Pharmacological Mechanisms and the Modulation of Pain, the newest volume in the Advances in Pharmacology series, presents the pharmacological mechanisms and the modulation of pain. With a variety of chapters and the best authors in the field, this volume is an essential resource for pharmacologists, immunologists, and biochemists alike.

Myofascial pain is the most common pain; it is estimated that 60-70 per cent of all pain is of myofascial origin. There are many common diagnoses - such as sciatica, lumbago, tendinitis, arthrosis, bursitis, tennis elbow, and frozen shoulder - that have a myofascial origin. They are not life threatening, but they abate the quality of life and reduce functional capacity, creating stress and depression. They are also a big sanitary cost and cause for early retirement. There is a regrettable lack of knowledge surrounding myofascial pain and the existing possibilities to cure. With this manual, I try to spread my long experience in treating and curing these pains with my combination method. For the manual techniques, videos are included on the companion DVD to make the study easier.

Offering timely coverage of this complex field, Interventional Management of Chronic Visceral Pain Syndromes is a practical, evidence-based guide for the mechanisms, presentation, diagnosis, and treatments of chronic non-malignant and malignant abdominal pain syndromes. Experienced clinicians and academic leaders in pain medicine comprehensively discuss best-practice guidelines using the newest interventional techniques, including dorsal root ganglion stimulation, high frequency spinal cord stimulation, and low-dose intrathecal infusion pumps. Coverage includes malignant and non-malignant gastrointestinal pain, malignant and non-malignant pelvic pain in males and females, rectal pain, and chest pain. Discusses key demographic characteristics as well as clinical and diagnostic presentations of the most common and esoteric visceral pain syndromes that will enable clinicians to identify pain generators. Provides a truly systematic approach to the treatment of chronic visceral pain, including the use of pharmacologic, non-interventional, interventional, and multidisciplinary therapies with evidence-based data. Covers the indications, contraindications, and outcomes results of the newest interventional treatments that all clinicians should be aware of, including neuromodulation and intrathecal pump therapy.

Internationally-recognized pain expert Don Goldenberg helps readers better understand the intricacies of chronic pain through the lens of personal stories, including his own. One out of three Americans lives with chronic pain. Pain is the number one reason we seek medical care and accounts for 40% of doctor visits. Chronic pain is the most common cause of work loss world-wide. The yearly cost of chronic pain in the United States is between $560-$630 billion, higher than that of heart disease, diabetes and cancer combined. Despite this, physicians and the public are woefully ill-informed about chronic pain. The litany of self-help books available to the public are largely misleading, quick-fix, junk-science. Although there is a major push to better inform primary health-care providers on chronic pain, they have been provided no authoritative treatment of the subject. The Pain Epidemic provides the latest medical information and pathways to better understanding and treatment of chronic pain. Dr. Don Goldenberg, an internationally known expert on pain, here discusses such hot topics as the opioid epidemic, mind/body interactions in chronic pain, and gender bias, as well as the role of cannabis and new potential pain treatment. Interested readers will come away with not only a better understanding of the pain epidemic but of pain itself.

There are numerous types of headaches, each with a unique cause, pain profile, and set of treatment options. This book offers readers a broad introduction to this common, yet often misunderstood, group of conditions. What exactly is going on in your body during a headache? How can they be prevented or managed? How can you tell if your splitting headache is actually a brain tumor? This book provides the answers to these and many other questions. What You Need to Know about Headaches is the latest volume in Greenwood's Inside Diseases and Disorders series. This series profiles a variety of physical and psychological conditions, distilling and consolidating vast collections of scientific knowledge into concise, readable volumes. A list of "top 10" essential questions begins each book, providing quick-access answers to readers' most pressing concerns. The text follows a standardized, easy-to-navigate structure, with each chapter exploring a particular facet of the topic. In addition to covering such basics as causes, signs and symptoms, diagnosis, and treatment options, books in this series delve into issues that are less commonly addressed but still critically important, such as effects on loved ones and caregivers. Case illustrations highlight key themes discussed in the book and are accompanied by insightful analyses and recommendations. A holistic approach to the subject covers such often-overlooked areas as societal perceptions and impact on family and friends An Essential Questions section provides quick answers to the questions readers are most likely to have and serves as a springboard to explore the content of the book in more detail Case Illustrations provide relatable, real-world examples of concepts discussed in the text An annotated Directory of Resources points readers toward useful books, organizations, and websites, acting as a gateway to further study and research

This accessibly written book examines the most commonly used substances and techniques for managing pain, exploring why they work (or don't), their risks and benefits, and key research findings regarding their use. No one is a stranger to pain. From sudden injuries to post-operative discomfort to nagging aches and stiffness, pain is an unwelcome but familiar part of life. There are numerous methods for managing pain, but it can be difficult to know which is the best fit and to separate truth from hype. Pain Management: Fact versus Fiction examines 30 well-known options for combating pain, whether acute or chronic. Utilizing a standardized structure, each entry discusses a particular substance or technique's origins and underlying principles, how and in what context it's used, and its advantages and disadvantages. Summaries of key research studies are included to help readers better determine which treatments may be a good choice for them. Introductory materials give readers a foundational understanding of what pain is, how it's categorized and measured, and the impact it can have on individuals' physical and psychological well-being. A Further Reading section at the end of each entry points readers toward additional resources to expand and deepen their knowledge. Provides unbiased, evidence-based information to help readers make better decisions about how to manage their pain Summarizes and contextualizes key research findings in easy-to-understand language Utilizes a standardized structure to make it easy for readers to find the exact information they're looking for Covers allopathic therapies as well as complementary and alternative treatments

This book offers an in indictment of the nation's drug enforcement approach focusing on the short-sighted policies that often deny patients suffering from chronic pain the medications they need. Pain Control and Drug Policy: A Time for Change focuses on America's national crisis in pain management caused by the widening divergence between the enormous contributions of opioids ("narcotics") to pain management in the clinical setting and the mistaken belief that they are dangerous, highly addictive drugs. After dissecting the strategy and tactics of the War on Drugs from medical, historical, legal, socioeconomic, and geopolitical perspectives, Guy Faguet MD indicts the 40-year-long War on Drugs for having failed to stem the supply of illicit drugs in America despite expenditures of half a trillion dollars, despite violating the basic human right to pain relief of tens of millions of American chronic pain sufferers, and despite fomenting organized crime, government corruption, racial injustice, and social disruption in both the United States and the producer countries. He concludes with a clarion call for the abandonment of the War on Drugs, disbanding the Drug Enforcement Administration, and encouraging Congress to repeal the Controlled Substances Act. As a clinical and research oncologist responsible for the chronic pain management of thousands of cancer patients over the course of his 30-year career, Dr. Faguet knows that the most effective and safest way to manage most cases of chronic pain is with opioids. All modern pain-management textbooks advocate "titration to effect" in cases where opioids help: that is, gradually increasing the dosage until either the pain is acceptably controlled or the side effects begin to outweigh the pain-relief benefits. Yet the vast majority of doctors don't practice what the medical textbooks teach and instead prescribe opioids very reluctantly and conservatively. As a result, only half of all chronic pain sufferers-and fewer than half of all cancer patients-get adequate pain relief from their doctors. Why do physicians radically undertreat pain that is susceptible to opioid analgesics? They fear that if they prescribe Schedule II opioids in accordance with the professional standards of pain management set by such medical bodies as the American Pain Society, they will be investigated by the DEA, stigmatized, prosecuted as criminals, stripped of their licenses, and sent to jail. Visit Guy B. Faguet, MD's website here: www.faguet.net.

The incidence of neuropathic pain continues to rise, yet it is an affliction often misdiagnosed or inadequately treated. Although in recent years considerable research has been dedicated to understanding its mechanisms, there have been few advances in treatment. The contributors to this book are internationally renowned leaders in the fields of peripheral neuropathy and neuropathic pain. They discuss clinical approaches to diagnosis and treatment of neuropathic pain, its underlying mechanisms, and strategies for prevention. In addition, chapters cover timely issues, including legal and ethical concerns surrounding pain treatment, the status of clinical trial methods, and educational efforts. Comprehensive yet concise, this book serves as a guide for diagnostic approaches and treatment of neuropathic pain for the student, resident, practicing physician, researcher, and specialist.

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

Yes, today she feeds the goose that lays the golden eggs But her life once read like a mystery, because for forty-five years she had spasms of the face and neck, her head would ring and, most baffling of all, she had an ache deep in her chest like she was having a heart attack. Unbeknownst to her family, she lived with depression from the age of ten, until finally ending up in a psychiatrist's little crash pad shortly after having a beautiful little girl. From here she began a quest to try to do herself in-she tried six times Then it finally became apparent she was living with chronic pain, and a sublime head injury that kept her from accomplishing her quest of a nursing career. Then, in 2002, at the age of fifty-four, she finally threw up her arms and became willing to do whatever it took to get her life back. She began the twelve-step process of recovery that would open her life to healing. She soon found herself, strangely, thanking God for her affliction. Then, one day in June of 2002, she decided to live. Today she still has the pain but no longer suffers. Now it is a blessing to have lived, because her life has become part of one very big, ongoing miracle, a miracle of which you, the reader, are a part.

This book critiques the current approach to the self-management of persistent pain. The drive towards self-management of chronic pain is flourishing as healthcare systems struggle to facilitate the care of those with long term health conditions. In this book Karen Rodham argues that albeit an empowering idea, self-management has not yet been fully translated from idea to practice and as such, runs the risk of blaming and shaming the person living with a chronic condition for failing to manage their condition effectively. She contends that the additional stress of this tension may in fact worsen their condition. Drawing from the research evidence as well as her practice experience, she advocates a move away from the terms 'self' and 'management' towards a more collaborative approach. One which takes account of the life-context of the person who is living with persistent pain. This book explores the shortcomings of the tendency to focus on self-management without taking into account life context and considers how we got here and what can be done. It will be a valuable resource to researchers and practitioners, especially in the field of health psychology.

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs.

A practical and empathetic guide to a revolutionary approach to living well with chronic pain, based on the fundamental principles that: all pain experienced is real; wherever the trouble originates in the body, pain is experienced in the brain; all pain is unique to the individual sufferer; the key to overcoming pain is not to strive to be pain-free but to minimise the experience of it. Dr Miranda, based on her medical practice as a pain specialist and on her experience as a pain patient, shows how to do this through a series of clearly explained tools and strategies.

The book begins with a public health/epidemiologic examination of the situation, with a systematic view of the problem based on classic (infectious disease) epidemiologic principles applied to this behavioral health issue. This application is expanded to take into account the fact that unlike most epidemics in our species' history, a unique factor that must be accounted for in any public health analysis is that the host (opioid-dependent/misusing patient) is generally not under sufficiently strong motivation to avoid the disease. The introduction concludes with a survey of recent containment approaches, categorized epidemiologically by target (agent, vector, host.) The remainder of the book is organized according to this framework, addressing agent, vector/transmission and host, respectively. Sections Three and Four comprise the major focus of the book, and are dedicated primarily to practical education for primary care providers in preventing opioid use disorder, and overcoming it after the fact.

Dr. Stephen Krau, Consulting Editor of Critical Care Nursing Clinics, is stepping into the Guest Editor role, with colleague Dr. Maria Overstreet, to address the topic of pain management in the critically ill. The review articles in this issue will provide an up-to-date look at the current strategies to improve patient outcomes in pain management for those patients in the ICU. Top authors will be writing on the following topics: Physiology of Pain; Classifications of Pain; Current Trends in Pain Assessment; Spiritual Aspects of Pain; Pharmacologic Interventions for Pain Management; Non-Alliopathic Interventions for the Management of Pain; Pain Associated with Chest Tube Removal; Discomfort Associated with Respiratory Issues; Pain Management in Obstetrics; Technological Interventions for Acute Pain Management; Pain Management Services and Policy; and Management of Chronic Cardiac Angina. Readers will come away with the current knowledge in this important field.

Cannabis sativa has a long history; however, it has not been fully exploited for its beneficial uses. This plant can solve many present challenges, including challenges found in the pharmaceutical and cosmetic industries. Bioprospecting of this very important plant can generate economic upliftment of weaker sections of society and states if properly used under rules and regulations. Cannabis sativa Cultivation, Production, and Applications in Pharmaceuticals and Cosmetics discusses in detail the current research conducted in the area of Cannabis sativa in order to make it more useful and sustainable for the future. It further focuses on the exploration of Cannabis sativa phytoconstituents in various fields, especially in the pharmaceutical and cosmetic industries. Covering topics such as bioactive properties, molecular modeling, and soil pollutants, this premier reference source is an excellent resource for pharmacologists, pharmacists, health professionals, food scientists, agricultural scientists, botanists, chemists, students and educators of higher education, librarians, researchers, and academicians.