An expert summary of our current understanding of bipolar disorder, this reference examines existing theories, treatment regimens, and clinically relevant applications by world authorities in psychiatric research. Divided into four main sections, this guide delves into the diagnosis and epidemiology of bipolar disorder and progresses to discussions of patient care, emerging management approaches, and the underlying biology of the disease.

This revised and updated second edition is a rhetorical analysis of written communication in the mental health community. As such, it contributes to the growing body of research being done in rhetoric and composition studies on the nature of writing and reading in highly specialized professional discourse communities. Many compelling questions answered in this volume include:
* What "ideological biases" are reflected in the language the nurse/rhetorician uses to talk to and talk about the patient?
* How does language figure into the process of constructing meaning in this context?
* What social interactions -- with the patient, with other nurses, with physicians -- influence the nurse's attempt to construct meaning in this context?
* How do the readers of assessment construct their own meanings of the assessment?
Based on an ongoing collaboration between composition studies specialists and mental health practitioners, this book presents research of value not only to writing scholars and teachers, but also to professional clinicians, their teachers, and those who read mental health records in order to make critically important decisions. It can also be valuable as a model for other scholars to follow when conducting similar long-range studies of other writing-intensive professions.

With the development of rapidly increasing medical imaging modalities and their applications, the need for computers and computing in image generation, processing, visualization, archival, transmission, modeling, and analysis has grown substantially. Computers are being integrated into almost every medical imaging system. Medical Image Analysis and Informatics demonstrates how quantitative analysis becomes possible by the application of computational procedures to medical images. Furthermore, it shows how quantitative and objective analysis facilitated by medical image informatics, CBIR, and CAD could lead to improved diagnosis by physicians. Whereas CAD has become a part of the clinical workflow in the detection of breast cancer with mammograms, it is not yet established in other applications. CBIR is an alternative and complementary approach for image retrieval based on measures derived from images, which could also facilitate CAD. This book shows how digital image processing techniques can assist in quantitative analysis of medical images, how pattern recognition and classification techniques can facilitate CAD, and how CAD systems can assist in achieving efficient diagnosis, in designing optimal treatment protocols, in analyzing the effects of or response to treatment, and in clinical management of various conditions. The book affirms that medical imaging, medical image analysis, medical image informatics, CBIR, and CAD are proven as well as essential techniques for health care.

Informed by more than thirty years of experience, this guide provides a wealth of insight into the clinical observation, diagnosis and treatment of elderly patients. Organized geographically from (literally) head to toes, it concentrates on the basic geriatric physical examination with each chapter providing general information as well as helpful approaches to specific regional complaints. Emphasis is placed on assisting the dedicated clinician in becoming a more perceptive observer of elderly patients with honed skills in geriatric bedside diagnostic evaluation. The text also includes historical vignettes and anecdotes of great physical diagnosticians to demonstrate the evolution of clinical skills. Tables and line drawings complement the text.

For many centuries, people have tried to learn about the state of their health. Initially, in the pre-technological period, they had to rely only on their senses. Then there were simple tools to help the human senses. The discovery of X-rays, which allowed people to look "inside" the body, turned out to be a major breakthrough. Contemporary medical diagnostics is increasingly being assisted by information technology that allows, for example, thorough image tissue analysis or pathology differentiation. They also allow very early preventive diagnostics. Influenced by information technology, "classic" diagnostic techniques change and new ones arise. Information Technology in Medical Diagnostics presents selected and extended conference papers from Polish, Ukrainian and Kazakh scientists. They address problems of the application of new methods of image processing for analysis of medical images, new methods of classification of medical data as well as new medical imaging methods. Some of the presented technologies are inspired by the functioning of living organisms. Information Technology in Medical Diagnostics is of interest not only to academics and engineers, but also to professionals involved in biomedical engineering, and seeking for solutions for issues that cannot be solved with the help of "traditional" technologies.

This straightforward guide to taking patient history comprehensively covers all of the commonly seen OSCE scenarios within the current undergraduate medical curriculum. The Easy Guide to Focused History Taking for OSCEs includes introductory chapters with general OSCE guidance, mapping onto the Calgary-Cambridge model. These include tips from recently qualified doctors and highly respected physicians and surgeons who commonly examine OSCEs, as well as a sample OSCE marking scheme. The book then covers 56 histories based on presenting complaints - more than any other text on the market - thoroughly testing both knowledge and examination technique. Each history is based around the exam requirements, with mnemonics, 'red flag' symptom boxes and list-based breakdowns to aid prompt recall. Common and serious differentials are highlighted, as well as investigations to help rule out the serious conditions. Each section concludes by outlining key aspects for each differential diagnosis as well as a list of investigations and management options. With this book, every student will be well equipped to tackle any clinical problem, in the OSCE examination and also in their continued professional practice.

Addressing the early clinical diagnosis of Alzheimer disease, this book was written to evaluate the relevance of current research on the subject. It uncovers the present lack of clinical utility in research methodologies such as neuro-imaging, drug challenges, electro-encephalographic studies and brain biopsy. The essays addressing each of these issues will provide the reader with a perspective on the role of each technology in clinical practice and an in-depth introduction to the technologies and research findings in each of the areas reviewed.

Updated to reflect changes in the field since publication of the first edition in 1979. Provides a detailed review of the methodology available for assessing the diagnosis and prognosis of cancer patients including data on the application of tumor marker assays and other immunodiagnostic procedures

The extent to which teachers should make use of theoretical and expert knowledge as opposed to tacit experiential knowledge, and how these might be combined, is a perennial issue in discussions on pedagogy. This book addresses these debates through a creative development of the concept of productive uncertainty. Using case studies focusing on teachers working with children with autism, a particularly fertile crucible for considering uncertainty, the book explores how the radical 20th century psychoanalyst Wilfred Bion's epistemological approach to uncertainty can be used to re-frame Donald Schoen's concept of reflection in action, offering a new perspective on the practice of teachers and other caring professionals. Several areas of potential uncertainty are identified, including uncertainty relating to areas of practice including diagnosis, the relationship between expert knowledge and practice, the implications of autism for autonomy and agency, and uncertainties in relation to the understanding of and use of new technologies. A strong argument is made, based on both theoretical and empirical grounds, that in juggling between theoretical and tacit knowledge in the classroom there is more to be gained by staying with the struggle with uncertainty than by fleeing from it too early, into the promise of expert solutions. Consideration is also given to the relative importance of specific theoretical training for teachers, both in general and in relation to working with children with special educational needs, in the context of international and UK policy developments in this area. This book will be of key value to researchers and postgraduates in the fields of education studies, teacher thinking and research, psychoanalytically informed psychosocial studies, as well as to practitioners working in special educational needs/autism education.

This unique and comprehensive atlas by an expert practioner provides an innovative pictorial guide to flexible bronchoscopy, one of the most exciting and challenging procedures in respiratory medicine today. Includes the very latest procedures and techniques Comprehensive coverage, guides you through the range of anatomical and pathological possibilities A step-by-step guide to the use of bronchoscopic techniques, interpretation of images and differential diagnoses Integrates naked eye, bronchoscopic and radiological anatomy to give you a thorough understanding of the procedure Numerous full colour illustrations and sound practical advice make this a key text for learning and refining your technique The book will be invaluable to those training in respiratory medicine, plus also specialist respiratory nurses and practising pulmonologists who wish to expand their practice and knowledge of the technique.

This book highlights assessment techniques, issues, and procedures that appeal to practicing clinicians. Rather than a comprehensive handbook of various tests and measures, The Clinical Assessment of Children and Adolescents is a practitioner-friendly text that provides guidance for test selection, interpretation, and application. With topics ranging from personality assessment to behavioral assessment to the assessment of depression and thought disorder, the leaders in the field of child and adolescent measurement outline selection and interpretation of measures in a manner that is most relevant to clinicians and graduate students. Each chapter makes use of extensive case material in order to highlight issues of applicability.

For centuries the analysis of the heart rhythm has belonged to the foundations of medical art. We know that doctors in ancient Tibet used the interpretation of the heart rate to draw prognostic conclusions-somehow a modern rationale-that deserves further attention. The rapid advancement of science is providing more and more information about the details, but the subatomic resolution of structures hides the risk and the complex procedures are fragmented into static impressions. The same has happened to the ECG. The revolutionary development, acknowledged by the Nobel Prize for Einthoven, ledfromtheanalysisofthedynamicheartratetothestaticanalysisofthe heartstream curve. It is only with the ECG Holter recording over longer periods that the cardiologists rediscovered the old dynamic. With the continuous recording of the heart rate and its periodicity, it became accessible to a new dimension, a dim- sion that requires technically well-de?ned foundations for accurate data coll- tion, detailed knowledge of the electrocardiologic particularities of arrhythmia, and medical knowledge for the translation of the results into a diagnostic synthesis. With the ECG Holter the issue is no longer just to detect an arrhythmia, but also to determine dynamic circumstance in which the critical event occurred. In fact, we investigate the trigger, the event, and the context, and we have to integrate all of that information within the clinical picture, from the pathology right through to the symptom-indeed a multi-dimensional task.

Recent advances in medicine for resuscitation and care have led to an increased number of patients that survive severe brain damage but who are poorly responsive and non-communicative at the bedside. This has led to a striking need to better characterize, understand, and manage this population who present a real challenge for the assessment of pain and for planning treatment. This edited collection provides clinicians with a guide to recent developments in research on pain perception and assessment, and the detection of consciousness and communication in patients with disorders of consciousness (DOC). With contributions from leading global researchers, the book gives an overview of issues concerning the assessment of pain. It also covers the development of suitable tools both to improve pain management and to detect consciousness and communication in these patients, to influence their prognosis and treatment, and their quality of life. Methodological and ethical issues concerning the implication for future research are also considered. The book will be an invaluable guide for clinicians, medics and therapists working in rehabilitation and acute care, particularly in the demanding field of pain perception, pain assessment and detection of consciousness and communication in patients with DOC. It will also be useful for students and researchers in neuropsychology and medical sciences.

Recent advances in medicine for resuscitation and care have led to an increased number of patients that survive severe brain damage but who are poorly responsive and non-communicative at the bedside. This has led to a striking need to better characterize, understand, and manage this population who present a real challenge for the assessment of pain and for planning treatment. This edited collection provides clinicians with a guide to recent developments in research on pain perception and assessment, and the detection of consciousness and communication in patients with disorders of consciousness (DOC). With contributions from leading global researchers, the book gives an overview of issues concerning the assessment of pain. It also covers the development of suitable tools both to improve pain management and to detect consciousness and communication in these patients, to influence their prognosis and treatment, and their quality of life. Methodological and ethical issues concerning the implication for future research are also considered. The book will be an invaluable guide for clinicians, medics and therapists working in rehabilitation and acute care, particularly in the demanding field of pain perception, pain assessment and detection of consciousness and communication in patients with DOC. It will also be useful for students and researchers in neuropsychology and medical sciences.

When the first edition of this pioneering text was published, only a few dermatologists were trained to utilize the dermatoscope for the diagnosis and follow-up of hair diseases. The technique is now more popular worldwide, prompting the development of this updated second edition, which now includes a section devoted entirely to nail dermoscopy and also covers many hair disorders that were not previously discussed. Topics covered include alopecias, hair shaft disorders, hair root evaluation, pediatric hair disorders, hair weathering, inflammatory scalp disorders, infections, dermoscopy of the black scalp, body hair disorders, and dermoscopy-guided biopsies. Also covered is dermoscopy of the nail plate, the proximal nail fold, the hyponychium, and the distal edge of the nail plate. The book discusses inflammatory nail disorders, traumatic nail disorders, onychomycosis, melanonychia, and nail tumors. This essential new edition facilitates diagnosis of hair disorders and provides clinicians with important clues about disease stage and progression.

Assessing Psychosis: A Clinician's Guide offers both a practical guide and rich clinical resource for a broad audience of mental-health practitioners seeking to sharpen their understanding of diagnostic issues, clinical concepts, and assessment methods that aid in detecting the presence of psychotic phenomena. Practicing psychiatrists, psychologists, social workers, and psychiatric nurses will find this a valuable resource for clinical practice, training, and teaching purposes.

Differential Diagnosis of Autism Spectrum Disorder provides a framework for clinical considerations and best practices related to diagnosing children with autism spectrum disorder (ASD) versus commonly co-occurring conditions. Differential diagnosis is a complex process, and it is common for clinicians to observe symptom overlap between conditions. In this comprehensive text, the authors focus on the similarities and differences between ASD and a second diagnosis. Leading experts provide practical guidance in the diagnostic process for ASD versus a second condition, such as anxiety or attention deficit/hyperactivity disorder. Each chapter includes clinical case studies to provide real-world examples of how clinicians make diagnostic decisions. Ample illustrations and 'decision trees' provide a visual representation of clinical decision-making.

The past few years have witnessed rapid progress in the characterization of mechanisms that underlie the generation and processing of inter- and intracellular signals. While there have been significant corollary advances in the area of signaling in disease processes, there is as yet no single resource that connects these advances with an understanding of disease processes and applications for novel therapeutics. Collecting chapters from the leading experts in their respective fields, editors Toren Finkel and Silvio Gutkind deliver a much-needed introduction to signaling and a fruitful discussion of promising directions for future research.

Signal Transduction and Human Disease capitalizes on the current emphasis on translational research and biological relevance in biotechnology and, conversely, the importance of molecular approaches for clinical research. Each chapter conveys the sense of a disease process, what it affects, how it presents, how common it is, and what the treatments are. Clinical descriptions are not exhaustive but rather serve as an outline regarding the disease’s manifestations and current treatment options. Following this introduction, the authors present an in-depth discussion of one or two signal transduction pathways or biological processes relevant to the disease. The editors divide their study into five sections:

• Cardio-Pulmonary Disease
• Oncology
• Endocrinology
• Infectious Disease
• Allergy/Rheumatology
• Neurology/Psychiatry

Biochemists, molecular and cell biologists, immunologists, pharmacologists, and clinical researchers, as well as graduate students in a variety of scientific disciplines, will find Signal Transduction and Human Disease to be an invaluable addition to the literature.

Combining a professional development course on diagnostic endoscopy from SPIE (the international society advancing light-based research) and the authorsa (TM) graduate course on biomedical optics, this work is written for researchers in medical optics and biomedical engineering as well as graduate medical optics students. It uses extensive examples/case studiesto familiarize readers with the the basics of endoscopic optics, the pros and cons of white light endoscopy and fluorescence endoscopy for diagnostic applications, and various microscopic endoscopy imaging modalities.It covers basic optics, details of design and biomedical uses, as well as microscopic endoscopy, and endoscopic spectroscopy.

In today's medical education curriculum, it is necessary for students to learn the proper techniques for taking medical histories, performing physical exams, and the appropriate way to educate and inform patients. The best way for a student to learn these skills is through hands-on training with a Standardized Patient (SP) - an actor who has been hired to portray a specific set of health problems and symptoms. This type of training allows students to grasp concepts more quickly and enables faculty physicians to directly observe student's progress and asses their need for further instruction. Working with SP's has become so important in medical education that it is now a component of the USMLE clinical skills assessment exam. As with any tool that is used for teaching, assessment, and certification, it is easier to provide the best service when there are general guidelines for preparers to follow. The coaches who prepare SP's are no exception and there needs to be a guide for those who train SP's for their roles in new doctor education. This handbook is intended as that guide and as a support for those who are involved in training Standardized Patients, from the art of coaching through preparing SP's for the physical exam, to encourage each coach to develop a system that will deliver the best results and, in the end, help train the most competent doctors.

This unique and comprehensive atlas by an expert practioner provides an innovative pictorial guide to flexible bronchoscopy, one of the most exciting and challenging procedures in respiratory medicine today. Includes the very latest procedures and techniques Comprehensive coverage, guides you through the range of anatomical and pathological possibilities A step-by-step guide to the use of bronchoscopic techniques, interpretation of images and differential diagnoses Integrates naked eye, bronchoscopic and radiological anatomy to give you a thorough understanding of the procedure Numerous full colour illustrations and sound practical advice make this a key text for learning and refining your technique The book will be invaluable to those training in respiratory medicine, plus also specialist respiratory nurses and practising pulmonologists who wish to expand their practice and knowledge of the technique.

"PACS: A Guide to the Digital Revolution, Second Edition," is a textbook of modern information sciences that fills an incredible need in the blossoming field of radiology. The emphasis is on a review of technological developments associated with the transition of radiology departments to filmless environments. As leaders in the field of computerized medical imaging, the editors and contributors provide insight into emerging technologies for physicians, administrators, and other interested groups. Each chapter addresses key topics in current literature with regard to the generation, transfer, interpretation, and distribution of images to the medical enterprise.

This new edition has been updated to present recent developments in PACS, including: 1. An overview of the latest medical imaging standards; 2. A discussion of security issues as they relate to PACS, especially regarding HIPAA; 3. An introduction to current information on PACS workstations, including the impact of new software and hardware on radiologists; 4. An updated explanation of data storage and compression that highlights how advancements are applied; 5. A section on how PACS influences research and education, emphasizing how both educators and trainees are affected.

Since health care organizations throughout the world are generating filmless implementation strategies, this exhaustive review is valued as a vital aid to leaders in the development of health care.

Written specifically for urological trainees by a distinguished team of contributors, this third edition of The Scientific Basis of Urology provides the reader with a thorough coverage of urology. Every area, function, illness and treatment of the urinary tract, along with specific discussions of the relevant anatomy and physiology, is included in clearly written text, abundantly illustrated with full color photographs and diagrams. Each chapter takes the basic principles of its topic area and expands upon them to ensure maximum understanding.

Entirely new chapters in the Third Edition:

• Genetic and Biological Alterations in Cancer
• The Scientific Basis of Male Hypogonadism
• Minimally Invasive Technologies in the Treatment of Renal and Prostate Cancer
• Preoperative Assessment

This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.