The third edition of ENT: An Introduction and Practical Guide provides an essential introduction to the clinical examination, treatment options and surgical procedures within ENT. It encompasses the most frequently encountered conditions in the emergency setting, on the ward and in the outpatient clinic. The text has been updated to include new content on implantation surgery for hearing loss. It also includes significant changes in the indications for surgery, patient assessment, management, and surgical techniques. The subject of dizziness and vertigo have also been updated to include novel interventions. With its highly practical step-by-step approach, this book will be invaluable to all surgical trainees studying for higher postgraduate examinations in ENT, and an essential guide for otorhinolaryngologists, primary care practitioners and specialist ENT nurses in their early years of training.

In this volume, Akhtar addresses the intricacies of in-depth psychotherapy. He has deliberately limited his exploration five specific areas in order to be able to explore them thoroughly: initial assessment; boundaries; money; disruptions; and suicidal crises.Akhtar s more than three decades of clinical experience has taught him that most problems in the course of dynamic psychotherapy involve these areas; therefore their proper understanding and management is key to productive therapeutic work. Each chapter of this compact book tackles one of these areas in detail, outlining not only the conceptual issues at hand but also the technical strategies that emanate from them. While theoretical grounding does serve as a preamble for the delineation of its technical strategies, the book is replete with clinical vignettes and explicatory comments that illustrate the interventions. This work is designed to introduce the younger generation of therapists to ways of thinking and working that experienced practitioners have found clinically useful."

"This book claims to be 'like no other' and that is so true. The editors and authors each add quality guidance around distributed leadership to readers, providing evidence-based examples, useful websites and key reading material to support and supplement the ideas being presented." Bridie Kent, Professor in Leadership in Nursing, University of Plymouth, UK "This book, thankfully, isn't about self-defined heroic organizational leaders or power-hungry political leaders - it tells the stories of the people doing leadership every day in their work to make healthcare happen." Scott Taylor, Business School Director of Admissions, University of Birmingham, UK This innovative book brings together experts from health sciences, nursing, business and management backgrounds to provide a broad analysis of the growing field of distributed leadership. The book offers health professionals practical guidance on applying distributed leadership, resulting in more effective forms of collaborative clinical teamwork and lasting improvements in care. The text: *Offers a comprehensive collection of perspectives, featuring chapters by expert clinical, nursing and management studies contributors *Synthesizes and explores recent developments in the leadership and distributed leadership research literature *Supports research and theory with examples of cases of effective distributed leadership in clinical practice, service quality, patient safety, leadership development, general nursing, midwifery education, oncology services, intellectual disability, evidence-based practice and organizational change and development *Provides an international focus, to encourage reflection on learning from experiences across Europe and beyond Distributed Leadership in Nursing and Healthcare is essential reading for health professionals, undergraduate and postgraduate students, and researchers working in the field of leadership. Edited by: Elizabeth A. Curtis, Assistant Professor, Trinity College Dublin, Ireland Martin Beirne, Emeritus Professor of Management and Organisational Behaviour at the University of Glasgow, UK John G. Cullen, Associate Professor, Maynooth University, Ireland Ruth Northway, Professor of Learning Disability Nursing, University of South Wales, UK Siobhan M. Corrigan, Assistant Professor, Trinity College Dublin, Ireland

How can we learn from previous food production mistakes and pave a way for producing sustainable, nutritious, local meat? The Covid-19 pandemic exposed the vulnerabilities of our globalised food system and highlighted the desperate need for local and regional supplies of healthy meat. We must replace industrial feed models, which are responsible for significant climate emissions, nitrogen pollution and animal suffering. Grass-Fed Beef for a Post-Pandemic World outlines a hopeful path out of our broken food system via regional networks of regeneratively produced meat. In 2017, Ridge Shinn and Lynne Pledger went to market with Big Picture Beef, a company that partners with farmers across the northeastern United States to provide high-quality, 100% grass-fed beef. Their model has increased participating farmers' access to wholesale markets, and their holistic grazing management techniques offer multiple benefits for the health and wellbeing of consumers, the environment and livestock. In Grass Fed-Beef for a Post-Pandemic World, you'll find information assembled from the fields of ecology, climate science, nutrition and animal welfare, along with stories from Ridge's travels as a consultant on farms all over the world. You'll discover how regenerative grazing can: restore degraded farmland protect against droughts and floods increase biodiversity combat climate change by reducing emissions and sequestering carbon contribute to regional economic development produce nutrient-dense, healthy meat for consumers Grass-Fed Beef for a Post-Pandemic World is not just for beef producers, but for anyone wondering how our farmers can raise cattle while caring for the local and global environment.

"When I sat down to read this book, I decided to fasten my seat-belt. There are people so desperate that they are willing to commit terrible crimes to get their message across, and there are carers so assaulted that they must put safety before care. Not a book to read before bedtime you might say. However I'm not sure that this is setting the scene correctly, because, when I read it, in addition to the psychopathology of desperation, there is the capacity to reflect on it, and to give despair the meaning it should have, and to do so with a greatly reassuring power."--From the Foreword by Bob Hinshelwood, Member of the British Psychoanalytic Society, Fellow of the Royal College of Psychiatrists and Professor in the Centre for Psychoanalytic Studies, University of Essex, UK "[The book] may stand as an unusually bold and uncompromising example of psychodynamically informed action research and the contribution this can offer, drawing on the intelligence afforded by emotional experience, to the restoring of both meaning and agency. Viewed in this way, the book both speaks to and has a relevance for practitioners, managers and consultants well beyond the boundaries of just one signal enterprise."--From the Afterword by David Armstrong, Principal Consultant at the Tavistock Consultancy Service, the Tavistock and Portman NHS Foundation Trust

From mRNA vaccines to gene therapies, the next frontier of medical innovation is here. In Building Breakthroughs, Raju Prasad tells the story of important advancements in biotechnology and medical innovation from gene therapies to mRNA vaccines, providing historical context and examining cutting-edge research. Based on in-depth interviews with both the scientists who developed these discoveries and the patients who have benefited from them, Building Breakthroughs reveals the key players behind drug development and the inner workings of this essential business. Through stories of patients and their families, and of the researchers creating new treatments, Prasad reveals how cell therapies are advancing to treat childhood leukemia and a form of lymphoma, how a gene therapy was established to treat the rare disease spinal muscular atrophy type I, and potentially curative therapies that are being developed for sickle cell disease. By examining the clinical trial and regulatory paths each therapy took to reach approval, Prasad uncovers the building blocks of biotechnology innovation and the investments that must be made to catalyze the development of future breakthroughs. He also explores issues of scientific communication and misinformation, providing recommendations for improvements in the future. For those seeking to understand the vitally important processes that lead to new medicines and the surrounding ecosystem that is enabling the next generation of innovative medicines with the potential to transform patient outcomes, Building Breakthroughs is essential reading.

New York Times best-selling author and renowned science journalist Ed Yong compiles the best science and nature writing published in 2020. "The stories I have chosen reflect where I feel the field of science and nature writing has landed, and where it could go," Ed Yong writes in his introduction. "They are often full of tragedy, sometimes laced with wonder, but always deeply aware that science does not exist in a social vacuum. They are beautiful, whether in their clarity of ideas, the elegance of their prose, or often both." The essays in this year's Best American Science and Nature Writing brought clarity to the complexity and bewilderment of 2020 and delivered us necessary information during a global pandemic. From an in-depth look at the moment of the virus's outbreak, to a harrowing personal account of lingering Covid symptoms, to a thoughtful analysis on how the pandemic will impact the environment, these essays, as Yong says, "synthesize, evaluate, dig, unveil, and challenge," imbuing a pivotal moment in history with lucidity and elegance. THE BEST AMERICAN SCIENCE AND NATURE WRITING 2021 INCLUDES - SUSAN ORLEAN - EMILY RABOTEAU - ZEYNEP TUFEKCI - HELEN OUYANG - HEATHER HOGAN BROOKE JARVIS - SARAH ZHANG and others

'Essential reading for everyone' - Marian Keyes It's high time we renovated and elevated this life change. Despite the centuries of speculation and propaganda, we are not overheating or inherently cold, we are not hysterics or boiling vats of toxic poisons, we are not dried up or washed up, we are simply menopausal. It's time for us to start talking about the menopause. Cracking the Menopause, from straight-talking broadcaster Mariella Frostrup and health journalist Alice Smellie, has all the information you need, delivered with characteristic wry humour. Mariella shares her own journey through the menopause, along with the latest science, advice from leading experts and humorous illustrations - to provide an informative source of wisdom and enlightenment. Featuring case studies from women in every walk of life and all stages of their menopause journey, Cracking the Menopause opens up the conversation about an urgent topic that half the population will experience, but barely anyone is talking about. Designed to equip you with the knowledge to manage your symptoms from perimenopause onwards, this essential book separates the myths from the reality and offers expertise, hope and advice. 'I inhaled this book, it's fantastic. Women of all ages need to read it.' - Claudia Winkleman 'Mariella and Alice have just written one of the most important books of the year, bravo.' - Gabby Logan

Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.

A growing new area of study; Top quality editors and authors; Wide range of international coverage.

While interest in the relations of power and identity in food explodes, a hesitancy remains about calling these racial. What difference does race make in the fields where food is grown, the places it is sold and the manner in which it is eaten? How do we understand farming and provisioning, tasting and picking, eating and being eaten, hunger and gardening better by paying attention to race? This collection argues there is an unacknowledged racial dimension to the production and consumption of food under globalization. Building on case studies from across the world, it advances the conceptualization of race by emphasizing embodiment, circulation and materiality, while adding to food advocacy an antiracist perspective it often lacks. Within the three socio-physical spatialities of food - fields, bodies and markets - the collection reveals how race and food are intricately linked. An international and multidisciplinary team of scholars complements each other to shed light on how human groups become entrenched in myriad hierarchies through food, at scales from the dining room and market stall to the slave trade and empire. Following foodways as they constitute racial formations in often surprising ways, the chapters achieve a novel approach to the process of race as one that cannot be reduced to biology, culture or capitalism.

Foreword by Brendan Rodgers, Leicester City FC manager. Nutrition plays a crucial role in the match performance and recovery of the athlete. To apply the principles of sports nutrition in football, this book provides nutrition basics as well as insight into the physiological demands of the game itself by looking into what elite players eat and drink. Appropriate food choices and timing are also important for a player to perform hard, avoid illness, and recuperate from injury. This book uses the UEFA 2020 Expert Group Consensus Review on Nutrition in Elite Football to give evidence-based guidelines for optimizing football performance through appropriate nutrition and the latest comprehensive information on nutrition guidelines for professional players-also relevant to the amateur player. Included are the specific needs of female players and match officials and relevant issues such as eating during travel and food hygiene. Finally, the book provides some example meal plans and snacks for training, match, and recovery days. Meal recipes are provided by elite performance chefs, Rachel Muse and Bruno Cirillo, who regularly prepare meals for elite players. The science behind sports nutrition is evolving fast. Knowing what the top professional players are eating and drinking can help amateur players improve their own performance, recovery, and health.

When Walt Larimore, MD, moved his young family to Kissimmee, Florida, to start a small-town medical practice in 1985, he had no idea he was embarking on an enterprise that would change his life in ways both large and small. Dr. Larimore shared some of these heartwarming and heartbreaking tales in The Best Medicine. Now he offers up more charming stories of his time as a family physician in a rural, small-yet-growing town in The Best Gift. Ideal for anyone wrestling with the inevitable and difficult storms of life, as well as fans of Dr. Larimore's popular Bryson City series, The Best Gift is a tender and insightful collection of stories chronicling one young doctor's spiritual growth as a physician, husband, father, and community member. Filled with characters colorful and crusty, warmhearted and hotheaded, witty and winsome, these captivating stories glow with drama, heartbreak, warmth, love, and humor. You'll laugh. You'll cry. You'll learn some of life's greatest lessons. And you'll wish Dr. Larimore was your doctor.

A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

If you're fed up with life, questioning whether you should stay married or thinking you might be better of with someone else, marital therapist Andrew G. Marshall has a radical idea to help you move from the first half to the second of your life without messing everything up. In part one of this essential new book he explains:* The three central questions you need to answer (and why everybody else is distracting themselves and avoiding facing them).* How to put what's happening now into the context of your whole life journey.* How to avoid the tempting short-cuts that cause more heartache in the long term.* Why if you pass this mid-life test everything is up from here.If it's your partner who has turned grumpy, critical and blames you for everything, you will be feeling alone and full of despair. Don't worry, in part two of this compassionate book, he explains:* A whole new vocabulary for discussing the mid-life crisis without putting your partner's back up.* What's really going on in your partner's head.* What causes depression and how to help.* Five killer replies to the blocks that stops you talking properly about your marriage.Together you will learn three new skills that will either change your marriage into the connected, fulfilling and loving relationship of which you've always dreamed or help you separate amicably and be great co-parents together.

Quinine: The Jesuits discovered it. The Protestants feared it. The British vied with the Dutch for it, and the Nazis seized it. Because of quinine, medicine, warfare, and exploration were changed forever.

For more than one thousand years, there was no cure for malaria. In 1623, after ten cardinals and hundreds of their attendants died in Rome while electing Urban VII the new pope, he announced that a cure must be found. He encouraged Jesuit priests establishing new missions in Asia and in South America to learn everything they could about how the local people treated the disease, and in 1631, an apothecarist in Peru named Agostino Salumbrino dispatched a new miracle to Rome. The cure was quinine, an alkaloid made from the bitter red bark of the cinchona tree.

From the quest of the Englishmen who smuggled cinchona seeds out of South America to the way in which quinine opened the door to Western imperial adventure in Asia, Africa, and beyond, and to malaria's effects even today, award-winning author Fiammetta Rocco deftly chronicles the story of this historically ravenous disease.

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, McCance and Huether's Pathophysiology: The Biologic Basis for Disease in Adults and Children, 9th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. It's the most comprehensive and authoritative pathophysiology text available! Unparalleled coverage of pathophysiology content makes this the most comprehensive and authoritative pathophysiology text on the market. Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment. Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes ? more than in any other pathophysiology text. Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes. Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content. Coverage of rare diseases and epigenetics further explores genetic disease traits. Obesity and Nutritional Disorders chapter thoroughly covers these growing global concerns. Chapter summary reviews provide concise synopses of the main points of each chapter. More than 30 3D animations on the companion Evolve website bring difficult concepts to life for a new perspective on disease processes. NEW! More than 50 new or revised illustrations visually reinforce pathophysiology concepts. NEW! Emerging Science boxes highlight the most current research and clinical developments.

Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19, and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.

In recent years a lot of emphasis has been placed on obtaining consent for surgical and medical procedures to avoid litigation. This has become an integral part of clinical risk management and clinical governance. Problems relating to consent are the reason for a great proportion of medico-legal claims. Adequate, informed consent and better record keeping will avoid a lot of complaints and litigation. This book aims to help to understand the types of consent , how to obtain consent, and its medico-legal implications when things go wrong. It is designed to help in obtaining consent for common procedures undertaken in obstetrics and gynaecology. It is intended not only for doctors, but also for midwives, nursing staff, medical students and allied health professionals. And it is also particularly relevant for overseas doctors who are new and generally less familiar with the risk management, clinical governance and litigation system in the UK. Another use of this book is to provide an invaluable on the spot reference for various operations and their complications, ways and means of minimising risk, and dealing with difficult situations. The speciality of obstetrics and gynaecology is sued more frequently than any other. This book should help all those who are involved in the ob/gyn department to minimise the risk and danger of incurring such action.

* Teaches parents how to support their child with Autism Spectrum Disorder at home and in school, as well as when to seek out and identify qualified professionals. * Evidence-based, but written with a "get to the point quick" style for easy reading and application. * Relevant to all parents with ASD children, this book addresses emerging trends and discusses myths, misunderstandings, and unproven therapies. * Written by experts in the field of Special Education, Noelle Balsamo and James W. Forgan.

Develop 21st-century professional skills with ADMINISTRATIVE MEDICAL ASSISTING, Ninth Edition! This streamlined learning package provides step-by-step guidance to help you master front-office medical assisting and office management, while honing the critical-thinking and job skills you'll need for success as an allied health professional. The text features detailed coverage of fundamental administrative competencies, including professional responsibilities, interpersonal and written communications, records management, financial administration and office management. Simulated test questions, mapped competencies and updated certification standards add depth to every chapter and help you prepare for certification exams. New and revised content keeps you up-to-date on key developments in the field, including the newest requirements for electronic technology, insurance regulations, coding, health care reform, legal compliance and much more. Robust and reader-friendly, this trusted guide is essential reading for medical assistants who want to succeed in today’s allied health careers.

This book has been specifically designed to help GP trainees pass the compulsory AKT examination. Each topic has been skilfully refined to correlate directly with primary care and the RCGP curriculum, revealing how and why critical appraisal and evidence based medicine are essential for good medical practice throughout a career as an independent, knowledgeable, caring and thoughtful general practitioner. It includes invaluable preparation suggestions and an overall outline of the AKT, an introduction to statistics and qualitative methods, quantitative methods, epidemiology, common research methods and outcomes, useful tests used in epidemiological studies, research ethics, measures of mortality and economic analyses. Each chapter features unique, topic specific questions to reinforce comprehension, with an entire final chapter devoted to sample questions, comprehensively testing expertise and developing confidence. Ideal for revision and self-examination, RCGP AKT: Research, Epidemiology and Statistics gives GP trainees vital edge when preparing for the AKT.

This book is about how to maintain an aliveness to the possibilities in therapy and practice and how to challenge ideas of orthodoxy in theory and methodologies that can become stale or followed like religions. The central metaphor is the performance of practice emphasized in the spoken word and expressed in all its non-verbal complexity. How practitioners use every aspect of their being to communicate with the other in practice, how they shape and mold their words through gesture and other non-verbal actions in response to the gestures and words of others is a continually recursive process. Therapy is an enactment, a performance that is created between all the participants."This is Jim Wilson's second book in our series. He might call it his second act. His first book, Child Focused Practice, was very popular because it offered practical approaches to working with children for practitioners from diverse backgrounds. This current volume is written in the same spirit but takes his thinking and techniques into new areas. He is interested in two things: how therapists can release more of their own creativity when working with children and how they can use enactment to explore difficult family emotions. The influence of systemic thinking on the family therapy world has often led to theories and techniques that have often overlooked the value of simply talking to and playing with children. This book goes some way to redressing that balance. It is loaded with examples of conversations with children, playful metaphors, enacted scenarios of traumatic events, and discussions that connect children to the other relationships in the family. The sheer pleasure Wilson gets from working directly withchildren is evident throughout the book and he is clearly drawing on his personal style, yet the book does not neglect the theorizing that helps answer the question of why Wilson does what he does and why it is effective."- David Campbell and Ros Draper, from the Series Editors' Foreword

Resolve the 7 types of hormone imbalance naturally with simple changes to your food and lifestyle habits. Looking for relief from debilitating menstrual cycles, PMS, PMDD, weight gain, low energy, and mood fluctuations caused by a hormonal imbalance, but don't want the side effects and expense of drugs and surgery? Based on therapeutic nutrition principles, The Hormone Type Cookbook gives you accessible solutions to address common hormone imbalances like low progesterone, estrogen dominance, low thyroid, adrenal fatigue, and other issues. Whatever stage of your lifecycle, this guide is your holistic hormone health companion! Expert author Madeline Mackinnon, creator of the popular handle @NaturalHormoneHealing, guides your entire journey of hormonal health, from menstrual health and fertility to postpartum, perimenopause, and menopause. You will finally understand the "why" of your hormone imbalances, not just the "what." Madeline also debunks nutritional myths and shows how certain popular diets can actually disrupt hormone balance. Drawing upon the latest hormone nutrition research, the book contains: Hormone quizzes and assessments, so you can determine your specific imbalance and then eat to treat it The foundations of hormone health How to structure meals to keep your hormones happy Guidance on lifestyle habits and what things in your environment, such as endocrine disruptors, are creating issues All the while, you'll be eating your choice of 75 delicious hormone-supporting breakfasts, lunches, dinners, drinks, and snacks, such as: Hot Flash Elimination Smoothies Thyroid-Loving Lunch Bowl Libido-Boosting Freezer Fudge Stress-Support Matcha Latte Start your healing journey to hormone balance today.