Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

PRE-ORDER THE ACCOMPANYING JOURNAL LEARN TO LET GO NOW 'Life-changing' - Sara Makin, Founder & CEO of Makin Wellness If you learn to let go, your life will take off. When you let go, you live intuitively. Everything flows, because you are no longer attached to things being a certain way, to being a certain person or always being right. What a relief. The irony is that when you feel stuck in any area of your life - career, relationships, purpose, health or money - letting go can seem very hard. You cling on for dear life just at the moment you need to take the leap. In The Power of Letting Go, John Purkiss explains why we should let go and how we can do it, using proven techniques to make things happen. The stages of letting go: -Be Present and Enjoy Each Moment -Let Go of the Thoughts that Keep You Stuck -Let Go of the Pain that Runs Your Life -Surrender and Tune into Something Far More Intelligent than Your Brain

Das Buch dokumentiert die Beitrage des internationalen Symposiums "Assistierter Suizid: Der Stand der Wissenschaft" vom 15. Juni 2015 in Berlin. Es bietet einen einmaligen Uberblick uber die aktuellen empirischen Untersuchungen zum Thema, die in der politischen Debatte teilweise schlicht ignoriert wurden und immer noch ignoriert werden. Es enthalt ausserdem die Transkripte aufschlussreicher Pro-Contra Debatten zwischen Vertretern unterschiedlicher Positionen aus den Fachgebieten Recht, Medizin und Ethik. Am Schluss steht eine ausfuhrliche Kommentierung des neuen Gesetzes "zur Strafbarkeit der geschaftsmassigen Forderung der Selbsttotung" aus rechtlicher, medizinischer und ethischer Perspektive.Die Autoren und Herausgeber sind international ausgewiesene Experten aus Deutschland und aus anderen Staaten, in denen die Totung auf Verlangen und/oder der assistierte Suizid gesetzlich geregelt sind (Niederlande, Schweiz, USA).

"Unrelieved chronic pain is a worldwide epidemic"Chronic pain has been subject to multiple international initiatives through the World Health Organization. Interventional Pain Medicine, use of minimally invasive techniques to relieve pain, is the best approach when simpler measures such as physical therapy or medications fail. However, these procedures can be associated with significant risk and expense. Establishing uniformity in diagnostic criteria and procedural performance can reduce both morbidity and unnecessary procedures, and hence healthcare expenditures.

While other texts explain how to perform these procedures, little focus has been given to diagnostic considerations: if and when these procedures should be performed. "Evidence-based Interventional Pain Practice" uniquely focuses on how the establishment of an accurate and specific diagnosis relates to the effectiveness of the interventions. It provides the evidence for the use of interventional pain techniques across all areas of chronic pain including:

- Head, neck and shoulder pain - Spinal pain - Pain in the joints and extremities- Complex Regional Pain Syndrome- Phantom pain

"Evidence-based Interventional Pain Practice" provides essential knowledge for anyone who uses, or intends to use, interventional pain techniques.

Many patients suffer from problems in their muscles or nerves in combination with pain. This book is about the complex interplay between the causes of these problems and the puzzle they pose. Pain is the subjective experience of a psychophysical phenomenon arising from a defined area in the body. It is a cry for help and challenges the physician to ask the right questions and to carry out the right examinations. If they succeed in doing so, the patient's signs and symptoms will be translated into the present knowledge of pain concepts to initiate appropriate therapy. With this goal in mind, this book summarizes the latest scientific information on pain states and their mechanisms. It provides a deeper understanding of the different pain conditions and allows physicians to form strategies for better pain therapy. The second edition includes more graphs, tables, and illustrations. It is updated with the current and dynamically expanding knowledge on the therapy of several disease states and explains in more detail the processing of pain in the central nervous system. When puzzling symptoms of sensory, motor, and autonomic deficits are evident, an examination has to be performed systematically in order to reach the correct diagnosis. This calls for suitable anatomical knowledge. Depending on where a lesion exists within a peripheral nerve, the root or the plexus, typical patterns of paralysis can be detected. Numerous illustrations in the book help physicians to more easily understand and solve problems of peripheral nerve and root injuries and their sequelae in their daily work.

Pain in one form or another is probably the most common symptom presented to medical and healthcare professionals. Long a subject of biomedical interest, more recent biopsychosocial theories have extended the study of pain as a concept which is highly individual in the way it is experienced. Today s landscape offers a broad array of approaches to understanding pain and, crucially, to alleviating its impact. This concise and accessible volume aims to make sense of what is at first sight an eclectic mix of theoretical and practical work on pain, from a distinctly sociological perspective. While there has been much quantitative medical research on pain, in exploring sociology s important contributions to this field Elaine Denny offers insight into the world of those living with pain and the meaning it has in their lives. She provides readers with a range of explanations of pain and various influences on the experience of pain, critically analysing competing schools of thought and embedding this work in the everyday practice of providing care. The result is an illuminating volume for students of health and medical professions studying pain, the body, and the sociology of health and illness.

This book focuses on the reciprocal interactions between pain, emotion and cognition. International experts report on their findings, clinical experience and the most recent literature on the complex relations between these three domains. Clinical, psychological, behavioral and neuroimaging approaches converge towards aiding patients suffering from pain, cognitive impairment or emotional distress. Beyond the pathophysiological aspects of pain, difficulties encountered with patients are analyzed and strategies are proposed to optimize treatment, doctor-patient relationships, and patient well-being. This work will appeal to a broad readership, from clinical medical practitioners to psychologists, nurses and pain specialists.

As a nation, we are facing an unprecedented opioid crisis that is killing more than 65,000 people a year. It is destroying our families and decimating our neighborhoods. And it is costing us billions. As more and more people are dealing with chronic pain, and as the opioid crisis reaches epic proportions, alternative approaches to understanding pain and its management are necessary. Here, Dr. Akhtar Purvez, a seasoned researcher, pain specialist, and pain advocate, offers basic information about pain and pain conditions and considers how we approach pain from cultural, biological, and medical perspectives. He discusses the latest minimally invasive, interventional approaches like nerve blocks and ablation procedures, and neuromodulation techniques like peripheral nerve, spinal cord, and brain stimulation. The uses of marijuana and associated interventions is reviewed, and Purvez walks readers through the process of assessing pain, finding a doctor who can treat it, and methods for coping with pain through non-medical approaches like meditation. Anyone coping with pain or helping someone who is will find here a ready resource that offers hope and understanding.

This book will enable the reader to gain a sound understanding of contemporary and futuristic evidence-based interventions and assessment procedures for pelvic floor disorders. It gathers the experiences of some of the most important experts on electrical stimulation techniques, offering a multidisciplinary and problem-oriented approach organized according to therapeutic goals. Interventions are recommended that are consistent with theory and display clinical efficacy for specific disorders, including urinary incontinence or retention, fecal incontinence, constipation, pelvic pain, sexual dysfunction and neurological diseases involving the pelvic floor. All of the surgical or rehabilitative techniques requiring electrical stimulation for the treatment of these disorders are explored and essential background information is provided on functional anatomy, neurophysiology and concepts in electrotherapy. This volume will be a very useful tool for urologists, general or colorectal surgeons, gynecologists and anesthesiologists and also physiotherapists and alternative medicine practitioners (a specific chapter focuses on electroacupuncture). It will assist in their clinical practice as they seek to help the very many patients who suffer from any of the wide range of functional pelvic floor disorders.

Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

This practical manual presents the main drugs and protocols currently used in the psychopharmacological treatment of psychiatric disorders in cancer and palliative care settings and explores the principal issues involved in such treatment. Significant clinical challenges encountered in the psychopharmacological management of various psychiatric conditions are discussed, covering aspects such as side-effects and drug-drug interactions. Attention is also paid to the emerging theme of adjuvant use of psychotropic drugs for the treatment of symptoms or syndromes not primarily related to psychiatric disorders. In addition, practical suggestions are provided for dealing with special populations, including children and the elderly. The book is designed to be easy to read and to reference, with helpful concise tables and boxes. The authors include some of the most renowned clinicians working in the field of psycho-oncology.

Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology (TM) series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls. Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside.

Using rodent models, this volume explores the basic neurobiology of the relationship among chronic pain, opioid pharmacology, and addiction.

The advancements of medical technology, improvements in medical care, and increased patients' life span make pain research and related drug development high priorities for both the research community and pharmaceutical companies. Rapid development of basic science research tools, such as techniques of flurometric labeling, genomic and proteomic high throughput screening, and genetically modified animals, promotes the swift acceleration of pain research to a stage allowing integrated investigations of pain processing mechanisms at the single cell and/or molecule level, and in a spatially and temporally controlled manner. Using multidisciplinary approaches, we can dissect the complicity of the sensory circuits connecting peripheral stimulation to maladaptive changes in the sensory pathways as well as pain perceptions at the central nervous system. Pain Research: Methods and Protocols, Second Edition provides advanced techniques and animal models that are critical for integrated pain research. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Pain Research: Methods and Protocols, Second Edition serves as an ideal guide to novice pain researchers who may not have extensive experiences in the field, or to experienced pain researchers who would like to expand their research in new directions and/or to new mechanisms in different models.

This book proposes a didactic approach to the different aspects of pain in mental health. The various chapters cover the myths, neurophysiology, perception, measurement and management of pain in mental health. The most common problems, including mood disorders, schizophrenia, anxiety, somatoform disorders and pervasive developmental disorders, are covered. Each chapter addresses the problem of pain by putting an emphasis on the characteristics of different populations of patients suffering from mental illness. The book helps specialists working in different areas of mental health to appreciate the importance of pain problems in mental health and also offers avenues for the measurement and treatment of pain in these patients. Mental health and pain are complex issues. They also share certain mutually influential neurophysiological mechanisms, which makes it even more difficult to identify their specific individual characteristics. This duality between the somatic and psychic components can become a pitfall for the specialist in mental health since it can be difficult to disentangle the evolution of a painful condition from the mental illness.

"This book is a 'must have' resource in every physician/clinician practice setting."--Martin Grabois, M.D., Professor of PM&R, Baylor College of Medicine, Houston,TX. Dr. Vasudevan draws upon an accumulated reservoir of clinical expertise to provide readers with an up-to-date and highly readable guide to multidisciplinary pain management. . . . If only this book was available years ago"--Francis J. Keefe, PhD. Professor of Psychology, Psychiatry and Anesthesiology, Duke University, Durham, NC. This practical volume brings multidisciplinary innovations to the treatment of chronic pain. It argues expertly for the benefits of a biopsychosocial approach over current pain treatments more suited to acute care. The author's insights into the complexity of chronic pain and critiques of common but inconsistent unimodality pain management methods underscore the need for targeted multi-disciplinary pain programs. Among a wealth of useful clinical nuggets, readers will find guidance on adding "virtual" support to a pain management team, details on ways patients can take an active role in dealing with their chronic pain, and the original concept of the "back attack." Included in the coverage: Pain theories and factors behind chronic pain-its application in treatment. Cognitive behavioral coping strategies. Treatments that have questionable or controversial evidence. Evaluation of disability in patients with chronic pain. Creating a virtual multidisciplinary team. Common pain problems: low back pain, complex regional pain syndrome, myofascial pain syndrome, fibromyalgia. Multidisciplinary Pain Management will enhance the work of diverse practitioners, including health and clinical psychologists, family and other primary care physicians, psychiatrists, occupational and physical therapists, and rehabilitation specialists.

Specialists estimate that as many as 60 million Americans suffer from chronic pain, and approximately 20 percent of the population in most developed countries reports having chronic pain. According to one study, chronic back pain alone afflicts more than four million Americans, and nearly 50 percent of these are disabled by it. Pain is the most frequent cause of disability in the United States, with as many as 50 million Americans on short- or long-term disability leave from work at any one time. As these figures suggest, chronic pain is extremely difficult to treat successfully-it is a complex and baffling phenomenon, poorly understood even in the medical centers devoted to its diagnosis and treatment. In Heal the Pain, Comfort the Spirit Dorene O'Hara, an anesthesiologist with extensive training in pain management and clinical pharmacology, explores treatment techniques developed over many years of studying, treating, and lecturing on chronic pain. She also examines the important contributions made by other clinical professionals and by practitioners of alternative medicine. Combining a general survey of the forms of pain therapy with suggestions for how patients can find the most appropriate treatment plan for themselves, Heal the Pain, Comfort the Spirit provides needed answers for pain sufferers as well as practitioners.

The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Key features: * Provides a clear explanation for many of the pain generators in low back pain and illuminate this perplexing and ubiquitous problem. * Addresses a gap in the existing literature, as "non-specific" or mechanical lumbosacral spine pain accounts for by far most chronic spinal pain sufferers' complaints for clinicians dealing with spinal pain syndromes like general medical practitioners, and spinal specialists in various fields such as sports medicine. * Illustrates anatomical structures that can be injured and thus become responsible for causing mechanical lumbosacral spine pain, frequently, such injuries cannot be detected on sophisticated imaging such as MRI.

Pelvic Pain Management is an evidence-based guide to understanding the basics of pain mechanisms, pharmacology, invasive and noninvasive treatment modalities, and pain management protocols related to the complex problem of pelvic pain. The book addresses all aspects of pain management essentials, new technologies and devices, chronic pain issues, opioid and non-opioid pharmacology, including newly approved drugs, and special populations including pediatrics, the elderly, and patients with co-existing disease. It provides information on performing a proper physical exam, diagnosing the origins of the pain, and developing a treatment plan with emphasis on multidisciplinary management. This is an ideal resource for physicians, trainees, and nurses looking to recognize, diagnose and manage all major issues related to pelvic pain.

This in-depth text addresses how to approach and treat the chronic pain patient struggling with problematic opioid use. It discusses the approach for patients who may be at high risk of problematic use, such as those with a history of mental illness or substance use disorder. The first part covers diagnosis and treatment, focusing on common best practices that practitioners can adapt to any practice. Two of the chapters detail alternative and replacement therapies for opioid. Two more cover special issues in the treatment of women and older patients. The second part reviews the ethical, legal, regulatory, and policy issues surrounding the treatment of patients with comorbid pain and addiction. The book includes strategies for documentation that mitigate the risk of legal issues or ethical boundary crossings. The last part of the book addresses treating comorbid pain and opioid use disorder in different medical settings and the treatment of co-occurring mental illnesses and substance abuse. Treating Comorbid Opioid Use Disorder in Chronic Pain is of great value to psychiatrists, pain physicians, primary care providers, social workers, drug rehabilitation centers, and other behavioral health professionals.

Written by leading authorities in the field, Chest Pain with Normal Coronary Arteries comprehensively reviews the clinical presentation and the pathogenesis of the condition, as well as its management. This book provides a practical tool for the clinician and a bank of information and new ideas for research scientists and clinical researchers interested in understanding the causes and mechanisms of chest pain with normal coronary arteries. Whether the pain be of gastroenterologic, cardiac or endocrine in origin, the book focuses on effective diagnosis, treatment and management of different pathologies in patients. Chest Pain with Normal Coronary Arteries is an essential read for all clinicians involved in managing patients with chest pain, and those that should be aware of non-cardiac chest pain.

Surgical Pain Management is an essential, step-by-step guide to surgical techniques and the perioperative management of chronic pain patients whose treatment includes implantable therapies. Chapters review the steps necessary for defining a potential candidate for implant and the infrastructure to support the perioperative period and beyond, controversies in approaches for both intrathecal and spinal cord stimulation implants, healthcare education for patients with these devices, neuroaxial drug delivery, electrical stimulation of the peripheral and central nervous system, and a variety of invasive procedures for chronic and cancer pain. Appendices provide supplemental information regarding guidelines, physiology, technologies available, troubleshooting, and documentation required to organize an interventional service. This book details a range of approaches from basic implant therapies to more advanced therapies, making it an ideal companion to an advanced training program in interventional pain management and a useful resource for developing a team that will optimize care for some of the most difficult to treat chronic pain patients.

This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis. This includes clinicians involved in trials determining which type of post surgical pain management can minimize the risk of recurrence or metastasis, researchers working on animal models and studying the effect of morphine on tumors, and most importantly the mechanism for this effect, and lastly cell biologists. There is currently a lot of research going on trying to reconcile the pro- and anti-cancer aspects of opioids actions.