Apprentices to Genius: A tribute to Solomon H. Snyder, a volume in the Advances in Pharmacology series, presents a tribute to Dr. Solomon H. Snyder, highlighting chapters submitted from a broad range of his students. It covers many different areas of neuroscience and pharmacology, with this volume exploring how receptor binding and drug discovery, the emerging role of glutamate in the pathophysiology of mental illness, nitric oxide signaling in neurodegeneration and cell death, carboxypeptidase E and the identification of novel neuropeptides as potential therapeutic targets, the regulation of mitochondrial functions by TSPO, clozapine and its translational investigation, and more.

The study guide includes key learning objectives for each chapter, outlines of key sections, self-test questions, and sets of problems similar to those in the text to help you succeed in the course.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention.

Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.
Highly focused on ocular transportersMost up-to-date research compilationDetailed description of role of transporters and receptors in ocular drug discovery and delivery

A range of new and innovative tools used for preformulation and formulation of medicines help optimize pharmaceutical development projects. Such tools also assist with the performance evaluation of the pharmaceutical process, allowing any potential gaps to be identified. These tools can be applied in both basic research and industrial environment. Formulation tools for pharmaceutical development considers these key research and industrial tools.
Nine chapters by leading contributors cover: Artificial neural networks technology to model, understand, and optimize drug formulations; ME_expert 2.0: a heuristic decision support system for microemulsions formulation development; Expert system for the development and formulation of push-pull osmotic pump tablets containing poorly water-soluble drugs; SeDeM Diagram: an expert system for preformulation, characterization and optimization of tables obtained by direct compression; New SeDeM-ODT expert system: an expert system for formulation of orodispersible tablets obtained by direct compression; and 3D-cellular automata in computer-aided design of pharmaceutical formulations: mathematical concept and F-CAD software.
Coverage of artificial intelligence tools, new expert systems, understanding of pharmaceutical processes, robust development of medicines, and new ways to develop medicinesDevelopment of drugs and medicines using mathematical toolsCompilation of expert system developed around the world

Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.
Provides a list and description of commercially available therapeutic drug products and their formulationsA comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinicDiscusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

"Progress in Medicinal Chemistry" provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

Extended timely reviews of topics in medicinal chemistryTargets and technologies relevant to the discovery of tomorrow s drugs.Analyses of successful drug discovery programmes"

Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology).
"Fundamentals of Toxicologic Pathology 2e" updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists.

NOW FEATURING:

25% brand new information, fully revised throughout

New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology

New color photomicrographs detailing specific toxicant-induced diseases in animals

Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels"

This introductory textbook of pharmacoeconomics is ideal for all those working in, aspiring to work in or interested in the pharmaceutical industry. It assumes no prior knowledge of this subject but is written at a level appropriate, for example, for those studying for a postgraduate degree or diploma in pharmaceutical medicine and who already have a first degree in science or medicine. Emphasizes how pharmacoeconomics can be of assistance in "real world" decision making. Covers the development of insuring, financing and delivery of health care in the developed world and the increasing role of governments. Explains the trend towards the critical scrutiny of health service activity. All topics explained assuming no specialist knowledge.

The Mechanics of Inhaled Pharmaceutical Aerosols, An Introduction provides a unique and comprehensive treatment of the mechanics of inhaled pharmaceutical aerosols. The book covers a wide range of topics and many new perspectives are given by drawing on research from a variety of fields. Novel, in-depth expositions of the most common delivery devices are given, including nebulizers, dry powder inhalers and propellant metered dose inhalers. The behaviour of aerosols in the respiratory tract is explained in detail, with complete coverage of the fundamentals of current deposition models.
The book begins by providing a comprehensive introduction to aspects of aerosol mechanics that are relevant to inhaled pharmaceutical aerosols. It then gives an exhaustive pedagogical description of the behaviour of evaporating and condensing droplets (both aqueous and propellant-based), an introductory chapter on lung geometry and inhalation patterns, and coverage of relevant aspects of fluid mechanics in the lung. Finally, the book provides invaluable, detailed coverage on the mechanics of common pharmaceutical aerosol delivery systems and deposition in the respiratory tract. Throughout the book are many detailed numerical examples that apply the salient concepts to typical inhaled pharmaceutical aerosols.
This book will be of interest to scientists and engineers involved in the research and development of inhaled pharmaceutical aerosol products. Experienced practitioners will find many new perspectives that will greatly enhance their understanding of this complex and rapidly growing field. For those delivering therapeutic agents to the lung, this book is a must-have. Students and academics will find this book an invaluable tool and for newcomers it is a worthy guide to the diverse fields that must be understood to work in the area of inhaled pharmaceutical aerosols.

This volume examines recent developments in the use of intelligent materials and systems for drug delivery. Controlled release technology is moving from being a simple carrier of active agents to becoming a powerful and flexible method that permits subtle modulation of the delivery profile based on the needs of the biological host. The chapters collected here cover recent advances in materials with responsive properties, novel concepts in controlled release technology, new applications, and microanalytical techniques for rapid and accurate measurements of small samples.

The role of dopamine in schizophrenia has been a significant area of research. The measurement of the major dopamine metabolite, homovanillic acid (HVA), in various body fluids, especially in blood plasma, is one of the primary methods to assess brain dopamine neuronal activity in schizophrenic patients.

Written by leading researchers in the field, "Plasma Homovanillic Acid in Schizophrenia" provides the most comprehensive and current collection of information on plasma HVA levels to be found anywhere. It provides a concise synthesis and critique of current data as well as interesting proposals for future research.

This book will be of great value to any serious student of the biology of schizophrenia and other psychiatric disorders involving abnormal levels of plasma HVA.

This book focuses on broadly defined areas of chemical information science- with special emphasis on chemical informatics- and computer-aided molecular design. The computational and cheminformatics methods discussed, and their application to drug discovery, are essential for sustaining a viable drug development pipeline. It is increasingly challenging to identify new chemical entities and the amount of money and time invested in research to develop a new drug has greatly increased over the past 50 years. The average time to take a drug from clinical testing to approval is currently 7.2 years. Therefore, the need to develop predictive computational techniques to drive research more efficiently to identify compounds and molecules, which have the greatest likelihood of being developed into successful drugs for a target, is of great significance. New methods such as high throughput screening (HTS) and techniques for the computational analysis of hits have contributed to improvements in drug discovery efficiency. The SARMs developed by Jurgen and colleagues have enabled display of SAR data in a more transparent scaffold/functional SAR table. There are many tools and databases available for use in applied drug discovery techniques based on polypharmacology. The cheminformatics approaches and methodologies presented in this volume and at the Skolnik Award Symposium will pave the way for improved efficiency in drug discovery. The lectures and the chapters also reflect the various aspects of scientific enquiry and research interests of the 2015 Herman Skolnik award recipient.

Psychiatric Pharmacogenomics is a book written to help clinicians to use pharmacogenomic testing to improve the pharmacotherapy that they provide for their patients. It is designed to teach clinicians how to order pharmacogenomic tests and interpret the results. Clinical examples are used to underscore the specific indications for pharmacogenomic testing and to clarify the clinical usefulness of identifying atypical genotypes that result in problematic responses to medication.
The first section of the book begins with a basic review of molecular genetics. Additionally, the book also includes an extensive glossary of technical terms associated with molecular genetics and pharmacogenomics. The clinical utility of pharmacogenomic testing is demonstrated throughout the book by describing the implications of genetic variations for the care of individual patients.
The second section of the book is organized into fourteen chapters that each focus on the clinical implications of testing for specific genes for which variants have been associated with either therapeutic response or side effects of psychotropic medications. Each of these chapters is structured in the same manner and involves a description of the gene and its significant variants. Each chapter also includes one or more clinical vignettes.
The third section of the book discusses the clinical usefulness of pharmacogenomic testing, ethical issues associated with pharmacogenomic testing, and provides predictions for the future development of more sophisticated pharmacogenomic testing.

Some of the questions from the earlier editions have been deleted and many new questions relevant to the current information have been added and updated. The answers to these MCQs are based on the current eighth edition of Essentials of Medical Pharmacology authored by KD Tripathi. Additionally, it has incorporated explanatory answers for the MCQs in the current edition. This will assist the students to understand the reasoning behind the correct answers. MCQs in Pharmacology is based on the widely used textbook Essentials of Medical Pharmacology, 8th edition authored by KD Tripathi. It presents MCQs relevant to fundamental principles including factual information about drugs needed for their judicious clinical application. The key highlight of this book is that the answers of MCQs have been explained in detail from the Essentials of Medical Pharmacology, 8th edition for better student understanding. The explanation to the MCQs have been appropriately presented along with mentioning the page number from which they have been cited from Essentials of Medical Pharmacology, 8th edition for further student reading. This MCQ book helps the students in preparing for various entrance examinations. The questions are designed to provide a means of self-study and self-assessment. The book will assist assimilation and recall of accurate pharmacological knowledge.

Quality Assurance Management: A Comprehensive Overview of Real-World Applications for High Risk Specialties demonstrates how to best design and implement standard operating procedures (SOPs) to ensure protocol and regulation adherence. The book showcases similarities and differences between healthcare and academic quality assurance systems, resulting in counter-productivity and performance issues, in addition to regulatory inspection preparedness. It uses the processes and standards of the UK to demonstrate how to combine QA and research building into ‘building blocks’ that share a common pathway for effective project design, analysis and unbiased interpretation of collated data.This book fills a gap, providing original research in QA that especially focuses on specialist areas. It will be of use to research and clinical staff working in clinical research within healthcare, academia and industry.

Save time and money with two books in one + online Q&A! Half pharmacology, half dosage calculations—plus an intensive, yet clear & simple review of basic math + online quizzing!Here’s the must-have knowledge and guidance you need to gain a solid understanding of pharmacology and the safe administration of medications in one text. A body systems approach to pharmacology with a basic math review and a focus on drug classifications prepare you to administer specific drugs in the clinical setting. Now with online Q&A practice in Davis Edge! Purchase a new, print copy of the text and receive a FREE, 3-year subscription to Davis Edge, the online Q&A program with 1,600 questions in all, 800 for Medical Assisting and 800 for Nursing. Davis Edge helps you to create quizzes in the content areas you choose to focus on, build simulated practice exams, and track your progress every step of the way. The Text New! Pronunciations for key terms at the beginning of each chapter New! Word-building and gerontological issues features New! New appendix on intravenous therapy Basic math review helps students learn to perform the calculations necessary to administer medications correctly. Medication administration presented through pharmacology basics, techniques and procedures, supplies, safety and regulations, and prescriptions and label “Master the Essentials� tables cover side effects, precautions, contraindications, and interactions for each classification. Drug classification review tables reinforce need-to-know information in each class. “Fast Tip� boxes offer quick facts and mnemonics. “A Closer Look� boxes examine important information in detail. “Check-up Questions� throughout each chapter promote understanding and help students retain and apply the information. Coverage of specific drugs provides context for learning drug classifications. Critical-thinking exercises encourage students to think beyond the chapter and apply their new knowledge to real-life scenarios. Review questions at the end of each chapter reinforce learning. Davis Edge Online Q&A FREE, 3-year access with purchase of new, print text 800 questions for Medical Assisting and 800 for Nursing “Quiz Builder� lets you select practice questions by exam section or topic area. Rationales for correct and incorrect responses provide immediate feedback. “Student Success Center� dashboard monitors your performance over time, helping to identify areas for additional study.

For years, psychiatrists have provided & ldquo;medication backup& rdquo; for patients who are in therapy with a non-physician therapist. During the past decade, this practice, also known as collaborative treatment, has expanded as a result of important breakthroughs in clinical psychopharmacology and ongoing pressure to reduce the costs of mental health care.

"Psychopharmacology and Psychotherapy: A Collaborative Approach" serves as a roadmap for the growing numbers of health professionals who are teaming up to provide psychotherapy and pharmacotherapy to patients. The complicated issues involved in medication backup are addressed in a comprehensive, practical manner. It covers: The positive aspects and pitfalls to avoid in collaborative treatment Useful information about the education and training backgrounds of the various mental health professionals participating in collaborative treatment arrangements The complicated legal and ethical issues, such as the following: Who is ultimately responsible for patient treatment& #63; How will patient treatment liability be shared between collaborative practitioners& #63; How can risk be managed in medication backup arrangements& #63; Insight into the complex relationship dynamics between and among physician, therapist, and patient Residency training issues and models of successful collaborative treatment that can be used by the busy clinician in formulating treatment plans The unique problems encountered by psychiatrists who provide medication backup in managed care environments

Throughout the book, case vignettes are extensively used to illustrate the principles presented. This well-referenced volume is the first of its kind toprovide practical guidelines for maximizing the process of collaborative treatment for all involved professionals& mdash;with the ultimate goal of improving the care of all patients.

Drugs in Use: Case Studies for Pharmacists and Prescribers helps you to bridge the gap between theoretical knowledge about medicines and the practical application to your patients. With an ever increasing shift of focus from theory to practice this book promotes evidence-based medicine and illustrates how you can optimise drug therapy in response to the needs of your individual patients. It will prove a valuable resource to pharmacists and prescribers. The cases have been updated to reflect recent changes in medicines use and this new edition boasts: New evidence concerning optimal care; Additional coverage of situations with difficulties in treatment optimisation; Significant focus on major advances in therapeutics; Self study questions and answers within each case. With self study questions and answers to accompany each case, you will find this a useful resource throughout your career. As a student, it will assist your studies and as a practicing pharmacist or prescriber in hospital or community it will aid your continuing professional development.

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.

Antioxidants Effects in Health: The Bright and the Dark Side examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants' historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.