A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.

This book presents a contemporary view of pharmacy practice research covering theories, methodologies, models and techniques that are applicable. It has thirteen chapters covering the range of quantitative, qualitative, action research and mixed methods as well as management theories underpinning change in pharmacy practice. “Pharmacy Practice Research Methods” examines the evidence and impact as well as explores the future. Pharmacy practice is rapidly transforming and as such it is to be adaptable as student and academic researchers and to not only understand techniques and methodologies, but as champions to nurture the field. There is a literature in this area but few integrated texts which cover the wide range of pharmacy practice including methodologies, evidence, practice and policy. This book provides a solid foundation for exploring these phenomenon further, and is expected to serve as a valuable resource for academics, students, policy makers and professional organisations.

This "FASTtrack" book systematically reviews important concepts and facts relating to the delivery and targeting of drugs. Relevant examples of delivery systems are given throughout the book with a focus on delivery systems that have actually reached clinical reality.

This book introduces novel and groundbreaking theories on social medicine, social medicine therapy and pharmacogelotology. Aimed at improving the global health care system in terms of cost-effectiveness and efficiency, the research included in this book represents a paradigm shift from traditional drugs to social medicine. Tracing the history of social medicine, from Natural Healing Power (NHP), Oriental Medicine's vitalism, to Homeostasis (Natural Healing Strength) and Reciprocity (Social Healing Strength), the book first focuses on laying the theoretical foundations. It then highlights how social medicine can be specialized into various social medicine therapies (i.e., aromatherapy, stone therapy, diet therapy, exercise therapy, light therapy, etc.), just like stem cells. This is followed by arguments that 21st century pharmacy should be a harmonious system where the replacement of traditional drug products (i.e., herbal, chemical, and biological products) with new social medicine takes precedence. To that end, the author focuses on the '4+2 system' with 4 representing diet, body, stress, and facial-image control, and 2 representing the complementary and alternative medical methods of evacuation(-) and filling(+). In the context of pharmacogelotology, the book then goes on to present findings on theories of laughter and laughter therapy practices, which are systematically examined and described in detail. Finally, it calls for the development of social-medicine structures by governments that aim to help local authorities use their resources effectively, and for local governments to establish the long-term planning on social-medicine therapy for healthy ageing.

The Art, Science, and Technology of Pharmaceutical Compounding, 6th Edition has been completely revised and covers all aspects of pharmaceutical compounding. Featured are the regulations,technology, scientific foundation, and clinical consulting aspects of the dosage forms that can be compounded. It also contains example formulas for all dosage forms along with the ingredients, quantities, use of each ingredient, and instructions for preparation. In addition to formulation development including flavoring, sweetening, preservation and compliance and compatibility considerations, quality control and areas of potential errors are also presented. More than ever, there is a need for a practical compounding reference that integrates the science and practice of compounding while emphasizing the need for caution, innovation, and patient counseling. KEY FEATURES: Covers all aspects of nonsterile and sterile as well as nonhazardous and hazardous compounding. Blends the scientific and technologic aspects of compounding to support an understanding of the importance of each compounded dosage form. Presents different technologies for compounding various dosage forms, as well as example. Formulations for all dosage forms presented in the book. Features an entirely new chapter emphasizing the pharmacist's role in addressing incompatibilities and their potential clinical effects.

This authoritative Fourth Edition summarizes the advances of the past decade concerning the structure, mechanism, and biochemistry of cytochrome P450 enzymes, with sufficient coverage of earlier work to make each chapter a comprehensive review of the field. Thirteen chapters are divided into two detailed volumes, the first covering the fundamentals of cytochrome P450 biochemistry, as well as the microbial, plant, and insect systems, and the second exclusively focusing on mammalian systems. Volume 1 begins with an exploration of the biophysics and mechanistic enzymology of cytochrome P450 enzymes, with a discussion of the structures of P450 enzymes and their electron donor partners, the mechanisms of oxygen activation and substrate oxidation, and the approaches and nature of cytochrome P450 inhibition. Two more chapters discuss the nature and roles of cytochrome P450 enzymes in microbes, plants and insects, and an eighth chapter is a survey of the potential utility of P450 enzymes in biotechnology. The first chapter of Volume 2 examines the roles of P450 enzymes in mammals, mainly humans. Four further chapters then deal with the genetic and hormonal regulation of P450 enzymes and their specific roles in the processing of sterols and lipids. Cytochrome P450: Structure, Mechanism, and Biochemistry is a key resource for scientists, professors, and students interested in fields as diverse as biochemistry, chemistry, biophysics, molecular biology, pharmacology and toxicology.

Hospital Pharmacy outlines the changes in pharmacy practice within the hospital setting and discusses the vast range of services that are provided. Each chapter is devoted to an area of pharmacy practice and discusses its history, current practice and future developments. This new edition has been completely revised and updated and includes new chapters on: pharmacy in the acute independent sector; controlled drugs in hospital pharmacy; pharmacist prescribing; mental health; and consultant pharmacists. This book is essential reading for pharmacy undergraduates, pre-registration graduates and newly qualified pharmacists as well as a key reference text for all hospital pharmacists departments. With its broad all-encompassing coverage it will also be of interest to other healthcare professionals.

The syringe driver is a simple and cost-effective method of delivering a continuous subcutaneous infusion (CSCI). A CSCI provides a safe and effective way of drug administration and can be used to maintain symptom control in patients who are no longer able to take oral medication. There have been several developments in this field since the third edition of this highly successful book. The text in this edition has been completely revised, incorporating new treatment options and an extensive list of new compatibility data. This book serves as a valuable reference source, providing comprehensive review of syringe driver use and administration of drugs by CSCI. The first chapter provides an overview of syringe drivers and CSCIs, including a useful array of frequently asked questions. The second chapter provides information about the chemistry of drug incompatibility and degradation. The third chapter comprises revised and referenced information relating to most drugs likely to be administered by CSCI using a syringe driver. The fourth chapter discusses the control of specific symptoms that are often encountered when CSCIs are required. The fifth and final chapter contains an extensive, referenced list of compatibility and stability data relating to drug combinations administered by CSCI.

Medicines Use Reviews: A practical guide provides evidence-based information, tips and guidance on how to conduct successful Medicines Use Reviews (MURs). The ten main chapters identify and discuss specific medical conditions seen in community pharmacy while further sub chapters include advice on treatment options and relevant practical tips. This comprehensive book also includes: an overview of MURs; explanation of the accreditation process; advice on MUR form documentation; guidance on providing a patient-focused service. This excellent reference will enable pharmacists to provide high quality advice to patients. It will be invaluable for all pharmacists carrying out MURs, pre-registration and newly registered pharmacists, clinical pharmacy students, accredited pharmacists setting up a MUR service, pharmacy students and lecturers in pharmacy practice.

Pharmacists have been responsible for compounding medicines for centuries. Although most modern medicines are not compounded in a local pharmacy environment, there are still occasions when it is imperative that pharmacists have this knowledge. Pharmaceutical Compounding and Dispensing provides a comprehensive guide to producing extemporaneous formulations safely and effectively. The book covers three core sections: the history of compounding; pharmaceutical forms and their preparation; product formulae. This is a modern, detailed and practical guide to the theory and practice of extemporaneous compounding and dispensing. Fully revised and updated, this new edition will be an indispensable reference for pharmacy students and practicing pharmacists. Supplementary videos demonstrating various dispensing procedures can be viewed online.

This book provides a comprehensive introduction to advanced drug delivery and targeting, covering their principles, current applications, and potential future developments. This edition has been updated to reflect significant trends and cutting-edge advances that have occurred since the first edition was published. All the original chapters have been retained, but the material therein has been updated. Eight new chapters have been added that deal with entirely new technologies and approaches. Features: Offers a comprehensive introduction to the fundamental concepts and underlying scientific principles of drug delivery and targeting Presents an in-depth analysis of the opportunities and obstacles afforded by the application of nanotechnologies for drug delivery and targeting Includes a revised and expanded section on the major epithelial routes of drug delivery currently under investigation Describes the most recent, emerging, and innovative technologies of drug delivery Provides real-life examples of the clinical translation of drug delivery technologies through the use of case studies Discusses the pertinent regulatory hurdles and safety issues of drug delivery and targeting systems-crucial considerations in order to achieve licensing approval for these new technologies

Are your exams coming up? Are you drowning in textbooks and lecture notes and wondering where to begin? Take the FASTtrack route to study successfully for your examinations. FASTtrack provides the ultimate lecture notes and is a must-have for all pharmacy undergraduate students wanting to revise and test themselves for forthcoming exams. Law and Ethics focuses on what pharmacy students really need to know in order to pass exams providing concise, bulleted information, key points, and an all-important self-assessment section which includes MCQs. Pharmacy law and ethics, along with the knowledge of drugs and their uses, forms the foundation upon which professional pharmacy practice is built. This FASTtrack book aims to cover key legislation affecting pharmacy and the pharmacist practitioner, including how laws are made, how they come into effect and are enforced. It is an invaluable resource either as a study aid or as a companion to the established textbook, Dale and Appelbe's Pharmacy Law and Ethics and Medicines, Ethics and Practice. Covering all areas of the pharmacy degree, the first titles in the series include: Applied Pharmaceutical Practice (based on the textbook of the same name) Complementary and Alternative Medicine (based on the textbook of the same name) Law and Ethics in Pharmacy Practice (due March 2010) Managing Symptoms in the Pharmacy Pharmaceutical Compounding and Dispensing (based on the textbook of the same name) Pharmaceutics - Dosage Form and Design Pharmaceutics - Drug Delivery and Targeting Pharmacology Physical Pharmacy

Handbook of Extemporaneous Preparation is a comprehensive and easy-to-follow guide to good practice in extemporaneous compounding. It incorporates the key findings and outputs from the UK National Advisory Board study, including advice on purchasing unlicensed medicines. It will be adopted as the standard for extemporaneous dispensing for NHS patients. Although the standards set out in this book are primarily written for implementation in NHS hospitals, the principles should be equally applied across the profession internationally. Written in two parts, this book provides: standards for extemporaneous dispensing; stability summaries for the 50 most commonly prepared extemporaneously prepared medicines in NHS hospitals. Compounding of pharmaceutical formulations remains a core skill of pharmacists and is taught at undergraduate level. Written by experts in the field with input from the UK NHS Pharmaceutical Quality Assurance Committee, this book will be an invaluable reference for any clinical or procurement pharmacist, pharmacy technician or student involved with extemporaneous preparation.

MCQs in Pharmaceutical Calculations aims to help pre-registration trainees and pharmacy students with their study enabling them to perform calculations accurately and with confidence. Pharmacists frequently perform simple calculations as part of their professional practice. It is therefore vital that they are able to employ basic numeracy skills accurately so as not to compromise patient safety. The pharmaceutical societies of Great Britain and Northern Ireland (RPSGB and PSNI) have introduced compulsory calculations elements into the registration examinations. These sections must be passed independently of the rest of the examination. Many Schools of Pharmacy worldwide have also recently increased their emphasis on numeracy skills. It includes: * 360 calculations questions in three commonly used multiple choice formats * questions based on important areas in pharmaceutical science and practice: * manipulation of formulae and dilutions * dosing * pharmacokinetics * formulation and dispensing * pharmaceutical chemistry * descriptive answers giving the reasoning behind the answers Note: This book is accompanied by an additional 100 calculation-based multiple choice questions, arranged into five 1-hour tests, which will be available from the Pharmaceutical Press FASTtrack website. Importantly, these questions are available in the format of both The Royal Pharmaceutical Society and the Pharmaceutical Society of Northern Ireland registration examinations. The fourth title in the Tomorrow's Pharmacist series, MCQs in Pharmaceutical Calculations, will be indispensable to pre-registration trainees and pharmacy students to help them prepare for their future career. Also available in this series: Hospital Pre-registration Pharmacist Training Pre-registration Interview, The Registration Exam Questions

After the successful introduction of acupuncture to the West, recent advances in analytical methods in chemistry, molecular biology and systems biology - especially the development of the "omic" technologies - have again brought Chinese drugs into the focus of research on Traditional Chinese Medicine (TCM). With more than 1000 publications on the chemistry, molecular biology and pharmacology of TCM drugs in international journals over the last 10 years, Chinese drugs are gaining increasingly reputation and impact. These data offer great opportunities for the development of new pharmaceuticals for various clinical applications. International scientists have compiled relevant and trend setting research results in this book. Topics range from the latest methods of quality and safety assurance by chemical and genetic fingerprints to the development of new pharmaceuticals for a future evidence-based therapy e.g. for cancer, cardiovascular, inflammatory or infectious diseases as well as to recent experimental results on multitarget and synergy research for the preparation of multi-extract-pharmaceuticals from TCM.

Completed revised and updated, Radiopharmaceuticals in Nuclear Pharmacy and Nuclear Medicine, 4th Edition is the radiopharmaceutical bible for nuclear pharmacists, nuclear medicine physicians, and nuclear medicine technologists. Useful in educational programs across these disciplines, it also serves as a key reference in preparation for specialty board examination in nuclear medicine and nuclear pharmacy. The book contains essential information required by state and federal radiation licensing organization for specialty practitioners preparing to become authorized nuclear pharmacists or authorized nuclear medicine physicians. KEY FEATURES: All chapters are entirely reorganized and revised to reflect the latest developments in the field Chapters new to the fourth edition cover of range of topics including Adverse Reactions to Radiopharmaceuticals, Pregnancy and Pediatrics, Localization Mechanisms of Radiopharmaceuticals, Non-Radioactive Pharmaceuticals, PET Manufacturing, and Radiopharmaceutical Distribution Over 500 figures and 200 tables-many in full-color-underscore key concepts

The sixth edition of PharmacyPractice brings the contents completely up to date, reflecting emerging new roles for pharmacists both within the traditional employment areas of hospital and community pharmacy, as well as other developing roles supporting the public health agenda, governance, risk management, prescribing and pharmaco-economics. Each chapter begins with Study Points and ends with Key Points to reinforce learning. Appendices include medical abbreviations, Latin terms and abbreviations, systems of weights and measurements and presentation skills. Some chapters also carry self-assessment questions for more complex areas of pharmaceutical practice. New editor on the team, Louise Cogan. Many new contributors, comprising practising pharmacists, teachers of pharmacy, and pharmacists with joint appointments between hospital/community pharmacy and universities. Now with companion e-book included on StudentConsult New chapters on Consent History Taking/ Gathering Information Advice giving and the pharmacist as a Health Trainer Using calculations in pharmacy practice Continuing professional development and revalidation Intra and inter professional working, The role of the pharmacist in medicines optimization

Are your exams coming up? Are you drowning in textbooks and lecture notes and wondering where to begin? Take the FASTtrack route to successful study for your examinations. FASTtrack is a new series of indispensable revision/study guides created especially for pharmacy students. Each book focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples. The FASTtrack series provides the ultimate lecture notes and is a must-have for all pharmacy students wanting to revise and test themselves for forthcoming exams. Therapeutics is a basic study guide in therapeutics and will cover all the main systems of the body with a summary of therapeutics in these areas. Covering all areas of the pharmacy degree, the first titles in the series include: Applied Pharmaceutical Practice (due September 2009) Complementary and Alternative Medicine Managing Symptoms in the Pharmacy Pharmaceutical Compounding and Dispensing (based on the textbook of the same name) Pharmaceutics - Dosage Form and Design Pharmaceutics - Delivery and Targeting (due August 2009) Pharmacology (due August 2009) Physical Pharmacy (based on Florence & Attwood's Physicochemical Principles of Pharmacy) Therapeutics

A thorough guide for readers to quickly gain an update on standard diagnosis and treatment methods for axial spondyloarthritis. Approximately 80 illustrations and images are used throughout the text to exemplify the disease and diagnostic and treatment algorithms. Easily accessible text and tables review the current treatment recommendations and emerging treatment options based on recent clinical trials.

This is a no-nonsense guide to drug treatment in the intensive care unit. It covers the most commonly encountered conditions and is organized by system. Management of each condition is tersely outlined step-by-step in table format. The book also includes non-drug information that is essential to making informed, evidence-based pharmacotherapy decisions, such as risk scores, scales, and assessment tools. The Second Edition has been revised to reflect the latest critical care practice guidelines and up-to-date drug and non-drug information.

Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

ASHP's significantly updated 4th edition of our widely popular Preceptor's Handbook for Pharmacists expands the content to include current challenges and issues impacting preceptors since fundamental changes have occurred that greatly affect modern practice including: The onboarding process Wellness and resiliency Misconduct and inappropriate behaviors Teaching across diverse student populations Ethics To be an effective preceptor, a pharmacist should exhibit clinical competency skills, possess excellent communication skills, and also demonstrate humanistic skills. This edition includes perspectives from across the country and from different or unique practice programs to bring a wide variety of expertise to this edition. The intent is for this book to be reflective on broad practice guidelines.

Whilst most pharmacy undergraduate texts are subject specific, "Pharmacy Case Studies" encourages students to take an integral approach to pharmacy via a series of pharmacy cases. Knowledge gained within the individual areas of law and ethics, pharmaceutics, pharmacology and pathology are tested by each example, bringing together all areas taught on the degree course. Each chapter contains five case studies, starting with uncomplicated cases and increasing in complexity as they expand.

The biologics market continues to witness an impressive rate of growth and the monoclonal antibody market, in particular, has contributed remarkably to the expansion of this segment within the pharmaceutical industry. In 2006, close to 80% of the annual biologics growth rate in the United States (US) was attributed to cancer and anti-TNF antibodies, with increases in growth of 56% and 25%, respectively, compared to those in the previous year. Additionally, the monoclonal antibody sector is anticipated to achieve a growth rate of approximately 14% by 2012, easily outstripping the predicted 0.6% growth rate in the small molecules market. The robust late-stage antibody pipeline within the biotech sector has drawn an increasing amount of interest from the large pharmaceutical industry and has triggered the largest product and platform deals in 2006, with values more than $2.1 and $5.1 billion in partnering and mergers and acquisitions, respectively. Additionally, with the forthcoming emergence of biogenerics, next-generation bio-improved antibodies have drawn much attention and increasingly contribute to the growth of the biologics segment. As next-generation monoclonal antibodies confront their first-generation rivals, it is critical that these next-generation products offer a clear differentiating advantage against the existing competition. Successful strategies for the development of monoclonal antibodies require integration of knowledge with respect to target antigen properties, antibody design criteria such as affinity, isotype selection, Fc domain engineering, pharmacokinetic and pharmacodynamic (PK/PD) properties, antibody cross-reactivity across species, market differentiation opportunities for the first- and next-generation leads, and regulatory requirements from the early stages of antibody development. Biophysical measurements are one of the critical components necessary for the design of effective translational strategies for lead selection and evaluation of relevant animal species for preclinical safety and efficacy studies. Incorporation of effective translational strategies from the early stages of the antibody development process is a necessity, and when considered, it not only reduces development time and cost, but also fosters implementation of rational decision-making throughout all phases of antibody development. Translational strategies for development of antibody-based therapeutics should allow understanding of the relationship between the unit dose and unit effect with respect to both beneficial and deleterious effects from early stages of development. The flow of information from later to earlier stages of development should provide opportunities to facilitate selection of more effective and novel next-generation drug candidates. Selection and evaluation of relevant biomarkers in early preclinical development in relevant animal models should allow for identifying potential risks to humans and establishing safe First-In-Human (FIH) dosing strategies. Hence, integration of knowledge with respect to target antigen properties such as antigen distribution, expression profile, kinetic properties, target pharmacology, antigen isoforms and pharmacological redundancy in health and disease, as well as antibody design criteria, such as antibody isotype, affinity, PK/PD and safety is a critical necessity for the design of effective translational strategies. Additionally, these factors will further offer critical differentiating characteristics for next-generation antibodies, and novel technologies prove instrumental in generation of bio-improved antibody candidates for market entry. This book will examine many important considerations necessary for the design of effective translational strategies during the development of antibody-based therapeutics."