"Handbook of Pharmacogenomics and Stratified Medicine" is a
comprehensive resource to understand this rapidly advancing field
aiming to deliver the right drug at the right dose to the right
patient at the right time. It is designed to provide a detailed,
but accessible review of the entire field from basic principles to
applications in various diseases. The chapters are written by
international experts to allow readers from a wide variety of
backgrounds, clinical and non-clinical (basic geneticists,
pharmacologists, clinicians, trialists, industry personnel,
ethicists) to understand the principles underpinning the progress
in this area, the successes, failures and the challenges ahead.
Tobe accessibleto the widest range of readers, the clinical
application section introduces the disease process, existing
therapies, followed by pharmacogenomics and stratified medicine
details.
Medicine isthe cornerstone of modern therapeutics prescribed on
the basis that its benefit should outweigh its risk. It is well
known that people respond differently to medications and in many
cases the risk-benefit ratio for a particular drug may be a gray
area. The last decade has seen a revolution in genomics both in
terms of technological innovation and discovering genetic markers
associated with disease. In parallel there has been steady progress
in trying to make medicines safer and tailored to the individual.
This has occurred across the whole spectrum of medicine, some more
than others. In addition there is burgeoning interest from the
pharmaceutical industry to leverage pharmacogenomics for more
effective and efficient clinical drug development.
Provides clinical and non-clinical researchers with practical
information normally beyond their usual areas of research or
expertiseIncludes an basic principles section explaining concepts
of basic genetics, genetic epidemiology, bioinformatics,
pharmacokinetics and pharmacodynamicsCovers newer technologies-
next generation sequencing, proteomics, metabolomicsProvides
information on animal models, lymphoblastoid cell lines, stem cells
Provides detailed chapters on a wide range of disease conditions,
implementation and regulatory issuesIncludes chapters on the global
implications of pharmacogenomics"
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