsult.com. Sharpen your interpretive and diagnostic skills in 3-D echo!

The aim of Hematologic Malignancies: Methods and Techniques is to review those methods most useful for the diagnosis and subsequent mana- ment of hematologic malignancies. The scope of coverage is intentionally broad, ranging from routine procedures to highly sophisticated methods not currently offered by most clinical laboratories. The latter methods were selected especially to bring into focus recent advances in molecular biology that, since they provide us with strong tools for assessing the outcome of upcoming therapeutic modalities intent on disease eradication, are expected to impact the future diagnosis and management of these diseases. Thus, the c- mon thread among all chapters is clinical relevance, whether sanctioned by past experience or by the expectation that seemingly esoteric research techniques of today will prove clinically valuable in the future. Hematologic Malignancies: Methods and Techniques is primarily a compilation of methods presented in sufficient detail-by authors with extensive expertise in their field-to serve not only as a reference for seasoned research and clinical laboratory pers- nel, but also as a guide for the less experienced. Moreover, the contributing authors also discuss the pathophysiologic bases and the diagnostic usefulness that underscore each method's clinical relevance. Thus, this volume should be also valuable to clinicians-especially hematologists, oncologists, and path- ogists-often bewildered by an ever increasing flow of new scientific inf- mation, the practical application of which is often either not clearly disclosed or difficult to discern.

The first pocket-size resource to guide PA students through their emergency medicine rotation.Prepare for and thrive during your clinical rotations with the quick-access pocket guide series, The Physician Assistant Student's Guide to the Clinical Year. The Emergency Medicine edition of this 7-volume series delineates the exact duties required in this specialty. Written by experienced PA educators, this guide details the clinical approach to common presentations such as chest pain, altered mental status, and headache. It also provides a systems-based approach to more than 40 of the most frequently encountered disease entities you will see in this rotation, including traumatic injury, cerebrovascular accident, and acute coronary syndrome. Distinguished by brief, bulleted content with handy tables and figures, the reference offers all pertinent laboratory and imaging studies needed to confirm a diagnosis, with medication and management guidelines. This guide also describes the most common procedures you will learn during the emergency medicine rotation, including incision and drainage, wound repair, and foreign body removal. Also included is a special chapter on non-medical situations you'll find in the emergency department, such as drug-seeking behavior, violent or incarcerated patients, and malingering and factitious disorders. Key Features: Provides a pocket-size overview of the PA emergency medicine rotation Describes common clinical presentations, disease entities, and procedures Offers clinical pearls throughout Reflects the 2019 NCCPA PANCE blueprint Includes three bonus digital chapters! Guided case studies to reinforce clinical reasoning, 25 rotation exam-style questions with remediating rationales, and additional resources to enhance your emergency department experience Other books in this series: The Physician Assistant Student's Guide to the Clinical Year: Family Medicine; Internal Medicine; Surgery; OB-GYN; Pediatrics; Behavioral Health

Diagnosing Autism Spectrum Disorders: A Lifespan Perspective is the first book of its kind to provide authoritative information for medical and mental health professionals on how to properly evaluate and diagnose autism spectrum disorders in individuals of all ages. * The first book of its kind which demonstrates how to conduct an appropriate diagnostic interview to assess a child for an Autism Spectrum Disorder * Considers the issues of Autism Spectrum Disorders in children, teenagers, and adults * Aimed at both medical and mental health professionals * Includes an in-depth treatment of the entire diagnostic process

Primary care diagnostics involves interpreting and applying information obtained directly from the patient. It re-emphasises the importance of the patient's input into the diagnostic process and of using investigations only after careful consideration has been given to the costs and benefits from both the patient's and the health service's perspectives. The first edition of this book, Patient-Centred Diagnosis, was acclaimed for returning the patient to the centre of diagnostic input and focusing on the interaction between doctor and patient. This revised and augmented new edition, Primary Care Diagnostics, expands on that success; it reflects the broader and equally important issues considered by clinicians or commissioners focusing on the diagnostic approach within primary care, and includes entirely new chapters on cancer and commissioning. Family doctors and other healthcare professionals in the primary care team will find this an enlightening guide. Private and commercial providers of primary care clinical assessment and diagnostic services will also find it of great interest, as will healthcare managers, as well as policy makers and shapers. From reviews of the First Edition: 'Even the more technical sections are expressed in a straightforward language. The style is clear, flowing and engaging. Useful.' THE BRITISH JOURNAL OF GENERAL PRACTICE 'Thought provoking. Clear, understandable and uses real examples from general practice. This is a book for GPs who wish to take a step back from daily practice and think about the reasons behind their actions.' PULSE

The first pocket-size resource to guide PA students through their OB/GYN rotation.Prepare for and thrive during your clinical rotations with the quick-access pocket guide series, The Physician Assistant Student's Guide to the Clinical Year. The OB/GYN edition of this 7-volume series delineates the exact duties required in obstetrics and gynecology. Written by an experienced PA educator, this guide details the clinical approach to common obstetric and gynecologic presentations such as pelvic pain, abnormal uterine bleeding, and an overview of the initial prenatal visit. It also provides treatment and management details for more than 30 of the most frequently encountered disease entities you will see in this rotation, including cervical dysplasia, dysmenorrhea, and ectopic pregnancy. Distinguished by brief, bulleted content with handy tables and figures, the reference offers all pertinent laboratory and imaging studies needed to confirm a diagnosis, with medication and management guidelines. This guide also describes the most common procedures you will learn during your OB/GYN, including PAP test, colposcopy, labor induction, and cesarean delivery. A special chapter on urgent gynecologic and obstetric conditions, such as placental abruption, sexual assault, and severe uterine bleeding, is also included. Key Features: Provides a pocket-size overview of the PA OB/GYN rotation Describes common clinical presentations, disease entities, and procedures Offers clinical pearls throughout Presents frequently encountered diagnostic studies and their indications Reflects the 2019 NCCPA PANCE blueprint Includes two bonus digital chapters! Three guided case studies to reinforce clinical reasoning plus 25 rotation exam-style questions with remediating rationales Other books in this series: The Physician Assistant Student's Guide to the Clinical Year: Family Medicine; Internal Medicine; Emergency Medicine; Surgery; Pediatrics; Behavioral Health.

This issue of Critical Care Nursing Clinics, guest edited by Stephen Krau, PhD, RN, on the topic of Diagnostic Testing will include the following article subjects: Overview of Diagnostic Testing; Electrodiagnostic Testing; Endoscopic Studies; Bronchoscopy Studies; Radiographic Studies; Angiography; Nuclear Scanning Studies; Intravenous Pyleogram;? Manometric Studies; Ultrasound Studies; Urine Tests; Stool Tests; and Centesis Studies.

This is the second edition of a successful textbook which puts emphasis on the study and knowledge of normality in physical diagnosis, in order to better appreciate, describe, diagnose and treat the abnormal. Clearly written and generously illustrated, it describes in practical step-by-step, head to-toe procedures, the diagnostic examination of the newborn, child and adolescent. It provides a novel approach to the recognition and description of physical findings. The book is divided into 4 sections - Introduction to the Concept of Normality, Taking the History, Physical Examinations, and Specialised Examinations. It emphasises the importance of both subjective and objective observations, of distinguishing between the two, and of the use of exact measurements whenever possible. The book is comprehensive and easy to use, the text flows easily and understandably, unusual or key words are defined, rare diseases, unusual syndromes and name-dropping are avoided wherever possible. In short, this new edition of Pediatric Physical Diagnosis is an enjoyable, invaluable reference for both the beginner and the experienced physician and for trainees specialising in pediatrics and neonatology.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of thoracic pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Thoracic, 3rd Edition, is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of pulmonary, pleural, and mediastinal entities Features an updated chapter on severe acute respiratory syndrome (SARS) pneumonia with current knowledge, statistics, and pathophysiology on COVID-19, including new images that encompass the radiology, gross pathology, and histopathology of the disease Includes updated criteria, terminology, and classifications for a wide range of tumors from the 2021 World Health Organization Classification of Tumors of the Lung, Pleura, Thymus and Heart, reflecting changes to currently used terminologies for adenocarcinoma, squamous cell carcinoma, neuroendocrine tumors, mesothelioma, soft tissue tumors, benign tumors, and more Covers the recent explosion of molecular genetic information, including new Molecular Pathology sections with new information on the genetic underpinnings of diseases Specifies genetic mutation types associated with each tumor and covers numerous types of molecular tests, including next-generation sequencing studies and how the specific genetic alterations are used to differentiate disease and aid in diagnosis Features over 3,900 high-quality images, including histologic images, gross pathology images, radiologic images, and full-color illustrations as well as more than 750 additional online-only images to help practicing and in-training pathologists reach a confident diagnosis Contains multiple recent consensus clinical practice guidelines for thoracic disease diagnosis, including those for molecular genetic testing and predictive biomarker testing from the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.

The practice of medicine is both learned and advanced through the compilation and study of cases -- vignettes that record the presentation, diagnosis, and treatment of individual patients and diseases. This is especially true of psychosomatic medicine (PSM), which depends on the "compelling case" to distill clinical knowledge and communicate it to students, residents, and clinicians. An invaluable contribution to the field, the Casebook of Psychosomatic Medicine describes the psychiatric symptoms and/or illnesses managed by the PSM psychiatrist in collaboration with other medical colleagues. The book presents a broad range of cases illustrating the medical, psychosocial, and intertwined situations psychiatrists are likely to encounter in an academic medical center setting.

No other single volume offers a broader range of engaging, detailed, and nuanced PSM cases, or grounds them so firmly in a psychiatric, psychosocial, and spiritual context. Here are just a few of this patient-centered book's most impressive and useful features: - The relevant science underlying each case is addressed in discussion sections, allowing the book to be read as a stand-alone volume. Alternatively, the cases can be read as instructive and insightful illustrations by the reader who has already absorbed the fundamentals of PSM from standard textbooks in the field.- This user-friendly book is organized by the organ system or disease type of the presenting illness or symptom.- Content rare in volumes of this kind includes detailed coverage of the diagnosis and management of cognitive disorders; the management of drug toxicity states; determinations of decisional capacity for medical decision making; and "stress and adaptation," an issue the PSM psychiatrist encounters daily.- The authors strongly believe that one of the most crucial roles for the psychiatrist is in the medical center, and the book reflects that orientation. - The book addresses the importance of understanding the impact of patients' systemic illnesses on their psychiatric symptoms, and modifying interventions and care accordingly. These abilities are critical to sound PSM practice.

Although PSM has a long and noble history, it is the newest of the psychiatric subspecialties, and as the literature expands, more and more clinicians will incorporate PSM treatment modalities into their practice. The Casebook of Psychosomatic Medicine is an essential contribution to that body of knowledge and establishes a new standard with which to face the future of this exciting field.

Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile acids become associated with disease. This breaching of control mechanisms can occur through dietary means (e.g. in obesity) whereby excessive levels of Bile acids are produced and converted (via the bacterial flora) to damaging secondary Bile acids. Furthermore, lack of re-absorption of Bile acids can lead to liver pathologies. The atypical movement of Bile acids into the oesophagus, stimulated by episodes of reflux, is linked to oesophageal cancer. In recent years there have been tremendous advances in the understanding of the mechanisms behind the toxicity and bioactivity of different Bile acids and these are covered at length in this book. Prior to the publication of this book there was no single source of information on the toxicology and bioactivity properties of Bile acids. The book also uniquely collects all the relevant information together regarding the role of Bile acids in human disease and the mechanisms underlying Bile acid induced pathology. Additionally, as Bile acids are synthesised from cholesterol, there is wide recognition of the role for Bile acids in obesity linked diseases and this is also covered in this new publication. The book is edited by two experts in the field who have been involved in Bile acid research for several years and who are closely involved with major research groups in the UK, Europe and the US actively engaged in Bile acid research. The Editors have brought together world experts in their own fields to discuss the contribution of Bile acids to various disease pathologies, as well as discussing the mechanisms behind their activity. The book details the plethora of biological activities of this fascinating group of naturally occurring chemicals and provides a one-stop reference for scientists wishing to gain a fuller understanding of Bile acid activity and function.

The sixth edition of Ellestad's classic text on cardiac stress testing has been extensively updated and re-written to communicate contemporary understanding of the classical principles of stress testing to clinicians and researchers, students and seasoned practitioners alike. The current techniques for performing stress tests presented herein reflect major technologic advances in imaging, physiologic monitoring and the assessment of cardiovascular risk, addressing fundamental paradigm shifts in interventional, surgical and medical treatment of heart disease. Moreover, the text addresses the dramatic changes that are occurring in patient demographics and the environmental, socioeconomic, gender and genomic factors that crucially impact heart disease and warrant attention when performing cardiac stress testing. Chapters on the physiology of exercise testing including practical details regarding protocols for conducting the stress test, proper supervision, important parameters to be monitored, and the diagnostic and prognostic information to be gleaned from the electrocardiogram set the stage for expanded chapters on the use of cardiac imaging in conjunction with stress testing. Physiologic and metabolic considerations during stress testing are covered in detail. Application of stress testing to special populations, such as women, children, athletes, and individuals in both high and low risk groups are covered in new chapters. Finally, the authors address the use of stress testing in limited resource environments and discuss global changes in the incidence of atherosclerosis, and suggest how stress testing may evolve.

Pocket Guide to Gene Level Diagnostics in Clinical Practice is an abbreviated, pocket-size, quick-reference guide that provides a point-by-point synopsis of the vast wealth of information contained in CRC Handbook of Gene Level Diagnostics in Clinical Practice. All sections and subsections in the Pocket Guide are cross-referenced to corresponding pages in the Handbook. The book works well on its own as a quick reference, but also can be used in conjunction with the larger Handbook for detailed coverage and references to specific information. Pocket Guide to Gene Level Diagnostics in Clinical Practice also includes extensive supplements featuring material not included in the Handbook. These are intended to provide an up-dated, practical source of information useful to anyone involved in molecular diagnostic research and/or service. Supplements are cross-referenced to the main text of the Pocket Guide, that complement and enhance the material covered. Pocket Guide to Gene Level Diagnostics in Clinical Practice will be a handy reference for professionals and students in pathology, biotechnology, biology, and medicine.

The first pocket-size resource to guide PA students through their surgery rotation.Prepare for and thrive during your clinical rotations with the quick-access pocket guide series, The Physician Assistant Student's Guide to the Clinical Year. The Surgery edition of this 7-volume series delineates the exact duties required in this specialty. Written by an experienced PA educator, this guide details common surgical procedures you'll see, such as thyroidectomy, hernia repair, mastectomy, and appendectomy. It also provides important information on surgical emergencies, including gastrointestinal bleeding, perforated viscus, and limb ischemia. System-based chapters reviewing the presentation and management of common conditions that may require surgery are also included. Advice on taking good SOAP notes, guidance on how to prepare patients for surgery, and tips on surgical etiquette will help you excel during this intense rotation. Additional chapters on pre- and post-operative management of patients, sterile technique, and common wound closure methods will arm you with the knowledge you'll need to succeed. Key Features: Provides a pocket-size overview of the PA surgery rotation Describes common surgical procedures and emergencies Offers clinical pearls throughout Includes key abbreviations you'll need to decipher in documentation Reflects the 2019 NCCPA PANCE blueprint Includes two bonus digital chapters! Three guided case studies to reinforce clinical reasoning plus 25 rotation exam-style questions with remediating rationales Other books in this series: The Physician Assistant Student's Guide to the Clinical Year: Family Medicine; Internal Medicine; Emergency Medicine; OB-GYN; Pediatrics; Behavioral Health

Here's a powerful quick reference and clinical tool - small enough to fit into your pocket, yet complete enough to cover any assessment test you need to perform! Detailing every test included in Illustrated Orthopedic Physical Assessment, 3rd Edition, this handy, thoroughly illustrated pocket guide includes only the essential information you need to know. Information for each test is presented in a consistent manner for quick reference, and includes: name of the test, alternate names for the test, suspected syndrome, concise description of the testing procedure, clinical pearl, and photo(s) of the procedure. Plus, just as in the parent text, each test also contains a corresponding orthopedic gamut which provides a summary of key points in a concise list, serving as a diagnostic rubric for use in patient exams. Fits in your lab coat pocket, giving you easy access to frequently used assessment and testing information. Every test from the parent textbook, Illustrated Orthopedic Physical Assessment, 3rd Edition, is included in this pocket guide. A consistent format for each test (the same format as the parent text) ensures that you'll find the information you need quickly and easily. Clinical pearls appear with almost every test, detailing author's own clinical experience and providing valuable insight to both students and practitioners. Nearly 400 orthopedic gamuts concisely cover anatomy, motion assessment, muscle function, and imaging elements - essential concepts for effective assessment and diagnostic decision-making. A complete index of tests appears on the inside cover in alphabetical order, as well as by body system, so you can see at a glance which tests are covered and where to find them. Nearly 500 illustrations (line drawings and photographs) show key moves of each test, and other necessary maneuvers, anatomy, and pathologies. A glossary of key abbreviations is included at the end of the book, familiarizing you with common clinical terms and notation. A comprehensive bibliography provides helpful references for further research and study. All-new photos clearly illustrate every assessment test. Updated content ensures you have the latest assessment information at your fingertips.

This book provides a complete overview of all modalities used for hand and wrist imaging, along with a complete overview of the various disease entities that can be diagnosed. As a state-of-the-art overview of hand and wrist imaging it is a reference work for radiologists, hand surgeons, orthopedists, traumatologists, rheumatologists and internists and their residents in training. The chapters are written by experts in musculoskeletal radiology from various European countries and the USA.