Multiple sclerosis is the most common neurological cause of debilitation in young people; it affects approximately 85,000 people in the UK, 400,000 people in the US and approximately 2.5 million people worldwide. The disease commonly manifests in the second or third decade of life, and in most cases it leads to progressive disability, which explains its enormous impact on the economy (estimated at around GBP1.4 billion annually). The disease is incurable and the precise causes are still unknown. Part of the Oxford Neurology Library series, this practical pocketbook summarises the latest understanding of what might cause the disease, the methods of diagnosis and assessment, and current management techniques. The book also includes chapters on variants of multiple sclerosis, on childhood-onset disease and future therapies. This pocketbook will serve as an invaluable reference for trainee neurologists, consultants needing rapid access to core facts, interested general practitioners and specialist MS nurses.

A concise, quick-reference handbook on history taking and physical examination Pocket Guide to Physical Assessment is a compact yet comprehensive reference for students and practitioners alike, employing a step-by-step framework for effective patient assessment, diagnosis and planning of care. This valuable guide covers topics including cardiovascular, respiratory, neurological and musculoskeletal system examinations, patient interviews, history taking and general health assessments. Clear diagrams and checklists illustrate key points, while easy-to-follow instructions and concise descriptions of clinical situations and diseases aid in clinical decision-making. Compact, pocket-sized guide that contains only the essential information for physical assessment Instructs readers on best clinical practice and how to present and communicate cases Develops and improves necessary skills for physical clinical examinations Ideal for use on the ward or as a companion to the accompanying textbook, Physical Assessment for Nurses and Healthcare Professionals Pocket Guide to Physical Assessment is an invaluable reference for healthcare students, newly qualified and advanced nurse practitioners, and allied health practitioners.

The diagnosis and treatment of benign prostatic hyperplasia (BPH) is considered to be one of the most important topics in urology and afflicts millions of older men world-wide. Although it is not life threatening, its clinical manifestation as lower urinary tract symptoms (LUTS) reduces the patient's quality of life over many years. Patients often suffer from LUTS due to BPH for a long time. If left untreated, the patients are at significant risk of potentially severe complications. Over the last decade, new diagnostic approaches and treatment options such as prostate lasers have become more accepted in the urological community. This pocketbook provides an update of several aspects related with BPH / LUTS and covers the entire background, diagnostic process and treatment options available to patients suffering from LUTS due to BPH. It will give trainees in urology and general physicians a quick, concise but complete overview of diagnostic processes and recommended treatment options.

"Ureteroscopy: Indications, Instrumentation& Technique" provides a comprehensive and state-of-the-art review of ureteroscopy and will serve as a valuable resource for urologists throughout the world. The volume provides evidence based outcomes to support the expanding indications for ureteroscopy as well as a strong emphasis on appropriate patient selection. The book also provides detailed recommendations for the step-by-step approach to ureteroscopy from both an instrumentation and techniques perspective. The work is extensively illustrated with endoscopic images and accompanied by a web site of video clips which further highlight the clinical application of available endoscopic techniques. The text also includes highly practical presentations of complex endourologic case presentations with expert analysis and editorial commentary. Example cases would include common but challenging cases of ureteroscopy for transitional cell cancer, horseshoe kidneys, hutch diverticulum, and pregnancy.

"Ureteroscopy: Indications, Instrumentation& Technique" provides a unique and valuable resource in the field of ureteroscopy and will include basic instructions for those currently in training or those who have yet to adapt intrarenal ureteroscopy into their surgical armamentarium. Advanced ureteroscopic approaches are also covered for those wishing to enrich their current clinical expertise. "

Second Edition was a winner of the AJN Award! ""Unique to this book, and what sets it apart from other books on simulations and clinical scenarios, are the personal experiences...that the authors bring to the chapters. The authors' passion, enthusiasm, and inspiration are truly reflected and demonstrated in each chapter. Authors talk about lessons learned, teaching strategies, and in-depth research... Key highlights in the book include the practice application of how to develop, implement, and evaluate clinical simulations in your nursing program. The authors make understanding simulation pedagogy an easy journey and one that is exciting that educators will want to try and embrace even when there is hesitation and uncertainty."" - Pamela R. Jeffries, PhD, RN, FAAN, ANEF; Professor, Dean; George Washington University School of Nursing; From the Foreword When employed as a substitute for real clinical time, simulation scenarios have proven effective in bridging the gap between theory and practice. Written by educators for educators, this book provides all the knowledge, skills, and tools needed to make simulation feasible, enjoyable, and meaningful for students. In this edition, there are 25 new chapters, 20 of them scenarios for all levels and specialties, and 11 of those representing interprofessional education and team training. This acclaimed text for nursing faculty provides detailed, step-by-step guidance on all aspects of clinical simulation. Each scenario is broken down into objectives, pre-scenario checklists, implementation plans, evaluation criteria, debriefing guidelines, and recommendations for further use. Replete with diverse scenarios, this comprehensive resource covers geriatric, pediatric, trauma, obstetric, and community-based patient scenarios. Chapters cover all levels of nursing students from pre-licensure to doctoral level, and contain the authors' own advice and experiences working in simulation around the globe. All scenarios have been updated to adhere to the new best practice simulation standards for design, facilitator and participant criteria, interprofessional criteria, and debriefing processes. A template for creating scenarios spans the text and includes student preparation materials, forms to enhance the realness of the scenario, and checklists for practice assessment and evaluation. The revised edition now includes scenarios easily adaptable to an instructor's own lab, an international perspective, and a section on graduate nursing education and eleven new interdisciplinary clinical scenarios. New to the third edition: 20 brand-new scenarios in anesthesia, midwifery, pediatric, disaster, and other specialty focused situations, plus five new chapters Updated to encompass new simulation pedagogy including best practice standards New scenarios easily adapted to an instructor's own lab Integrating disability into nursing education with standardized patients and the use of IV simulations Interprofessional and international scenarios focused on areas of global concern: obstetric hemorrhage, neonatal hypoglycemia, deteriorating patients A new section on how to ""write like a nurse"" in clinical simulation environments Teaching and evaluating therapeutic communication with a review of instruments for assessment Key Features: Includes information on how to integrate simulation into curricula Addresses conceptual and theoretical foundations of simulation in nursing education, including an expanded chapter on the Framework for Simulation Learning in Nursing Education Includes a wide variety of practical scenarios in ready-to-use format with instructions Provides a template for scenario development Delivers recommendations for integration of point-of-care decision-making tools Offers opportunities for enhancing complexity, incorporating interprofessional competencies, and debriefing guidelines Provides insight into pedagogical intergration of simulation throughout every aspect of the nursing curriculum with scenarios mapped to North American standards and the NCLEX-RN Blueprint Includes details on: learning lab and staff development from fundraising and building a lab (Ch. 6), to placement of AV (Ch. 7) to faculty development (Ch. 5) and self-assessment for certification and accreditation (Ch. 54). A trauma-informed approach to women's health (Ch. 33) Scenarios with authors from North America (USA & Canada), Brazil, and Hong Kong

This book is a compilation of endoscopic images of the upper gastrointestinal tract. The 3rd edition is enriched with high-resolution digital images highlighting the classification and staging of endoscopically relevant diseases. Serial documentation of diseases and procedures like corrosive injury, variceal obliteration, peptic ulcer etc. provides a complete, informative and interesting perspective. Rare conditions like Dieulafoy's disease and Gastric antral vascular ectasia (GAVE) have been extensively discussed along with common diseases of the GI tract. This book outlines the technique and interpretation of endoscopic images proving to be a helpful guide to endoscopy practitioners. Key Features Explores various GI tract diseases through coloured, high resolution clinical photographs. Serves as a useful reckoner for trainee endoscopists and practitioners pursuing gastroenterology or gastrointestinal endoscopy. The text is updated with tables, flowcharts, classifications and international treatment guidelines.

The Handbook of Electrogastrography is the first textbook dedicated to reviewing the physiology of gastric myelectrical activity and the measurement of this electrical activity with electrodes placed on the abdominal surface - the electrogastrogram. The Handbook is divided into three major sections. The first section (Chapters 1-3) focuses on the history of electrogastrography, electrical activity of the interstitial cells of Cajal, the cells from which gastric electrical rhythmicity emanates. The cellular level of gastric electrical rhythmicity provides an understanding of the physiological basis of the electrogastrogram signal.

The second major section of the book (Chapters 4-6) incorporates the practical aspects of recording a high quality electrogastrogram and approaches to the analysis of the electrogastrogram using visual inspection and computer techniques. This section focuses on the authors' combined experience of examining EGG recordings for more than sixty years. From this rich research and clinical experience, the clinical application of EGG recordings in an approach to patients with unexplained nausea and vomiting is described. Neuromuscular disorders of the stomach involving gastric dysrhythmias are reviewed.

The third major section of the book (Chapters 7-9) comprises many examples of gastric dysrythmias ranging from bradygastrias to tachygastrias and mixed dysrythmias. Current understanding of the mechanisms of gastric dysrhythmias is reviewed. Artifacts in the EGG signal, which may be confused with gastric dysrhythmias, are also presented.

The Handbook of Electrogastrography will be a valuable reference for physicians interested in recording gastric electrical activity in clinical practices or in clinical research. Gastroenterologists, internists, psychologists and others with an interest in gastric myoelectrical events will also find extensive and relevant information for recording and interpreting EGGs in the Handbook.

EEG-Based Diagnosis of Alzheimer Disease: A Review and Novel Approaches for Feature Extraction and Classification Techniques provides a practical and easy-to-use guide for researchers in EEG signal processing techniques, Alzheimer's disease, and dementia diagnostics. The book examines different features of EEG signals used to properly diagnose Alzheimer's Disease early, presenting new and innovative results in the extraction and classification of Alzheimer's Disease using EEG signals. This book brings together the use of different EEG features, such as linear and nonlinear features, which play a significant role in diagnosing Alzheimer's Disease.

Real-life primary care case studies* from more than 50 primary care providers, including physician assistants, nurse practitioners, and physicians! 101 Primary Care Case Studies offers real-life patient scenarios and critical thinking exercises to help you work through a patient's chief complaint. Through narrative case studies, you will determine how best to diagnose, treat, and manage your patient based on the history of present illness, review of systems, relevant history, and physical examination findings. This workbook will ask probing questions to help you determine differential and most likely diagnoses, diagnostic tests to order, and appropriate patient management strategies using relevant and timely references to support your decisions. The organization of each case study simulates the patient care journey from chief complaint to outcome. Serving as a virtual clinical preceptor, this workbook can be used independently or in a classroom setting. It is accompanied by a robust online student supplement that provides answers to all questions, real outcomes of the cases, and valuable personal insights from the authors on how the patient was successfully managed. Not only will this workbook help you work through patient cases clinically, it will also share important, but often overlooked, bedside manner skills needed to successfully communicate with and care for your patients. Covering conditions across all organ systems and across the lifespan, this workbook is organized by chief complaint, providing an authentic perspective on what to expect in the patient care environment. It even includes information on pathophysiology and how to use ICD-10 and CPT (E/M) codes in your documentation. The book uniquely weaves together both the science and art of medicine by including personal insights into quality and compassionate care. Key Features Provides real-life patient cases from an interprofessional author team of physician assistants, nurse practitioners, and physicians Uses a templated case study design and critical thinking exercises to help you methodically work through various patient scenarios Teaches clinical and bedside manner skills imperative for delivering quality patient care Covers patients across the lifespan, including pediatric, adolescent, adult, and geriatric populations Offers additional insight on patient education, medical and legal concerns, and interprofessional collaboration Includes a robust online student supplement with valuable insights from the authors on how they successfully managed the cases Provides instructors with a table of contents that is filterable by chief complaint, diagnosis, patient population, and organ system

With rapid advancements in technology, body imaging or components thereof, have become ubiquitous in medicine. While the biomedical devices such as the MRI, CT, X-rays, Ultrasound, PET/SPECT and Microscopy etc, provide us with high resolution images, the challenges that have continued to confront us with, lie in the interpretation of the vast amounts of data generated by these devices. Biomedical applications are the a ~bottom-linea (TM) essentials in the diagnostic world. It is this diagnostic interpretation feature that forms the core niche for these books and will serve the needs of a broad spectrum of audience including researchers, research clinicians, and students.

Together the three volumes will illustrate the role of the fusion of registration and segmentation systems for complete biomedical applications therapy delivery benefiting the biomedical doctors, clinical researchers, radiologists and others.

Developments in deep learning in the past decade have led to phenomenal growth in AI-based automated medical diagnosis, opening a door to a new era of both medical research and medical industry. It is a golden age for researchers involved in the development and application of advanced machine learning techniques for medical and clinical problems. This book captures the most recent important advances in this cross-disciplinary topic and brings the latest advances to a wide audience including experts, researchers, students, industry developers and medical services.

For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, eat or speak. His diagnosis? The mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) which affects 20 million people around the world who largely suffer in silence because the condition is little known and much misunderstood. Waiting for Superman follows Whitney's father, groundbreaking geneticist Ron Davis, as he uncovers new possibilities for treatments and potentially a cure. At its heart, this book is about more than just cutting-edge research or a race to find an answer - it's about the lengths to which a parent will go to save their child's life.

This is the second edition of a full colour reference atlas published first to excellent reviews in 1994. Every renal unit needs to have a reference text of this kind and urine microscopy is an important diagnostic aid in nephrology. After the 'Historical Introduction' by J Stewart Cameron, chapter 1 descibes the methods used to prepare and analyse the urine samples. Chapter 2, which is the most important section of the book, describes with the help of 249 illustrations (over 200 in full colour) the elements of the urinary sediment. Chapter 3 deals with the urinary sediment of the normal subject, while chapter 4 deals with the urinary changes which are observed in the main diseases of the kidney and urinary tract. Chapter 5 describes the changes of the urinary sediment caused by drugs. Chapter 6 is about the interpretation of the urinary findings shown in the previous chapters. Chapter 7 covers the new systems to analyse the urinary sediments. An appendix shows how to adjust the microscope to analyse the urine specimens. The primary audience is practising nephrologists and nephrologists in training, and also those in internal medicine rotating through the renal unit who perform routinely the analysis of the urinary sediment. Clinical pathologists would also find this an attractive and useful book. The illustrations are outstanding and additional clinical information has been added in this new edition. From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet

The purpose of this book-the fourth volume of a series on Can cer Markers-is intended to provide an updated "status report" on today's use of cancer markers in the diagnosis and monitoring of can cer, with an emphasis on cancer markers detected in the serum. It has been 7 years since the publication of the last volume in this series. The 1980, 1982, and 1985 volumes covered the development of cancer markers, not only in their roles of unraveling the basic biology of can cer, but also as increasingly important players in the management of patients with cancer. During the last 7 years we have seen the applica tion of a number of markers identified by monoclonal antibodies, as well as the beginnings of the use of genetic markers defined by mo lecular probes. Measurements of oncogenes in tissues or cells prom ise many applications for the future, but as yet, these genes have not shown to be useful as serum markers of cancer. The commercial interest in serum markers for cancer, particu larly for the diagnosis and monitoring of tumor patients, is indicated in Chapter 24 by Owen, where the total worldwide market for cancer markers is projected to increase from $148 million in 1988 to $232 million in 1993. The degree of research interest in cancer markers is reflected in the fact that in 1988 a separate category for tumor mark ers was added to Index Medicus."

Not sure how to interpret the wealth of data in front of you?

Do you lack confidence in applying the results of investigations to your clinical decision making?

Then this pocket-sized, quick reference guide to data interpretation may be just right for you.

"The Hands-on Guide to Data Interpretation" is the perfect companion for students, doctors, nurses and other health care professionals who need a reference guide on the ward or when preparing for exams. It focuses on the most common investigations and tests encountered in clinical practice, providing concise summaries of how to confidently interpret investigative findings and, most importantly, how to apply this to clinical decision making.

The benefits of this book include: An overview of the normal ranges of test results, followed by a consideration of the differential diagnoses suggested by variance from these valuesArranged by system to allow quick access to the key investigations encountered in different specialtiesA summary 'patient data' chapter to bring the different specialties together, providing an overview to completing investigation documentation and chartsSummary table and bullet point format, with a full index, to aid rapid retrieval of informationEach chapter reviewed by a specialist to ensure an accurate, practical approach to data interpretation

Take the stress out of data interpretation with "The Hands-on Guide"

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.

Advances in Clinical Chemistry, Volume 77, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring.

Acute Medical Algorithms is an original and compact text designed to aid the clinician in dealing with acute medical conditions. The book includes 70 algorithms - either problem-orientated or related to specific conditions - together with complementary notes and references. It will therefore be relevant to all grades of hospital doctor, and to medical students and general practitioners also.

Physical Examination Procedures for Advanced Practitioners and Non-Medical Prescribers provides readers with the necessary knowledge and skills to conduct successful physical examinations of adult patients. This evidence-based book, organized by anatomical system, features tables that list physical examination procedures along with potential pathologies. Quick reference summaries for performing each examination are also included. In addition, the book features a chapter on mental health with a checklist covering the main criteria for a thorough mental health examination. Readers can test their skills by answering case study questions at the end of each chapter. Reflective stories are also included to demonstrate the difficulties encountered in everyday practice and to remind readers of the important professional and ethical issues surrounding their work. This book is designed as an aide-memoire for use in practice or revision for exams but can also be a useful resource for medical students, teachers of physical examination skills and other qualified health professionals.

Developmental cancer products (oncodevelopmental markers, ODM) not only serve as diagnostic and prognostic indicators but also may be used to study the nature of the carcinogenic process and the biology of tumors. For many years oncologists have searched for markers of cancer cells that would permit unequivocal recognition of cancer in contrast to noncancerous tissue. The earliest and still most widely used method of identification of cancer tissue or cells is the structural resemblance of cancer tissue to fetal or immature tissue. Pathologists not only recognize cancer by its morphologic similarity to fetal tissues, but also in many instances can relate the behavior of a given tumor to the degree of tissue differentiation. Thus, poorly differentiated tumors that resemble fetal tissue generally grow more rapidly and metastasize earlier than do well-differentiated tumors that more closely resemble adult tissue. In recent years the commonality of fetal and cancer tissue has been extended to products of tumor cells that, can be analyzed by biochemical, immunological, or physiological techniques. Increas ingly, products of cancer cells similar to fetal products are being identified and studied. These products range from cell-surface markers (fetal or differentiation antigens), placental proteins, hormones, and isoenzymes to a multitude of products, such as carcinoembryonic antigen (CEA), alphafetoprotein (AFP), lymphocyte markers, and nucleic acids, such as tRNA, that are produced in small amounts by v vi PREFACE continually differentiating cells in the adult but in much greater amounts by tumors."

The purpose of this monograph is both to introduce and review developed tomograhic methods for discovering 2D and 3D structures of the ionosphere and to discuss the experimental implementation of these methods. The theoretical part deals with the solution of the inverse problem of diffraction tomography for a wide range of properties of ionospheric media. Examples are given to illustrate the experimental reconstruction of electron-density distributions in ionospheric sections. In addition to addressing the specialist researcher, the detailed derivations and explanations make this book an excellent starting point for nonspecialists and graduate students who wish to enter this exciting new field to which the authors have made pioneering contributions.

Disruptive Trends in Computer Aided Diagnosis collates novel techniques and methodologies in the domain of content based image classification and deep learning/machine learning techniques to design efficient computer aided diagnosis architecture. It is aimed to highlight new challenges and probable solutions in the domain of computer aided diagnosis to leverage balancing of sustainable ecology. The volume focuses on designing efficient algorithms for proposing CAD systems to mitigate the challenges of critical illnesses at an early stage. State-of-the-art novel methods are explored for envisaging automated diagnosis systems thereby overriding the limitations due to lack of training data, sample annotation, region of interest identification, proper segmentation and so on. The assorted techniques addresses the challenges encountered in existing systems thereby facilitating accurate patient healthcare and diagnosis. Features: An integrated interdisciplinary approach to address complex computer aided diagnosis problems and limitations. Elucidates a rich summary of the state-of-the-art tools and techniques related to automated detection and diagnosis of life threatening diseases including pandemics. Machine learning and deep learning methodologies on evolving accurate and precise early detection and medical diagnosis systems. Information presented in an accessible way for students, researchers and medical practitioners. The volume would come to the benefit of both post-graduate students and aspiring researchers in the field of medical informatics, computer science and electronics and communication engineering. In addition, the volume is also intended to serve as a guiding factor for the medical practitioners and radiologists in accurate diagnosis of diseases.

Continuing a legacy of excellence that spans nearly five decades, Bates' Nursing Guide to Physical Examination and History Taking, 3rd Edition, adapts the proven techniques and vibrant visuals of Bates' gold-standard assessment text specifically for the needs of today's nursing students. Thoroughly updated, evidence-based coverage emphasizes the healthy patient and clearly details common findings and diseases to help students develop and practice key skills in physical examination and history taking. Content is logically organized by Foundations, Body Systems, and Special Lifespan Considerations, incorporating essential review of anatomy and physiology, as well as critical practice in health history review, recording findings, and health promotion. Reflecting the latest research in the field, including emerging issues such as vaping, the opioid crisis, and the COVID-19 pandemic, the 3rd Edition combines trusted approaches with current clinical perspectives to equip your students for success throughout their nursing careers.

There is an urgent need to develop and integrate new statistical, mathematical, visualization, and computational models with the ability to analyze Big Data in order to retrieve useful information to aid clinicians in accurately diagnosing and treating patients. The main focus of this book is to review and summarize state-of-the-art big data and deep learning approaches to analyze and integrate multiple data types for the creation of a decision matrix to aid clinicians in the early diagnosis and identification of high risk patients for human diseases and disorders. Leading researchers will contribute original research book chapters analyzing efforts to solve these important problems.