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Pain and Neurogenic Inflammation (Hardcover, 1999 ed.)
Loot Price: R6,332
Discovery Miles 63 320
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Pain and Neurogenic Inflammation (Hardcover, 1999 ed.)
Series: Progress in Inflammation Research
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Pain and inflammation are inextricably linked phenomena. The
observation that chemical mediators with combined pro-inflammatory,
algesic and/or hyperalgesic activity occur at the site of
inflammation is fundamental not only to our present understanding
of the inflammatory process but also to our attempts to devise
clini- cally useful anti-inflammatory therapies. Over a hundred
years ago it was recognised that primary sensory neurones play a
crucially important "dual" role in inflammation. By affecting the
transfer of infor- mation from peripheral nociceptors to the spinal
cord, a subpopulation of sensory nerves {"pain fibres"} initiate
algesia and hyperalgesia, whose sensations are then modified and
fine-tuned in the central nervous system. Equally important is the
release from the peripheral terminals of sensory neurones of
neuropeptides, the acute effects of which are observed as changes
in microvascular tone and perme- ability leading to neurogenic
inflammation. Over the last decade it has become increasingly clear
that this view of the func- tion of sensory nerves is somewhat
over-simplified. For example, the mechanisms underlying
hyperalgesia may, in certain circumstances, be mimicked in other
condi- tions such as the hypersensivity associated with asthma.
Furthermore, it has become increasingly evident that over a longer
time period the release of neuropeptides from peripheral sensory
nerve endings may also have modulating effects on inmune cells and
that this may be relevant to chronic inflammatory disease and
possibly also to inflammatory hyperalgesia.
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