Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention.

The GLP regulations have been enacted since 1978 and are currently under a proposed FDA amendment to revise terminology and accommodate other changes relating to advances in technology related to the industry. This book provides a unique opportunity to access interpretation of the 21CFR58 regulatory requirements from leading industry experts with a vast knowledge and expertise in their fields. The approach used takes the regulations, provides interpretations and references to examples and regulatory actions. Data integrity and the use of electronic systems in compliance with 21CFR11 Electronic Records: Electronic Signatures are also discussed. * Unique volume covering FDA inspections of GLP facilities * Provides a detailed interpretation of GLP Regulations * Presents the latest on electronic data management in GLP * Describes GLP and computer systems validation * Can be referenced repeatedly in supporting daily hands on implementation of the CFR requirements

Presents a new method for producing simple and complex metal oxide and fluoride nanopowders Based on the "evaporation-condensation" process using pulsed electron beam evaporation (PEBE) Presents the results of more than 10 years of study of the characteristics of nanopowders produced using the aforementioned method. Useful for the researchers in nanotechnology, physical chemistry, biomedicine, and pharmaceuticals, especially those with an interest in drug delivery or cancer therapy.

1. Cutting-edge synthesis of key areas in substance use and misuse, which sets it apart from competing biopsychology textbooks 2. Each chapter is written by leading experts on the topic in question, recruited from research teams around the world (including UK, US, Europe, New Zealand, Canada, Asia), who have a detailed knowledge of the relevant literature. 3. Important methodological and ethical issues are explored, with reference to various cultural contexts.

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

A UN report presented to the UN Human Rights Council in 2017 recognized that, "although pesticide use has been correlated with a rise in food production, it has had catastrophic impacts" on human health and the environment. The report acknowledged that "increased food production has not succeeded in eliminating hunger worldwide because of the many interacting factors involved. Reliance on hazardous pesticides is a short-term solution that undermines the rights to adequate food and health for present and future generations." It is hoped that the knowledge available in Synthetic Pesticide Use in Africa: Impact on People, Animals, and the Environment will both enlighten the reader to present serious concerns on the use of synthetic pesticides, and motivate society to make the changes necessary for the sustainable production of safe, nutritious, and affordable food for the anticipated 250 billion inhabitants of this Earth in 2050. Key Features: * Explains the relationship of synthetic pesticides to escalating noncommunicable human and animal diseases in Africa and developing countries. * Discusses the impact of the herbicide glyphosate on the health of humans, animals, and the environment. * Reviews the disease causing mode of action of glyphosate and other synthetic pesticides on nutrient density and human and animal bodies. * Warns of the special vulnerability of children to synthetic pesticide toxicity. * Recommends needed legal initiatives to use synthetic pesticides more judiciously. The book is divided into seven (7) sections: I. General Impact, explains the general impact of synthetic pesticides on the African people, their animals, and environment. II. Human Health, covers the impact of synthetic pesticides on the human body, while III, Children's Health, focuses on the special vulnerability of children to synthetic pesticides. IV. Animal Health describes the synthetic pesticide threats to animal production and sustainability. V. Environmental Health presents the threat of synthetic pesticides to soil microbiota and sustainable remediations. VI. Control Strategies discusses biologically-based alternatives to synthetic pesticides. Finally, VII. Reglatory Control presents some legal initiatives to combat the misuse of synthetic pesticides.

This book examines social processes that have contributed to growing pesticide use, with a particular focus on the role governments play in urban aerial pesticide spraying operations. Beyond being applied to sparsely populated farmland, pesticides have been increasingly used in densely populated urban environments, and when faced with invasive species, governments have resorted to large-scale aerial pesticide spraying operations in urban areas. This book focuses on New Zealand's 2002-2004 pesticide campaign to eradicate the Painted Apple Moth, which is the largest operation of its kind in world history, whether we consider its duration (29 months), its scope (at its peak the spraying zone was 10,632 hectares/26,272 acres), the number of sprayings that were administered (the pesticide was administered on 60 different days), or the number of people exposed to the spraying (190,000+). This book provides an in-depth understanding of the social processes that contributed to the incursion, why the government sought to eradicate the moth through aerial pesticide spraying, the ideological strategies they used to build and maintain public support, and why those strategies were effective. Urban Aerial Pesticide Spraying Campaigns will be of great interest to students and researchers of pesticides, environmental sociology, environmental history, environmental studies, political ecology, geography, medical sociology, and science and technology studies.

Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers "General Considerations" and Volume II is devoted to "Specific Metals." A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals.

Organ Specific Drug Delivery and Targeting to the Lungs provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, including advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watchouts, limitations, and 'bookend' boundaries involved in the stages of testing and development. Additional Features Include: Provides an account of particle engineering, discovery, biology, development, and delivery in relation with the advancements of nanotechnology, unlike any previous book. Brings together the leading experts and researchers in the field to critically assess and discuss various topics influencing drug delivery. Highlights the interplay of different scientific disciplines and the balance of requirements that are critical to molecule and product design. With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets.

Various foods, herbs and spices are used to treat or prevent disease and there have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. Contributions are from leading national and international experts including those from world renowned institutions. Please target oncologists, cancer specialists, physicians, health scientists, healthcare workers, pharmacologists, and research scientists. The audience also includes federal and state program directors. It is valuable to academic libraries that cover the domains of health and medical sciences. It is also suitable for undergraduates, postgraduates, lecturers, and academic professors.

Practical Psychopharmacology takes the novel approach of writing at three different levels-beginning, intermediate, and advanced-to give the practicing psychopharmacologist a tailored experience. Each chapter focuses on a specific DSM-5 disorder and outlines abbreviated treatment guidelines to help the reader understand where their knowledge base and clinical practice currently resides. At the first level, the book teaches novice prescribers practical diagnostic skills and provides a brief overview of pertinent genetic and neuroimaging findings to increase prescribing confidence. Next, it provides mid-level clinicians with intermediate techniques and guidelines for more difficult cases. The final level provides nuanced guidance for advanced practitioners or those who see the most treatment-resistant patients. This approach allows a clinician to access this book periodically throughout the care of an individual patient and to gradually progress through a series of more advanced psychopharmacological techniques for making accurate and efficient diagnoses. Readers can also visit the book's eResource page to download a bonus chapter on eating disorders as well as case studies and multiple-choice questions for each chapter.

1. Provides hands on information on the current regulatory regulations working in the field of nutraceutical and dietary supplements 2. Gives explicit information regarding the recent evidenced-based knowledge on different stages of clinical trials of nutraceuticals and dietary supplements on various diseases. 3. Includes case studies in different disease conditions for better understanding of nutraceuticals and dietary supplements. 4. Discusses exclusive comparison with generic products which would establish a wide platform for acceptance of highly economical and ostentatious nutraceuticals.

This third volume in an exciting and detailed series on contact allergens provides monographs of all 384 topical drugs which have caused contact allergy/allergic contact dermatitis. The monographs present: Identification section; Contact allergy (general population, patients with dermatitis, case reports and case series); Cross-reactions; Patch test sensitization; Photocontact allergy; and Immediate contact reactions (contact urticaria). Separate chapters present an overview of all aspects of allergic contact dermatitis to topical drugs, contact allergy to non-drug ingredients in topical pharmaceuticals and a preview of delayed-type allergy to systemic drugs (to be discussed in Volume 4). Key Features: Presents monographs of all known topical drugs which have caused contact allergy/allergic contact dermatitis Provides a full literature review of relevant topics of allergenic topical drugs Identifies IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing Presents non-drug allergens in topical pharmaceuticals Covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy

Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text. Features : This book summarizes the current status, successes, difficulties, advancements, limitations, and challenges in medical interventions that impact patients' quality of life. Includes concise descriptions of all relevant cell and molecular biology concepts including evolutionary paradigms, hallmarks of cancer, and heterogeneity to help understand the pathophysiology of cancer, cancer-associated disease conditions, and effective cancer therapy. Contains an array of colorful figures and schematics summarizing complex informative pathological, physiological, and biochemical concepts. Covers a multitude of sub-topics pertaining to cancer biology including diagnosis; chemotherapy, radiotherapy and targeted therapy; metastasis; disseminated and circulating tumor cells, and cancer stem cells; drug resistance and cellular reprogramming; complex epigenetics; tumor-derived exosomes; oncogenic viruses; metabolic syndrome and cancer metabolism; convoluted neovascularization; efficient biomarkers; immunotherapy; role of nutraceuticals and natural products. Provides perspectives on how to improve pre-clinical understandings, and outcomes, linking toxicological, and pharmacological aspects in patient care. This timely, relevant comprehensive assortment of scientific literature has educational value to a wider audience including as part of an academic course, seminar, or as a supplementary text.

This book examines Malaysia's ambitious reform agenda and educational landscape, drawing upon the eleven key shifts in the Malaysia Education Blueprint 2013-2025. It provides a comprehensive plan for a rapid and sustainable transformation of the Malaysian education system, and what is needed in shaping the educational reforms in Malaysia, especially post-COVID, through to 2025. The contributors to this volume - scholars, researchers and practitioners who possess a deep and embedded understanding of Malaysian education - focus on the interplay of prevailing and persistent problems, and what is needed in shaping the educational reforms in Malaysia. As a critical assessment of the Malaysian Education Blueprint reform efforts and policies, this edited book will be of particular interest to educators, scholars, and policymakers on the latest trends and challenges in Malaysian education policy.

Named a 'Best Book of the Year' by Kirkus Reviews 'Urgent and eye-opening, the book serves as a loud-and-clear alarm.' - The Boston Globe From an MIT scientist, mounting evidence that the active ingredient in the world's most commonly used weedkiller is contributing to skyrocketing rates of chronic disease. Glyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Over 300 million pounds of glyphosate-based herbicide are sprayed on farms - and food - every year. Agrochemical companies claim that glyphosate is safe for humans, animals and the environment. But emerging scientific research on glyphosate's deadly disruption of the gut microbiome, its crippling effect on protein synthesis and its impact on the body's ability to use and transport sulfur - not to mention several landmark legal cases - tells a very different story. In Toxic Legacy, senior research scientist Stephanie Seneff, PhD, delivers compelling evidence based on countless published, peer-reviewed studies - all in frank, illuminating and always accessible language. As Rachel Carson did with DDT in the 1960's with Silent Spring, Seneff sounds the alarm on glyphosate, giving you guidance on simple changes you can make right now and essential information you need to protect your health, your family's health and the planet on which we all depend. 'A game-changer that we would be foolish to ignore.' - Kirkus Reviews (starred) 'Toxic Legacy will stand shoulder to shoulder with Rachel Carson's Silent Spring. [This is] unquestionably, one of the most important books of our time.' - David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain 'Dr. Seneff's work will change the way we all think about food.' - Mark Hyman, MD, New York Times bestselling author

Prescribing Mental Health Medication is a comprehensive text for all practitioners who treat mental disorders with medication. This new (third) edition is fully updated and includes a variety of additional chapters. Prescribing Mental Health Medication covers the latest digital methodologies including Internet-based mental health treatment, electronic medical records and prescriber use of social media. Including information on all psychotropic medications in use in the United States and the United Kingdom, the book incorporates clinical tips, sample dialogues for talking about mental health medications to patients, and information specifically relevant in primary care settings. It looks at: * how to determine if medication is needed, proper dosing and how to start, stop and change medication * specific mental health symptoms and appropriate medication * special populations including non-adherent patients, medication abusers, those mixing alcohol and psychotropics, confused patients, children, adolescents, pregnant women and seniors * management of medication side effects and avoidance of medication risk * prescription of generic preparations * organizing a prescriptive office and record keeping. The additional chapters in this new edition of Prescribing Mental Health Medication cover topics such as combining specific medications, combining medications and psychological therapies, use of 'natural' substances in mental health treatment, successfully managing patient relapse, and appropriate prescriptions of potentially controversial medications such as stimulants and benzodiazepines. This practical text explains the entire process of medication assessment, management and follow up for general medical practitioners, mental health practitioners, students, residents, prescribing nurses and others perfecting this skill.

Organic chemistry research has moved rapidly toward synthesis and medicinal application of nitrogen-containing compounds such as triazenes, triazines, and hydroxytriazenes due to their excellent biological activities. Many of them are presently in clinical trials. Triazene compounds have excellent medicinal properties and limited toxicity. Hydroxytriazenes are excellent chelating agents for transition metals. Newer studies show very promising biological and medicinal applications of these classes of compounds. Hydroxytriazenes and Triazenes: The Versatile Framework, Synthesis, and Medicinal Applications highlights synthetic methods, recent advances, and potential applications of triazines, triazenes, and hydroxytriazenes. This book includes holistic information on synthetic methods for novel compounds based on this moiety, up-to-date information on the how and why of their diverse or even multitargeted medicinal application, and future state of the art of both aspects. Other features include: Highlights recent advances and diverse possible applications of biological functions Covers the chemistry of triazine, triazene, and hydroxytriazene systems On the basis of in silico predictions, the book highlights synthetic methods and their applications A valuable source of information for those actively engaged in medicinal chemistry, drug discovery, and synthetic organic chemistry

Key Features- Highlights recent advances in phytomedicine formulation development based on nanotechnology approaches, while also discussing the pharmacological property of Green synthesized ZnO particles focusing on the clinical perspective. Explores development of nanoparticles, synthesis techniques, characterization techniques, tissue engineering applications, biological applications, and multi-functional applications for cancer, inflammatory diseases, Alzheimer's disease and diabetes. Serves as a valuable guide for early career researchers, young scientists, academics and scientists working in various field like pharmaceutical, life sciences, Nano biotechnology about the applications of nanoparticles derived from plant sources.

Apart from diet and exercise, the strategic use of different classes of prescribed or non-prescribed xenobiotic compounds for the restoration of euglycemic levels in the body is well known. The ongoing rivalry between the recommended usage of allopathic medicines versus ayurvedic remedies has encouraged many researchers to focus their studies on thoroughly isolating and characterizing the extracts from different parts of plants and then evaluating their relative activities via in vitro, in vivo and in some cases clinical studies. Alternative Medicines for Diabetes Management: Advances in Pharmacognosy and Medicinal Chemistry provides a holistic view of all oral therapies for diabetes mellitus that are available to the public by removing the silos and stigmas that are associated with both allopathic and ayurvedic medicines. Additional Features Include: Highlights the potential role of dietary and medicinal plant materials in the prevention, treatment, and control of diabetes and its complications. Educates readers on the benefits and shortcomings of the various present and potential oral therapies for diabetes mellitus. Allows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compounds. Presents the history, nomenclature, mechanisms of action and shortcomings for each of the various sub-classes of allopathic therapeutants for diabetes mellitus and then introduces ayurvedic medicines. Section C discusses various metallopharmaceuticals and provides a holistic view of all available and potential therapies for the disease.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

Include advance knowledge and detailed developments in natural product science Discusses about the most important phytopharmaceuticals used in pharmaceutical industries Explores the analysis and classification of novel plant-based medicinal compounds Includes standardization, quality control, global trade of natural products Gives a deep understanding related to recent advances in the herbal medicines to treat various ailments Discusses about national and WHO regulations and policies related to herbal medicine Covers the complete profile of some important traditional medicinal plants especially their historical background, biology and chemistry

This volume provides informative research on the scientific evidence of the health benefits that can be derived from medicinal plants and how their efficacies can be improved. It is divided into three sections that cover the phytochemistry of medicinal plants, disease management with medicinal plants, and novel research techniques in medicinal plants. The pharmacological benefits of several specific plants are discussed, addressing health issues such as metabolic and mental disorders, acute mountain sickness, polycystic ovarian syndrome, and specific diseases such as Huntington's. It also looks at the role of antioxidants in disease management. Additionally, the book covers recent problems of drug resistance and how medicinal plants can serve as antibiotic, anthelmintic, and antiparasitic drugs that will be helpful for human and animals.

Provides a comprehensive review of challenges and opportunities as related to the applications of big data, AI, and machine learning in the entire spectrum of drug R&D Discusses regulatory developments in leveraging big data and advanced analytics in drug review and approval Offers a balanced approach to data science organization build Presents real-world examples of AI-powered solutions to a host of issues in the lifecycle of drug development Affords sufficient context for each problem and provides detailed description of solutions suitable for practitioners with limited data science expertise