Chronic pain is a complex phenomenon, which continues to remain undertreated in the majority of affected patients thus representing a significant unmet medical need, but the development of cellular, subcellular, and molecular methods of approaching this epidemic of pain shows great promise. In Analgesia: Methods and Protocols, experts in the field present thorough coverage of molecular analgesia research methods from target discovery through target validation and clinical testing to tolerance and dependence, with extensive chapters on emerging receptor classes as targets for analgesic drugs and innovative analgesic strategies. As a volume in the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes sections with tips on troubleshooting and avoiding known pitfalls.

Comprehensive and essential, Analgesia: Methods and Protocols promises to aid and enrich the research of all those scientists and clinicians who are interested in what the increasingly molecular future has in store for analgesia research, from the molecular research bench through the animal laboratory to the bedside.

Millions of people suffer from debilitating chronic pain from arthritis, fibromyalgia, low back pain, chronic headache syndromes, neuropathies, or other painful conditions. People contending with chronic pain often spend considerable time, energy, and money searching for answers and visit multiple doctors, trying anything to find relief. When the source of pain is unclear or difficult to diagnose, their experiences are additionally frustrating, exhausting, and depressing. This book offers a hands-on approach to improving life with chronic pain, whatever the underlying cause. As a sociologist, psychotherapist, and someone with firsthand experience with chronic pain, the author understands the challenges that accompany pain and has devised realistic strategies to fare better. Paintracking provides a systematic method that empowers individuals to navigate the otherwise overwhelming array of treatment options and incorporate the effective ones into their lives for continued, incremental progress. Its cornerstone is a self-study tool that enables readers to improve. Readers are instructed on how to track and interpret their experience, whether using a pen and paper or the online tool offered as a companion to the book. By cultivating awareness of how their body responds in different situations and to different therapies, readers will become capable self-advocates, able to make informed choices. Written in clear, understandable prose and filled with sociological insights, therapeutic lessons, practical tips, and empathy, this book offers realistic hope to individuals who often feel hopeless in the face of confusing, debilitating pain.

This book proposes a didactic approach to the different aspects of pain in mental health. The various chapters cover the myths, neurophysiology, perception, measurement and management of pain in mental health. The most common problems, including mood disorders, schizophrenia, anxiety, somatoform disorders and pervasive developmental disorders, are covered. Each chapter addresses the problem of pain by putting an emphasis on the characteristics of different populations of patients suffering from mental illness. The book helps specialists working in different areas of mental health to appreciate the importance of pain problems in mental health and also offer avenues for the measurement and treatment of pain in these patients.

Mental health and pain are complex issues. They also share certain mutually influential neurophysiological mechanisms, which makes it even more difficult to identify their specific individual characteristics. This duality between the somatic and psychic components can become a pitfall for the specialist in mental health since it can be difficult to disentangle the evolution of a painful condition from the mental illness.

None of the literature in the field of terminal care provides a full treatment of the laws, documents, and policies relating to the difficult issues arising at the end of life. When Life Ends was written to fill this gap by an attorney who serves on the bioethics committee of a large public hospital. It is an invaluable resource and practical tool for physicians, nurses, medical staffs, legal professionals, hospital administrators, and hospital bioethics committees because it provides: 1) in-depth legal commentaries on the refusal of life-sustaining treatment, advance directives, surrogate decision making, and the Patient Self-Determination Act; 2) more than 70 medical and legal documents to be used in connection with end of life decisions; and 3) hospital policies and procedures to suggest guidelines to hospital bioethics committees as they carry out their functions of developing policies and procedures to address end of life legal and ethical issues.

The second edition of the Handbook of Pain Relief in Older Adults: An Evidence-Based Approach expands on the first edition by providing a number of timely new features. Most important of these are the revised recommendations from the American Geriatrics Society on prescribing that reflect the many new agents available since the last guidelines were released in 2001. Additionally, concepts such as synergy in prescribing for older adults have been better delineated in this edition. The most salient features of the original edition have been retained and updated, including the full range of approaches for pain assessment and prevention, interventional strategies, guidance on pharmacotherapy and nonpharmacologic pain relief strategies for seniors, preventive analgesia, the role of rehabilitation in sound pain treatment, legal and public policy issues in pain care for seniors, pain management in long-term care, and even the issue of spirituality as an adjunct to pain management. The second edition also includes a new chapter on resources, which includes organizations, internet websites, and guidance on acquiring additional consultation for pain intervention. Of particular interest is an updated discussion of the effect that electronic medical records and internet-based personal health records will have on pain relief in older adults and a new chapter that serves as a resource guide for patients and caregivers trying to navigate the waters of pain relief assistance. This issue has not been addressed substantively in the pain management literature and the ramifications for older adults are particularly poignant. Comprehensive and practical, the Handbook of Pain Relief in Older Adults: An Evidence-Based Approach (Second Edition) is a comprehensive resource with targeted, practical information that will be of vital importance for all clinicians who provide care for seniors.

"I just wish I had armfuls of time." These are the words of a four year old facing a life-threatening illness. This text portrays the psychological experience of such children, who are irreversibly changed from the moment of diagnosis. Barbara Sourkes is a psychologist who specializes in psychotherapy with children who have cancer and other serious diseases. In the account, she describes how she works with these children, using drawings, soft toys and dolls, stories and real medical instruments to allow them to communicate their experience of the illness, the treatment they undergo, their relationship with their families, and their feelings of grief and loss in coming to terms with the prospect of death. Making use of the words of children, offering interpretations and practical advice, this is a book that should be useful reading for those concerned with the care of terminally ill children.

This interactive workbook covers all the physiological and pharmacological aspects of pain and pain control. Each topic such as the central nervous system, the human experience of pain and pain management is concisely covered in nine separate sessions. The workbook includes activities, assignments, worked examples, self-assessment questions relating to learning objectives and learner profiles to assess current knowledge. The style is clear with diagrams, personal profiles, resources and areas to make your own notes. It is a companion to the text listed below and is a valuable tool for initial training and professional development.

This thoughtful new book presents strategies for helping end-stage renal disease patients and their families deal with the psychosocial aspects of the chronic long-term illness. Technological advances in the treatment of this disease have offered much hope for improved quality in living which has led caregivers to have a greater concern for preserving the quality of life of their patients. In Psychosocial Aspects of End-Stage Renal Disease leaders in the field of many disciplines share knowledge and reveal problems that are still evident to them in the confrontation with this potentially fatal illness.Five comprehensive sections devote special attention to the different areas of concern for the psychosocial well-being of end-stage renal disease patients. The impact of renal disease on family relationships is covered by examining issues of family responses and coping measures such as marital and family reactions to home and hospital dialysis treatment. Ethical issues in treatment are explored, including the ethics of treatment refusal and a Jewish perspective on kidney transplants. Relations between staff and patients and a timely section on renal disease and special populations, particularly the elderly and AIDS patients, make up the final two sections of this informative volume. Professionals in all allied health disciplines will benefit from this important volume as it demonstrates a model approach, if not the definitive one, for the treatment of the psychosocial aspects of end-stage renal disease as well as other chronic illnesses.

Pain is a complex experience, influenced by many variables. There is currently growing interest in the influence of sex and gender on the experience of pain. The fact that there are sex differences in pain and analgesia is now a well-recognized phenomenon within the field of pain medicine. However, the specific mechanisms underlying these differences remain somewhat poorly understood. Traditionally, these sex differences in pain experience have been attributed largely to psychological, behavioral and socio-cultural variables - in particular, a perceived greater willingness on the part of women to report painful symptoms and seek medical attention. Although psychosocial factors do influence pain perception, there is now substantial evidence to support a strong role for hormonal factors mediating sex differences in pain modulation. In Pain in Women: A Clinical Guide, a renowned group of experts in pain medicine breaks new ground in the field by synthesizing and elucidating the range of biological and neurohormonal factors underlying these conditions and clarifying potential treatment options based on these factors. The initial section of this unique title introduces the topic of pain in women and its importance and then goes on to describe hormonal and myofascial considerations in this patient population. The second section addresses specific pain disorders common in women and the various treatment options for these, including rehabilitative and complementary and alternative medicine (CAM) treatments. The third and final section covers the specific populations of the pregnant/postpartum woman, issues related to breast cancer, the female athlete, menopausal considerations and the role of physical therapy in women s health. Timely and state-of-the-art, Pain in Women: A Clinical Guide is an important new reference that fills a significant need in the developing area of pain medicine."

One might think working as a physician would lead to disrespect for the human body. After all, most of the bodies we see are broken or malfunctioning in some way. In my case, however, the opposite is true. My practice as a pain specialist (particularly chronic pain) has drawn me into areas beyond the usual options for medical treatment. In the process, that has led to a fascination with the human brain and its myriad properties. I think it's safe to say that most of us take our brains for granted. If we think about them at all, it's in terms of comparative mental accomplishment (in our prime of life) or dysfunction (beyond our prime). Rarely do we stand in awe of all that this eight-pound organ does for us. With this book, I'm hoping to do my part to change that. The focus is on the brain's relationship with pain, but discussing that opens a door to broader considerations. Meanwhile, the potential readership is literally universal -- all of us have brains, and almost all of us (except for those with a rare condition described in the book) have felt pain. What most of us may not realize is that research into the causes of pain began thousands of years ago. The ancient Egyptians pondered the question, and Greek philosophers such as Aristotle, Plato, and Galen made it an important part of their overall philosophies. Hippocrates was laying the foundation for modern brain and pain study as early as the late fifth century and other scientific icons, such as Rene Descartes and Charles Sherrington, built on what he had discovered and postulated. By the 20th century, some new revelation about pain and its possible treatment was being reported in the scientific journals nearly every month. That has only accelerated over the past few years, which makes the study of the brain and pain one of the livelier medical specialties. Meanwhile, there has been a significant change in the attitude toward pain by 20th century physicians, researchers and hospital personnel. Previously, pain was simply linked to whatever condition might be afflicting a patient, leading to the belief that when that condition was cured or managed, the pain would automatically disappear. Now, though, it has become apparent that pain might be more than just a symptom. In some cases, it becomes a condition all to itself. Since pain is literally a product of the brain, which announces it after being warned by a small army of nocioceptors stationed throughout the body, it is also open to glitches in that process. Chronic pain often occurs when the brain "remembers" pain, even though the condition that caused it may have been dealt with. This book has a clinical core, but I have broadened the scope to include not only research history but touch on several peripheral issuers involving pain. That includes a chapter on masochism and congenital insensitivity to pain, another on the opioid epidemic.

Readers have access to legions of books dealing with the molecular, genetic, neurochemical, neurophysiological, neuroanatomical, neuroradiological and psychological aspects of pain as well as with the clinical approaches to pain from various medical disciplines. Why then is it necessary to publish a book on the pathophysiologyofpain perception? Pain can result either from noxious events due to lesions, injuries, diseases, etc. , or from disturbances in the system transducing, transforming, and processing the potential pain signal or from an interaction of both. Under certain pathological conditions, the pain-processing system, which includes both physiological and psychological components, can produce the experience of pain in the absence of any peripheral noxious event. This book primarily ex- amines these pathological alterations in the pain-signalling system, and the authors provide information on the functioning of the pain-processing system under normal and pathological conditions. The understanding of pain perception is essential for optimal diagnosis and treatment of acute and chronic pain. Considerable evidence now indicates that alterations in pain per- ception are characteristic of many clinical pain states. Whether disturbed pain perception is a truly etiological or only a maintaining factor-c-or even a mere epiphenomenon of chronic functional pain-is reviewed in detail by L. Arendt-Nielsen, C. R. Covelli, R. B. Fillingim,]. M. Gillespie, T. Graven-Nielsen, E. Kosek, S. Lautenbacher, M. Peters, A. Pielsticker, DO. Price, G. B. Rollman, P. Svensson and G. N. Verne for headache, back pain, fibromyalgia, myofascial pain, temporomandibular pain disorder, irritable bowel syndrome and menstrual cycle-related pain disorders.

This unique new guide integrates recent advances in the biopsychosocial understanding of chronic pain with state-of-the-art cognitive therapy and mindfulness techniques to offer a fresh, highly-effective MBCT approach to helping individuals manage chronic pain. * There is intense interest from clinicians, researchers and patients alike in mindfulness-based therapeutic techniques, and the integration of mindfulness theory and practice with CBT * Provides everything a therapist needs to integrate MBCT into their practice and optimize its delivery, including a manualized 8-session program and guidance on how to teach MBCT skills * Features case studies and real-world examples that help practitioners to avoid common pitfalls and optimize the delivery of MBCT for chronic pain for their own individual clients * Features links to guided meditations, client and therapist handouts and other powerful tools

With a focus on practical acute pain management in adults in the hospital setting, this book provides health professionals with simple and practical information to help them manage patients with acute pain safely and effectively. * Combines evidence-based information with practical guidelines and protocols * Covers the pharmacology of opioids, local anesthetics, and nonopioid and adjuvant analgesic agents * Discusses management of acute pain in both surgical and nonsurgical acute pain settings including in patients with spinal cord or burns injuries and selected medical illnesses * Includes evidence-based information about management of acute pain in some specific patient groups , including the older patient, opioid-tolerant patients, and those with addiction disorders, pregnant or lactating patients and patients with obstructive sleep apnea or who have renal or hepatic impairment * Considers the role of acute pain management in the context of the current opioid epidemic and identifies possible strategies to minimise the risks. This resource will be helpful to a variety of professionals in assessing and managing acute pain.

Ampossible is the go-to guide for every amputee from the first day after limb loss to the day they get their life back. Thousands of amputations happen each day and millions happen every single year around the world. Yet, what an amputee actually experiences minutes after surgery, what's endured through the heart-wrenching recovery, to the time they get their life back, is rarely addressed in its complexity. Almost every amputee experiences an onslaught of emotions filled with confusion, grief, anxiety, depression, and immense physical pain. AMPOSSIBLE offers a glimpse into the realities of limb loss for those who experience it and answers the many questions amputees often have surrounding their very immediate medical needs as well as the long-term challenges, both physical and emotional, amputees must face. The book is a no-holds-barred real-world depiction of life as an amputee. Jeffrey A. Mangus, a below the knee (BKA) amputee, delivers straightforward information for both the amputee and his or her family and support network. Covering the basics of wound care and rehabilitation, he also addresses the very real emotional needs of living a new reality without a part of the body intact. Offering hope and guidance, however, Mangus encourages readers to challenge themselves to overcome the downsides and live a full and engaged life.

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniques Introductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies. Clinical chapters define pain in conditions such as post-herpetic and post-traumatic neuralgias, plantar fasciitis, low back pain, post-surgical pain syndromes and migraine in detail, provide discussion of current modes of treatment and updated information on BoNT therapy. Each chapter also includes illustrative case histories. The new edition is updated with all the new findings since the explosion in research and literature since 2015. New chapters on the history and pain in dentistry round out the update. Botulinum Toxin Treatment of Pain Disorders provides an invaluable resource for clinicians and researchers involved in the treatment of pain disorders including neurologists, pain medicine specialists, anesthesiologists, internists, those conducting research in pharmacology and toxicology as well as students in these areas.

Yoga Bones, written by author, occupational therapist, and yoga instructor Laura Staton, guides readers to manage their pain, be it from injury or after orthopedic surgery, with yoga-inspired and occupational therapist-approved stretches and exercises designed to increase strength and decrease pain.

Organized by sections of the body, each chapter includes a curated menu of fully-photographed yoga asana-based exercises, guiding anyone from yoga experts to newbies..

Yoga Bones also includes Functional Wellness sections designed to explore the emotional components of healing. For example, a reader with neck pain can find both a menu of physical stretches which can help lessen the pain, but also energetic exercises and meditations for a healing that is holistic.

Talking Back delivers tools for rebuilding an active life and enjoying the benefits of wellness, even if you cannot get rid of your chronic back pain. Talking Back brings the reader into the classroom with people disabled by chronic back pain to experience the insights and lessons that have helped thousands of them to regain the physical and emotional capacities to resume productive lives and wellness. Through the stories of sufferers and the steps they took to take back their lives, Dr. Rowland Hazard reveals their pathways to recovery.. When back pain limits their work, recreation, and even simple activities of daily life, people become disconnected from their former lives and relationships. Each chapter in Talking Back takes the reader through one of Dr. Hazard's classes developed from his 30 years of listening to patients' narratives and needs. The topics begin with how people become disconnected and how to reconnect by setting personally meaningful life goals and safely achieving the flexibility, strength, and endurance required by those goals. Strategies include dealing effectively with doctors and drugs and owning the skills of deep relaxation and physical self-care to combat acute flare-ups of pain and to overcome the fear of pain that disables people even more than the pain itself. Talking Back delivers tools for rebuilding an active life and enjoying the benefits of wellness, even if you cannot get rid of your pain.

Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

Linking theory to practice through the use of authentic clinical cases, Dr. Steven D. Waldman's Pain Medicine: A Case-Based Learning Series helps readers acquire the valuable skill of effective diagnostic thinking in daily practice. The Shoulder and Elbow volume uses an in-depth case format, preparing you to correctly analyze clinical vignettes and formulate a clinically sound, evidence-based approach to realistic patient scenarios. This highly effective leaning and assessment tool provides practical clinical insights into the best methods for diagnosis and treatment for the successful management of patients with shoulder and elbow-related pain. Presents real-world patients in a real-world clinical setting, making learning fun and engaging. The Case-Based Learning approach focuses learners and clinicians on the key elements for each diagnosis and helps develop a deep understanding of how to diagnose and treat each condition. Covers everyday clinical problems such as Glenohumeral and Acromioclavicular Joint Pain, Subacromial Impingement Syndrome, Bursitis, Tendinitis, Nerve Entrapment, Rotator Cuff Disease, Tennis and Golfer's Elbow, Pronator Syndrome, and more. Cases unfold just the way they do in your clinic. Each case is accompanied with thoughtful clinical commentary and key messages from the author. Each chapter uses high-quality radiographic images, clinical photos, and full-color drawings to facilitate a clear, easy-to-understand approach to evaluation and diagnosis. An ideal self-assessment and review tool for pain medicine practitioners and trainees, as well as those preparing for the American Board of Anesthesiology Pain Medicine certification and recertification exam. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

PRE-ORDER THE ACCOMPANYING JOURNAL LEARN TO LET GO NOW 'Life-changing' - Sara Makin, Founder & CEO of Makin Wellness If you learn to let go, your life will take off. When you let go, you live intuitively. Everything flows, because you are no longer attached to things being a certain way, to being a certain person or always being right. What a relief. The irony is that when you feel stuck in any area of your life - career, relationships, purpose, health or money - letting go can seem very hard. You cling on for dear life just at the moment you need to take the leap. In The Power of Letting Go, John Purkiss explains why we should let go and how we can do it, using proven techniques to make things happen. The stages of letting go: -Be Present and Enjoy Each Moment -Let Go of the Thoughts that Keep You Stuck -Let Go of the Pain that Runs Your Life -Surrender and Tune into Something Far More Intelligent than Your Brain

Here is the perfect text you need to provide your learners with real-life clinical scenarios that are ideal for Case-Based Learning and Discussion. Presents real-world patients in a real-world clinical setting, making learning fun and engaging. The Case-Based Learning approach focuses learners and clinicians on the key elements for each diagnosis and helps develop a deep understanding of how to diagnose and treat each condition. Covers everyday clinical problems such as migraine and other headaches, occipital neuralgia, temporal arteritis, trigeminal neuralgia, temporomandibular joint dysfunction, and more. Cases unfold just the way they do in your clinic. Each case is accompanied with thoughtful clinical commentary and key messages from the author. Each chapter uses high-quality radiographic images, clinical photos, and full-color drawings to facilitate a clear, easy-to-understand approach to evaluation and diagnosis. An ideal self-assessment and review tool for pain medicine practitioners and trainees, as well as those preparing for the American Board of Anesthesiology Pain Medicine certification and recertification exam. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.