Consumer interest in diet and nutritional supplements is increasing dramatically. Patients and members of the public are seeking advice from health professionals, nutritionists and food scientists. This book is designed to meet the needs of those professionals who are called upon to advise patients and the general public. It provides also a valuable text for those who are researchers or decision makers in the food and pharmaceutical industries. The text presents a thorough account of this topical subject and enables the reader to appreciate the functions of nutrients in health and common disease states, to understand the current debates over the roles of nutrients and supplements in the diet, and to answer those questions frequently asked by patients and consumers.

Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology. Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.

This volume was planned to provide a comprehensive survey of the role of the anabolic-androgenic steroids in the vital economy exclusive of the androgenic (sexual) functions. It seemed appropriate to bring together all of this information in an organized fashion in one volume at this time not only to serve as a source of information but also to indicate and suggest areas that need further exploration. The anabolic action of the steroid hormones has gone through a period of great activity in both basic and clinical research. A complete understanding of the manifold anabolic effects still remains to be elucidated and the art of clinical application is only gradually becoming apparent. This volume should be useful not only to the experienced investigator in both basic and clinical research but also for the novice. Furthermore, it should serve as a source of information for the careful use of these steroids in certain metabolic diseases. These steroids have had wide clinical application with variable results. In many instances further careful exploration is suggested. Other instances have demonstrated varying degrees of usefulness.

"Der wichtigste Schritt in der Fortentwicklung aller Naturwissenschaften ist mit der Einfuhrung der Messung von Grossen gemacht worden. " (J. C. MAXWELL, Theorie der Warme, Dt. uber- setzung nach der 4. Aufl. , 1877) Die Analyse des Elektrolyt- und Wasserhaushaltes bei Patienten mit generali- sierten Odemen hat ergeben, dass die Unfahigkeit des Organismus, die mit der Nahrung zugefuhrten Natriumionen quantitativ zu eliminieren, ein gemeinsames Merkmal dieser Erkrankungen ist. Die Ansammlung von Wasser im extracellularen Raum ist lediglich die Folge dieser Natriumretention. Der Anteil der Niere an der Entstehung solcher Storungen des Elektrolyt- und Wasserhaushalts beruht auf der I mbalance glomerular-tubularer Funktionen, die renale und extrarenale Ursachen haben kann. Die Minderung der glomerularen Filtration ist fur die Entstehung der Odeme sicher von geringerer Bedeutung als die zu intensive Ruckgewinnung des Primarharns unter den pathologischen Bedingungen, die den Ausgleich der gestorten Salz- und Wasserbilanz verhindert. Prinzipiell kann eine Vermehrung der Harnausscheidung sowohl durch Ver- grosserung der glomerularen Filtration als auch durch Hemmung der tubularen Ruckgewinnung des Primarharns erreicht werden. Die heute gebrauchlichen Diuretica verandern ganz uberwiegend tubulare Funktionen und beeinflussen daher den an zweiter Stelle genannten Prozess.

All practitioners and pharmacists interested in treatment with herbal remedies should have this book at their disposal. It is the definitive practice-oriented introduction - now in its fifth edition - to phytotherapy. Methodically classified by organic systems and fields of application, the text provides a quick insight into dosage, form of application and effects of the most important herbal remedies. Only those herbal remedies that are of pharmacological and clinical efficiency have been considered. The authors are highly experienced in the field of postgraduate medical education, and, with this work, present an indispensable reference book for the medical practice.

Over the past few years, increasing attention has been paid to the search for bioactive compounds from natural sources. The success of plant-derived products such as paclitaxel (Taxol) in tumor therapy or artemisinin in the treatment of malaria has provided the impetus for the introduction of numerous research programmes, especially in Industry. A great deal of effort is being expended in the generation of novel lead molecules of vegetable, marine and microbial origin by the use of high throughput screening protocols. When interesting hits are found, it is essen tial to have methods available for the rapid isolation of target compounds. For this reason, both industry and academia need efficient preparative chromatographic separation techniques and experience in their application. Purified natural products are required for complete spectro scopic identification and full characterization of new compo unds, for biological testing and for the supply of pharmaceuti cals, standards, and starting materials for synthetic work. Obtaining pure products from an extract can be a very long, te dious and expensive undertaking, involving many steps. Sometimes only minute amounts of the desired compounds are at hand and these entities may be labile. Thus it is an advantage to have access to as many different methods as possible in order to aid the isolation process. Although a certain amount of trial and error may be involved, nowadays there is the possibility of devising suitable rapid separation schemes by a judicious choice of the different techniques available."

As the growing field of pharmacogenomics continues to impact daily practice and offer promising new drug therapies, understanding this complex science is critical for all pharmacists - students, residents, and established practitioners. To meet this need, ASHP's Concepts in Pharmacogenomics has been completely updated for the second edition, covering both the fundamentals of pharmacogenomics and the latest genomic technologies. Written by pharmacists and geneticists, it not only covers basic science concepts but also includes expanded coverage of therapeutic applications. Each chapter features key definitions, case studies, and clinical pearls, with figures and summary tables to further support learning. This new edition includes: Updated methodologies such as next generation sequencing. Advances in therapeutic applications. Expanded use of point-of-care genetic testing. Role of pharmacogenomics in the individualisation of chemotherapy. New chapters on pharmacogenomics of drug addiction and antidiabetic drugs. A clearly written, comprehensive guide to the evolving science of pharmacogenomics, the second edition can help students and clinicians acquire a deep understanding of this important new scientific field and become current with today's latest developments.

Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one's research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction.

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Unique analysis of drugs and poisons to facilitate testing in all laboratories even by inexperienced chemists

Includes source of chemicals needed for the experiments

Texts are composed by 67 experts in analyzing the respective compounds

Clear and uniform structure of chapters for ease of reading

The text is illustrated by many diagrams and tables

This 1984 book, part of the series Progress in Clinical Pharmacy, provides an authoritative account of developments in clinical pharmacy in Europe. It is prefaced by chapters on the American experience in clinical pharmacy education and on patient education. The book reports the proceedings of the twelfth European symposium on clinical pharmacy, held in Barcelona in October 1983. Two of the great challenges facing pharmacy were how better to educate pharmacists to fulfil a clinical or extended role in healthcare and how to meet an important part of such a role, that is the better education of patients in the use of medicines. These two complementary topics were the twin themes of this symposium. As well as papers on these themes, other articles on clinical pharmacy were presented and are published in these proceedings. The book will continue to interest any pharmacist contemplating the development of clinical pharmacy.

This 1983 book reports the proceedings of the eleventh European symposium on clinical pharmacy which was held in Brussels in October 1982. The theme of the symposium was the concept of the therapeutic team and the relative contributions and responsibilities of pharmacists, nurses and physicians to the planning and implementation of drug treatment regimens. The first section of the volume provides an introduction to the concept of the therapeutic team and reflects the views several medical professionals. The later sections cover the practice of the therapeutic team in parenteral nutrition, oncology, dermatology, epilepsy, internal medicine, nuclear medicine and drug selection. Not only did this book review achievements and experiences in clinical pharmacy, but it also looked towards the future of clinical pharmacy development in Europe. It will still be of significant interest to clinical pharmacy specialists today.

Integrating advances in molecular biology into bioprocesses presents a continuous challenge to scientists and bioengineers. This series is conceived to help meet this challenge. It examines and assesses the feasibility of new approaches for the modification of cellular function such as gene expression, protein processing, secretion, glycosylation, immortalisation, proliferation, and apoptosis as well as the systematic study of the metabolic genotype-phenotype relationship. The series provides detailed coverage of the methodology for improving cellular properties of cells used in the production of biopharmaceuticals, gene and cell therapies and tissue engineering. It also seeks to explain the cellular mechanisms underlying in vitro physiological activity and productivity. This volume, which is based on presentations at the European Workshop on Animal Cell Engineering' held in Costa Brava, Spain, contains a collection of chapters relating to cellular function and modification by leading authorities in several different areas of basic research and the biopharmaceutical industry.

A detailed examination of China 's increasingly important chemical and pharmaceutical industry. Numerous case studies describe how western companies, such as BASF, Bayer, Bicoll, Ciba, Degussa, DSM and Novartis are managing their market entry in China.

In Tumor Targeting in Cancer Therapy, Dr. Michel Page and a panel of authoritative experts from the drug industry, clinics, and academia introduce the principles and techniques of tumor targeting and critically survey their applications from laboratory to bedside. By concisely synthesizing the many technical details, the authors illuminate this innovative technique, ranging from the fundamentals of drug targeting and in vivo and in vitro experimentation, to such emerging therapeutic uses as radioimmunotherapy, radioimmunodetection, therapy with cytotoxic antibodies, immunotoxins, enzyme prodrug immunotherapy, and immunotherapeutics with fusion proteins. There are also reviews of targeting tumors with radioimmunoconjugates, photodynamic therapy, and magnetic drugs, as well as discussions of the internalization of antibodies, bioconjugation and biodistribution, the use of cytotoxic drugs, and the pros and cons of targeting by antibody or ligand.

A cutting-edge collection of readily reproducible in vitro and in vivo methods to elucidate the mechanisms associated with cannabinoid function in health and disease. The techniques can be used in studies across the board from genes to behavior. The molecular neurobiological methods are invaluable in analyzing the structure, the polymorphisms, and the molecular expression of the cannabinoid receptors (CBrs), as well as their association with polysubstance abuse. There are also methods for localizing cannabinoid receptors in different systems, visualizing cannabinoid effects using brain slice imaging and elctrophysiological approaches, and designing and synthesizing cannabinoids and endocannabinoids. The protocols follow the successful Methods in Molecular Medicine (TM) series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

In 1860, Oliver Wendell Holmes pointedly expressed himself to the Massachusetts Medical Society: "I firmly believe that if the whole Material Medica, as now used, could be sunk to the bottom of the sea, it would be all the better for mankind, and all the worst for the fishes." Should one think the same about the current approach in drug discovery from plants? Probably yes. Despite the spending of billions of US dollars, and three decades of efforts, high-throughput screenings have only allowed the discovery of a couple of drugs. One could have reasonably expected the discovery of an arsenal of drugs from the millions of plant extracts randomly tested, but "hits" can be inactive in vitro or too toxic, some molecules need to be metabolized first to be active, and false-positive and false-negative results are common. The bitter truth is that the robotic approach in discovering drugs from plants has proven, to date, its inability to excavate the hundreds of molecules that will contribute to the health progress of Man. However, one can reasonably see that the last patches of primary rainforest on earth hold still hundreds of spectacularly active drugs that await discovery.

Essential Spanish for Pharmacy, Fourth Edition is intended to be a supplemental quick reference to assist pharmacy professionals in interacting with Spanish-speaking patients. This book includes phrases, keywords, questionnaires, and pictograms to guide a Spanish-based conversation with a patient. It is best used by someone who has a basic understanding of the language and needs more guidance for pharmacy and medical-specific vocabulary. This book also includes basic phases for anyone to make a patient feel welcome with the additional use of a trained interpreter and other resources available.

"The streets of Vienna are paved with history of medicine," the famous Viennese writer and journalist Karl Kraus could have said. In fact, an attentive visitor cana (TM)t move through the city without being reminded by all the street names, historical buildings, monuments or memorial stones that Vienna has been a capital of medicine where students and doctors from all over the world came to learn.

This city guide is meant for all the visitors of this fascinating city, who are interested in the history of medicine. 15 walks through the city show the reader the traces of the old medical Vienna: the Foolsa (TM) Tower, Freuda (TM)s private practice and apartment, the workplaces of many famous physicians, through the Old General Hospital, the old university, or the most important pathological museums. Many unknown details and anecdotes are included as well as a short history of Vienna and some gourmet tips and the famous Viennese coffee shops for relaxing.

Mastery of pharmacokinetics is more important than ever. To exercise the best possible judgment in patient care, medication plans should be selected for the maximum efficacy and safety for each individual patient. Be confident in your approach with ASHP's Basic Applied Pharmacokinetics Self Assessment, a new resource from John E. Murphy, author of ASHP's Clinical Pharmacokinetics, Fifth Edition, which offers questions and exercises with answers and detailed solutions to help gauge your understanding. Whether you are a student, a new pharmacist, or a long-time practitioner, it is essential that you not only acquire and maintain your therapeutic knowledge, but also stay on top of new developments in pharmacokinetics. This is a valuable review book designed to test skills for using equations and the application of pharmacokinetic parameters. It is the perfect book to review content you have learned and practiced, in addition to learning new areas not previously covered in your training. As an added feature, the YouTube channel, Basic Applied Pharmacokinetics Self Assessment Videos, is available as a complementary companion to the book, which includes a library of videos created by John Murphy to help you through the major pain points and help further support your self assessment.

This is a comprehensive guide to applying research methods to practice problems. It uses case-based examples and activities rooted in practice to support development of knowledge, skills, and confidence in applying evidence-based research methods. An array of different methodologies and qualitative/quantitative methods are described. Examples of topics include distinction between methodologies and methods, ethics protocols, as well as design/implementation/data analysis/interpretation of findings using methods such as surveys, interviews, focus groups, observational research, database mining, text and document analysis, quality improvement (PDSA cycles), economic (cost/benefit) evaluations. Perfect for MPharm students doing their research thesis, but relevant to all bioscience students undertaking research projects. Use of pharmacy practice case examples (in community, hospital, ambulatory, primary care and other settings) throughout. Examples of how to tackle a research question from different perspectives, e.g. which is the best way to answer each question and why. Inter-professional practice and research emphasized. Self-assessment and self-reflection questions to help readers confirm their understanding/learning. Over 140 questions online. A one-stop research-method teaching resource for faculty. Free e-book with the print book on StudentConsult.

This book combines emulsion knowledge into a single, comprehensive volume, ideal for professionals and students involved in the areas of pharmaceutical science who are looking to learn about this emergent research concept. Compiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes