Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals. In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books. Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.

Emergence of Pharmaceutical Industry Growth with Industrial IoT Approach uses an innovative approach to explore how the Internet of Things (IoT) and big data can improve approaches, create efficiencies and make discoveries. Rapid growth of the IoT has encouraged many companies in the manufacturing sector to make use of this technology to unlock its potential. Pharmaceutical manufacturing companies are no exception to this, as IoT has the potential to revolutionize aspects of the pharmaceutical manufacturing process, from drug discovery to manufacturing. Using clear, concise language and real world case studies, this book discusses systems level from both a human-factors point-of-view and the perspective of networking, databases, privacy and anti-spoofing. The wide variety of topics presented offers readers multiple perspectives on a how to integrate the Internet of Things into pharmaceutical manufacturing.

Integrating advances in molecular biology into bioprocesses presents a continuous challenge to scientists and bioengineers. This series is conceived to help meet this challenge. It examines and assesses the feasibility of new approaches for the modification of cellular function such as gene expression, protein processing, secretion, glycosylation, immortalisation, proliferation, and apoptosis as well as the systematic study of the metabolic genotype-phenotype relationship. The series provides detailed coverage of the methodology for improving cellular properties of cells used in the production of biopharmaceuticals, gene and cell therapies and tissue engineering. It also seeks to explain the cellular mechanisms underlying in vitro physiological activity and productivity. This volume, which is based on presentations at the European Workshop on Animal Cell Engineering' held in Costa Brava, Spain, contains a collection of chapters relating to cellular function and modification by leading authorities in several different areas of basic research and the biopharmaceutical industry.

Encyclopedia of Pharmacy Practice and Clinical Pharmacy, Three Volume Set covers definitions, concepts, methods, theories and applications of clinical pharmacy and pharmacy practice. It highlights why and how this field has a significant impact on healthcare. The work brings baseline knowledge, along with the latest, most cutting-edge research. In addition, new treatments, algorithms, standard treatment guidelines, and pharmacotherapies regarding diseases and disorders are also covered. The book's main focus lies on the pharmacy practice side, covering pharmacy practice research, pharmacovigilance, pharmacoeconomics, social and administrative pharmacy, public health pharmacy, pharmaceutical systems research, the future of pharmacy, and new interventional models of pharmaceutical care. By providing concise expositions on a broad range of topics, this book is an excellent resource for those seeking information beyond their specific areas of expertise. This outstanding reference is essential for anyone involved in the study of pharmacy practice.

Pharmacy Registration Assessment Questions 3 follows on from the previous, highly popular Pharmacy Registration Assessment Questions. It features more than 400, entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own. All the questions are in line with current GPhC guidance on the preregistration exam. This invaluable tool will not only help you familiarise yourself with the current style of questions, but will also enable you to revise ahead of your exams. Questions are based on print versions of BNF 76 and BNF for Children 2018-2019, alongside the most current treatment guidelines available at the time of writing the book. This book also includes questions featuring prescriptions, patient information and pictorial representation of conditions, replicating the type of questions you may encounter in the real exam. This revision aid gives you the opportunity to practice a variety of question styles ahead of the assessment including: - single best answer questions - extended matching questions - calculations This volume is written by a team of experienced authors who all work with pre-reg pharmacists every day and includes questions that are practical and will truly challenge you. In essence, this book is your handy guide to prepare for your exams. Nadia Bukhari is Senior Teaching Fellow in Pharmacy Practice & Pre-Registration Co-ordinator at the UCL School of Pharmacy. She is also the chairwoman for the Royal Pharmaceutical Society Pre-Registration conferences.

Pharmaceutical Quality by Design: Principles and Applications discusses the Quality by Design (QbD) concept implemented by regulatory agencies to ensure the development of a consistent and high-quality pharmaceutical product that safely provides the maximum therapeutic benefit to patients. The book walks readers through the QbD framework by covering the fundamental principles of QbD, the current regulatory requirements, and the applications of QbD at various stages of pharmaceutical product development, including drug substance and excipient development, analytical development, formulation development, dissolution testing, manufacturing, stability studies, bioequivalence testing, risk and assessment, and clinical trials. Contributions from global leaders in QbD provide specific insight in its application in a diversity of pharmaceutical products, including nanopharmaceuticals, biopharmaceuticals, and vaccines. The inclusion of illustrations, practical examples, and case studies makes this book a useful reference guide to pharmaceutical scientists and researchers who are engaged in the formulation of various delivery systems and the analysis of pharmaceutical product development and drug manufacturing process.

Pharmaceutical Care in Digital Revolution demonstrates how blending human and digital pharmaceutical care can establish optimal Apothecary Intelligence (AI). Organized into four parts, it examines digital health advances that will synergize the pharmaceutical care process and prepares stakeholders for a dynamic future, fueled with innovation. Beginning with the global picture on health care systems, patients' expectations, and current pharmaceutical care practices, the book covers details of relevant digital technologies as well as compliance, ethical, educational, and cultural aspects to take successful steps towards digital pharmaceutical care. The text includes links to lectures and technology facts, tutorials on how to implement advances in your own working environment, and examples of stakeholders who are successful in building synergy between digital and pharma. Pharmaceutical Care in Digital Revolution is a practical resource to equip pharmaceutical care stakeholders, such as pharmacists, physicians, pharmacy technicians, and students as well as those in surrounding ecosystems like payers or regulators. It is a crucial reference to understand how technological innovation is changing the paradigm in which we provide current and future pharmaceutical care and how to keep it accessible, affordable, and sustainable.

The aim of this unique volume is to help medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables the researcher-with no background in statistics-to determine sample size and write statistical considerations for their protocols. It provides critical language which can help with FDA submissions and/or research grants. It also provides the mathematical justification of the material at a level consistent with one year of undergraduate mathematical statistics. It presents survival analysis methods at a more elementary level than any known text. Filled with tables, figures, plus an extensive appendix, this one-of-a-kind reference is an absolute must for all clinical researchers and biostatisticians.

This book provides an up to date review on antimicrobials dosing in obese patients, including practice recommendations for clinical use. The book is written by a group of doctors and pharmacists working in infectious diseases practice and research. The introductory chapter outlines the important physiological changes in obesity including factors affecting the dosing of antimicrobials in obese patients. The introductory chapter is followed by ten chapters covering the major classes of antibiotics, antifungals, and antivirals. Each chapter briefly discusses the pharmacokinetics changes related to obesity and a summary of the relevant up-to-date literature. Specific dosing recommendations are provided for each class supplemented by real-life examples as clinical cases that are included as an appendix to the book. The book is a useful resource for clinicians, students and researchers needing up-to-date information on antimicrobial dosing in obese patients. Doctors, pharmacists, nurses working in hospital settings, and students of health courses (medical, pharmacy and nursing students) will find this book particularly useful.

Pharmacy Registration Assessment Questions 2 follows on from the previous, highly popular Pharmacy Registration Assessment Question. If features more than 400, entirely new, closed book and calculation questions. It can be used in conjunction with the previous volume or on its own. All the questions are in line with current GPhC guidance on the preregistration exam. This invaluable tool will not only help you familiarise yourself with the current style of questions, but will also enable you to revise ahead of your exams. Questions are based on BNF74 and BNF for Children 2017-2018, alongside the most current treatment guidelines available at the time of writing the book. This book also includes questions featuring prescriptions, patient information and pictorial representation of conditions, replicating the type of questions you may encounter in the real exam. This revision aid gives you the opportunity to practice a variety of question styles ahead of the assessment including: single best answer questions extended matching questions calculations This volume is written by a team of experienced authors who all work with pre-reg pharmacists every day and includes questions that are practical and will truly challenge you. In essence, this book is your handy guide to prepare for your exams. Nadia Bukhari is Senior Teaching Fellow in Pharmacy Practice & Pre-Registration Co-ordinator at the UCL School of Pharmacy. She is also the chairwoman for the Royal Pharmaceutical Society Pre-Registration conferences.

This new edition of Non-prescription Medicines has been revised and updated to reflect amendments in legal category status of several products from prescription-only (POM) to pharmacy sale (P) status. Over-the-counter (OTC) medicines currently available in the UK are reviewed in alphabetically arranged chapters on the conditions that they are licensed to treat. Each chapter includes: an introduction to the condition; - detailed description of the available products - mode of action - side-effects, cautions and contraindications - interactions and dosage; - product selection points and product recommendations. Non-prescription Medicines is the only publication in the UK that deals with available OTC medicines comprehensively and in depth. This vital resource will enable pharmacists, GPs, nurses and other healthcare professionals to make well-informed recommendations and to give sound advice to their patients.

Cannabis is one of the oldest cultivated plants dating back 12,000 years and demonstrates medicinal properties including immune support, anti-inflammatory effects, and cancer-fighting potential. As cannabis receives regulatory approval in the United States, clinicians will need guidelines to prescribe medical marijuana for various health conditions. This book presents information to healthcare professionals focusing on medical cannabis. It is a science-based overview providing clinical recommendations and dosing guidelines for practitioners to advise patients appropriately. Features: Discusses the endocannabinoid system role in homeostasis, pain control, and regulatory function in health and disease Advises clinicians on cannabis use in patients with cancer; cardiovascular, brain, and liver function; mood disorders; and patients receiving palliative care Includes information on cannabis nutrition as well as the cannabis microbiome Features information on cannabis quality control for safe and effective delivery Cannabis: A Clinician's Guide is written for clinicians providing a resource guide to help them assess the medicinal value of cannabis, answer patient and consumer questions, and recommend its use optimally. The book is divided into three sections covering cannabis science, use in clinical practice, and regulations and standards. It includes practical information on dosing guidelines and dispensary insights, personal cannabis stories, and an in depth look at the nutritional benefits of cannabis and how to use it in daily life. From the Author: "As a clinical nutritionist, I have been involved in the use of cannabis since 1981 while researching diabetes in India. Ayurvedic medicine listed cannabis as a beneficial herb with curing properties. In 1983, a Chinese medicine doctor in the Peoples Republic of China gave me a cannabis herbal supplement for sleep that he claimed Chairman Mao took regularly. Upon returning to the United States, no one would even talk to me about cannabis because of its Schedule I status. During an Antioxidants class taught for Everglades University, I included information on cannabis, but was restricted from including it in the course description. Cannabis: A Clinician's Guide unveils deceit on this herbal medicine used for thousands of years providing insight into the science behind its use and how to incorporate cannabis into daily life, especially for those suffering from neurological disorders, cancer, and mood disorders."

View the Table of Contents. Read the Introduction.

aThese challenging essays mark the transformation of medication from a tradition of need assessed by physicians, to a culture that far exceeds a basic threshold for drugs on demand on the part of the public.a
--"Choice"

"Nowhere do pharmaceutical companies sell more drugs, make more money, affect more lives, or wield more power than in the United States. These sophisticated but accessible essays trace the history of eight types of prescription blockbusters, from antibiotics to Viagra, and show how they have changed Americans' thinking about disease, consumer rights, and normality itself. They force us to confront the paradox of a pill-taking society that wages war on some drugs but avidly seeks out others to economically profitable if not always therapeutically benign effect."
--David Courtwright, author of "Forces of Habit" and "Dark Paradise"

aA set of fascinating case studies. . . . Anyone who has taken prescription medications can benefit by reading it.a--"Metapsychology Online Reviews"

With Americans paying more than $200 billion each year for prescription pills, the pharmaceutical business is the most profitable in the nation. The popularity of prescription drugs in recent decades has remade the doctor/patient relationship, instituting prescription-writing and pill-taking as an integral part of medical practice and everyday life.

Medicating Modern America examines the meanings behind this pharmaceutical revolution through the interconnected histories of eight of the most influential and important drugs: antibiotics, mood stabilizers, hormone replacement therapy, oral contraceptives, tranquilizers, stimulants, statins, and Viagra. All of these drugs have been popular, profitable, influential, and controversial, and the authors take a historical approach to studying their development, prescription, and consumption. This perspective locates the histories of prescription medicines in specific cultural contexts while revealing the extent to which contemporary debates about pharmaceutical drugs echo concerns voiced by Americans in the past.

Exploring the rich and multi-faceted history of pharmaceutical drugs in the United States, Medicating Modern America unveils the untold stories behind America's pharmaceutical obsession.

Contributors include: Robert Bud, Jennifer R. Fishman, Jeremy A. Greene, David Healy, Suzanne White Junod, Ilina Singh, Andrea Tone, and Elizabeth Siegel Watkins.

Pharmacy Education in the Twenty First Century and Beyond: Global Achievements and Challenges offers a complete reference on global pharmacy education, along with a detailed discussion of future issues and solutions. This book begins with a brief overview of the history of pharmacy education, covering all levels of education and styles of learning, from undergraduate, continuing professional education, and methods for self-learning and development. Teaching strategies such as team-based learning, problem-based learning and interdisciplinary education are also described and compared to conclude why certain pharmacy programs attract students, and why educators prefer particular teaching strategies, assessment tools and learning styles. As a result, this book provides pharmacy educators, administrators, students and practitioners with a comprehensive guide to pharmacy education that will enable readers to choose the best approaches to improve, reform or select a program based on worldwide experience and the latest available evidence and research.

This important book introduces pharmacists and pharmacy students to the basics of disaster and emergency management, illustrating not only the different roles that pharmacists can play within any disaster or emergency, but the practical steps they can take to prepare for these events. Starting with the UN-recognised Sendai Framework for disaster risk reduction, the book introduces the key concepts and models that pharmacists should understand, before detailing the place of pharmacists within each stage of an emergency or disaster. It also includes interviews with experts in disaster management, shedding light not only on the place of pharmacy within disaster and emergency management, but also the challenges and barriers involved in fulfilling this role. Concluding with practical advice and guidance, as well as how the lessons of disaster and emergency management can inform the everyday role of pharmacists within wider community healthcare, this will be essential reading for both professionals and students in the field.

Remington Education: Drug Information & Literature Evaluation teaches students how to effectively and efficiently locate and analyze up-to-date drug information and literature. It succinctly examines key drug information and literature-evaluation principles - the proper approach for answering drug/health information questions, tertiary and secondary resources, and practice guideline, systematic reviews and meta-analyses. Every chapter includes self-assessment questions; answers are located at the back of the book.

Now fully updated for its fourth edition, Pharmacy: What It Is and How It Works continues to provide a comprehensive review of all aspects of pharmacy, from the various roles, pathways and settings of pharmacists to information about how pharmacy works within the broader health care system. Beginning with a brief historical perspective on the field, the book discusses the many facets of the pharmacy profession. It describes the role of pharmacists in different settings and provides information ranging from licensing requirements to working conditions, highlighting the critical role of pharmacists within the health care system. The author examines the drug use process with sections on distribution, prescribing, dispensing, and pricing. He also discusses the role of pharmacy support personnel. A chapter on informatics explores how pharmacy has evolved through information technology and automation. Additional chapters cover poison control, pharmaceutical care, pharmacy organizations, the drug approval process, and career development. Designed for classroom and professional use, the book contains numerous tools to facilitate comprehension, including: Learning objectives to help readers focus on the goals of each chapter Informative tables and figures summarizing data Summary paragraphs tying in salient points Discussion questions and exercises to test assimilation "Challenges" which place the material in broader context Websites and references to encourage further study This valuable text provides a look into the profession that is both broad and deep, supplying a one-stop introduction to a promising career in pharmacy.

Until the latter part of the 19th century, the majority of known drugs were either herbs or extracts of active ingredients from botanical sources. At this point, the world witnessed two major cornerstone achievements that laid the foundation of modern drug discovery and development: the emergence of pharmacology as a contemporary science through the work of Schmiedeberg (considered by many as the father of modern pharmacology) at the University of Strasbourg, and Woehler's landmark synthesis of urea from ammonium cyanate (the first synthesis of an 'organic' molecule from an 'inorganic' source) which heralded the birth of modern organic chemistry. Drug discovery has evolved from relying on luck, accident and serendipity to a complex endeavor that is at the interface of several disciplines (e.g. pharmacology, biology, chemistry), and is built on the understanding of mechanisms and causes of diseases. This book is produced to celebrate the evolution of drug discovery and development. It will prove useful to synthetic organic chemists in both pharmaceutical industry and in academia, and can serve as a teaching tool to students who want to learn and understand the processes and challenges of drug discovery and development with real examples from top pharmaceutical companies. The chapters contain citations of a large number of valuable selected references to the primary literature. The book highlights the tireless efforts of discovery and process chemists, and their roles in the advancement of drug discovery and development. The chapters presented in this book are written by a selected group of outstanding, very accomplished medicinal and process chemists with noted experiences and diverse backgrounds, representing some of the top pharmaceutical companies. The chapters highlight examples of emerging concepts, new developments and challenges arising in the discovery of new drug candidates and the development of new practical synthetic chemistry processes to produce these drug candidates on large scale. The discovery of each drug or drug candidate is presented by the discovery chemist(s) and the process chemist(s) who developed the drug. These writing teams describe the drug's development to give the reader a complete story of drug discovery and development.

Pharmaceutical Medicine and Translational Clinical Research covers clinical testing of medicines and the translation of pharmaceutical drug research into new medicines, also focusing on the need to understand the safety profile of medicine and the benefit-risk balance. Pharmacoeconomics and the social impact of healthcare on patients and public health are also featured. It is written in a clear and straightforward manner to enable rapid review and assimilation of complex information and contains reader-friendly features. As a greater understanding of these aspects is critical for students in the areas of pharmaceutical medicine, clinical research, pharmacology and pharmacy, as well as professionals working in the pharmaceutical industry, this book is an ideal resource.

Social and Administrative Aspects of Pharmacy in Low- and Middle-Income Countries: Present Challenges and Future Solutions examines the particularities of low- and middle-income countries and offers solutions based on their needs, culture and available resources. Drawing from the firsthand experience of researchers and practitioners working in these countries, this book addresses the socio-behavioral aspects of pharmacy and health, pharmacoeconomics, pharmaceutical policy, supply management and marketing, pharmacoepidemiology and public health pharmacy specific to low- and middle-income countries. While some practices may be applied appropriately in disparate places, too often pharmacy practice in low- and middle-income countries is directly copied from successes in developed countries, despite the unique needs and challenges low- and middle-income countries face.

Lippincott (R) Connect Featured Title Purchase of the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. The most trusted source on the subject available today, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems, 12th Edition equips pharmacy students with everything they need to master the intricacies of pharmaceutical dosage form design and production and achieve successful outcomes in their courses and beyond. Reflecting the latest CAPE, APhA, and NAPLEX (R) competencies, this trusted, extensively updated resource clarifies the interrelationships between pharmaceutical and biopharmaceutical principles, product design, formulation, manufacture, compounding, and the clinical application of the various dosage forms in patient care, as well as regulations and standards governing the manufacturing and compounding of pharmaceuticals. New and revised content throughout keeps students up to date with current approaches to key coverage areas, and additional case studies demonstrate concepts in action to reinforce understanding and prepare students for the clinical challenges ahead. NEW! Patient counseling content in each chapter helps students confidently address this increasing role for pharmacists. UPDATED! Content familiarizes students with the latest practices and approaches to pharmaceutical dosage form design and production, including emerging topics such as biologics. UPDATED! Additional clinical case studies demonstrate pharmaceutical concepts in a real-world context and ready students for practice. UPDATED! Chapter review questions test students' retention and understanding of key content. Clinical emphasis ensures the scientific understanding and practical application for success in practice. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.

Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines. This revision aid will not only help you familiarise yourself with the new style of questions, but will also enable you to revise ahead of your exams. Questions are based on BNF72 and BNF for Children 2016-2017, alongside the most current treatment guidelines available at the time of writing the book. This book also includes questions featuring prescriptions, patient information and pictorial representation of conditions, replicating the type of questions you may encounter in the real exam. This revision aid gives you the opportunity to practice a variety of question styles ahead of the assessment including: single best answer questions extended matching questions calculations This volume is written by a team of experienced authors who all work with pre-reg pharmacists every day and includes questions that are practical and will truly challenge you. In essence, this book is your handy guide to prepare for your exams. All the best for your exam! Nadia Bukhari is Senior Teaching Fellow in Pharmacy Practice & Pre-Registration Co-ordinator at the UCL School of Pharmacy. She is also the chairwoman for the Royal Pharmaceutical Society Pre-Registration conferences. Her team includes Oksana Pyzik, Ryan Hamilton, Amar Iqbal and Babir Malik

The aim of this unique volume is to help medical researchers design clinical trials to improve survival, remission duration, or time to recurrence of disease. Written in a user-friendly step-by-step format, this work enables the researcher-with no background in statistics-to determine sample size and write statistical considerations for their protocols. It provides critical language which can help with FDA submissions and/or research grants. It also provides the mathematical justification of the material at a level consistent with one year of undergraduate mathematical statistics. It presents survival analysis methods at a more elementary level than any known text. Filled with tables, figures, plus an extensive appendix, this one-of-a-kind reference is an absolute must for all clinical researchers and biostatisticians.

Until the latter part of the 19th century, the majority of known drugs were either herbs or extracts of active ingredients from botanical sources. At this point, the world witnessed two major cornerstone achievements that laid the foundation of modern drug discovery and development: the emergence of pharmacology as a contemporary science through the work of Schmiedeberg (considered by many as the father of modern pharmacology) at the University of Strasbourg, and Woehler's landmark synthesis of urea from ammonium cyanate (the first synthesis of an 'organic' molecule from an 'inorganic' source) which heralded the birth of modern organic chemistry. Drug discovery has evolved from relying on luck, accident and serendipity to a complex endeavor that is at the interface of several disciplines (e.g. pharmacology, biology, chemistry), and is built on the understanding of mechanisms and causes of diseases. This book is produced to celebrate the evolution of drug discovery and development. It will prove useful to synthetic organic chemists in both pharmaceutical industry and in academia, and can serve as a teaching tool to students who want to learn and understand the processes and challenges of drug discovery and development with real examples from top pharmaceutical companies. The chapters contain citations of a large number of valuable selected references to the primary literature. The book highlights the tireless efforts of discovery and process chemists, and their roles in the advancement of drug discovery and development. The chapters presented in this book are written by a selected group of outstanding, very accomplished medicinal and process chemists with noted experiences and diverse backgrounds, representing some of the top pharmaceutical companies. The chapters highlight examples of emerging concepts, new developments and challenges arising in the discovery of new drug candidates and the development of new practical synthetic chemistry processes to produce these drug candidates on large scale. The discovery of each drug or drug candidate is presented by the discovery chemist(s) and the process chemist(s) who developed the drug. These writing teams describe the drug's development to give the reader a complete story of drug discovery and development.