Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.

Drugs in Use: Case Studies for Pharmacists and Prescribers helps you to bridge the gap between theoretical knowledge about medicines and the practical application to your patients. With an ever increasing shift of focus from theory to practice this book promotes evidence-based medicine and illustrates how you can optimise drug therapy in response to the needs of your individual patients. It will prove a valuable resource to pharmacists and prescribers. The cases have been updated to reflect recent changes in medicines use and this new edition boasts: New evidence concerning optimal care; Additional coverage of situations with difficulties in treatment optimisation; Significant focus on major advances in therapeutics; Self study questions and answers within each case. With self study questions and answers to accompany each case, you will find this a useful resource throughout your career. As a student, it will assist your studies and as a practicing pharmacist or prescriber in hospital or community it will aid your continuing professional development.

Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.

Antioxidants Effects in Health: The Bright and the Dark Side examines the role that antioxidants play in a variety of health and disease situations. The book discusses antioxidants' historical evolution, their oxidative stress, and contains a detailed approach of 1) endogenous antioxidants, including endogenous sources, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; 2) synthetic antioxidants, including sources, chemistry, bioavailability, legal status, mechanisms of action, beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies; and 3) natural antioxidants, including sources, chemistry, bioavailability, mechanisms of action, possible prooxidant activity; beneficial and detrimental effects on health, in vitro evidence, animal studies and clinical studies. Throughout the boo, the relationship of antioxidants with different beneficial and detrimental effects are examined, and the current controversies and future perspectives are addressed and explored. Antioxidants Effects in Health: The Bright and the Dark Side evaluates the current scientific evidence on antioxidant topics, focusing on endogenous antioxidants, naturally occurring antioxidants and synthetic antioxidants. It will be a helpful resource for pharmaceutical scientists, health professionals, those studying natural chemistry, phytochemistry, pharmacognosy, natural product synthesis, and experts in formulation of herbal and natural pharmaceuticals.

Dihydropyrimidinones as Potent Anticancer Agents gives readers a unique update on scientific knowledge, accomplishments and recent advances in the medicinal chemistry of dihydropyrimidinones in cancer treatment. Dihydropyrimidinones are known to be active scaffold and have been reported to show some exceptional results with regards to malignancies. With ever increasing knowledge and information about synthesis, pharmacology and other aspects of dihydropyrimidinones, there is need to document such information in one place. Since the field of medicinal chemistry is dynamic, with new emerging trends, it provides readily available updated information on chemistry and pharmacology aspects of dihydropyrimidinones in cancer. This book covers everything about dihydropyrimidinones from synthesis, derivatives, mode of action and potential therapeutic targets. It will also provide insights about the clinical trials and way forward in cancer research of dihydropyrimidinones.

From Current to Future Trends in Pharmaceutical Technology explores the current trends of this field and creates a multi-aspect framework for the reader. The book covers topics on pharmaceutics, pharmaceutical engineering, pre-formulation protocols, techniques, innovative excipients, bio-printing techniques, scale-up based on formulas on-a-chip, and regulatory aspects based on new scientific achievements. Modified dosage forms, new aspects on the compatibility of drug excipients interactions, and drug release by various dosage forms are included. Physical pharmacy (physical and biological stability of dosage forms), innovative excipients, patents on innovative formulations and regulatory issues related to the approval process of medicines are also discussed. The book is a valuable resource for a wide audience of academics, industrial researchers and professionals working in this field as the development of efficient and safe medicines is critical to future needs.

Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

Phytopharmaceuticals and Herbal Drugs: Prospects and Safety Issues in the Delivery of Natural Products explores the delivery aspects of plant-based drugs, providing insights into formulation constraints associated with plant-based drugs, the development of novel delivery systems based on polymers or lipids, and how combining natural products with technological advancements in drug delivery is making large strides. Some of the best-selling drugs for the treatment of diseases like cancer, ulcers and malaria are either natural products or their derivatives, all of which are covered in this comprehensive resource. This book will be useful to researchers working in plant-derived medicines and the development of their delivery systems, including sections on their derivatives and analogs that represent over 50% of all drugs in clinical use. Active ingredients originated from plant resources generally exhibit compromised desired effects limited by issues such as stability, solubility, molecular size, bioavailability and toxicity.

Hygienic Design of Food Factories, Second Edition includes updates on existing chapters, along with new sections on cold storage, the control of air in food refrigeration facilities, and prevention of contamination when building during production and regulations in Asian countries (other than Japan). Sections cover the implications of hygiene and construction regulation in various countries on food factory design, describe site selection, factory layout and the associated issue of airflow, and address the hygienic design of essential parts of a food factory, including walls, ceilings, floors, selected utility and process support systems, entry and exit points, storage areas, and more. With its distinguished editors and international team of contributors, this book continues to be an essential reference for managers of food factories, food plant engineers, and all those with an academic research interest in the field.

Medicines for Cancer: Mechanism of Action and Clinical Pharmacology of Chemo, Hormonal, Targeted, and Immunotherapies is a comprehensive volume covering most of the known anti-cancer therapeutics. Cancer is the second leading cause of death worldwide, with its various forms resulting in nearly one out of every six mortalities each year. This book describes all US FDA-approved drugs (up to 2021), such as small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapy, and immunotherapies are considered, and information about their generic and brand names, medical uses, details dosage, mechanisms of actions, pharmacokinetics, and side effects. Chemical structures of small molecules, small peptides, antibody-drug conjugates are also provided. Medicines for Cancer: Mechanism of Action and Clinical Pharmacology of Chemo, Hormonal, Targeted, and Immunotherapies is ideal for medicinal chemists, oncologists, and pharmacologists, this book will be indispensable for professional researchers, whether they are working in the clinic or the pharmaceutical industry.

Phytochemicals have been present in human diet and life since the birth of mankind, including the consuming of plant foods and the application of herbal treatments. This coevolutionary interaction of plants and people has resulted in humans' reliance on food and medicinal plants as sources of macronutrients, micronutrients, and bioactive phytochemicals. Phytochemicals can be used as adjuvant agents and sensitizers in traditional antibiotic and anticancer therapy, reducing the potential of selecting resistant microbial strains and cancer cells. Recent Frontiers of Phytochemicals addresses the many processes of potential phytochemical evaluation of known sources, with a focus on phytochemical and pharmacological evaluations, and computational research into the structures and pharmacological mechanisms of natural products and their applications in medicine, food and biotech.

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world's leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.

Environmental Carcinogenesis, Volume 96 in the Advances in Pharmacology series, reports on work done with carcinogenic metals and the mechanisms of their carcinogenicity, including Arsenic and Chromate. Chapters in this release include Breast cancer carcinogenesis by organophosphate pesticides, Polyadenylation of Canonical histone H3.1 in Carcinogenesis, Epigenomic reprogramming in iAs-mediated carcinogenesis, MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis, Environmental epigenetics and new mechanistic markers of chemical exposure, Arsenic carcinogenesis by inhibition of DNA repair, Genetic and environmental reprogramming of the sarcoma epigenome, Mechanism of chromate carcinogenesis by chromatin alterations, and more. Other chapters cover Arsenic carcinogenesis and microRNAs, Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis, The dark side of NRF2 in arsenic carcinogenesis, and Chemical mechanisms of DNA damage by carcinogenic chromium(VI).

Standardizing Pharmacology: Assays and Hormones, Volume Two in the Discoveries in Pharmacology series, presents selected articles from historic discoveries that are enhanced with commentary from contemporary scholars who present discussions on the importance of each chapter, along with an updated bibliography on the subject and contributions from a Nobel Prize winner and other pioneers in pharmacology. Academic and industry researchers in pharmacology and medicine, as well as advanced students will find this series a useful teaching tool and launch to new discoveries. Sections cover key discoveries in receptor theory, pharmacological methods and the development of hormone therapy, including J. Parascandola on the development of receptor theory, R.S. Yalow on radioimmunoassay, M. van Rossum and J.T L.A. Hurkmans on bioassays, M. Tausk on androgen therapy and C. Djerassi on oral contraceptives, with commentaries from experts such as T. Hoekfelt and V.C. Jordan.

Oxetane Synthesis rings play an important role as versatile motifs both in the overall formation of natural products and in synthetic organic chemistry. Oxetanes are important motifs in pharmaceutical chemistry that can confer improved metabolic and physicochemical properties. These developments continue to enhance the use of oxetanes in medicinal chemistry. Thanks to the growing commercial accessibility of oxetane possessing building blocks, together with improved approaches for the formation, oxetanes are likely to be progressively utilized in medicinal chemistry programs. Oxetanes are becoming valuable as a result of their vast diversity of uses in medicinal chemistry and varying applications. Several procedures have been developed for the formation and ring-opening of oxetanes to give important compounds in agrochemical, medicinal and material sciences. Novel approaches have been developed for the synthesis of oxetanes. These methods depend on both established synthetic approaches and development of many novel approaches for the formation of oxetanes.

Theoretical and Computational Photochemistry: Fundamentals, Methods, Applications and Synergy with Experimental Approaches provides a comprehensive overview of photoactive systems and photochemical processes. After an introduction to photochemistry, the book discusses the key computational chemistry methods applied to the study of light-induced processes over the past decade, and further outlines recent research topics to which these methods have been applied. By discussing the synergy between experimental and computational data, the book highlights how theoretical studies could facilitate understanding experimental findings. This helpful guide is for both theoretical chemists and experimental photochemistry researchers interested in utilizing computational photochemistry methods for their own work.

Mathematics for Physical Chemistry, Fifth Edition includes exercises that enable readers to test their understanding and put theory into practice. Chapters are constructed around a sequence of mathematical topics, progressing gradually into more advanced material, before discussing key mathematical skills, including the analysis of experimental data and-new to this edition-complex variables. Includes additional new content on Mathematica and its advanced applications. Drawing on the experience of its expert authors, this book is the ideal supplementary text for practicing chemists and students wanting to sharpen their mathematics skills and understanding of key mathematical concepts for applications across physical chemistry.

Biomedical Applications of Green Composites reviews the use of green composite materials in drug delivery, with a focus on capsules, resins and ceramides in biomedical fields. Chapters present green composites of polymeric origin and targeted delivery of drugs into various parts of the human body. Other sections in the book cover topics related to the applications of green composites in areas such as antimicrobial agents, pathogen control, surgical applications, dentistry and cancer therapy.

Biocompatibility Protocols for Medical Devices and Materials provides comprehensive coverage of the basic science and toxicological testing protocols necessary for the risk assessment and safety of medical devices and materials which are based on ISO guidelines for body contact and duration of contact. Sections cover device/component selection for toxicological experiments and provide an introduction to topics such as sensitization, irritation tests, material-mediated pyrogenicity, and bacterial-mediated pyrogenicity. Toxicology-related chapters explain protocols around cytotoxicity, acute systemic toxicity, repeated-exposure systemic toxicity, genotoxicity, carcinogenicity, and reproductive toxicity. This practice guide provides step-by-step toxicological protocols, from materials selection to data interpretation for toxicologists, biomedical research and healthcare professionals, product developers, and others working in risk assessment and the safety of medical devices.

Mangroves with Therapeutic Potential for Human Health: Global Distribution, Ethnopharmacology, Phytochemistry, and Biopharmaceutical Applications explores, for the first time in a book, the exciting potential of mangroves for therapeutic applications in medicine and pharmacology. This authoritative, illustrated and clearly written book pairs the fascinating biodiversity of mangroves with their promising pharmacological propensities. Providing a comprehensive and authoritative overview, the book explores the important aspects related to mangroves, including global distribution, medicinal values and pharmaceutical applications in one source. This book is a valuable resource for researchers, academics in the field of herbal medicine, pharmacology, pharmacognosy, medicinal chemistry, biochemistry, natural product chemistry, ethnopharmacology, biotechnology, marine biology, microbiology, as well as professionals in the pharmaceutical industries.