This accessible book uses case studies to explore issues around intimacy, sexual function and sexual development over the lifespan, introducing applied principles and practices when working with sexuality-related issues. Introducing an easy-to-use 'Reflect and Respond' model as a framework for interactions, this book discusses a broad selection of topics and life stages, including hidden loss, gender identity, disability, early years experiences and older age. Exposing anonymized real-life experiences of intimacy, sexual function, and sexual development from birth to end of life, this book develops the reader's insight into sexual wellbeing and confidence in communicating about it. The experiential learning and research-based content in readable style will educate and inspire readers with an interest in sexual wellbeing and how this impacts on physical and mental health. Demonstrating how being open to talk about sex and intimacy can change lives, this guide is suitable for a wide range of health and social care professionals, including nurses, doctors, occupational therapists, social workers, psychologists and counsellors.

The US political system has come to depend upon money too much. The US health care industry spends the most on political lobbying among all the 13 industrial sectors in the US economy. The government regulatory agencies at both federal and state levels have been "captured" by the health industry interest groups meaning that the regulatory agencies respond to the interests of the industry but not those of citizens. This book employs a broad theoretical framework of crony capitalism to understand US health care system dysfunction. This framework has not been applied before in any serious manner to understand the shortcomings in the US health care system. Specifically, the book examines the role of seven key players using this framework - politicians/interest groups, pharmaceutical companies, private health insurers, hospitals/hospital networks, physicians, medical device manufacturers, and the American public. Crony capitalism is a destructive force and is rampant in US health care system, causing much waste, inefficiencies, and malaise in the system. Current efforts and initiatives, such as patient-centered medical homes and precision medicine, for improving/reforming the system are of mere academic interest and tantamount to taking aspirin to treat cancer. They do not even pretend to address the root cause of the problem, namely, crony capitalism. Offering prescriptions to fix the U.S. health care system based on a comprehensive diagnosis of the dysfunction, this book will be of interest to researchers, academics, policymakers, and students in the fields of health care management, public and non-profit management, health policy, administration, and economics, and political science.

Includes a new chapter on organized abuse, with complete and updated discussion of advances in the field, the Covid-19 pandemic, telehealth, and more Readers need this book so that they can stay updated with the latest techiques for treating dissociative children and so that they have at their fingertips answers to puzzling clinical quandaries. Readers should choose this book over its closest competitor because it is very readable and accessible; it organizes therapy in a step by step way and incorporates the most recent clinical and neuropsychological research and theory about childhood dissociation.

Principles and Practice of Health Promotion and Public Health brings together the disciplines and fields of study that inform the work of promoting health into one book and provides many examples of practice. It starts with understanding ourselves and our health and continues with chapters on working in health promotion and public health; epidemiology; research methods and evidence-based practice; health psychology; communicating health; health education; health promotion; public health; health protection; arts and health; tackling tobacco, alcohol and drugs; tackling overweight; promoting health in workplaces and promoting health within the National Health Service. Together these communicate the core principles of how to prevent disease and promote health when working with individuals, communities and populations in any country across the world. The book focusses on adults' health and includes international and UK examples. Principles and Practice of Health Promotion and Public Health complements Priorities for Health Promotion and Public Health, published in 2021. Both are core texts for those studying health promotion or public health and supplementary texts for students of healthcare and social care. They are ideal for public health practitioners and members of the wider public health workforce.

A sweeping global history that looks beyond European urban centers to show how slavery, colonialism, and war propelled the development of modern medicine. Most stories of medical progress come with ready-made heroes. John Snow traced the origins of London’s 1854 cholera outbreak to a water pump, leading to the birth of epidemiology. Florence Nightingale’s contributions to the care of soldiers in the Crimean War revolutionized medical hygiene, transforming hospitals from crucibles of infection to sanctuaries of recuperation. Yet histories of individual innovators ignore many key sources of medical knowledge, especially when it comes to the science of infectious disease. Reexamining the foundations of modern medicine, Jim Downs shows that the study of infectious disease depended crucially on the unrecognized contributions of nonconsenting subjects—conscripted soldiers, enslaved people, and subjects of empire. Plantations, slave ships, and battlefields were the laboratories in which physicians came to understand the spread of disease. Military doctors learned about the importance of air quality by monitoring Africans confined to the bottom of slave ships. Statisticians charted cholera outbreaks by surveilling Muslims in British-dominated territories returning from their annual pilgrimage. The field hospitals of the Crimean War and the US Civil War were carefully observed experiments in disease transmission. The scientific knowledge derived from discarding and exploiting human life is now the basis of our ability to protect humanity from epidemics. Boldly argued and eye-opening, Maladies of Empire gives a full account of the true price of medical progress.

Our brain is recognized by all specialists as the most complex entity created in nature. Regarding the extraordinary capacities of its functioning, still incompletely known, the control of the brain by our dietary lipids may seem very improbable to many people. Yet, research has shown that an imbalance in the intake of essential fatty acids is related to conditions as prevalent as depression, bipolar disorder and schizophrenia. Research on psychological disorders including attention deficit hyperactivity disorder, autism, aggressiveness and suicidal behavior are discussed in this text. Several neurodegenerative diseases, such as Alzheimer's, Parkinson's and multiple sclerosis are also explored. Several observations prove that not only are omega-3 fatty acids actively involved in maintaining the noble functions of our brain, but other lipids, including cholesterol, liposoluble vitamins (A, D and E) and some carotenoids play roles as well and are presented in this book. Dietary Lipids for Healthy Brain Function focuses on this important research for human health. This book brings readers, doctors, dietitians and nutritionists arguments that could improve brain development in young people, prevent many nervous diseases and slow down the age-related decline of higher brain functions. This book provides helpful information to improve health in the young as well in the old, using practical and personalized recommendations for preventing and treating nervous pathologies. Features: * Focuses on the importance of dietary lipids on the proper brain functioning. * Provides relevant references demonstrating the efficiency of dietary lipids to maintain a healthy brain. * Introduces lipid sources and describes their roles by lipid groups in behavior issues and various chronic nervous diseases.

1. Explains the clear role of geospatial data in managing pandemics. 2. Discusses Covid-19 and its relevance to location intelligence. 3. Includes a big population trajectory tracking and reasoning. 4. Analyses population behavior modeling and simulation, using location-based service. 5. Integrates community prevention, surveillance, and risk assessment.

This book explains how the U.S. federal system manages environmental health issues, with a unique focus on risk management and human health outcomes. Building on a generic approach for understanding human health risk, this book shows how federalism has evolved in response to environmental health problems, political and ideological variations in Washington D.C, as well as in-state and local governments. It examines laws, rules and regulations, showing how they stretch or fail to adapt to environmental health challenges. Emphasis is placed on human health and safety risk and how decisions have been influenced by environmental health information. The authors review different forms of federalism, and analyse how it has had to adapt to ever evolving environmental health hazards, such as global climate change, nanomaterials, nuclear waste, fresh air and water, as well as examining the impact of robotics and artificial intelligence on worker environmental health. They demonstrate the process for assessing hazard information and the process for federalism risk management, and subsequently arguing that human health and safety should receive greater attention. This book will be essential reading for students and scholars working on environmental health and environmental policy, particularly from a public health, and risk management viewpoint, in addition to practitioners and policymakers involved in environmental management and public policy.

Magnesium is an essential mineral required by humans, playing an important role in multiple biochemical processes as well as preventing and managing several diseases and disorders. Deficiencies of magnesium can lead to a wide range of medical conditions, including cardiovascular disease, diabetes, and hypertension. With myocardial infarction and stroke being the first and fifth cause of mortality in the United States, the pharmaceutical industry has been trying to produce therapies that reduce co-morbidity and mortality. Recent observational studies of magnesium have added to the list of potential therapeutic modalities that have been proven useful in reducing hypertension, stroke sequalae, metabolic syndrome/dyslipidemia, and inflammatory diseases. Magnesium therapeutic modalities also have impacts in the fields of neurology, the elderly, and in obstetrics. Magnesium: Applications in Clinical Medicine explores the many uses of magnesium and its applications in clinical medicine. Features: Presents information on the impacts magnesium has on various aspects of health conditions and disease prevention. Describes magnesium usage in treating and managing several conditions including dyslipidemia, migraine, metabolic syndrome, and high blood pressure. Discusses magnesium therapy in stroke and magnesium deficiency in attention deficit hyperactivity disorder. Promotes knowledge of overall health and wellness that can be applied in any specialty of medicine. This book encompasses various uses of magnesium in a clinical setting ranging from its role in maintaining homeostasis, to its uses in the fields of dermatology, cardiology, neurology, and in obstetrics. Written by contributors who are experts in their fields, it is a comprehensive collaboration of this ubiquitous dietary supplement's applications in clinical medicine.

Affecting more than 800 million people, food insecurity is a global problem that runs deeper than hunger and undernutrition. In addition to the obvious impact on physical well-being, food insecurity can result in risky coping strategies, increased expenditures on medical costs or transportation, and mental health issues. A review of the concepts and impacts of food insecurity through the lens of public health, Food Insecurity and Public Health details the complex issue of food insecurity and explores its reach beyond economics and agronomics. The book guides you through the fundamentals, beginning with theory, and the challenges in measuring it, and moving on to the impact of food insecurity on health. The book details the implications of food insecurity on public health practice, including epidemiology and outcomes of diseases such as HIV, TB, and non-communicable diseases, and the specific impact on women's health. It closes with case studies from the Navajo Nation, Kenya, and Southern Africa, offering the opportunity to learn from real-life successes and challenges. Each chapter also considers programs or interventions that have been used to attempt to address the issue, including a discussion of the US federal food stamps program. In truth, however, there continues to be a dearth of data on the ways in which programs can effectively address the problem of food insecurity at the household, community, or district level in either the short or long term-beyond, of course, the elimination of poverty, which is no doubt a root cause of the problem. The book gives you context for considering the links between food insecurity and health, and a framework for seeking integrated solutions to both problems.

Sharing the care of children in families is increasingly becoming the norm in modern-day society as more mothers enter paid work and government campaigns endeavour to increase the number of men working in childcare. However, running alongside debates of gender imbalance in childcare, there has also been mounting anxiety from the media and public about the risks of child abuse, often perceived as being mostly perpetrated by men and calling for firmer regulation of men's involvement with children. This book asks whether men's care for children, both as fathers and practitioners, actually differs at all from the care provided by mothers and female carers? In what ways do men and concepts of masculinity need to change if they are to play a greater role in the care of children or are such societal perceptions based on outdated gender stereotypes? Bringing together cutting-edge theory, up-to-date research and current practice, this book analyses the role of both fathers and male professionals working with children and highlights the implications of this for future policy and practice. It also examines dominant notions of masculinity and representations of male carers in the media and popular culture, asking how our societal expectations may need to evolve if men are to play an equal role in the care of children as demanded by current policy and wider social developments.

Lycopene is a potent antioxidant carotenoid found in fruits and vegetables; particularly high amounts exist in red tomatoes. It is not an essential nutrient for humans, but can be a potential therapeutic agent for preventing several human diseases. Since the publication of the previous book on lycopene, extensive advances have been made with respect to the role of lycopene and tomatoes in human health. Whereas the initial focus of research was on cancer, Lycopene and Tomatoes in Human Nutrition and Health represents the next major step in documenting advances in understanding the chemistry, bioavailability, metabolism; mechanisms of action of lycopene; and its role in preventing human diseases other than cancer as discussed in the various chapters of the book. The book includes chapters that discuss genetic polymorphisms; and lycopene's relationship to cardiovascular diseases, cardiometabolic diseases, bone health, and other health disorders including male infertility, skin diseases, respiratory disorders and neurodegenerative diseases. The book includes information addressing regulatory aspects of natural health products and, in particular lycopene, presenting industrial insights. The contents of the book are selected carefully to provide the readers with the most current information available on lycopene and tomato bioactives.

For readers of Mary Roach and Jared Diamond, an innovative look at the histories of different epidemics and what it meant for society, alongside what lessons different diseases have to teach us as society battles the novel coronavirus. Throughout history, there have been numerous epidemics that have threatened mankind with destruction. Diseases have the ability to highlight our shared concerns across the ages, affecting every social divide from national boundaries, economic categories, racial divisions, and beyond. Whether looking at smallpox, HIV, Ebola, or COVID-19 outbreaks, we see the same conversations arising as society struggles with the all-encompassing question: What do we do now? In "poignant yet relevant detail" (Niki Kapsambelis, author of The Inheritance), Quarantine Life from Cholera to COVID-19 demonstrates that these conversations have always involved the same questions of individual liberties versus the common good, debates about rushing new and untested treatments, considerations of whether quarantines are effective to begin with, what to do about healthy carriers, and how to keep trade circulating when society shuts down. This vibrant social and medical history tracks different diseases and outlines their trajectory, what they meant for society, and societal questions each disease brought up, along with practical takeaways we can apply to current and future pandemics--so we can all be better prepared for whatever life throws our way.

Powerful stories of the debilitating effects of neglected tropical diseases throughout the world, highlighting the successes and challenges of those fighting to eliminate them. Neglected tropical diseases (NTDs) affect over one billion of the world's poorest people. More than 170,000 people die from NTDs each year, and many more suffer from blindness, disability, disfigurement, cognitive impairment, and stunted growth. Yet NTDs are treatable and preventable, and the annual cost of treatment is incredibly low. In Under the Big Tree, public health leader Ellen Agler and award-winning writer Mojie Crigler tell the moving stories of those struggling with these diseases and the life-saving work that can be-and has been-done to combat NTDs. They introduce readers to people from all walks of life-from car washers in Lake Victoria and surgeons on motorbikes to under-resourced local nongovernmental organizations (NGOs) and Big Pharma scientists-as they chronicle what has been called the largest public health program in the world. On the one hand, the solutions are simple: deliver medication to people who need it and leverage local systems to offer prevention, treatment, and education. On the other hand, solutions are complex: navigating local and national politics, delivering treatment to some of the most remote, vulnerable communities, and coordinating global and local donors, international NGOs, thousands of health workers, and millions of citizens. Drawing on interviews with major players in the NTD world who share their cutting-edge research and frontline experiences, Under the Big Tree is a moving introduction to the science, the tactics, and the partnerships working to address these terrible diseases that affect the most vulnerable people in the world. With a foreword by Bill Gates, this book fascinates, inspires, and gives readers concrete steps for further engagement.

This fascinating book gives readers an appreciation of how biomedical research should work and how the reality is all too often seriously flawed. Explaining the logical basis of the different research approaches used by biomedical research scientists and their relative merits, it will help readers to make more realistic appraisal of media reports linking aspects of lifestyle, environment or diet to health outcomes and thus judge whether such claims are a real effect worthy of consideration for behavior change or deserving of further research resources. Key features: increases awareness of research fraud and some of the characteristics of fraudulent science and scientific fraudsters shows that whilst outright fraud may be uncommon, fudging of results to help achieve statistical significance may be more prevalent incorporates real-life case studies highlighting some of the infamous cases of research fraud and major scientific mistakes and the impact that they have had provides a convenient overview of the research process in the biomedical sciences, with a focus on research strategy rather than individual methods find supplemental detail on the author's blog https://drgeoffnutrition.wordpress.com/about/ By raising awareness of the possibility that research data may have been dishonestly generated and outlining some of the signs and symptoms that might suggest data fabrication, Error and Fraud: The Dark Side of Biomedical Research will help students and researchers to identify the strengths and limitations of different research approaches and allow them to make a realistic evaluations of their own and others' research findings.

Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis. It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results. The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations. The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language. The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. Features Offers first-hand, in-depth guidance on Mendelian randomization from leaders in the field Makes the diverse aspects of Mendelian randomization understandable to newcomers Illustrates technical details using data from applied analyses Discusses possible future directions for research involving Mendelian randomization Software code is provided in the relevant chapters and is also available at the supplementary website This book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues. Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added. The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development

Signal Detection for Medical Scientists: Likelihood Ratio Based Test-Based Methodology presents the data mining techniques with focus on likelihood ratio test (LRT) based methods for signal detection. It emphasizes computational aspect of LRT methodology and is pertinent for first-time researchers and graduate students venturing into this interesting field. The book is written as a reference book for professionals in pharmaceutical industry, manufactures of medical devices, and regulatory agencies. The book deals with the signal detection in drug/device evaluation, which is important in the post-market evaluation of medical products, and in the pre-market signal detection during clinical trials for monitoring procedures. It should also appeal to academic researchers, and faculty members in mathematics, statistics, biostatistics, data science, pharmacology, engineering, epidemiology, and public health. Therefore, this book is well suited for both research and teaching. Key Features: Includes a balanced discussion of art of data structure, issues in signal detection, statistical methods and analytics, and implementation of the methods. Provides a comprehensive summary of the LRT methods for signal detection including the basic theory and extensions for varying datasets that may be large post-market data or pre-market clinical trial data. Contains details of scientific background, statistical methods, and associated algorithms that a reader can quickly master the materials and apply methods in the book on one's own problems

Infant, Child and Adolescent Nutrition: A Practical Guide, Second Edition, is an evidence-based, practical guide introducing readers to the theory behind optimal child nutrition. Containing practical advice on how to put that theory into practice, this new edition facilitates learning through case studies, key points, and learning activities. Divided into seven sections, chapters cover prenatal nutrition and nutrition throughout childhood from preterm babies to adolescents up to the age of 18. Sections throughout focus on topics ranging from nutrient requirements, balanced eating patterns and common problems to cultural influences on food choices and guidelines on assessing growth and dietary intakes. Prevention and management of obesity and allergies are covered in separate chapters. The first 1000 days are given particular consideration with chapters on diets for preconception, pregnancy, milk feeding and complementary feeding during infancy. The chapter on nutritional treatments covers common conditions such as diabetes and Crohn's disease, as well as more intricate feeding regimes and tube feeding required for children with rarer diseases and syndromes. New in this second edition are: * Changes in in food allergy prevention and oral immunotherapy treatments. * Causes and management strategies to deal with fussy and selective eating in toddlers. * The importance of iodine in diets before and during pregnancy to improve children's cognitive abilities. * Updated recommendations on vitamin D supplementation. This second edition is an essential reading for students taking courses in nutrition and paediatric healthcare. It serves as a useful reference for individuals responsible for the nutritional intakes of children in primary care and community settings including early years practitioners, midwives, health visitors, school nurses and governors, social workers, paediatricians and general practitioners. About the Author Judy More BSc, RD, RN is a Paediatric Dietitian, Honorary Lecturer at the University of Plymouth, UK and Director of Child-nutrition.co.uk Ltd, London, UK.

Film and the Chinese Medical Humanities is the first book to reflect on the power of film in representing medical and health discourse in China in both the past and the present, as well as in shaping its future. Drawing on both feature and documentary films from mainland China, the chapters each engage with the field of medicine through the visual arts. They cover themes such as the history of doctors and their concepts of disease and therapies, understanding the patient experience of illness and death, and establishing empathy and compassion in medical practice, as well as the HIV/AIDs epidemic during the 1980s and 90s and changing attitudes towards disability. Inherently interdisciplinary in nature, the contributors therefore provide different perspectives from the fields of history, psychiatry, film studies, anthropology, linguistics, public health and occupational therapy, as they relate to China and people who identify as Chinese. Their combined approaches are united by a passion for improving the cross-cultural understanding of the body and ultimately healthcare itself. A key resource for educators in the Medical Humanities, this book will be useful to students and scholars of Chinese Studies and Film Studies as well as global health, medical anthropology and medical history.

Statistical methods that are commonly used in the review and approval process of regulatory submissions are usually referred to as statistics in regulatory science or regulatory statistics. In a broader sense, statistics in regulatory science can be defined as valid statistics that are employed in the review and approval process of regulatory submissions of pharmaceutical products. In addition, statistics in regulatory science are involved with the development of regulatory policy, guidance, and regulatory critical clinical initiatives related research. This book is devoted to the discussion of statistics in regulatory science for pharmaceutical development. It covers practical issues that are commonly encountered in regulatory science of pharmaceutical research and development including topics related to research activities, review of regulatory submissions, recent critical clinical initiatives, and policy/guidance development in regulatory science. Devoted entirely to discussing statistics in regulatory science for pharmaceutical development. Reviews critical issues (e.g., endpoint/margin selection and complex innovative design such as adaptive trial design) in the pharmaceutical development and regulatory approval process. Clarifies controversial statistical issues (e.g., hypothesis testing versus confidence interval approach, missing data/estimands, multiplicity, and Bayesian design and approach) in review/approval of regulatory submissions. Proposes innovative thinking regarding study designs and statistical methods (e.g., n-of-1 trial design, adaptive trial design, and probability monitoring procedure for sample size) for rare disease drug development. Provides insight regarding current regulatory clinical initiatives (e.g., precision/personalized medicine, biomarker-driven target clinical trials, model informed drug development, big data analytics, and real world data/evidence). This book provides key statistical concepts, innovative designs, and analysis methods that are useful in regulatory science. Also included are some practical, challenging, and controversial issues that are commonly seen in the review and approval process of regulatory submissions. About the author Shein-Chung Chow, Ph.D. is currently a Professor at Duke University School of Medicine, Durham, NC. He was previously the Associate Director at the Office of Biostatistics, Center for Drug Evaluation and Research, United States Food and Drug Administration (FDA). Dr. Chow has also held various positions in the pharmaceutical industry such as Vice President at Millennium, Cambridge, MA, Executive Director at Covance, Princeton, NJ, and Director and Department Head at Bristol-Myers Squibb, Plainsboro, NJ. He was elected Fellow of the American Statistical Association and an elected member of the ISI (International Statistical Institute). Dr. Chow is Editor-in-Chief of the Journal of Biopharmaceutical Statistics and Biostatistics Book Series, Chapman and Hall/CRC Press, Taylor & Francis, New York. Dr. Chow is the author or co-author of over 300 methodology papers and 30 books.

Fraudulent, harmful, or at best useless pharmaceutical and therapeutic approaches developed outside science-based medicine have boomed in recent years, especially due to the commercialisation of cyberspace. The latter has played a fundamental role in the rise of false 'health experts', and in the creation of filter bubbles and echo chambers that have contributed to the formation of highly polarised debates on non-science-based health practices-online as well as offline. By adopting a multidisciplinary approach, this edited book brings together contributions of international academics and practitioners from criminology, digital sociology, health psychology, medicine, law, physics, and journalism, where they critically analyse different types of non-science-based health approaches. With this volume, we aim to reconcile different scientific understandings of these practices, synthesising a variety of empirical, theoretical and interpretative approaches, and exploring the challenges, implications and potential remedies to the spread of dangerous and misleading health information. This edited book will offer some food for thought not only to students and academics in the social sciences, health psychology and medicine among other disciplines, but also to medical practitioners, science journalists, debunkers, policy makers and the general public, as they might all benefit from a greater awareness and critical knowledge of the harms caused by non-scientific health practices.

Increased oxidative stress due to the production of excessive amounts of free radicals along with the effects of chronic inflammation plays a major role in the initiation and progression of most chronic diseases. In addition, increased release of glutamate plays a central role in the pathogenesis of various disorders. This second edition of Micronutrients in Health and Disease proposes a novel concept that in order to simultaneously and optimally reduce oxidative stress, chronic inflammation, and glutamate, it is essential to increase levels of antioxidant enzymes as well as levels of dietary and endogenous antioxidant compounds at the same time. This is accomplished by activating the Nrf2 pathways and by increasing the levels of antioxidant compounds and B-vitamins through supplementation. This book proposes a mixture of micronutrients that achieves this above goal. The mixture of micronutrients together with modification in diet and lifestyle may reduce the risk of chronic diseases and in combination with standard care, may improve the management of these diseases. KEY FEATURES * Provides evidence in support of the idea that increased oxidative stress, chronic inflammation, and glutamate are involved in the pathogenesis of chronic diseases. * Contains three new chapters on Huntington's disease, Autism spectra, and Prion disease. * Discusses the role of microRNAs in the pathogenesis of chronic diseases. * Presents information on regulation of the expression of microRNAs by reactive oxygen species and antioxidants. Micronutrients in Health and Disease, Second Edition serves as a valuable resource for those seeking to promote healthy aging and prevent and improved management of chronic diseases.

"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.

Diabetes occurs at such an alarming rate that it can be described as a global epidemic. Following its predecessor, Nutrition and Diabetes: Pathophysiology and Management, Second Edition, is a comprehensive resource that describes various factors that drive the accumulation of excess body weight and fat resulting in obesity. The book discusses the metabolic aberrations found in obesity and how they lead to the association of obesity with diabetes. This new edition highlights the role played by diet and the interrelationships in the metabolism of key nutrients in the pathogenesis of obesity and diabetes which provides the scientific basis for treatment and management approaches. Features Highlights the role of nutrition in the pathogenesis of obesity and diabetes Organized logically into two easy-to-use sections - Pathophysiology and Management of Obesity and Pathophysiology and Treatment of Diabetes Features emerging therapeutic approaches for management of obesity and diabetes Discusses experience in the management of obesity and diabetes in developing countries Presents challenges in insulin therapy and provides guidelines to overcome them The first section of the book retains key topics from the previous edition and contains new chapters including genetic determinants of nutrient processing; fat distribution and diabetes mellitus; combined effect of diet and physical activity in the management of obesity; pharmacologic treatment of obesity; and the role of gut microbiota in the pathogenesis and treatment of obesity. The second section features updated versions of most of the other chapters in the first edition comprising a modified chapter on oxidative stress and the effects of dietary supplements on glycemic control in Type 2 diabetes. In addition, new chapters are added in this section and include the contribution of iron and transition metal micronutrients to diabetes; role of microbiota in the pathogenesis and treatment of diabetes; primary prevention of Type 2 diabetes; and the pathophysiology and management of Type 1 diabetes.

The Routledge Handbook of Diet and Nutrition in the Roman World presents a comprehensive overview of the sources, issues and methodologies involved in the study of the Roman diet. The focus of the book is on the Mediterranean heartland from the second century BC to the third and fourth centuries AD. Life is impossible without food, but what people eat is not determined by biology alone, and this makes it a vital subject of social and historical study. The Handbook takes a multidisciplinary approach in which all kinds of sources and disciplines are combined to study the diet and nutrition of men, women and children in city and countryside in the Roman world. The chapters in this book are structured in five parts. Part I introduces the reader to the wide range of textual, material and bioarchaeological evidence concerning food and nutrition. Part II offers an overview of various kinds of food and drink, including cereals, pulses, olive oil, meat and fish, and the social setting of their consumption. Part III goes beyond the perspective of the Roman adult male by concentrating on women and children, on the cultures of Roman Egypt and Central Europe, as well as the Jews in Palestine and the impact of Christianity. Part IV provides a forum to three scholars to offer their thoughts on what physical anthropology contributes to our understanding of health, diet and (mal)nutrition. The final section puts food supply and its failure in the context of community and empire.