Here's a user-friendly, readable introduction to the study of electrocardiography. It guides you in capturing and interpreting ECGs, with an eye towards clinical correlation for easy application to your practice. New in this edition are increased content on pediatric ECGs, implantable cardiodefibrillators, and pacemakers. Comprehensively and expertly describes how to capture and interpret all normal and abnormal ECG findings in adults and children. Features the expertise of internationally recognized authorities on electrocardiography, for advanced assistance in mastering the subtle but critical nuances of this complex diagnostic modality. Features new chapters on pediatric electrocardiography that explore rhythm problems associated with pediatric obesity, heart failure, and athletic activity. Presents a new chapter on recording and interpreting heart rhythms in patients with pacemakers. Includes new material on interpreting ECG findings associated with implantable cardioverter-defibrillators. Provides fully updated coverage on the increased importance of ECGs in stress testing.

Clinical Investigations at a Glance provides an up-to-date, evidence-based overview of diagnostic investigations, looking at their choice, importance and interpretation for commonly presenting symptoms and conditions. Designed to help develop the evidence-based use of investigations and interpret results properly, the book provides a unique perspective on many critical issues in medical testing, with the aim of improving diagnostic accuracy and reducing unnecessary tests or harm. Clinical Investigations at a Glance is structured in three parts: an overview of tests; common presentations (such as chest pain, nausea and vomiting, weight loss and anaemia,); and conditions organized by body system, such as cardiovascular disease, respiratory disease and nephrology. Key features include: How to interpret investigations, using high quality illustrations to compare normal and diseased results Evidence-based, including references How to select the most appropriate investigation, the accuracy of tests and how to manage incidental findings

Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile acids become associated with disease. This breaching of control mechanisms can occur through dietary means (e.g. in obesity) whereby excessive levels of Bile acids are produced and converted (via the bacterial flora) to damaging secondary Bile acids. Furthermore, lack of re-absorption of Bile acids can lead to liver pathologies. The atypical movement of Bile acids into the oesophagus, stimulated by episodes of reflux, is linked to oesophageal cancer. In recent years there have been tremendous advances in the understanding of the mechanisms behind the toxicity and bioactivity of different Bile acids and these are covered at length in this book. Prior to the publication of this book there was no single source of information on the toxicology and bioactivity properties of Bile acids. The book also uniquely collects all the relevant information together regarding the role of Bile acids in human disease and the mechanisms underlying Bile acid induced pathology. Additionally, as Bile acids are synthesised from cholesterol, there is wide recognition of the role for Bile acids in obesity linked diseases and this is also covered in this new publication. The book is edited by two experts in the field who have been involved in Bile acid research for several years and who are closely involved with major research groups in the UK, Europe and the US actively engaged in Bile acid research. The Editors have brought together world experts in their own fields to discuss the contribution of Bile acids to various disease pathologies, as well as discussing the mechanisms behind their activity. The book details the plethora of biological activities of this fascinating group of naturally occurring chemicals and provides a one-stop reference for scientists wishing to gain a fuller understanding of Bile acid activity and function.

The role and function of the nurse is rapidly changing, and nurses are now required to undertake a comprehensive clinical examination of patients, a responsibility traditionally undertaken by a doctor. Clinical Examination Skills is an accessible, introductory guide to helping nurses fulfil this role, enabling them to understand the core skills and knowledge needed to assess patients competently. This practice-based book will be invaluable to pre-registration nursing students and newly qualified nursing staff, empowering them to meet the challenges of autonomous practice.

This issue of Clinics in Geriatric Medicine, guest edited by Dr. John Morley, is devoted to Rapid Geriatric Assessment. Articles in this issue will address Frailty; Sarcopenia; Anorexia of Aging; Mild Cognitive Impairment; Cognitive Frailty; Falls; Hip Fracture; Depression; Delirium; and Advanced Directives and Palliative Care.

Objective Biometric Methods for the Diagnosis and Treatment of Nervous System Disorders provides a new and unifying methodological framework, introducing new objective biometrics to characterize patterns of sensory motor control underlying symptoms. Its goal is to radically transform the ways in which disorders of the nervous system are currently diagnosed, tracked, researched and treated. This book introduces new ways to bring the laboratory to the clinical setting, to schools and to settings of occupational and physical therapy. Ready-to-use, graphic user interfaces are introduced to provide outcome measures from wearable sensors that automatically assess in near real time the effectiveness of interventions. Lastly, examples of how the new framework has been effectively utilized in the context of clinical trials are provided.

Praise for the First Edition:"Developing a comprehensive differential diagnosis for a specific complaint is a daunting task even for experienced advanced practice nurses. This user-friendly clinical guide provides a strategy and standard format for working through this complex task. It is a wonderful tool for both students and new advanced practice nurses."–5 stars, Doody's This one-of-a-kind resource is designed to help Advanced Practice Provider students master the process of conducting a quality differential diagnosis. It contains 95 symptom-based cases that empower readers to practice and hone their clinical skills. Consistently formatted, patient-based case scenarios begin with a common symptom and provide expert guidance to help students work though a diagnosis. Diagnostic reasoning for each clinical scenario is presented step-by-step and each step is explicitly linked to the next. They are now organized by body system and coordinate with related texts for easy reference. Cases include focused patient history questions and responses, physical exam findings, a differential diagnosis table, a diagnostic examination table, and a summary analyzing the critical thinking process. Symptoms are presented via a systematic case study approach that encompasses chief complaint, past history, physical exam, case study, differential diagnosis, diagnostic exam, and clinical decision making. Boxes comparing clinical characteristics and differential diagnosis further help to illuminate the decision-making process. New to the Third Edition: Includes 23 completely new cases Delivers 55 Test Bank Multiple Choice Questions for instructors to assign Provides online access to 18 additional cases Reorganized by body system for easy reference Presented in two-color design for ease of use Key Features: Provides step-by-step approach to building sound clinical decision-making skills Links each step to the next for utmost clarity Guides APP students and novice practitioners in conducting a problem-focused history and examination Presents cases systematically for ease of use Includes unique differential diagnosis tables and diagnostic examination tables to clarify decision-making strategies Illuminates decision making with boxes comparing clinical characteristics and differential diagnosis

For the past six years, Whitney Dafoe has been confined to a bedroom in the back of his parents' home, unable to walk, eat or speak. His diagnosis? The mysterious disease myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) which affects 20 million people around the world who largely suffer in silence because the condition is little known and much misunderstood. Waiting for Superman follows Whitney's father, groundbreaking geneticist Ron Davis, as he uncovers new possibilities for treatments and potentially a cure. At its heart, this book is about more than just cutting-edge research or a race to find an answer - it's about the lengths to which a parent will go to save their child's life.

Back by popular demand: the world's most widely-used medical reference, now in its 20th edition. The Merck Manual of Diagnosis and Therapy has been thoroughly updated and expanded with a larger trim size to include 40% new and revised content, including 36 new chapters with more than 200 tables and 100 figures. Packed with essential information on diagnosing and treating medical disorders, this comprehensive guide was written by a team of renowned medical experts. It is intended for everyday use by healthcare professionals to ensure delivery of the best care to their patients. The new Merck Manual of Diagnosis and Therapy makes it easy to find the right information at the moment it's needed, with the help of section thumb tabs. It is a must-have for medical students, residents, practicing physicians, nurses, and allied health professionals. New larger trim 7 3/4 x 9 1/4 to accommodate 40% new content 36 completely new chapters Revised and expanded chapters in Cardiovascular, Genitourinary, Gynecologic, Neurologic, Pregnancy, and Infants and Children Pediatrics and trauma section significantly revised and expanded Key Points summarize the facts at-a-glance New Pearls & Pitfalls highlight noteworthy medical info and areas of caution 16-page full-color insert aids visual recognition of skin, eye, and oral disorders

Endoscopic access to the small bowel has advanced significantly since the introduction of video capsule endoscopy and deep enteroscopy in early 2000. Other major advances have occurred in imaging modalities involving computed tomography and magnetic resonance studies. Due to these advances, the recent 2015 ACG guideline changed the terminology from "obscure" to "small bowel" bleeding because the majority of cases now can be found to have a small bowel source. The improvements in technology have advanced our ability to visualized vascular findings, inflammatory lesions, and small bowel neoplasms. Articles in this issue are devoted to these improvements in technology.

GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible.

Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

This issue of Radiologic Clinics of North America focuses on Imaging of the Athlete, and is edited by Drs. Adam Zoga and Johannes Roedl. Articles will include: The Thrower's Shoulder; Multimodality Imaging and Imaging Guided Therapy for the Painful Elbow; The Skeletally Immature and Newly Mature Throwing Athlete; Imaging Throwing Injuries Beyond the Shoulder and Elbow; Imaging Adductor Injury and "The Inguinal Disruption"; Image Guided Core Intervention and Postop Imaging; Core Injuries Remote from the Pubic Symphysis; MRI and MR Arthrography of the Hip; Knee Meniscus Biomechanics and Microinstability; Imaging Turf Toe and Traumatic Forefoot Injury; Imaging the Postoperative Knee; The Hindfoot Arch: What Role does the Imager Play?; Using Imaging to Determine Return to Play; and more!

Atlas of Human Body: Central Nervous System and Vascularization is a multidisciplinary approach to the technical coverage of anatomical structures and relationships. It contains surface and 3D dissection images, native and colored cross sectional views made in different planes, MRI comparisons, demonstrations of cranial nerve origins, distribution of blood vessels by dissection, and systematic presentation of arterial distribution from the precapillary level, using the methyl metacrylate injection and subsequent tissue digestion method. Included throughout are late prenatal (fetal) and early postnatal images to contribute to a better understanding of structure/relationship specificity of differentiation at various developmental intervals (conduits, organs, somatic, or branchial derivatives). Each chapter features clinical correlations providing a unique perspective of side-by side comparisons of dissection images, magnetic resonance imaging and computed tomography. Created after many years of professional and scientific cooperation between the authors and their parent institutions, this important resource will serve researchers, students, and doctors in their professional work.

This unique text fills the gap between shorter texts, containing little explanatory material, and the compendia, for those advanced in the field of neurological disorders. It is written both for novices and for physicians who require an update on the subject. To understand the symptoms and signs requires a sound knowledge of the gross anatomy of the central nervous system and supporting tissues. This book achieves this using the author's own detailed diagrams, backed up with concise and practical guidance on diagnosis and treatment, as well as relevant case studies.The long-awaited second edition of this highly popular guide reflects such recent advances as computed tomography and MRI. The tutorial approach presents readers with an authoritative view of the fundamentals of practical neurology.

In this issue an impressive group of contributors at the forefront of sedation research has been assembled to provide endoscopists and dedicated nursing personnel alike a comprehensive review of important topics in the field sedation and analgesia. A discussion on the pharmacology and agents used to provide moderate and deep sedation provides the basic framework that is a crucial element in determining the driving force behind the developments in sedation and analgesia. An evidence-based approach on the use of unsedated endoscopy is also provided. Other topics included the use of propofol, patient-controlled sedation and analgesia, extended physiologic monitoring, risk management, and quality assurance as they apply to the spectrum of sedation in the endoscopy suite. Sedation and analgesia in the pediatric patient is also addressed.

This issue of the Cardiac Electrophysiology Clinics entitled "Ventricular Arrhythmias in Apparently Normal Hearts" is being edited by Drs. Frank M. Bogun, Thomas Crawford, and Rakesh Latchamsetty. The issue will cover topics including, the mechanisms of ventricular arrhythmias, the role of genetic testing, papillary muscle arrhythmias, fascicular arrhythmias, exercised induced VT, VF, and SCD in the normal heart, and various management techniques.

The topics covered in this issue, an update from what was first published in the Gastrointestinal Endoscopy Clinics in 2008, reflect the fact that NOTES is seeing a resurgence in popularity. Now, eight years later, there is more data to confirm safety, to look at the best options for using natural orifices, and to talk about optimal training scenarios. The Guest Editor has enlisted some of the top experts on NOTES to contribute articles devoted to Seminal Developments: SM Tunnel Technique; Peroral Endoscopic Myotomoy (POEM); Submucosal Tumor Endoscopic Resection; Endoscopic Full Thickness Resection; Submucosal Tunneling for NOTES Procedures Beyond Resection; Pyloromyotomy; New NOTES: Western Perspective; and Why Did the Old NOTES Fail: Lessons Learned that can Guide New NOTES Development.

Urgent Care Dermatology: Symptom-Based Diagnosis, by Drs. James E. Fitzpatrick, Whitney A. High, and Lamar Kyle, helps you quickly identify skin conditions and provide necessary treatment at the point of care. Concise, to-the-point text is highlighted by more than 1,000 high-quality photographs - all conveniently organized by lesion appearance - making this resource ideal for first-line clinicians to quickly identify and treat dermatologic conditions. Appearance-based format designed for non-specialists who diagnose and treat skin conditions, such as family practice physicians, urgent care providers, nurse practitioners, and physician assistants Organized by presentation (scaly lesions, blisters, etc.), with a full chapter on treatment pearls that offers expert advice pertaining to diagnosis and treatment Richly illustrated with more than 1,000 full-color clinical examples of lesions you're likely to see Each topic is covered in a two-page spread for quick reference - text on the left and images on the right Up-to-date coverage of morbilliform eruptions, scaly papular lesions, dermatitis (eczematoid reactions), and abscesses, as well as a timely chapter on cutaneous diseases of travelers organized by global region Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices Appearance-based format designed for non-specialists who diagnose and treat skin conditions, such as family practice physicians, urgent care providers, nurse practitioners, and physician assistants. Organized by presentation (scaly lesions, blisters, etc.), with a full chapter on treatment pearls that offers expert advice pertaining to diagnosis and treatment. Richly illustrated with more than 1,000 full-color clinical examples of lesions you're likely to see. Each topic is covered in a two-page spread for quick reference - text on the left and images on the right. Up-to-date coverage of morbilliform eruptions, scaly papular lesions, dermatitis (eczematoid reactions), and abscesses, as well as a timely chapter on cutaneous diseases of travelers organized by global region. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.

The Guest Editors have assembled key opinion leaders to provide state of the art articles on this important update on ERCP. A chapter on cannulation techniques and sphincterotomy will highlight recent literature on wire-guided cannulation, use of papillotomes, when and if to precut for entry and the use of smart circuitry for papillotomy. A chapter on surgically altered anatomy will highlight the increasing occurrence of biliary tract disease in patient's s/p gastric bypass for obesity along with other surgery and the use of balloon enteroscopes, overtubes and intraoperative procedures A chapter on EUS assisted biliary and pancreatic access will highlight the growing experience with these combine techniques. There is growing literature on preventing post-ercp pancreatitis which is changing the standard of care and Joe Elmunzer is the best person to highlight this. Stu Sherman will review advances in the management of bile duct stones and when to intervene in gallstone pancreatitis. Peter Cotton just published a landmark study on SOD that will change the standard of care and will review the state of the science on this disease as it relates to both biliary tract and pancreatic disease. The management of benign biliary strictures and leaks is evolving with the introduction of covered metal stents and Jacques Deviere is at the forefront. Amrita Sethi will discuss diagnosis of biliary malignancy highlighting the use of FISH, molecular markers and enhanced imaging such as pCLE. Michele Kahaleh will review recent experience with biliary tumor ablation using RFA probes and PDT. Alan Barkun helps endoscopists determine when to use plastic stents, metal stents, and covered stents and when to drain one, two or three segments of liver in patients with malignant biliary obstruction. George Papachristo and Dhiraj Yadav will review most recent data on endoscopic therapy for acute recurrent and smoldering acute pancreatitis. Nagy Reddy will provide on update on endotherapy for painful chronic pancreatitis. Finally, Raj Shah will update on advances in pancreatoscopy and cholangioscopy including the use of ultra slim per-oral scopes and new digital mother/baby scopes.

This issue on Diagnostic Testing for Enteric Patholgens is led by two experts in the field of clinical pathology: Alexander J. McAdam and Collette Fitzgerald. Topics include Salmonella, Shigella and Yersinia; Escherichia coli; Campylobacter; Clostridium difficile; Use of markers of intestinal inflammation for diagnosis of infectious gastroenteritis; Antibiotic susceptibility testing of bacteria that cause gastroenteritis; Norovirus; Rotavirus; Intestinal Abebae; Intestinal coccidia and cryptosporidium; Intestinal microsporidia; and Multiplex PCR tests for gastroentieritis. An added features of this issues a Q and A on a controversial area in clinical microbiology, related to STI testing. Several participants from different fields each answer the same series of questions; specialists from clinical laboratory medicine, public health and clinical patient care participate. Each question is introduced by the lead Editors.