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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics

Epigenetics of Aging and Longevity, Volume 4 - Translational Epigenetics vol 4 (Hardcover): Alexey Moskalev, Alexander Vaiserman Epigenetics of Aging and Longevity, Volume 4 - Translational Epigenetics vol 4 (Hardcover)
Alexey Moskalev, Alexander Vaiserman
R3,453 R3,186 Discovery Miles 31 860 Save R267 (8%) Ships in 12 - 17 working days

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses-including cancer and cardiovascular, metabolic, and neurodegenerative diseases-are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.

Genomic and Precision Medicine - Cardiovascular Disease (Hardcover, 3rd edition): Geoffrey S. Ginsburg, Huntington F. Willard Genomic and Precision Medicine - Cardiovascular Disease (Hardcover, 3rd edition)
Geoffrey S. Ginsburg, Huntington F. Willard
R2,990 R2,446 Discovery Miles 24 460 Save R544 (18%) Ships in 12 - 17 working days

Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders. Each chapter is organized for the application of genomics and personalized medicine tools and technologies to a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

Epigenetic Mechanisms in Cancer, Volume 3 (Hardcover): Sabita Saldanha Epigenetic Mechanisms in Cancer, Volume 3 (Hardcover)
Sabita Saldanha
R3,401 R3,162 Discovery Miles 31 620 Save R239 (7%) Ships in 12 - 17 working days

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes.

Metagenomics - Perspectives, Methods, and Applications (Paperback): Muniyandi Nagarajan Metagenomics - Perspectives, Methods, and Applications (Paperback)
Muniyandi Nagarajan
R2,815 Discovery Miles 28 150 Ships in 12 - 17 working days

Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics. A diverse range of chapters from international experts offer an introduction to the field and examine methods for metagenomic analysis of microbiota, metagenomic computational tools, and recent metagenomic studies in various environments. The emphasis on application makes this text particularly useful for applied researchers, practitioners, clinicians and students seeking to employ metagenomic approaches to advance knowledge in the biomedical and life sciences. Case-study based application chapters examine topics ranging from viral metagenome profiling, metagenomics in oral disease and health, metagenomic insights into the human gut microbiome and metabolic syndromes, and more. Additionally, perspectives on future potential at the end of each chapter provoke new thought and motivations for continued study in this exciting and fruitful research area.

Genetics of Bone Biology and Skeletal Disease (Hardcover, 2nd edition): Rajesh V. Thakker, Michael P. Whyte, John Eisman,... Genetics of Bone Biology and Skeletal Disease (Hardcover, 2nd edition)
Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi Igarashi
R4,709 R4,286 Discovery Miles 42 860 Save R423 (9%) Ships in 12 - 17 working days

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets.

Suicide Gene Therapy - Methods and Protocols (Hardcover, 1st ed. 2019): Nejat Duzgunes Suicide Gene Therapy - Methods and Protocols (Hardcover, 1st ed. 2019)
Nejat Duzgunes
R2,961 Discovery Miles 29 610 Ships in 10 - 15 working days

This detailed volume explores the methods used for most of the recent approaches to suicide gene therapy of cancer, which exploits promoters that are specific to cancer cells, thereby ensuring (or greatly increasing the likelihood) that the therapeutic gene is expressed only in cancer cells. The book also contains chapters describing methods to improve the safety of cell therapy and techniques utilizing bone marrow mesenchymal cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Suicide Gene Therapy: Methods and Protocols serves as an ideal guide for researchers expanding upon our knowledge and application of this vital form of cancer therapy.

Imaging Genetics (Paperback): Adrian Dalca, Kayhan Batmanghelich, Mert Sabuncu, Li Shen Imaging Genetics (Paperback)
Adrian Dalca, Kayhan Batmanghelich, Mert Sabuncu, Li Shen
R2,813 R2,622 Discovery Miles 26 220 Save R191 (7%) Ships in 12 - 17 working days

Imaging Genetics presents the latest research in imaging genetics methodology for discovering new associations between imaging and genetic variables, providing an overview of the state-of the-art in the field. Edited and written by leading researchers, this book is a beneficial reference for students and researchers, both new and experienced, in this growing area. The field of imaging genetics studies the relationships between DNA variation and measurements derived from anatomical or functional imaging data, often in the context of a disorder. While traditional genetic analyses rely on classical phenotypes like clinical symptoms, imaging genetics can offer richer insights into underlying, complex biological mechanisms.

Endocrine Biomarkers - Clinicians and Clinical Chemists in Partnership (Hardcover): Hossein Sadrzadeh, Gregory Kline Endocrine Biomarkers - Clinicians and Clinical Chemists in Partnership (Hardcover)
Hossein Sadrzadeh, Gregory Kline
R2,315 R2,175 Discovery Miles 21 750 Save R140 (6%) Ships in 12 - 17 working days

Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests.

Journeys In Medicine And Research On Three Continents Over 50 Years (Hardcover): Moyra Smith Journeys In Medicine And Research On Three Continents Over 50 Years (Hardcover)
Moyra Smith
R2,248 Discovery Miles 22 480 Ships in 12 - 17 working days

This book presents clinical and research aspects of medicine and social dimensions of healthcare. It is designed for an audience with interest in health and societal factors. It is in part autobiographical, based on different phases of the author's life in medicine over 50 years, who revisited cases and problems encountered as she worked in different countries, including South Africa, Scotland, England and North America. Essays encompass aspects of clinical medicine and aspects of research, particularly in Genetics and Genomic Medicine. New information on the topic or disorder and current opinions and approaches to finding solutions are reviewed.

Genetics and Genomics in Nursing - Guidelines for Conducting a Risk Assessment (Paperback): Quannetta T. Edwards, Ann H.... Genetics and Genomics in Nursing - Guidelines for Conducting a Risk Assessment (Paperback)
Quannetta T. Edwards, Ann H. Maradiegue
R1,421 R1,070 Discovery Miles 10 700 Save R351 (25%) Ships in 12 - 17 working days

Delivers complex information in an easy-to-read, step-by-step format. The genomic era encompasses the entire spectrum of DNA - all of the genes, and the interaction and inter-relationship of genes (genome) to the environment. Rapidly changing research has led to numerous advances in genetic testing, diagnosis, and treatments, and it is essential that APRNs be able to integrate genetic risk assessment into clinical care. This quick reference delivers complex information in an easy-to-read, step-by-step format with bitesize info boxes and bulleted information to provide the tools necessary to understand genetics/genomics and identify ""red flags"" that can appear in patient assessments. In an age of personalized and precision medicine, genetic risk assessment has never been more important. Genetics and Genomics in Nursing begins with an overview of genetics and the science behind inheritance. Chapters then break down the processes that make up risk assessment, and walk the reader through data collection and review, identification and calculation of risk, and patient communication. Finally, the last section of this text discusses special populations and key facts nurses need to know about their risk assessment. Key Features: Provides a clear introduction to a complex topic Describes important elements of the genomic risk assessment process for use in clinical settings when evaluating patients Illustrates how to develop a three-generation pedigree Applies commonly-used standardized pedigree symbols and familial patterns to aid in risk interpretation Discusses the challenges and limitations of pedigree interpretation Explains common concepts and includes helpful genomic resources Incorporates genomic risk assessment into patient evaluation

miRNA and Cancer, Volume 135 (Hardcover): Kenneth D. Tew miRNA and Cancer, Volume 135 (Hardcover)
Kenneth D. Tew; Volume editing by Paul B. Fisher, Carlo M. Croce
R3,857 Discovery Miles 38 570 Ships in 12 - 17 working days

miRNA and Cancer, Volume 135, the latest volume in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents original reviews on research bridging oncology and gene expression, and includes specific chapters on Non-coding RNAs as Biomarkers of Cancer, The Enigma of microRNA Regulation in Cancer, Animal Models to Study microRNA functions, Non-coding RNAs and Cancer, microRNAs in Cancer Susceptibility, ts-RNAs versus microRNAs, microRNAs and AML, and microRNAs and Epigenetics.

Fusion Genes And Cancer (Hardcover): Ajaikumar B. Kunnumakkara, Ganesan Padmavathi, Nand Kishor Roy Fusion Genes And Cancer (Hardcover)
Ajaikumar B. Kunnumakkara, Ganesan Padmavathi, Nand Kishor Roy
R4,078 Discovery Miles 40 780 Ships in 12 - 17 working days

Development of cancer, a dreadful disease of mankind, is a multi-stage process involving numerous molecular alterations at both genomic and proteomic levels. Immense research for the past several decades in the field of cancer identified many such mutations and their role in carcinogenesis. Concept of 'fusion genes' seeded way back in 20th century has now grown into a new field of cancer research. However, there is a lack of knowledge among scientists about these fusion genes and their importance in cancer, which can be mainly attributed to unavailability of a comprehensive book on this topic. Therefore, this book is first of its kind and aims at giving a detailed idea on the formation of gene fusions and their importance in the development and progression of cancer; techniques to identify novel gene fusions; and therapeutics available to target various fusion proteins and their impact in cancer therapy by compiling the information from the literature available till date.

Genomics in Endocrinology - DNA Microarray Analysis in Endocrine Health and Disease (Hardcover, 2008 ed.): Stuart Handwerger,... Genomics in Endocrinology - DNA Microarray Analysis in Endocrine Health and Disease (Hardcover, 2008 ed.)
Stuart Handwerger, Bruce J Aronow
R4,849 R4,490 Discovery Miles 44 900 Save R359 (7%) Ships in 12 - 17 working days

In recent years, the development of new technologies capable of monitoring genome function has resulted in fewer hopeful estimates and increasingly solid depictions of genome output from individual samples. Genomics in Endocrinology focuses on exciting new advances in endocrinology resulting from DNA microarray studies and includes a comprehensive introduction to the use of DNA microarrays in endocrinology. The volume provides the basis for further understanding of the usefulness of microarray analyses in endocrinology research. Topics discussed are the methodology of DNA microarrays and general methods for the analysis of microarray data, as well as studies of a wide variety of normal and abnormal endocrine cells.

In the introductory chapter, the volumea (TM)s editors describe several issues in hypothesis formulation, experimental design, data analysis, and follow-up studies that may corroborate, validate, and extend hypotheses gained through microarray analyses. The contributed chapters span a variety of applications that we have divided into the areas of (1) genomic insights into molecular mechanisms responsible for hormone action, (2) genomic characterizations of endocrine producing tissues, and (3) genomic manifestations of diseases of hormonal systems.

A volume on the cutting-edge of technology, Genomics in Endocrinology will provide researchers with an authoritative volume on the most recent advances in monitoring genome function.

Encyclopedia of DNA Repair and Human Health: Volume I (Hardcover): Nas Wilson Encyclopedia of DNA Repair and Human Health: Volume I (Hardcover)
Nas Wilson
R1,857 Discovery Miles 18 570 Ships in 12 - 17 working days
RNA Therapeutics - Function, Design, and Delivery (Hardcover, 2010): Mouldy Sioud RNA Therapeutics - Function, Design, and Delivery (Hardcover, 2010)
Mouldy Sioud
R4,626 Discovery Miles 46 260 Ships in 12 - 17 working days

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular Biology (TM) series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Epigenetics In Human Reproduction And Development (Hardcover): Anna K. Naumova, Teruko Taketo-Hosotani Epigenetics In Human Reproduction And Development (Hardcover)
Anna K. Naumova, Teruko Taketo-Hosotani
R3,491 Discovery Miles 34 910 Ships in 12 - 17 working days

Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.

Genetics of Dyslipidemia (Hardcover): Pascale Benlian Genetics of Dyslipidemia (Hardcover)
Pascale Benlian
R4,540 Discovery Miles 45 400 Ships in 12 - 17 working days

Profound mortality rates, due to cardiovascular disease, are a worldwide problem. Cardiovascular disease results from complications of a silent and chronic arterial disease: atherosclerosis. The challenge for the practitioner is adapting diagnostic and therapeutic responses to prevent this common and complex disease. Dyslipidemia, are disorders of the metabolism of soluble transporters of lipids in extracellular spaces of the human body (including blood), called lipoproteins. They are major cardiovascular risk factors, causally related with atherosclerosis and are themselves multifactorial diseases, resulting from interactions between genetic and environmental factors. The study of genetic factors has recently taken a new path with the study of DNA as an experimental object. More than fifty genes of lipoprotein metabolism have been identified in both their physiological actions and their contribution to the pathogenesis of human dyslipidemia. The diversity of observations has refined our current knowledge of the control of lipid metabolism and energy homeostasis in living organisms beyond the limits of the cardiovascular system (e.g., brain, immune system, and development). These studies have given way to a shake-up of former phenotypic classifications, distinguishing new entities, defining targeted therapeutic strategies, providing a basis for different patterns of disease distribution in human populations.

Genetic Databases - Socio-Ethical Issues in the Collection and Use of DNA (Hardcover, New): Oonagh Corrigan, Richard Tutton Genetic Databases - Socio-Ethical Issues in the Collection and Use of DNA (Hardcover, New)
Oonagh Corrigan, Richard Tutton
R5,221 Discovery Miles 52 210 Ships in 10 - 15 working days

Over the past few years there has been a proliferation of genetic databases and biobanks, which promise to increase scientists' understandings of the way our genes interact with the environment. These biomedical research projects involve hundreds of thousands of people worldwide who are asked to donate blood and tissue samples as well as personal information. The control, exploitation and ownership of such detailed personal medical information by governments and by commercial companies is generating social and ethical controversy. contradictions and limitations of the current regulatory frameworks for and policy debates about genetic databases. Drawing on original empirical research and theoretical debates in the fields of sociology, anthropology and legal studies, the contributors to this book challenge the prevailing orthodoxy of informed consent and explore the relationship between personal privacy and the public good. They also consider the multiple meanings attached to human tissue and the role of public consultations and commercial involvement in the creation and use of genetic databases. representation of participation that is often at odds with the experiences and understandings of those taking part. The findings present a serious challenge for public policy to provide mechanisms to safeguard the welfare of individuals participating in genetic databases. The book is written in an accessible style that will appeal to a multidisciplinary and international audience, and is relevant to policy discussions in Europe and in North America, as well as other countries that are developing similar initiatives. It will be of great interest to academics and students of medical sociology, health studies, public health, public policy and ethics.

Gene Therapy for HIV and Chronic Infections (Hardcover, 2015 ed.): Ben Berkhout, Hildegund C. J. Ertl, Marc S. Weinberg Gene Therapy for HIV and Chronic Infections (Hardcover, 2015 ed.)
Ben Berkhout, Hildegund C. J. Ertl, Marc S. Weinberg
R4,080 R3,504 Discovery Miles 35 040 Save R576 (14%) Ships in 12 - 17 working days

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990's. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

Unravelling Complexities In Genetics And Genomics: Impact On Diagnosis Counseling And Management (Hardcover): Moyra Smith Unravelling Complexities In Genetics And Genomics: Impact On Diagnosis Counseling And Management (Hardcover)
Moyra Smith
R2,682 Discovery Miles 26 820 Ships in 12 - 17 working days

Unravelling Complexities in Genetics and Genomics: Impact on Diagnosis Counseling and Management reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders.Physicians, nurses, genetic counselors, graduate students in genetics and genomics will find this book a valuable read.

Engineering the Human Germline - An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children... Engineering the Human Germline - An Exploration of the Science and Ethics of Altering the Genes We Pass to Our Children (Hardcover)
Gregory Stock, John Campbell
R1,341 R1,186 Discovery Miles 11 860 Save R155 (12%) Ships in 12 - 17 working days

This book gives an overview of the potential and the practical details that need to be resolved in order to make human germline engineering possible. It presents the ethical and social concerns, and implications of our fast-approaching capability to alter our own germline and take an active role in the future evolution of our own species. It provides explanations of how we have arrived at the capability to clone higher animals, and discusses the implications for human therapies and for our own future when these techniques are applied to the human germline.

Cardiac Gene Therapy - Methods and Protocols (Hardcover, 2nd ed. 2022): Kiyotake Ishikawa Cardiac Gene Therapy - Methods and Protocols (Hardcover, 2nd ed. 2022)
Kiyotake Ishikawa
R4,790 R4,499 Discovery Miles 44 990 Save R291 (6%) Ships in 12 - 17 working days

This second edition volume expands on the previous edition with updated techniques and discussions on topics such as gene suppression, editing, and reprogramming; cardiac gene therapy vectors and promoters; cardiac gene delivery methods; pulmonary hypertension; and patient screening and measuring the efficacy of cardiac gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cardiac Gene Therapy: Methods and Protocols, Second Edition is a valuable tool for researchers in cardiology who are conducting gene therapy research. This book will lead to further advancements and successful clinical translations in the field. Chapter "Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Handbook Of Forensic Genetics: Biodiversity And Heredity In Civil And Criminal Investigation (Hardcover): Antonio Amorim, Bruce... Handbook Of Forensic Genetics: Biodiversity And Heredity In Civil And Criminal Investigation (Hardcover)
Antonio Amorim, Bruce Budowle
R3,768 Discovery Miles 37 680 Ships in 12 - 17 working days

The use of genetics for the resolution of legal conflicts has recently been gaining a higher profile, largely as a result of scientific and technological advancements and the substantial broadening of applications. The theoretical framework underlying forensic genetics is the same irrespective of the materials and technology involved, however a great divide still exists in the manner and processes related to human and non-human analyses.This advanced handbook intends to overcome the historical barriers between the scientific fields of legal medicine, biodiversity and conservation, and food analysis by presenting a unifying, global perspective on the implications of genetic analyses on forensic affairs. This global perspective is presented in three parts: modes of inheritance and reproduction and taxonomic implications; current technological approaches and future perspectives; and a comprehensive systematization of the types of applications and organisms. Finally, a critical revision of the current investigative/expert systems and future perspectives is undertaken.This book provides a collection of international research, thereby constituting a reference platform for the forensic community and an advanced textbook for graduate students. It encompasses the theoretical bases of the field, and presents in the context of both perspectives of forensic action - probative and investigative - a comprehensive coverage of the current applications and technological state of the art.

Negotiating Risk - British Pakistani Experiences of Genetics (Hardcover, New): Alison Shaw Negotiating Risk - British Pakistani Experiences of Genetics (Hardcover, New)
Alison Shaw
R2,945 Discovery Miles 29 450 Ships in 12 - 17 working days

Drawing on fieldwork with British Pakistani clients of a UK genetics service, this book explores the personal and social implications of a 'genetic diagnosis'. Through case material and comparative discussion, the book identifies practical ethical dilemmas raised by new genetic knowledge and shows how, while being shaped by culture, these issues also cross-cut differences of culture, religion and ethnicity. The book also demonstrates how identifying a population-level elevated 'risk' of genetic disorders in an ethnic minority population can reinforce existing social divisions and cultural stereotypes. The book addresses questions about the relationship between genetic risk and clinical practice that will be relevant to health workers and policy makers.

Personalized Nutrition as Medical Therapy for High-Risk Diseases (Paperback): Nilanjana Maulik Personalized Nutrition as Medical Therapy for High-Risk Diseases (Paperback)
Nilanjana Maulik
R1,455 Discovery Miles 14 550 Ships in 12 - 17 working days

Personalized nutrition involves the formulation of individualized nutritional recommendations to promote and maintain health based on an individual's genetic makeup and other unique intrinsic and extrinsic factors. Implementing personalized nutrition plans for individuals with certain diseases or who are in danger of developing health conditions could help control the onset and severity of symptoms. Personalized Nutrition as Medical Therapy for High-Risk Diseases offers a practical guide for physicians seeking to provide tailored dietary recommendations to their patients with disease treatment, modulation and prevention in mind. The book focuses on the biological mechanisms of specific diseases and provides evidence for how personalized nutrition positively impacts them. It explores conditions including cardiovascular diseases, hypertension, hypercholesteromia, diabetes, obesity, Crohn's disease, as well as multiple pediatric, renal and psychological disorders. Features: * Includes case studies that document how people respond differently towards food depending on their genetic structure and other factors. * Discusses genome wide association studies (GWIMS) to understand the interplay between genetic susceptibility and dietary interactions. * Provides users information to effectively implement personalized nutrition into practice. * Identifies possible challenges to the implementation of personalized nutritional interventions in a clinical setting. This book is for medical practitioners and will also appeal to researchers and students.

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