For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. For Volume 54, the series editors have invited established, well-known chemists to offer cutting-edge reviews of chromatographic methods applied in the life sciences that emphasize the underlying principle of separation science. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill.

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug's development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

This book is an all-embracing review of biotechnology, biomedical engineering, bioinformatics, pharmacy and medicinal chemistry, and biopharmaceutical technology. Existing theories and the latest findings are discussed. Researchers, engineers, academics, and industry professionals will find this book an invaluable read.

This is a new edition of a well-established textbook covering the diagnosis and management of disease symptoms frequently encountered in practice and how to establish whether referral to a medical practitioner is necessary. The sixth edition has been thoroughly revised with updated advice and also features the current most updated products available in the market.

Natural plant supplements have been used as medicine for millennia. With millions of products and varieties to choose from, it can be difficult to identify both the most effective and most relevant supplement for your needs. This book provides a reference for consumers and practitioners, with a carefully compiled list of pharma-standard natural products proven to prevent diseases or improve recovery.Split into two sections, the first provides an alphabetised directory of the most common and effective natural plant supplements, with beautifully illustrated pictures of the plants in their natural form. The second section provides guidance on testing, individualised treatment, and self-usage of pharma-standard supplements, based on real-life experiments and human observations.Through careful investigation of the existing market, specific criteria have been created to ensure only those supplements which have shown results are included. Additionally, as most supplements can be produced and used in countries where 'industrial' drug distribution is limited and costly, it gives people increased access to alternative medical treatment.This project is currently the first of its kind, created to establish a new field of supplements defined by pharmaceutical standards. It is perfect for pharmacists, healthcare providers, and those interested in increasing their knowledge of new standards for natural remedies.

Natural plant supplements have been used as medicine for millennia. With millions of products and varieties to choose from, it can be difficult to identify both the most effective and most relevant supplement for your needs. This book provides a reference for consumers and practitioners, with a carefully compiled list of pharma-standard natural products proven to prevent diseases or improve recovery.Split into two sections, the first provides an alphabetised directory of the most common and effective natural plant supplements, with beautifully illustrated pictures of the plants in their natural form. The second section provides guidance on testing, individualised treatment, and self-usage of pharma-standard supplements, based on real-life experiments and human observations.Through careful investigation of the existing market, specific criteria have been created to ensure only those supplements which have shown results are included. Additionally, as most supplements can be produced and used in countries where 'industrial' drug distribution is limited and costly, it gives people increased access to alternative medical treatment.This project is currently the first of its kind, created to establish a new field of supplements defined by pharmaceutical standards. It is perfect for pharmacists, healthcare providers, and those interested in increasing their knowledge of new standards for natural remedies.

This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.

Remington Education: Physical Pharmacy provides a succinct overview of the principles and applications of physical pharmacy.

Pharmacy has become an integral part of our lives. Nearly half of all 300 million Americans take at least one prescription drug daily, accounting for $250 billion per year in sales in the US alone. And this number doesn't even include the over-the-counter medications or health aids that are taken. How did this practice become such an essential part of our lives and our health? A Brief History of Pharmacy: Humanity's Search for Wellness aims to answer that question. As this short overview of the practice shows, the search for well-being through the ingestion or application of natural products and artificially derived compounds is as old as humanity itself. From the Mesopotamians to the corner drug store, Bob Zebroski describes how treatments were sought, highlights some of the main victories of each time period, and shows how we came to be people who rely on drugs to feel better, to live longer, and look younger. This accessible survey of pharmaceutical history is essential reading for all students of pharmacy.

Pharmacy has become an integral part of our lives. Nearly half of all 300 million Americans take at least one prescription drug daily, accounting for $250 billion per year in sales in the US alone. And this number doesn't even include the over-the-counter medications or health aids that are taken. How did this practice become such an essential part of our lives and our health? A Brief History of Pharmacy: Humanity's Search for Wellness aims to answer that question. As this short overview of the practice shows, the search for well-being through the ingestion or application of natural products and artificially derived compounds is as old as humanity itself. From the Mesopotamians to the corner drug store, Bob Zebroski describes how treatments were sought, highlights some of the main victories of each time period, and shows how we came to be people who rely on drugs to feel better, to live longer, and look younger. This accessible survey of pharmaceutical history is essential reading for all students of pharmacy.

Pharmacognosy, the science of nature-derived drugs, pharmaceuticals, and poisons, played a crucial role in the development of modern medicine, and now has an equally important place in healthcare all over the world. This wide scope ranges from traditional medicine systems and herbal and nutritional therapies, the preparation and use of highly standardised and clinically tested herbal medicines, to the production of potent drugs used only in a purified form. Natural sources mainly focus on plants, fungi and algae, but drug discovery of novel compounds and structures includes bacteria and even marine animals. Fundamentals of Pharmacognosy and Phytotherapy is a landmark textbook that covers this spectrum of medicinal plant use. Written by leading experts in this field, this book takes the reader through the history, identification, and quality assurance of plant-based medicines to their therapeutic properties, safety, and compatibility and interaction with prescribed drugs. Aimed at students of all healthcare professions, including pharmacy, medicine, nursing and complementary therapies, the comprehensively updated information in this textbook is also relevant to those companies and organisations concerned with the regulation and testing of herbal medicines (phytomedicines), other natural health products, nutraceuticals and dietary supplements. Introduces the concepts and scope of pharmacognosy Examines the scientific evidence of plant-based medicines for a range of health conditions Extended and updated referencing includes recent reviews, WHO and official documents (open access where available) for quick access to further scientific literature Antimicrobial natural products: as antibiotics and antiseptics, and their potential as bacterial resistance modifiers Anticancer natural products: scope now includes their role in chemoprevention and associated anti-inflammatory mechanisms New chapter on pharmacovigilance for herbal medicines and related products Quality assurance and pharmacopoeial methods extended, with many new figures and examples Plant medicines of recent scientific interest (popularity, or notoriety) added throughout

Safe and effective prescribing is one of the pillars of medical practice but is much more complicated than it seems. Many new prescribers find prescribing extremely challenging, and a plethora of independent, multidisciplinary prescribers are also seeking guidance. However, pharmacology textbooks are rarely practical. They warn to 'take care when prescribing erythromycin to a patient on warfarin, as the INR may rise'. But what should the prescriber actually do? Surviving Prescribing fulfils an important need by offering practical advice for real-world prescribing problems. The book complements existing educational resources but adds a new perspective. Written by experienced contributors from a variety of professional backgrounds, the content speaks directly to the problems routinely seen in hospital prescribing. And all in one, pocket-sized volume. Whether revising for the national Prescribing Safety Assessment, preparing for starting on the wards, or looking for a quick reference guide, this book is an essential companion.

Over the past years, the changing nature of pharmacy practice has caused many to realize that the practice must not only be managed, but also led. Leadership and Management in Pharmacy Practice discusses a variety of leadership and managerial issues facing pharmacists now and in the future. This second edition has been reorganized by placing leadership chapters up front, followed by management chapters, thus emphasizing the need for leadership first. The book is written by contributors from within and outside pharmacy practice-a reflection of the complexity of management in pharmacy settings. It offers a real-world approach to everyday issues in pharmacy leadership and management, written by authors who have faced these issues themselves. The book includes case studies which are thought provoking and promote critical thinking as well as problem solving-skills critical for effective pharmacy leaders or managers. References are also made throughout the text to changes occurring to the profession both internally and externally. Much of the material discussed applies to all settings of pharmacy practice: community, hospital, industry, ambulatory care, and long-term care. This book provides pharmacy students and new pharmacy leaders and managers a broad overview of the complexities and intricacies inherent in managing and leading the profession. It is a valuable resource for students in the professional years of their pharmacy curricula and those promoted recently into pharmacy leadership or management positions.

Covers chemistry, physics, engineering, and therapeutic aspects of packaging--universal to pharmaceutical, medical, and food applications This book covers the chemistry, physics, materials science, engineering, and therapeutic aspects of many different types of packaging materials, emphasizing throughout the applicability of various aspects of packaging science and technology. It also provides a simultaneous discussion of interrelated fields, and addresses the universal issues within these fields' application areas. Intended as a technical reference and as a study aid, it is relevant to anyone who studies or uses packaging or packaging materials. Packaging Technology and Engineering: Pharmaceutical, Medical and Food Applications begins with an overview of the history of the topic. It then offers chapters on the methods of obtaining raw materials, the chemistry of polymeric and non-polymeric packaging materials, physico-chemical quality parameters, and the manufacturing of packaging. Other topics look at: additives, use, suppliers, safety and environmental concerns, regulation, anti-fraud activities, new trends, and the future of packaging technology. The book also features numerous problems and worked solutions to aid student comprehension. Covers packaging and packaging materials, their properties and technologies Addresses the chemical engineering, physics, and chemistry of packaging materials, and the individual requirements for food, pharmaceutical, and medical device packaging Includes current issues such as environmental concerns and sustainability, recycling and after-use, anti-counterfeiting technology, and packaging regulations and guidelines Packaging Technology and Engineering: Pharmaceutical, Medical and Food Applications will appeal to all packaging technologists, scientists, and engineers in industry, and in regulatory agencies. It is also an excellent book for advanced students studying packaging courses, within pharmacy, pharmaceutical sciences, chemical sciences, biomedical sciences, medical sciences, engineering, product design and technology, and food science/technology.

Remington Education: Pharmaceutics covers the basic principles of pharmaceutics, from dosage forms to drug delivery and targeting. It addresses all the principles covered in an introductory pharmacy course. As well as offering a summary of key information in pharmaceutics, it offers numerous case studies and MCQs for self assessment.

View the Table of Contents. Read the Introduction.

aThese challenging essays mark the transformation of medication from a tradition of need assessed by physicians, to a culture that far exceeds a basic threshold for drugs on demand on the part of the public.a
--"Choice"

"Nowhere do pharmaceutical companies sell more drugs, make more money, affect more lives, or wield more power than in the United States. These sophisticated but accessible essays trace the history of eight types of prescription blockbusters, from antibiotics to Viagra, and show how they have changed Americans' thinking about disease, consumer rights, and normality itself. They force us to confront the paradox of a pill-taking society that wages war on some drugs but avidly seeks out others to economically profitable if not always therapeutically benign effect."
--David Courtwright, author of "Forces of Habit" and "Dark Paradise"

aA set of fascinating case studies. . . . Anyone who has taken prescription medications can benefit by reading it.a--"Metapsychology Online Reviews"

With Americans paying more than $200 billion each year for prescription pills, the pharmaceutical business is the most profitable in the nation. The popularity of prescription drugs in recent decades has remade the doctor/patient relationship, instituting prescription-writing and pill-taking as an integral part of medical practice and everyday life.

Medicating Modern America examines the meanings behind this pharmaceutical revolution through the interconnected histories of eight of the most influential and important drugs: antibiotics, mood stabilizers, hormone replacement therapy, oral contraceptives, tranquilizers, stimulants, statins, and Viagra. All of these drugs have been popular, profitable, influential, and controversial, and the authors take a historical approach to studying their development, prescription, and consumption. This perspective locates the histories of prescription medicines in specific cultural contexts while revealing the extent to which contemporary debates about pharmaceutical drugs echo concerns voiced by Americans in the past.

Exploring the rich and multi-faceted history of pharmaceutical drugs in the United States, Medicating Modern America unveils the untold stories behind America's pharmaceutical obsession.

Contributors include: Robert Bud, Jennifer R. Fishman, Jeremy A. Greene, David Healy, Suzanne White Junod, Ilina Singh, Andrea Tone, and Elizabeth Siegel Watkins.

With drug information rapidly migrating to the Web, the chronically poor standards of drug information available to consumers in the developed and the developing world are being further compromised. This book offers insight into the uncharted waters of prescription drug information and promotion on the internet and suggests how it might be transformed into an unprecedented agent for good. It traces the social and political history of prescription drug information and marketing to Western consumers, offers a social and communicative profile of prescription drug Web sites, and evaluates the most widely used sources of prescription drug information, from government organizations and information companies and TV-related sites, to health service provider sites, manufacturers' brand sites, and social media, including YouTube and Wikipedia. The focus throughout is on practical outcomes: How can information for consumer decision making be optimized and how can consumers use it responsibly?

Pharmaceutical manufacturers are constantly facing quality crises of drug products, leading to an escalating number of product recalls and rejects. Due to the involvement of multiple factors, the goal of achieving consistent product quality is always a great challenge for pharmaceutical scientists. This volume addresses this challenge by using the Quality by Design (QbD) concept, which was instituted to focus on the systematic development of drug products with predefined objectives to provide enhanced product and process understanding. This volume presents and discusses the vital precepts underlying the efficient, effective, and cost effective development of pharmaceutical drug products. It focuses on the adoption of systematic quality principles of pharmaceutical development, which is imperative in achieving continuous improvement in end-product quality and also leads to reducing cost, time, and effort, while meeting regulatory requirements. The volume covers the important new advances in the development of solid oral dosage forms, modified release oral dosage forms, parenteral dosage forms, semisolid dosage forms, transdermal drug, delivery systems, inhalational dosage forms, ocular drug delivery systems, nanopharmaceutical products, and nanoparticles for oral delivery.

Stockley's Herbal Medicines Interactions is now in its second edition and remains a unique collaboration between a team of experts in the fields of drug interactions, clinical herbal medicines, phytopharmacovigilance and regulation of herbal medicinal products. It provides an invaluable reference text for all healthcare professionals who require evidence-based information on the interactions of conventional medicines with herbal medicines, dietary supplements and nutraceuticals. Stockley's Herbal Medicines Interactions brings together available data on over 180 of the most commonly used herbal medicines, dietary supplements and nutraceuticals in highly structured, rigorously researched, and fully referenced monographs. Extensively updated for this second edition over 40 new monographs have been added for herbal medicines and dietary supplements, including Blue cohosh, Bergamot, Carnitine derivatives, Goat's rue, Hibiscus, Holy basil, Juniper, Kava and Squill. Substantial updates have been undertaken to the standing content, including revisions of the interactions of St John's wort, Milk thistle, Evening primrose oil, Ginkgo and many others. Key features include: Ease of use - structured format allows user to target key information at-a-glance. Clinically relevant - each monograph contains a concise summary on the available evidence and guidance on how the interaction can be managed. Ratings system - simple and intuitively understood, familiar to users of key drug interactions reference works. Worldwide appeal - as well as commonly used synonyms nomenclature includes approved pharmacopoeial names from Europe and the US. Indexing - full, comprehensive interactions indexing, with lead-ins from appropriate synonyms.

The North American Pharmacist Licensure Examination (c) (NAPLEX (c)) is the licensing exam that each U.S. college or school of pharmacy graduate must pass in order to practice as a pharmacist. This comprehensive yet concise review prepares the reader to succeed on the NAPLEX by focusing on the information most pertinent to the exam. The APhA Complete Review for Pharmacy is in an easy-to-read format with icons, key points, study guide checklists, figures, tables, and boxes to organize information. The best way to prepare for an exam is with practice questions. This book provides over XXX practice questions that include an answer key and explanations of the answer options. In addition to being a valuable resource for individuals preparing for the NAPLEX (c) exam, The APhA Complete Review for Pharmacy is a useful resource for busy pharmacists seeking to stay current. KEY FEATURES: Each of the 43 chapters and XXX review questions has been reviewed and revised by authors and the editorial team to provide up-to-date information. Chapters cover content specified by the NAPLEX Competency Statements (2021) The Top 100 drugs are indicated in bold face to indicate commonly used medications. Key Points and a Study Guide Checklist start each chapter, providing useful study points and an opportunity to self-assess prior to reading the chapter and taking the practice questions. The Complete Review contains more than 900 practice exam questions and answers, including explanations that reinforce key learning points.

Clarke's Analysis of Drugs and Poisons is the definitive source of analytical data for drugs and poisons. Written by over 40 international experts, the resource also boasts an editorial advisory board of over 45 world renowned scientists. This reference work has been completely revised and updated for the new edition, and comprises two volumes. * Volume one has been greatly expanded from 31 to 44 chapters providing extensive coverage of all methodology and analytical techniques. Of significant interest include: 1. Quality control and assessment - separated into two chapters to reflect the differing situations/purposes/remits of the toxicology laboratory versus the pharmaceutical industry (accreditation with ISO17025 becoming the international standard in labs) 2. Method development and validation - now present since reliable analytical techniques and data should be of the utmost importance to any analyst 3. 'Sampling, storage and stability', 'Measuring and reporting uncertainty' and 'Interpretation of results' now included to cover all aspects accreditation 4. Pharmacokinetics now coupled with Pharmacogenomics * All chapters have been updated, for instance the color test chapter now includes the analysis of metals, while newer analytical techniques, such as liquid chromatography-mass spectrometry (LC-MS) and atomic absorption spectrometry-inductively coupled- mass spectrometry (AAS-ICP-MS) are also covered. * Parts two and three now contain 2111 monographs (1730 in 3rd edition). This includes over 200 new monographs with retention of all monographs included in previous edition. New monographs include metals, natural toxins and weapons of mass destruction * Over 300 updated monographs including amphetamine, morphine and MDMA The book is essential for all forensic and clinical toxicologists, pathologists, hospital pharmacists, pharmaceutical analysts, clinical pharmacologists, clinical and forensic laboratories, and poison infor

The book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high performing carriers for specific uses.

This accessible and comprehensive book provides the thorough understanding of this discipline that will be needed for practising pharmacists and students to develop into effective public health practitioners. The role of pharmacists in improving the general health of the public is developing rapidly, directed by changes to health policy in the UK and elsewhere. Often the focus of the pharmacist is necessarily on individual patients, but the importance of pharmacy practice in population health should not be underestimated. Pharmacy in Public Health focuses on the important topics in public health relevant to all pharmacists. Case studies are used throughout the text to illustrate how public health initiatives can be implemented in different pharmacy sectors. Specific key concepts are outlined, including: determinants of health; pharmacy within public health - UK and international perspective; needs assessment and public involvement; evidence-based delivery; risks and benefits; health education opportunities; health protection; developing pharmacy services and preventing disease; and medicines management.