A compendium of the latest published diagnostic criteria for a diverse group of neurological conditions. The criteria cover a wide spectrum of neurological conditions whose diagnosis does not depend solely on histopathology (e.g., brain tumors), including cerebrovascular diseases, dementias and behavioral disorders, demyelinating disorders, and disorders of consciousness and brain death. Standardized criteria are also provided for epilepsy, genetic syndromes, headache, immune-based disorders, infectious diseases, movement disorders, neuromuscular disorders, and sleep disorders. A dazzling array of tables summarizes useful information on both common and uncommon neurological conditions, including many genetic and pediatric neurological disorders. Innovative and authoritative, Diagnostic Criteria in Neurology begins to do for neurology what the DSM (Diagnostic and Statistical Manual) did for psychiatry.

This book disseminates information on paper-based diagnostics devices and describes novel paper materials, fabrication techniques, and Basic Paper-based microfluidics/electronics theory. The section on sample preparation, paper-based electronics/sensors for developing paper-based point-of-care (POC) systems also contains detailed descriptions. In the application sections this book covers sensing technique for DNA/RNA, bacteria/virus and integration of lateral flow assay. The book provides deep understanding and knowledge of paper-based diagnostic device development in terms of concept, materials, fabrication and applications.

A detailed description of a new approach to perceptual analysis and processing of medical images is given. Instead of traditional pattern recognition a new method of image analysis is presented, based on a syntactic description of the shapes selected on the image and graph-grammar parsing algorithms. This method of "Image Understanding" can be found as a model of mans' cognitive image understanding processes. The usefulness for the automatic understanding of the merit of medical images is demonstrated as well as the ability for giving useful diagnostic descriptions of the illnesses. As an application, the production of a content-based, automatically generated index for arranging and for searching medical images in multimedia medical databases is presented.

The polymerase chain reaction (PCR) is one of the most important molecular biological methods ever devised, with numerous applications to cli- cal molecular medicine. Since its description in 1985, PCR has undergone tremendous improvements, and many variations on the basic PCR theme have been published. With such a large volume of PCR-related literature, a clinical scientist wishing to use the technique will have a difficult task loc- ing the relevant information to implement it effectively. There is thus clearly a need for an up-to-date volume with detailed protocols to facilitate the setting up of those techniques most relevant to clinical applications. Unlike some other books on this topic, Clinical Applications of PCR includes only methods that are of direct relevance in clinical settings. The book is organized in three parts: an introductory section, a section on general methodology, and a final section with specific clinical applications. The first section covers the basic principles of PCR and is most useful to those new to molecular diagnosis. The next chapter includes useful tips for setting up a PCR laboratory. Section 2 then outlines some of the most commonly used PCR-based techniques in molecular diagnosis. Section 3 includes carefully chosen examples that represent typical applications of PCR in diverse clinical fields, encompassing hematology, oncology, genetics, and microbiology.

The enormous advances in molecular biology that have been witnessed in . Not recent years have had major impacts on many areas of the biological sciences least of these has been in the field of clinical bacteriology and infectious disease . Molecular Bacteriology: Protocols and ClinicalApplications aims to provide the reader with an insight into the role that molecular methodology has to play in modern medical bacteriology. The introductory chapter ofMolecular Bacteriology: ProtocolsandCli- cal Applications offers a personal overview by a Consultant Medical Microbio- gist of the impact and future potential offered by molecular methods. The next six chapters comprise detailed protocols for a range of such methods . We believe that the use of these protocols should allow the reader to establish the various methods described in his or her own laboratory. In selecting the methods to be included in this section, we have concentrated on those that, arguably, have greatest current relevance to reference clinical bacteriology laboratories; we have deliberately chosen not to give detailed protocols for certain methods, such as multilocus enzyme electrophoresis that, in our opinion, remain the preserve of specialist la- ratories and that are not currently suited for general use. We feel that the methods included in this section will find increasing use in diagnostic laboratories and that it is important that the concepts, advantages, and limitations of each are th- oughly understood by a wide range of workers in the field .

"The Physical Lincoln Complete" combines two groundbreaking books -- "The Physical Lincoln" and "The Physical Lincoln Sourcebook" -- into one handy volume. It is the ultimate guide to the startling health history of Abraham Lincoln and his family. The first book, "The Physical Lincoln," offers a solution to one of the most enduring mysteries in American history: What made Abraham Lincoln so tall, thin, and less than attractive? What gave him his long limbs, large feet, high voice, odd lips, sluggish bowels, and astonishing joint flexibility? The never-before-proposed solution points to Lincoln's DNA and the rare genetic disorder called MEN2B. In addition to producing Lincoln's remarkable body shape, MEN2B gave him a sad-looking face that, for more than 150 years, has been consistently misinterpreted as depression. It tragically took his mother and three of his sons at early ages (Eddie, Willie, and Tad), and it was killing Lincoln in his last years. "The Physical Lincoln" upends the myth of a physically vibrant President, showing that, had he not been shot, Lincoln would have died from advanced cancer in less than a year, the result of MEN2B. Written in clear, non-technical language for the general reader, and using more than 180 illustrations, "The Physical Lincoln" offers fundamental new insights into Lincoln, and is the perfect book to stimulate a young person's interest in science and medicine. The second book, "The Physical Lincoln Sourcebook," organizes more than 5900 fully-referenced historical facts and three family trees into the fullest possible medical record for Lincoln and his family members. Nine special topics explore major issues such as Lincoln's smallpox, his gait, hisshooting, the possibility that he had syphilis, and the innumerable medical complaints of Mary Lincoln, his wife. Heavily annotated throughout, with an extensive bibliography and an on-line full-text index of the main sections, "The Physical Lincoln Sourcebook" is the definitive, comprehensive reference to all facets of Lincoln's anatomy and physiology. Scholars, Lincoln presenters, and anyone truly wishing to understand Abraham Lincoln will find it indispensable. See www.physical-lincoln.com for more information.

Medical Image Databases covers the new technologies of biomedical imaging databases and their applications in clinical services, education, and research. Authors were selected because they are doing cutting-edge basic or technology work in relevant areas. This was done to infuse each chapter with ideas from people actively investigating and developing medical image databases rather than simply review the existing literature. The authors have analyzed the literature and have expanded on their own research. They have also addressed several common threads within their generic topics. These include system architecture, standards, information retrieval, data modeling, image visualizations, query languages, telematics, data mining, and decision supports. The new ideas and results reported in this volume suggest new and better ways to develop imaging databases and possibly lead us to the next information infrastructure in biomedicine. Medical Image Databases is suitable as a textbook for a graduate-level course on biomedical imaging or medical image databases, and as a reference for researchers and practitioners in industry.

This volume contains the papers presented at the 14th International Conference on Information Processing in Medical Imaging. IPMI meetings have a a strong emphasis on the clinical relevance and validation of medical imaging. This book covers the whole spectrum: acquisition, tomographic reconstruction, registration, segmentation, knowledge-based analysis, display and image quality as well as several important applications. Several papers present significant advances in topics already discussed at previous meetings while others deal with new topics and methodology, opening new horizons in medical imaging. In addition to the 28 full-length papers, 30 short communications are included to sample the most current work in progress. Audience: An up-to-date and complete overview of ongoing research in medical imaging, beneficial to all physicists, computer scientists and physicians who wish to remain informed on state-of-the-art methodology in medical imaging.

This volume illustrates how microfluidic approaches can meet the requirement of clinical diagnosis based on molecular or cellular biomarkers. Microchip Diagnostics: Methods and Protocols is divided into four sections describing the business aspects of the microfluidic-based systems for diagnosis, demonstrating how versatile microfluidics can be regarding to protein bioassay integration, presenting microfluidic approaches for nucleic analysis based on mono or diphasic format, and highlighting recent contributions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

In the past, many tumor marker laboratory tests have not been sensitive enough for the very early detection of cancer. However, many of them have nonetheless proved useful in monitoring therapy, following the course of the tumor, and predicting prog- nosis. Today, cancer may be viewed as a genetic disease with various specific chromo- somal and nucleotide aberrations, such as mutations, deletions, gene amplification, gene rearrangements, and translocations occurring during the transformation of a nor- mal cell into a malignant cell. The considerable advances in technology during the past several years have greatly enhanced our ability to detect human cancers in the very early stages of tumor forma- tion. These technologies include: (1) nucleotide molecular assays (genomics); (2) proteomics (multiplex protein measurements); (3) DNA microarrays; and (4) bio- informatics. Many of these technologies are already helping in the integration and use of multiple biomarkers for tumors. Although the individual biomarkers may reveal only limited information, the use of multiple biomarkers can help markedly elevate the diagnostic capabilities for early detection of tumors.

MRCP PACES: 180 Clinical Cases offers a wealth of practice cases covering a wide range of topics for trainees preparing for the MRCP PACES exam. Chapters are mapped to the syllabus, and feature a unique signs and symptoms framework to provide structured revision in each clinical specialty. Presented in a clear layout, this book has been explicitly designed from the candidate's perspective, to enable trainees to approach clinical cases confidently and maximise chances of exam success. Provides model answers and invaluable suggestions to impress examiners and achieve the highest marks 180 clinical cases, covering the breadth of topics and skills tested in the exam Addresses every aspect of the exam, including the toughest component, Station 5 Highly illustrated to augment concise descriptions and enhance learning Complements MRCP Part 1: 400 BOFs and MRCP Part 2: 450 BOFs - the complete MRCP revision package

Addressing the origin, current status, and future development of point-of-care diagnostics, and serving to integrate knowledge and tools from Analytical Chemistry, Bioengineering, Biomaterials, and Nanotechnology, this book focusses on addressing the collective and combined needs of industry and academia (including medical schools) to effectively conduct interdisciplinary research. In addition to summarizing and detailing developed diagnostic devices, this book will attempt to point out the possible future trends of development for point-of-care diagnostics using both scientifically based research and practical engineering needs with the aim to help novices comprehensively understand the development of point-of-care diagnostics. This includes demonstrating several common but critical principles and mechanisms used in point-of-care diagnostics that address practical needs (e.g., disease or healthcare monitoring) using two well-developed examples so far: 1) blood glucose meters (via electrochemistry); and, 2) pregnancy tests (via lateral flow assay). Readers of this book will come to fully comprehend how to develop point-of-care diagnostics devices, and will be inspired to contribute to a critical global cause - the development of inexpensive, effective, and portable in vitro diagnostics tools (for any purpose) that can be used either at home or in resource limited areas.

With rapid improvements in instrumentation, lasers, fluorophores, and data analysis software, flow cytometry is riding the crest of unprecedented, innovative advances. This thoroughly revised and up-to-date third edition of Flow Cytometry Protocols highlights the expanding contribution of flow cytometry to basic biological research and diagnostic medicine. Written by leading experts in the field, the book presents cutting-edge topics such as polychromatic, quantitative, and high throughput flow cytometry, novel multiparametric data analysis which breaks the dimensionality barrier, standard practice and safety measures for aerosol-generating cell sorting, conventional and imaging flow cytometry as well as minimalist imaging cytometry. As a volume in the highly successful Methods in Molecular BiologyT series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and extensive notes on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Flow Cytometry Protocols, Third Edition presents established as well as new flow cytometric methodologies in order to introduce beginning users to basic applications while opening new avenues of innovation for seasoned users. Content Level Professional/practitioner

This volume is the first collection of applications of proteomics to analyze various human body fluids. Proteomics of Human Bodyfluids consists of two parts. The first provides basic principles and strategies for proteomic analysis of human body fluids. The second offers more details regarding methodologies and recent findings and clinical applications of each specific type of human body fluids.

Physics has been applied to medical diagnosis for very nearly 400 years, and has now become an essential element of medical practice. This book concentrates on the theoretical basis of the physics which supports diagnostic techniques in modern clinical practice. Arising out of over a decade of teaching a course on medical physics to third year undergraduate students, the book has been structured so that individuals with a non-physics background, such as medical students or practitioners, can also benefit.

As many as one in four adults in the workforce will suffer from psychiatric illness in a given year. Such illness can have serious consequences -- job loss, lawsuits, workplace violence yet the effects of mental health issues on job functioning are rarely covered in clinical training. In addition, clinicians are often asked to provide opinions on an employee s fitness for work or an evaluation for disability benefits, only to find themselves embroiled in complex legal and administrative conflicts. A unique collaboration between a renowned clinical professor of psychiatry and a noted legal expert, Evaluating Mental Health Disability in the Workplace approaches the topic from two distinct areas: the legal context and issues relevant to disability and disability-related evaluations, and the interplay of factors in the relationship between work and psychiatric illness. From this dual perspective, the authors advocate for higher professional standards ensuring that employers, evaluees, or third parties are provided with the most reliable information.

Key features of the book:

• A robust assessment model of psychological disability in the workplace
• Practice guidelines for conducting workplace mental health disability evaluations
• Legal and ethical aspects of employment evaluations, especially as they differ from clinical procedure
• Examination of the process of psychiatric disability development
• Issues specific to evaluations for Social Security, Workers Compensation, and other disability benefit programs
• Review of relevant administrative and case law.

As an introduction to these complex issues or for the further improvement of evaluation skills, Evaluating Mental Health Disability in the Workplace is a timely reference for psychiatrists, psychologists, forensic mental health specialists, and attorneys in this field."

Drugs in Use: Case Studies for Pharmacists and Prescribers helps you to bridge the gap between theoretical knowledge about medicines and the practical application to your patients. The sixth edition of this popular text has been extensively revised to ensure that a primary care focus is included whenever possible, in order to reflect the fact that drug management of chronic conditions increasingly takes place in primary care, and that this is an expanding role for pharmacists working in GP surgeries. There are new chapters on atrial fibrillation, chronic asthma, general surgery, sepsis, deprescribing and supporting adherence.

Medical image technologies play a significant role in visualization and interpretation methods in medical diagnosis and practice using decision making, pattern classification, diagnosis, and learning. Progressions in the field of medical imaging lead to interdisciplinary discovery in microscopic image processing and computer-assisted diagnosis systems, and aids physicians in the diagnosis and early detection of diseases. Histopathological Image Analysis in Medical Decision Making provides emerging research exploring the theoretical and practical applications of image technologies and feature extraction procedures within the medical field. Featuring coverage on a broad range of topics such as image classification, digital image analysis, and prediction methods, this book is ideally designed for medical professionals, system engineers, medical students, researchers, and medical practitioners seeking current research on problem-oriented processing techniques in imaging technologies.

Continuing a legacy of excellence that spans nearly five decades, Bates' Nursing Guide to Physical Examination and History Taking, 3rd Edition, adapts the proven techniques and vibrant visuals of Bates' gold-standard assessment text specifically for the needs of today's nursing students. Thoroughly updated, evidence-based coverage emphasizes the healthy patient and clearly details common findings and diseases to help students develop and practice key skills in physical examination and history taking. Content is logically organized by Foundations, Body Systems, and Special Lifespan Considerations, incorporating essential review of anatomy and physiology, as well as critical practice in health history review, recording findings, and health promotion. Reflecting the latest research in the field, including emerging issues such as vaping, the opioid crisis, and the COVID-19 pandemic, the 3rd Edition combines trusted approaches with current clinical perspectives to equip your students for success throughout their nursing careers.

Computational intelligence techniques are gaining momentum in the medical prognosis and diagnosis. This volume presents advanced applications of machine intelligence in medicine and bio-medical engineering. Applied methods include knowledge bases, expert systems, neural networks, neuro-fuzzy systems, evolvable systems, wavelet transforms, and specific internet applications. The volume is written in view of explaining to the practitioner the fundamental issues related to computational intelligence paradigms and to offer a fast and friendly-managed introduction to the most recent methods based on computer intelligence in medicine.

Complex disorders of the carbohydrate metabolism and associated complications cause many abnormalities detectable by radiography in the bones and joints. Mild clinical symptoms associated with very severe radiological changes were first rec ognized in relation to the gastroenterologic complications of diabetes. This phenomenon is more frequent in the skeletal system. For example, mild and painless swelling of the foot joints may often mask extremely severe bone destruction. Several other bone changes associated with diabetes are only detectable by radiography. Thus, the radiologist plays an important role in confirming these diabetic complications, furthermore he is involved in the therapeutic management of the patient. Although many details on this subject have been published, however no summarizing monograph has yet appeared. Manuals discussing diabetes include only short reviews on complications of the osseous system. The fact that the incidence of diabetes is very high, at present 1 %-2 % of the population is affected and their number is gradually increasing - dis plays the timeliness of this subject. Fifty years of experience with insulin therapy indicates that several important problems still remain to be solved. Insulin and modern oral antidia betic drugs proved extremely efficient in the management of hyperglycemia and ketosis, but the incidence of other complications has not decreased. Moreover, as the number of diabetics and their life expectancy increase, late complications become likewise more fre quent. Diabetic osteoarthropathy is one of these complications.

Handbook of Biomedical Image Analysis: Segmentation Models (Volume I) is dedicated to the segmentation of complex shapes from the field of imaging sciences using different mathematical techniques. This volume is aimed at researchers and educators in imaging sciences, radiological imaging, clinical and diagnostic imaging, physicists covering different medical imaging modalities, as well as researchers in biomedical engineering, applied mathematics, algorithmic development, computer vision, signal processing, computer graphics and multimedia in general, both in academia and industry . Key Features: - Principles of intra-vascular ultrasound (IVUS) - Principles of positron emission tomography (PET) - Physical principles of magnetic resonance angiography (MRA). - Basic and advanced level set methods - Shape for shading method for medical image analysis - Wavelet transforms and other multi-scale analysis functions - Three dimensional deformable surfaces - Level Set application for CT lungs, brain MRI and MRA volume segmentation - Segmentation of incomplete tomographic medical data sets - Subjective level sets for missing boundaries for segmentation