Am Rande des Third International Meeting on Boron Chemistry (IMEBORON 111, Munchen und Ettal 1976) wurde ich gelegentlich auf eine Veroeffentlichung*) angesprochen, in der ich einige Jahre zuvor, in begrenztem Umfang, uber Anwendungen und Wirkungen von Borverbindungen aus pharmazeutisch-chemischer Sicht referiert hatte. Bei diesen Gesprachen wurde deutlich, dass eine Nachfrage nach einem Gesamtuberblick uber die interdisziplinar breit verstreuten und oft "versteckten" Publikationen uber experimentelle und praktische Anwendungen von Borverbindungen in Arznei- mittelchemie, Medizin und den ubrigen Biowissenschaften besteht und dass eine umfassende Dar- stellung dieses Aspekts der Bor-Chemie eine Lucke in der UEbersichtsliteratur fullen wurde. Die entscheidende Anregung gab schliesslich Prof. Dr. Kurt Niedenzu (University of Kentucky, Lexington, USA) als verantwortlicher wissenschaftlicher Koordinator der "Bor"-Erganzungsbande zum Gmelin Handbuch der Anorganischen Chemie durch den Vorschlag, die seit Erscheinen jener Veroeffentlichung erheblich angewachsene Literatursammlung doch einem groesseren Interessenten- kreis zuganglich zu machen und ein geschlossenes Kapitel uber Borverbindungen unter biologisch- medizinisch-pharmazeutisch-chemischen Gesichtspunkten fur einen der Bande abzufassen. Wahrend der Arbeit an diesem Kapitel stellte sich heraus, dass der geplante Umfang wiederum nur eine partielle Wiedergabe des vorliegenden Materials ermoeglichen wurde. So kam es zur UEbereinkunft mit dem Gmelin-Institut (Frankfurt am Main), dem Thema eine eigene Monographie - unabhangig vom Gmelin Handbuch, aber als Erganzung zur gesamten Bor-Reihe - zu widmen. Dabei sollte in Erweiterung des ursprunglichen Konzepts die Toxikologie der Borverbindungen noch ausfuhrlicher mitberuck- sichtigt werden.

This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.

This book introduces "network pharmacology" as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.

This book presents recent advances in the use of ionic liquids in medicine and pharmaceutics with particular emphasis on addressing critical pharmaceutical challenges, including the low solubility, polymorphism, and bioavailability of drugs. It also provides insights into the development of the biologically functionalized ionic liquids suitable for medical and pharmaceutical applications. Ionic liquids have been used as potential solvents or materials in the fields of pharmaceutical drug delivery and formulations because of their unique and tunable physicochemical and biological properties. Readers find explanations of the diverse approaches to the application of ionic liquids in drug solubility, active pharmaceutical ingredient (API) formulation, and drug delivery systems, such as topical, transdermal, and oral delivery, with particular emphasis on recent developments. Particular attention is given to the development of ionic liquid-assisted effective drug delivery techniques for sparingly soluble or insoluble drug molecules. This book also discusses the biological activities of ionic liquids for possible applications in drug formulation and drug delivery systems. Scientists in disciplines such as chemistry, biology, and pharmaceutics find this book instructive and informative for developing ionic liquid-based drug formulations or drug delivery systems.

This book is the first text to provide a comprehensive assessment of the application of fundamental principles of dissolution and drug release testing to poorly soluble compounds and formulations. Such drug products are, vis-a-vis their physical and chemical properties, inherently incompatible with aqueous dissolution. However, dissolution methods are required for product development and selection, as well as for the fulfillment of regulatory obligations with respect to biopharmaceutical assessment and product quality understanding. The percentage of poorly soluble drugs, defined in classes 2 and 4 of the Biopharmaceutics Classification System (BCS), has significantly increased in the modern pharmaceutical development pipeline. This book provides a thorough exposition of general method development strategies for such drugs, including instrumentation and media selection, the use of compendial and non-compendial techniques in product development, and phase-appropriate approaches to dissolution development. Emerging topics in the field of dissolution are also discussed, including biorelevant and biphasic dissolution, the use on enzymes in dissolution testing, dissolution of suspensions, and drug release of non-oral products. Of particular interest to the industrial pharmaceutical professional, a brief overview of the formulation and solubilization techniques employed in the development of BCS class 2 and 4 drugs to overcome solubility challenges is provided and is complemented by a collection of chapters that survey the approaches and considerations in developing dissolution methodologies for enabling drug delivery technologies, including nanosuspensions, lipid-based formulations, and stabilized amorphous drug formulations.

Dieses Werk zu Liebigs 200. Geburtstag setzt die Schwerpunkte auf Liebigs eigene Ausbildung und die von ihm entwickelte weitreichende Schule der Chemie.
Viele seiner Sch ler werden bedeutende Wissenschaftler, Hochschullehrer, wissenschaftliche Schriftsteller und Industriechemiker. Sie kommen nicht nur aus Deutschland sondern aus vielen L ndern Europas, und sogar aus Nord- und S damerika. Anhand der ver ffentlichten Selbstzeugnisse Liebigs, seines umfangreichen Briefwechsels mit W HLER, BERZELIUS, dem Verleger VIEWEG und Sch lern wie HOFMANN u.a. wird das Wirken Liebigs f r eine neue Schule der Chemie dargestellt. Die Biographien der bedeutendsten Sch ler werden im Zusammenhang mit Liebigs Einfluss auf die Entwicklung der Chemie in Europa und in den USA behandelt und mit zahlreichen Zitaten aus seinem Briefwechsel erg nzt.

This book highlights recently discovered aspects of "middle-size molecules," focusing on (1) their unique bio-functions on the basis of derivatives and conjugates of natural products, saccharides, peptides, and nucleotides; (2) the synthesis of structurally complex natural products; (3) special synthetic methods for -conjugated functional molecules; and (4) novel synthetic methods using flow chemistry. Given its scope, the book is of interest to industrial researchers and graduate students in the fields of organic chemistry, medicinal chemistry, and materials science.

This open access book describes strategies and experiences of highly skilled professionals in improving oncology care worldwide. The book is structured into three main sections with several chapters each, reflecting the authors' individual, real-life experiences. It explores ways to improve oncology education and scientific training, how to set up and run a clinical research facility ethically and efficiently in low- and middle-income settings, addressing the challenges that the workforce encounters in the real world. The main challenges of today's oncologists seem to be the ever-growing patient care and administrative workload and the risk of burn-out. What are the best strategies to maintain a healthy work-life for the benefit of the patients, the physicians and society, taking into account the different needs, depending on factors like peace, social and gender equality? This book addresses oncologists all over the world and their allies throughout the associated industries to highlight the importance of shared and sustainable education, clinical research and global cancer care.

The book concentrates on powder flow properties, their measurement and applications. These topics are explained starting from the interactions between individual particles up to the design of silos. A wide range of problems are discussed - such as flow obstructions, segregation, and vibrations. The goal is to provide a deeper understanding of the powder flow, and to show practical solutions.

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.

This book provides the first diverse and multifaceted textual and cartographic overview of natural curative resources of mineral waters and peloids in Russia. In a readily understandable way the book informs about the genesis, history of exploration and geographical features of water springs, their properties and use as healing springs, as well as specifics and prospect of their contemporary use. The monograph features numerous color illustrations and photos and is oriented toward a general audience but also appeals to geographers, environmental and public health workers and other specialists interested in environmental and public health issues.

1 Einfuhrung.- Was dieses Buch will.- Welche Pflanzen werden behandelt ?.- Welche Pflanzen werden nicht behandelt ?.- Wie wird die Giftigkeit der Pflanzen bewertet ?.- Welche Angaben zur Behandlung der Vergiftung werden gemacht?.- 2 Hinweise zur Benutzung des Buches.- Allgemeine Voraussetzungen.- Bestimmungsablauf.- Fallbeispiel zur schnellen Identifizierung einer moeglicherweise giftigen Pflanzen.- Erlauterung der botanischen Terminologie.- 3 Bestimmungsschlussel.- Bestimmungsschlussel A bei Ingestion von Fruchten.- Bestimmungsschlussel B bei Ingestion gruner Pflanzenteile.- Bestimmungsschlussel C bei Ingestion von Wurzeln.- Bestimmungsschlussel D bei Ingestion von Zierpflanzen im Hause (Zimmerpflanzen und Schnittblumen) und Balkonpflanzen.- 4 Beschreibungen der Pflanzen.- Pflanzen mit hohem Giftgehalt (Kategorie I).- Pflanzen mit geringem bis mittelschwerem Giftgehalt (Kategorie II).- Pflanzen mit geringem oder fehlendem Giftgehalt (Kategorie III).- 5 Anhang.- Welche Pflanzen sind giftig?.- Welche Inhaltsstoffe der Pflanzen sind giftig?.- Therapie der Pflanzenvergiftungen.- 6 Weiterfuhrende Literatur.- 7 Giftinformationszentren der Bundesrepublik Deutschland.

This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.

This book covers recent advances of the fragment molecular orbital (FMO) method, consisting of 5 parts and a total of 30 chapters written by FMO experts. The FMO method is a promising way to calculate large-scale molecular systems such as proteins in a quantum mechanical framework. The highly efficient parallelism deserves being considered the principal advantage of FMO calculations. Additionally, the FMO method can be employed as an analysis tool by using the inter-fragment (pairwise) interaction energies, among others, and this feature has been utilized well in biophysical and pharmaceutical chemistry. In recent years, the methodological developments of FMO have been remarkable, and both reliability and applicability have been enhanced, in particular, for non-bio problems. The current trend of the parallel computing facility is of the many-core type, and adaptation to modern computer environments has been explored as well. In this book, a historical review of FMO and comparison to other methods are provided in Part I (two chapters) and major FMO programs (GAMESS-US, ABINIT-MP, PAICS and OpenFMO) are described in Part II (four chapters). dedicated to pharmaceutical activities (twelve chapters). A variety of new applications with methodological breakthroughs are introduced in Part IV (six chapters). Finally, computer and information science-oriented topics including massively parallel computation and machine learning are addressed in Part V (six chapters). Many color figures and illustrations are included. Readers can refer to this book in its entirety as a practical textbook of the FMO method or read only the chapters of greatest interest to them.

This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Die uberarbeitete Apothekenbetriebsordnung verpflichtet alle Apotheken zu einem Qualitatsmanagementsystem (QMS). Dieser ubersichtlich gestaltete und praxisorientierte Leitfaden gibt Apotheken alle wichtigen Details an die Hand, um ein QMS erfolgreich einzufuhren und auszubauen. Die erfahrenen Autoren zeigen von der Analyse der Ausgangssituation bis hin zur Unterstutzung bei Systemeinfuhrung die Vorteile des QMS. Checklisten, Beispiele, Hinweise auf potenzielle Fehler und komprimierte Zusammenfassungen leisten wertvolle Hilfe bei der Umsetzung."

This book presents an in-depth analysis of issues in trade law and EU pharmaceutical law concerning market access for traditional Chinese medicinal products. It discusses these issues from the standpoints of fundamental law, international law and EU law, so to offer a comprehensive perspective. Specifically, it points out the core legislative issues for EU policymakers who deal with market access for traditional medicinal products; describes the relation between law and science; and offers essential information on herbal medicinal product registration in the EU. Further, it compares EU law and Chinese law in this regard, which can offer inspirations for readers from other counties that have similar medicinal products. The book uses straightforward, accessible language to break down the key issues involved.

This encyclopedia scientifically describes 121 vegetable oils and fats. In addition to conventional oils, the book also covers lesser-known oils such as Amaranth, Chia, prickly pear, and quinoa. Author pays particular attention to root plants, extraction, and the ingredients included in information nutritionally relevant to fatty acid patterns. Applications in pharmacology, medicine, cosmetics and technology, as well as possible adverse effects, are discussed. The thoroughly researched reference book includes detailed descriptions along with the latest research results and methods.

Nurses working within the expanded role of prescriber will frequently be faced with prescribing decisions. This text provides easily accessible information upon which to base these decisions, ensuring safe and effective prescribing practices. Each chapter examines the preparations available to nurses in the extended formulary and their effects on the human body. Information including product dosage, contraindications, side effects, drug interactions, and specific nursing points is presented in detail. This text provides key background information from the relevant life sciences, as it applies to modern clinical practice. The authors have brought together widely available information in the form of a single, easy to use, practice-based text, which, in conjunction with the BNF, Drug Tariff and manufacturers' product information sheets, provides an essential guide to nurse prescribing.

Nanophytomedicine is a field that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology. This book assesses the clinical successes and failures of nanophytomedicine and also highlights emerging concepts in this field. The content is divided into three sections, the first of which describes core issues in the pharmaceuticals industry in connection with the successes, failures and prospects of nanophytomedicine. The second section highlights recent advances in phytomedicine formulation development based on nanotechnology approaches, while also discussing a variety of nanocarrier systems for the successful delivery of phytomedicines. Focusing on the clinical perspective, the third section addresses the current clinical status of nanophytomedicine as a single drug therapy or combinatorial drug therapy, pharmacovigilance, pharmacokinetics, drug interactions and toxicological profiles, while also providing concluding remarks on recent experimental findings, and considering ethical issues & regulatory challenges in nanophytomedicine. Given its scope, the book offers a valuable guide for early career researchers, young scientists, master level students, academics and industrial scientists working in various healthcare fields, e.g. the pharmaceutical and biological sciences, life sciences, biotechnology, biomedical engineering, and nanobiotechnology.

This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: * The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. * Study directors and principal investigators. * The nuts and bolts of study performance. * Electronic reporting requirements - SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). * Consultants and their roles. * An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs - where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities - and for auditing studies and projects at such facilities - are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.

This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.

Non-linear phenomena pervade the pharmaceutical sciences. Understanding the interface between each of these phenomena and the way in which they contribute to overarching processes such as pharmaceutical product development may ultimately result in more efficient, less costly and rapid implementation. The benefit to Society is self-evident in that affordable treatments would be rapidly forthcoming. We have aggregated these phenomena into one topic "Pharmaco-complexity: Non-linear Phenomena and Drug Product Development".

Prescribing for children is problematic. Children are not small adults in terms of their physiology, and they cannot be subjects in clinical trials. This makes prescribing for them something of an art and a daunting one at that for trainees. Will Carroll (co-editor of the Illustrated Textbook of Paediatrics amongst other titles for paediatrics trainees) with a team of fellow paediatricians and a hospital pharmacist have sought to demystify prescribing for children. The team has identified what from their experience are the most common drugs prescribed to children and have addressed each one, adding detail about how each medicine works. Each chapter follows the ABCDE structure covering Absorption, Biological effects, Clearance, Dosing and side Effects in children. This book is a succinct, portable reference, modelled closely on Hitchings et al.: The Top 100 Drugs. Written in conjunction with a hospital pharmacist for drug expertise. User-friendly double-page-spread approach. Each drug entry preceded by clinical pharmacology information with consistent headings: Why and when; Absorption; Biology. Each drug presented in consistent categories: Clearance; Dosing; Administration; Side effects and interactions; Monitoring and Cost.