A comprehensive, state-of-the-art review of our current
understanding of the molecular and structural biology of 5-HT
receptors and their potential use for drug discovery. The authors
describe the anatomical, cellular, and subcellular distribution of
5-HT receptors and demonstrate a powerful approach to elucidating
their physiological role using knockout mice in which the 5-HT
receptors were deleted. They also review our understanding of the
physiological role(s) of 5-HT receptors based mainly on studies
performed in genetically engineered mice. Highlights include
discussions of the behavioral phenotypes of 5-HT receptor knockout
animals, the molecular biology and pharmacology of 5-HT receptors,
and insights into the complexity of 5-HT receptor signal
transduction.
General
| Imprint: |
HumanaPress
|
| Country of origin: |
United States |
| Series: |
The Receptors |
| Release date: |
November 2010 |
| First published: |
2006 |
| Editors: |
Bryan L Roth
|
| Dimensions: |
229 x 152 x 35mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
618 |
| Edition: |
Softcover reprint of hardcover 1st ed. 2006 |
| ISBN-13: |
978-1-61737-647-4 |
| Categories: |
Books >
Medicine >
Nursing & ancillary services >
Pharmacy / dispensing
Promotions
|
| LSN: |
1-61737-647-7 |
| Barcode: |
9781617376474 |
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