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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Bile Acids - Toxicology and Bioactivity (Hardcover)
Loot Price: R2,337
Discovery Miles 23 370
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Bile Acids - Toxicology and Bioactivity (Hardcover)
Series: Issues in Toxicology, Volume 4
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Bile acids are increasingly being seen as extremely important
carcinogenic agents in cancers of the bile duct, liver, colon,
rectum, and oesophagus. They are essential agents involved in lipid
digestion and absorption in mammals, however, they also play
wide-ranging roles in a variety of disease states ranging from
diabetes to cancer. They have evolved exquisite mechanisms for
controlling their own synthesis and to ensure that they are
produced at correct concentrations and also kept in the correct
anatomical environment. It is only when these fine levels of
controls are breached that Bile acids become associated with
disease. This breaching of control mechanisms can occur through
dietary means (e.g. in obesity) whereby excessive levels of Bile
acids are produced and converted (via the bacterial flora) to
damaging secondary Bile acids. Furthermore, lack of re-absorption
of Bile acids can lead to liver pathologies. The atypical movement
of Bile acids into the oesophagus, stimulated by episodes of
reflux, is linked to oesophageal cancer. In recent years there have
been tremendous advances in the understanding of the mechanisms
behind the toxicity and bioactivity of different Bile acids and
these are covered at length in this book. Prior to the publication
of this book there was no single source of information on the
toxicology and bioactivity properties of Bile acids. The book also
uniquely collects all the relevant information together regarding
the role of Bile acids in human disease and the mechanisms
underlying Bile acid induced pathology. Additionally, as Bile acids
are synthesised from cholesterol, there is wide recognition of the
role for Bile acids in obesity linked diseases and this is also
covered in this new publication. The book is edited by two experts
in the field who have been involved in Bile acid research for
several years and who are closely involved with major research
groups in the UK, Europe and the US actively engaged in Bile acid
research. The Editors have brought together world experts in their
own fields to discuss the contribution of Bile acids to various
disease pathologies, as well as discussing the mechanisms behind
their activity. The book details the plethora of biological
activities of this fascinating group of naturally occurring
chemicals and provides a one-stop reference for scientists wishing
to gain a fuller understanding of Bile acid activity and function.
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