Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges. The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including: Active targeting Nucleic acid delivery and targeting Intracellular/organelle-specific strategies Prodrug strategies Organ or tissue-specific drug delivery Drug-polymer conjugates and micelles Stimuli-responsive systems The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.

The book studies the pharmaceutical industry of India. It is one of the most successful stories of economic expansion and improvements in public health. Indian firms have made access to quality medicines possible and affordable in many developing countries. Indian pharmaceuticals are also exported on a large scale to the United States and other highly regulated markets. A wave of mergers, acquisitions and tie-ups point to growing integration between Indian firms and global pharma multinationals. Please note: Taylor & Francis does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug's development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

This is a new edition of a well-established textbook covering the diagnosis and management of disease symptoms frequently encountered in practice and how to establish whether referral to a medical practitioner is necessary. The sixth edition has been thoroughly revised with updated advice and also features the current most updated products available in the market.

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 54, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Remington Education: Physical Pharmacy provides a succinct overview of the principles and applications of physical pharmacy.

Pharmacy in Senegal explores the rise and expansion of pharmacies in Senegal in the 20th century. In Senegal, as in many African nations, the pharmacy is often the center of biomedical care, where pharmacists provide examinations, diagnoses, and prescribe medicines. Donna A. Patterson notes that many pharmacists are women, which adds an important dimension to this story about medical training and the medical profession. In a health care landscape that includes traditional healers, herbalists, and Muslim healers, women pharmacists have become a mainstay of the local standard of care. Patterson provides a greater understanding of the role pharmacists play in bringing health care to the people they serve.

Pharmacy in Senegal explores the rise and expansion of pharmacies in Senegal in the 20th century. In Senegal, as in many African nations, the pharmacy is often the center of biomedical care, where pharmacists provide examinations, diagnoses, and prescribe medicines. Donna A. Patterson notes that many pharmacists are women, which adds an important dimension to this story about medical training and the medical profession. In a health care landscape that includes traditional healers, herbalists, and Muslim healers, women pharmacists have become a mainstay of the local standard of care. Patterson provides a greater understanding of the role pharmacists play in bringing health care to the people they serve.

Pharmacy has become an integral part of our lives. Nearly half of all 300 million Americans take at least one prescription drug daily, accounting for $250 billion per year in sales in the US alone. And this number doesn't even include the over-the-counter medications or health aids that are taken. How did this practice become such an essential part of our lives and our health? A Brief History of Pharmacy: Humanity's Search for Wellness aims to answer that question. As this short overview of the practice shows, the search for well-being through the ingestion or application of natural products and artificially derived compounds is as old as humanity itself. From the Mesopotamians to the corner drug store, Bob Zebroski describes how treatments were sought, highlights some of the main victories of each time period, and shows how we came to be people who rely on drugs to feel better, to live longer, and look younger. This accessible survey of pharmaceutical history is essential reading for all students of pharmacy.

Pharmacy has become an integral part of our lives. Nearly half of all 300 million Americans take at least one prescription drug daily, accounting for $250 billion per year in sales in the US alone. And this number doesn't even include the over-the-counter medications or health aids that are taken. How did this practice become such an essential part of our lives and our health? A Brief History of Pharmacy: Humanity's Search for Wellness aims to answer that question. As this short overview of the practice shows, the search for well-being through the ingestion or application of natural products and artificially derived compounds is as old as humanity itself. From the Mesopotamians to the corner drug store, Bob Zebroski describes how treatments were sought, highlights some of the main victories of each time period, and shows how we came to be people who rely on drugs to feel better, to live longer, and look younger. This accessible survey of pharmaceutical history is essential reading for all students of pharmacy.

Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case studies and MCQs for self assessment.

Understanding General Chemistry details the fundamentals of general chemistry through a wide range of topics, relating the structure of atoms and molecules to the properties of matter. Written in an easy-to-understand format with helpful pedagogy to fuel learning, the book features main objectives at the beginning of each chapter, get smart sections, and check your reading section at the end of each chapter. The text is filled with examples and practices that illustrate the concepts at hand. In addition, a summary, and extensive MCQs, exercises and problems with the corresponding answers and explanations are readily available. Additional features include: Alerts students to common mistakes and explains in simple ways and clear applications how to avoid these mistakes. Offers answers and comments alongside sample problems enabling students to self-evaluate their skill level. Includes powerful methods, easy steps, simple and accurate interpretations, and engaging applications to help students understand complex principles. Provides a bridge to more complex topics such as solid-state chemistry, organometallic chemistry, chemistry of main group elements, inorganic chemistry, and physical chemistry. This introductory textbook is ideal for chemistry courses for non-science majors as well as health sciences and preparatory engineering students.

Over the past years, the changing nature of pharmacy practice has caused many to realize that the practice must not only be managed, but also led. Leadership and Management in Pharmacy Practice discusses a variety of leadership and managerial issues facing pharmacists now and in the future. This second edition has been reorganized by placing leadership chapters up front, followed by management chapters, thus emphasizing the need for leadership first. The book is written by contributors from within and outside pharmacy practice-a reflection of the complexity of management in pharmacy settings. It offers a real-world approach to everyday issues in pharmacy leadership and management, written by authors who have faced these issues themselves. The book includes case studies which are thought provoking and promote critical thinking as well as problem solving-skills critical for effective pharmacy leaders or managers. References are also made throughout the text to changes occurring to the profession both internally and externally. Much of the material discussed applies to all settings of pharmacy practice: community, hospital, industry, ambulatory care, and long-term care. This book provides pharmacy students and new pharmacy leaders and managers a broad overview of the complexities and intricacies inherent in managing and leading the profession. It is a valuable resource for students in the professional years of their pharmacy curricula and those promoted recently into pharmacy leadership or management positions.

Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents and discusses the vital precepts underlying the efficient, effective, and cost effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development, which is imperative in achieving continuous improvement in end-product quality and also leads to reducing cost, time, and effort, while meeting regulatory requirements. The volume covers the important new advances in the development of solid oral dosage forms, modified release oral dosage forms, parenteral dosage forms, semisolid dosage forms, transdermal drug, delivery systems, inhalational dosage forms, ocular drug delivery systems, nanopharmaceutical products, and nanoparticles for oral delivery.

Stockley's Herbal Medicines Interactions is now in its second edition and remains a unique collaboration between a team of experts in the fields of drug interactions, clinical herbal medicines, phytopharmacovigilance and regulation of herbal medicinal products. It provides an invaluable reference text for all healthcare professionals who require evidence-based information on the interactions of conventional medicines with herbal medicines, dietary supplements and nutraceuticals. Stockley's Herbal Medicines Interactions brings together available data on over 180 of the most commonly used herbal medicines, dietary supplements and nutraceuticals in highly structured, rigorously researched, and fully referenced monographs. Extensively updated for this second edition over 40 new monographs have been added for herbal medicines and dietary supplements, including Blue cohosh, Bergamot, Carnitine derivatives, Goat's rue, Hibiscus, Holy basil, Juniper, Kava and Squill. Substantial updates have been undertaken to the standing content, including revisions of the interactions of St John's wort, Milk thistle, Evening primrose oil, Ginkgo and many others. Key features include: Ease of use - structured format allows user to target key information at-a-glance. Clinically relevant - each monograph contains a concise summary on the available evidence and guidance on how the interaction can be managed. Ratings system - simple and intuitively understood, familiar to users of key drug interactions reference works. Worldwide appeal - as well as commonly used synonyms nomenclature includes approved pharmacopoeial names from Europe and the US. Indexing - full, comprehensive interactions indexing, with lead-ins from appropriate synonyms.

Increase in antibiotic resistance has forced researchers to develop new drugs against microorganisms. Lipopeptides are produced as secondary metabolites by some microorganisms. Computer-aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates provides the identification of novel ligands for different antimicrobial lipopeptides. Along with identification, it also provides some of the in silico drug design processes, namely homology modelling, molecular docking, QSAR studies, drug ADMET studies and pharmacophore studies to check the ligand-lipopeptide interaction. Some lipopeptides have shown anti-cancerous properties too, and this book discusses the required templates to design new drugs using computational techniques. Key Features: Focuses on the use lipopeptides as new antimicrobial compounds Presents the basics of in silico modelling for design and development of new drug molecules, and is therefore of interest to beginners in the field Provides a step-by-step process for identification of drug molecules and testing its efficacy in silico Couples with courses on patents and intellectual property rights

Today, more than ever, the pharmacist is a full-member of the health team and many of the pharmacist's patients are using a host of other devices from various specialty areas of medicine and surgery. Medical Devices for Pharmacy and Other Healthcare Professions presents a comprehensive review of most devices that pharmacists and pharmacy personnel encounter during practice. The devices covered are relevant to pharmacists working in various work settings from hospitals, community pharmacies, and health insurance sector, to regulatory bodies, academia, and research institutes. Even if a pharmacist does not come across each of these devices on a regular basis, the book is a valuable reference source for those occasions when information is needed by a practitioner, and for instructing interns and residents. The book discusses devices needed for special pharmaceutical services and purposes such as residential care homes and primary care based with GPs, pharmacy-based smoking cessation services, pharmacy-based anticoagulant services, pain management and terminal care, medication adherence and automation in hospital pharmacy. Additional features include: Provides information on devices regarding theory, indications, and procedures concerning use, cautions, and place, in therapy. Assists pharmacists in understanding medical devices and instructing patients with the use of these devices. Focuses on providing the available evidence on effectiveness and cost-effectiveness of devices and the latest information in the particular field. Other healthcare providers interested in medical devices or involved in patients care where medical devices represent part of the provided care would benefit from the book.

Covers micro- and Nano- technologies approaches with current trends with safety and efficacy in product development. Presents overview of recent progress of stability testing, reverse engineering, validation and regulatory perspectives as per regulatory requirements. Provides comprehensive overview of latest research related to the micro and nanotechnological including designing, optimization, validation, scale of micro and nanotechnologies. This book is edited by the two-well known researchers by contribution of the vivid chapters from renowned scientists across the globe in field of pharmaceutical sciences.

Provides an understanding of (mostly) enzymatic reactions that are responsible for the function and maintenance of living things This innovative text for non-biochemistry majors includes introductory material at the beginning of each chapter that contextualizes chapter themes in real-life scenarios Online supporting materials with further opportunities for research and investigation Synthesis questions at the end of each chapter that encourage students to make connections between concepts and ideas, as well as develop critical-thinking skills

Clarke's Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons. Written by over 40 international experts, the resource also boasts an editorial advisory board of over 45 world renowned scientists. This reference work has been completely revised and updated for the new edition, and comprises two volumes. * Volume one has been greatly expanded from 31 to 44 chapters providing extensive coverage of all methodology and analytical techniques. Of significant interest include: 1. Quality control and assessment - separated into two chapters to reflect the differing situations/purposes/remits of the toxicology laboratory versus the pharmaceutical industry (accreditation with ISO17025 becoming the international standard in labs) 2. Method development and validation - now present since reliable analytical techniques and data should be of the utmost importance to any analyst 3. 'Sampling, storage and stability', 'Measuring and reporting uncertainty' and 'Interpretation of results' now included to cover all aspects accreditation 4. Pharmacokinetics now coupled with Pharmacogenomics * All chapters have been updated, for instance the color test chapter now includes the analysis of metals, while newer analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS) and atomic absorption spectrometry-inductively coupled- mass spectrometry (AAS-ICP-MS) are also covered. * Parts two and three now contain 2111 monographs (1730 in 3rd edition). This includes over 200 new monographs with retention of all monographs included in previous edition. New monographs include metals, natural toxins and weapons of mass destruction * Over 300 updated monographs including amphetamine, morphine and MDMA The book is essential for all forensic and clinical toxicologists, pathologists, hospital pharmacists, pharmaceutical analysts, clinical pharmacologists, clinical and forensic laboratories, and poison infor

Natural plant supplements have been used as medicine for millennia. With millions of products and varieties to choose from, it can be difficult to identify both the most effective and most relevant supplement for your needs. This book provides a reference for consumers and practitioners, with a carefully compiled list of pharma-standard natural products proven to prevent diseases or improve recovery.Split into two sections, the first provides an alphabetised directory of the most common and effective natural plant supplements, with beautifully illustrated pictures of the plants in their natural form. The second section provides guidance on testing, individualised treatment, and self-usage of pharma-standard supplements, based on real-life experiments and human observations.Through careful investigation of the existing market, specific criteria have been created to ensure only those supplements which have shown results are included. Additionally, as most supplements can be produced and used in countries where 'industrial' drug distribution is limited and costly, it gives people increased access to alternative medical treatment.This project is currently the first of its kind, created to establish a new field of supplements defined by pharmaceutical standards. It is perfect for pharmacists, healthcare providers, and those interested in increasing their knowledge of new standards for natural remedies.

This accessible and comprehensive book provides the thorough understanding of this discipline that will be needed for practising pharmacists and students to develop into effective public health practitioners. The role of pharmacists in improving the general health of the public is developing rapidly, directed by changes to health policy in the UK and elsewhere. Often the focus of the pharmacist is necessarily on individual patients, but the importance of pharmacy practice in population health should not be underestimated. Pharmacy in Public Health focuses on the important topics in public health relevant to all pharmacists. Case studies are used throughout the text to illustrate how public health initiatives can be implemented in different pharmacy sectors. Specific key concepts are outlined, including: determinants of health; pharmacy within public health - UK and international perspective; needs assessment and public involvement; evidence-based delivery; risks and benefits; health education opportunities; health protection; developing pharmacy services and preventing disease; and medicines management.

Multiple choice questions (MCQs) are a key assessment and study tool in pharmacy courses throughout the world. MCQs in Pharmaceutical Science and Technology will serve as an invaluable resource for students and instructors in pharmaceutical science. Comprised of 600 MCQs and answers divided into six sections, the book progresses logically from basic science through to clinical considerations. Questions included in each chapter cover basic, conventional and novel delivery systems and will allow students to gain valuable practice in this discipline. Topics covered include: physical pharmaceutics; pharmacokinetics and biopharmaceutics; particle science and calculations; dosage form design; advanced drug delivery systems; miscellaneous topics. This book, edited by Sanjay Garg and with contributions from a range of distinguished pharmacy educators worldwide, will provide a much-needed examination and revision guide for pharmacy students in the scientific aspects of their studies.

Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology.

A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers:

• Commercial development of devices and products based on transdermal physical enhancement technologies
• Selecting optimal enhancement technology for a specific drug molecule using case studies
• Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection
• Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines
• Practical information on experimental procedures and challenges related to skin irritation and safety issues

Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.