Covering the skills needed for pharmaceutical care in a patient-centered pharmacy setting, Clinical Skills for Pharmacists: A Patient-Focused Approach, 3rd Edition describes fundamental skills such as communication, physical assessment, and laboratory and diagnostic information, as well as patient case presentation, therapeutic planning, and monitoring of drug intake. Numerous case examples show how skills are applied in clinical situations. Now in full color, this edition adds more illustrations and new coverage on taking a medication history, physical assessment, biomarkers, and drug information. Expert author Karen J. Tietze provides unique, pharmacy-specific coverage that helps you prepare for the NAPLEX and feel confident during patient encounters. Coverage of clinical skills prepares you to be more involved with patients and for greater physical assessment and counselling responsibilities, with discussions of communication, taking a medical history, physical assessment, reviewing lab and diagnostic tests, and monitoring drug therapies. A logical organization promotes skill building, with the development of each new skill building upon prior skills. Learning objectives at the beginning of each chapter highlight important topics. Self-assessment questions at the end of each chapter help in measuring your comprehension of learning objectives. Professional codes of ethics are described in the Ethics in Pharmacy and Health Care chapter, including confidentiality, HIPAA, research ethics, ethics and the promotion of drugs, and the use of advance directives in end-of-life decisions. Numerous tables summarize key and routinely needed information. Downloadable, customizable forms on the companion Evolve website make it easier to perform tasks such as monitoring drug intake and for power of attorney. A full-color design and an increase to 150 photos and drawings better illustrates concepts, techniques, and equipment. Updated Taking Medication Histories chapter includes added coverage of the data to obtain while taking a medication history, as well as additional sections on obtaining medication names, on-demand medication information, and the pharmacist's role in immunization. Updated and expanded Physical Assessment Skills chapter includes detailed descriptions of commonly used equipment and vital signs, with more pharmacist-specific examples, so you can feel more confident in handling real-life situations. Updated Researching and Providing Drug Information chapter reflects current technology and information sources, and includes review questions on drug information. A new biomarker section in the Review of Laboratory and Diagnostic Tests chapter aids in treatment planning, explaining the different types of biomarkers and how they are used. Skills checklists cover how to perform clinical skills, such as developing a monitoring plan. Application activities at the end of each chapter include more case studies to help you apply concepts and solve problems. A Chapter Acronym Index conveniently located on the front and back inside covers offers easy lookup for many commonly used acronyms and their definitions. Video clips on the companion Evolve website show a pharmacist performing various clinical skills, including history taking and physical assessment. Animations on Evolve show key disease states and highlight other relevant concepts, and an audio glossary includes pronunciations of 241 terms.

This is a text for practicing pharmacists on the understanding, management and treatment of Obesity. Obesity is an important risk factor for a number of chronic conditions such as heart disease, stroke, some cancers and type two diabetes. It is responsible for more than 9000 premature deaths a year in England alone and is a growing problem both among adults and children especially in the UK and USA. Community pharmacists now have an increasingly important role in public health. The increased health promotion responsibility under the new contract in the UK and improved consultation facilities now available means that a book such as this is very timely. This text focuses on pharmacists care with the first part concentrating on the background and epidemiology of the problem, the current rates of obesity and the facts, also linking obesity with the emergence of potential public health crisis. Part two of the text focuses on the prevention of obesity including prevention on government level, psychological intervention and exercise and nutrition. The chapters then go on to include the pharmacological interventions including drugs available and also surgical interventions and diets. The closing chapter looks at the structure of the evolving services from community pharmacy nationally and internationally.

The book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high performing carriers for specific uses.

Applies the Principles of Informatics to the Pharmacy Profession Emphasizes Evidence-Based Practice and Quality Improvement Approaches Leading the way in the integration of information technology with healthcare, Pharmacy Informatics reflects some of the rapid changes that have developed in the pharmacy profession. Written by educators and professionals at the forefront in this field, the book shows how informatics plays a central role in providing productive and efficient healthcare services. After defining pharmacy informatics, the text explores the information and biomedical technologies that are the drivers of change. It then discusses the basics of maintaining the reliability and security of computers in a connected world, the need for standardization in the healthcare industry, and effective strategies for searching, evaluating, and managing the wide variety of information resources available today. The next section covers the types of information systems that exist in hospitals and pharmacies, including bar coding. The book then presents tools for evidence-based practice, computerized clinical pharmacokinetics methods, clinical decision support, and data mining methods to improve therapy, reduce adverse outcomes, and cut costs. The final section examines various developments driven by the Internet and how current informatics solutions must evolve to maximize their potential. The continual growth and increasing complexity of therapeutic information necessitate new ways for effectively handling medical data and ultimately providing better patient care. This book discusses how these changes affect pharmacy students and practicing pharmacists, preparing them for what lies ahead in this evolving field.

Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemical underpinnings of drug metabolism. While there are numerous resources available to medicinal chemists for understanding drug structure, and to pharmacologists for discerning drug metabolism from a biological standpoint, no resource currently exists that links the chemical and biological aspects in language accessible to both-making it challenging for both groups to fully comprehend how a drug is metabolized, as well as the potential effects of the metabolites. Drug Metabolism: Chemical and Enzymatic Aspects provides extensive material to help understand drug metabolism within a biological context, and for predicting and mitigating adverse drug reactions.

A firm grasp of the functions of living organisms is one of the most important prerequisites to pharmacy study. The long-awaited second edition of Essentials of Human Physiology presents concepts in physiology in a way that prepares students for their subsequent study of pathophysiology, pharmacology, and pharmacotherapeutics. Thoroughly revised and updated, this text maintains the clarity of the first edition, yet provides important new information to give students a solid grounding in some of the most important aspects of pharmacy. As with the first edition, the book begins with an overview of the fundamental aspects of cell membrane physiology with particular emphasis on nerve cell function. This is followed by a detailed discussion of the two major regulatory systems in the body: the nervous system and the endocrine system. The book then continues with in-depth presentations of the reproductive, muscular, cardiovascular, immune, respiratory, digestive, and renal systems. An important focus throughout the text is how tissue and organ function are regulated in order to maintain homeostasis. New in This Edition: * All 19 chapters updated and expanded * Revised and additional subsections of pharmacy applications * New sections on medical terms with pronunciations and definitions * New chapters on the reproductive and immune systems * Additional figures and tables to clarify information . This book was written by Laurie Kelly McCorry, a professor of physiology for eighteen years. Using simple, straightforward language, the text presents the science of physiology clearly so that undergraduate students will understand the relevance of these concepts as they relate to the practice of pharmacy. By studying and mastering the principles in this text, students will develop a secure foundation in human physiology so that they are better equipped to meet the challenges in their pharmacy career.

In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of polymeric nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. Beginning with the combinatorial approach for polymer design, it discusses star-shaped amphiphilic polymers, self-assembling polymer-drug conjugates, amphiphilic dendrimers, dendrimer nanohybrids, sustainable green polymeric nanoconstructs, chitosan-based nanogels, and multifunctional hybrid nanogels. The book provides all available information about these materials and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully.

The Silk Road, a complex network of trade routes linking China with the rest of the Eurasian continent by land and sea, fostered transformation of the ethnic, cultural, and religious identities of diverse peoples. In Natural Products of Silk Road Plants there is a treasury of plants, many indigenous to countries along the trading routes of the Silk Road, that yielded medicines, cereals, spices, beverages, dyes, and euphoric and exotic compounds previously unknown to the rest of the world. This entry in the Natural Products Chemistry of Global Plants series has been prepared for university students of chemistry and ethnobotany and for those wishing to broaden their knowledge. It opens a window on a vast region of Asia not well described for its flora and provides new and fresh insights on: Significant plants, some endangered Traditional and modern applications of extracts The biochemical and pharmacological properties of extracts Contains over 150 full colour figures The significance of the Silk Road is being revived today through immense investment by China and other eastern countries in major schemes of transport infrastructure.

When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed reviews of its various stages and contributing factors as well as relevant regulatory pathways and pre- and post-approval issues.

The Silk Road, a complex network of trade routes linking China with the rest of the Eurasian continent by land and sea, fostered transformation of the ethnic, cultural, and religious identities of diverse peoples. In Natural Products of Silk Road Plants there is a treasury of plants, many indigenous to countries along the trading routes of the Silk Road, that yielded medicines, cereals, spices, beverages, dyes, and euphoric and exotic compounds previously unknown to the rest of the world. This entry in the Natural Products Chemistry of Global Plants series has been prepared for university students of chemistry and ethnobotany and for those wishing to broaden their knowledge. It opens a window on a vast region of Asia not well described for its flora and provides new and fresh insights on: Significant plants, some endangered Traditional and modern applications of extracts The biochemical and pharmacological properties of extracts Contains over 150 full colour figures The significance of the Silk Road is being revived today through immense investment by China and other eastern countries in major schemes of transport infrastructure.

'...approaches the consultation intuitively ... The book oozes with patience for the patient and for the reader. What better prescription for the clinic could the practitioner need?' Glycosmedia (of the Fifth Edition) '... this is a book worth having available at the point of care for health professionals, including doctors, nurses, undergraduates and postgraduates, to help them make sense of common symptoms. With the help of the authors' opinions in combination with our own experience we should then be able to make better clinical decisions.' Sultan Qaboos University Medical Journal (of the Fourth Edition) Across its six editions, Symptom Sorter has excelled in redressing the balance between symptoms and diagnoses to become the essential handbook to accompany the consultation in primary care. Presenting a multitude of symptoms commonly encountered in primary care, these are meticulously explored using the red flags, top tips and ready reckoner format for sorting symptoms that have made previous editions so popular and respected. This revised and updated sixth edition includes several new chapters and features expanded coverage of paediatric symptoms. Key features: * Fully updated, with 'investigations' sections amended in line with latest guidelines and significant revisions throughout * Brand new chapters on acute abdominal pain in childhood, hand and wrist swellings, diarrhoea in children, loin pain, rectal bleeding in children, vomiting in babies, skinfold rash and dysuria * Consistent and logical presentation enables speedy access * Replicates accurately the experience in the consultation or clinic An invaluable reference for all general practitioners, especially GP trainers and registrars, this new edition of Symptom Sorter is also highly recommended for advanced nurse practitioners, A&E nurses and pharmacists requiring a concise, easy-to-use guide. The authors: Keith Hopcroft is a GP in Basildon, Essex, UK, an associate trainer, an editorial adviser to Pulse, and a medical writer and columnist. Vincent Forte is a former GP based in Norfolk, UK

In the fast-developing field of nanomedicine, a broad variety of materials have been used for the development of advanced delivery systems for drugs, genes, and diagnostic agents. With the recent breakthroughs in the field, we are witnessing a new age of disease management, which is governed by precise regulation of dosage and delivery. This book presents the advances in the use of metal-based and other nanomaterials for medical imaging, diagnosis, theranostics, and drug delivery. It discusses silver, hybrid gold, and surface-modified magnetic nanoparticles, fluorescent quantum dots, lipid bubbles, and nanobubbles. It provides all available information about these materials and describes in detail their advantages and disadvantages and the areas where they could be utilized successfully. The text also covers topics such as improving bioactivity of poorly soluble actives, cellular and molecular toxicology of nanoparticles, and biofate of nanoemulsions.

Integrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical enterprise and outlines the specific technologies used at various stages of drug development. With contributions from leaders in academia, information technology, and the pharmaceutical industry, each chapter illustrates how a particular area of biological science can benefit from the tools of informatics. The book first looks at intelligent automation, neurally based computational tools, and pharmacodynamic (PD) biomarkers. It then reviews a variety of novel technologies and approaches presently used in drug discovery at Johnson & Johnson. The text also describes how informatics can advance antibody technology and drug development for oncology. After focusing on forward genetic and reverse genetic strategies to identify relevant target genes for drug discovery, the book explains proteomic expression profiling and explores the application of laser microdissection in transcriptomics. Taking a systematic approach, this volume examines the impact of informatics tools on various areas in biopharmaceuticals by presenting in-depth analyses of emerging trends and future opportunities. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

Originally published in 1999 The Commercial Use of Biodiversity examines how biodiversity and the genetic material it contains are now as valuable resources. Access to genetic resources and their commercial development involve a wide range of parties such as conservation and research institutes, local communities, government agencies and companies. Equitable partnerships are not only crucial to conservation and economic development but are also in the interests of business and often required by law. In this authoritative and comprehensive volume, the authors explain the provisions of the Convention on Biological Diversity on access and benefit-sharing, the effect of national laws to implement these, and aspects of typical contracts for the transfer of materials. They provide a unique sector-by-sector analysis of how genetic resources are used, the scientific, technological and regulatory trends and the different markets in Pharmaceuticals, Botanical Medicines, Crop Development, Horticulture, Crop Protection, Biotechnology (in fields other than healthcare and agriculture) and Personal Care and Cosmetics Products. This will be an essential sourcebook for all those in the commercial chain, from raw material collection to product discovery, development and marketing, for governments and policy-makers drafting laws on access and for all the institutions, communities and individuals involved in the conservation, use, study and commercialisation of genetic resources.

Read this book in order to learn:
· Why medicines often fail to produce the desired result and how such failures can be avoided
· How to think about drug product safety and effectiveness
· How the main participants in a medications use system can improve outcomes and how professional and personal values, attitudes, and ethical reasoning fit into drug therapy
· What a properly designed and managed medications use system would look like - specific components, how the components fit together into a system, and how the system can be maintained and improved
· Ways to evaluate medications use systems, how to recognize ineffective systems operations, how to identify missing system components and how to correct them
· How the environment of medications use affects systems operations and patient outcomes, and why standards must change to improve drug safety and effectiveness

Drug-related illnesses and complications cost the health care system billions of dollars each year. Medical errors account for approximately 100,000 deaths each year, and drugs are the most common cause of medical errors in hospitals. Synthesizing research studies from seven nations, Preventing Medication Errors and Improving Drug Therapy Outcomes: A Management Systems Approach explores medications use from a social perspective. It identifies and describes the preventable adverse outcomes of drug therapy, discusses the safety, cost-effectiveness, and quality of medications use from a management systems perspective, and proposes systematic solutions.

This indispensable reference features the latest findings surrounding the physicochemical aspects of surfactant and polymer systems to facilitate the design and understanding of novel and advanced drug delivery formulations-highlighting the basics of surfactant and polymer surface activity and self-assembly, the various types of structures formed by such compounds, and how they may be used in drug delivery. Surfactants and Polymers in Drug Delivery discusses solubilization of drugs in micellar systems liquid crystalline phases formed by PEO-PPO-PEO block copolymers and other copolymers and surfactants triggered drug-release from liposome formulations microemulsions formed by ionic and nonionic surfactants microemulsions in oral and topical administration emulsions in parenteral, oral, and dermal drug delivery gels formed by polysaccharides, block copolymers, and polymer-surfactant mixtures chemically cross-linked gels responsive polymer systems in drug delivery experimental techniques for studying drug delivery systems drying of aqueous protein solutions, polymeric two-phase systems, emulsions, and liposomes bioadhesion With nearly 500 references, tables and figures, Surfactants and Polymers in Drug Delivery will benefit surface, pharmaceutical, colloid, polymer, and medicinal chemists; chemical, formulation, and application engineers; and pharmacists; and upper-level undergraduate and graduate students in these disciplines.

This is a basic introduction to evidence-based medicine describing the need for EMB and the tools used. The book guides the reader towards finding the right evidence and how to assess its value and quality, including a section on the Internet and how to make best use of it. The range of uses of evidence in pharmacy is shown and specific examples illustrate key points. Appendices give information on website addresses, journals and other publications from the Department of Essential Drugs and Medicines Policy.

Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals.

In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books.

Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.

Originally published in 1995, The History of Pharmacy is a critical bibliography of selected information on the history of pharmacy. The book is designed to guide students and academics through the history of science and technology. Topics range from medicine, chemical technology and the economics and business of pharmacy to pharmacy's influence in the arts. The bibliography includes an exhaustive selection of primary and secondary sources and is arranged chronologically. This book will be of interest to those researching in the area of the history of science and technology and will appeal to students and academic researchers alike.

Adverse reactions to medicines continue to present a considerable burden on healthcare, causing considerable morbidity and mortality. As well as knowing about the benefits of medicines, healthcare professionals need to understand the problem of adverse drug reactions and be aware of how they can be prevented and managed.

Provides the only single-volume reference for stability requirement in all major markets Discusses all aspects of stability testing, including ICH stability guidelines Supports the text with real-world examples In this book, recognized industry experts and regulatory inspectors from the world's pharmaceutical manufacturing regions provide stability requirements in all the major markets and discuss all aspects of stability testing and biotechnology. Participants in the ICH debates interpret the ICH guidelines. Other discussions focus on European requirements, the ICH initiatives, the US SUPAC initiative, matrixing and bracketing approaches from the cGMP and FDA perspective, and stability requirements in Japan, Australia, and WHO. Stress programs, testing of preservatives, and physical stability topics are addressed as well as various protocols and statistical approaches.