This book provides a compact introduction to the bootstrap method. In addition to classical results on point estimation and test theory, multivariate linear regression models and generalized linear models are covered in detail. Special attention is given to the use of bootstrap procedures to perform goodness-of-fit tests to validate model or distributional assumptions. In some cases, new methods are presented here for the first time. The text is motivated by practical examples and the implementations of the corresponding algorithms are always given directly in R in a comprehensible form. Overall, R is given great importance throughout. Each chapter includes a section of exercises and, for the more mathematically inclined readers, concludes with rigorous proofs. The intended audience is graduate students who already have a prior knowledge of probability theory and mathematical statistics.

Due to the non-biodegradability of plastic substances, coupled with poor waste management practices, plastic pollution has become a major environmental issue within the past decade. However, the negative effects of plastic pollution are rarely opposed, or the solutions proposed are costly or still damaging to the environment. New strategies must be undertaken to prevent irreparable environmental damage from disposable plastic products while maintaining and maximizing the benefits of plastics in specialized cases, such as medicine and public health. The Handbook of Research on Environmental and Human Health Impacts of Plastic Pollution is a collection of innovative research that assesses the negative impacts of plastic on the environment, human health, and ecosystems, and explores biotechnological approaches to solve plastic pollution. While highlighting topics including medical wastes, biodegradability, and phthalate exposure, this publication intends to provide readers with the latest solutions for reducing the burden of plastic on the environment. It is ideally designed for environmentalists, policymakers, instructors, researchers, graduate-level students, industrialists, and non-governmental organization professionals seeking current research on health and ecosystem concerns from the overconsumption of plastics.

In this timely and expansive book, Wakefield-Rann investigates how emerging disease ecologies are undermining definitions of health and immunity that have persisted since the 19th century, and had a formative influence over the design of not only homes, but entire cities. This wide-ranging account traces the links between the history of medicine, modernist design and architecture, the rise of inflammatory disease, the microbiomes of buildings and humans, antimicrobial resistance, and novel chemical pollutants, to show how indoor environments have made us as we have made them. In highlighting the processes that have been missed in designing perfectly controlled interior habitats, Life Indoors shows the limitations of dominant practices, classifications and philosophies to apprehend current indoor pathogen ecologies.

The COVID-19 pandemic had a tremendous effect on the mental health of people globally. It is critical to examine how people adapted to this new normal to understand the effects on society and its citizens. Community Mental Health and Well-Being in the New Normal discusses the mental health concerns of individuals during the pandemic, the new normal, and the transition stage. The book also examines the coping mechanisms utilized to overcome mental health concerns during turbulent times. Covering key topics such as social distancing, student mental health, and pandemics, this premier reference source is ideal for medical professionals, nurses, sociologists, psychiatrists, psychologists, policymakers, researchers, scholars, academicians, practitioners, instructors, and students.

This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.

After decades of the American "war on drugs" and relentless prison expansion, political officials are finally challenging mass incarceration. Many point to an apparently promising solution to reduce the prison population: addiction treatment. In Addicted to Rehab, Bard College sociologist Allison McKim gives an in-depth and innovative ethnographic account of two such rehab programs for women, one located in the criminal justice system and one located in the private healthcare system-two very different ways of defining and treating addiction. McKim's book shows how addiction rehab reflects the race, class, and gender politics of the punitive turn. As a result, addiction has become a racialized category that has reorganized the link between punishment and welfare provision. While reformers hope that treatment will offer an alternative to punishment and help women, McKim argues that the framework of addiction further stigmatizes criminalized women and undermines our capacity to challenge gendered subordination. Her study ultimately reveals a two-tiered system, bifurcated by race and class.

This book explores Native American literary responses to biomedical discourses and biomedicalization processes as they circulate in social and cultural contexts. Native American communities resist reductivism of biomedicine that excludes Indigenous (and non-Western) epistemologies and instead draw attention to how illness, healing, treatment, and genetic research are socially constructed and dependent on inherently racialist thinking. This volume highlights how interventions into the hegemony of biomedicine are vigorously addressed in Native American literature. The book covers tuberculosis and diabetes epidemics, the emergence of Native American DNA, discoveries in biotechnology, and the problematics of a biomedical model of psychiatry. The book analyzes work by Louise Erdrich, Sherman Alexie, LeAnne Howe, Linda Hogan, Heid E. Erdrich, Elissa Washuta and Frances Washburn. The book will appeal to scholars of Native American and Indigenous Studies, as well as to others with an interest in literature and medicine.

This book is dedicated to addressing the major challenges in fighting COVID-19 using artificial intelligence (AI) and machine learning (ML) - from cost and complexity to availability and accuracy. The aim of this book is to focus on both the design and implementation of AI-based approaches in proposed COVID-19 solutions that are enabled and supported by sensor networks, cloud computing, and 5G and beyond. This book presents research that contributes to the application of ML techniques to the problem of computer communication-assisted diagnosis of COVID-19 and similar diseases. The authors present the latest theoretical developments, real-world applications, and future perspectives on this topic. This book brings together a broad multidisciplinary community, aiming to integrate ideas, theories, models, and techniques from across different disciplines on intelligent solutions/systems, and to inform how cognitive systems in Next Generation Networks (NGN) should be designed, developed, and evaluated while exchanging and processing critical health information. Targeted readers are from varying disciplines who are interested in implementing the smart planet/environments vision via wireless/wired enabling technologies.

This book examines family interactions and relationships during the transition to parenthood. It offers a unique integration of different lines of research on prenatal family dynamics contributed by leading family researchers in North America and Europe who use observational approaches to study emergent family processes. The book explores prenatal dynamics in diverse families, including adolescent couples, same-sex couples, couples experiencing infertility, and couples expecting their second child. The introduction, anchored in family systems and structural theories, provides an overview of challenges couples commonly experience during the transition to parenthood and details prenatal family processes that predict postpartum adjustment in families. This sets the stage for subsequent chapters by emphasizing unparalleled windows into prenatal family dynamics provided by direct observation. Initial chapters focus on predictors of prenatal interactions and partners' representations of parenthood. Subsequent chapters describe original research on prebirth couple interactions and the coparenting relationship emerging during pregnancy. The volume includes several studies that rely on innovative research designs using observations of simulated couple encounters with their newborn, represented by a life-sized infant doll. The book concludes with a review of recent prenatal intervention programs designed to improve interpersonal and coparenting relationships of married and unmarried couples. The volume offers recommendations for future research on prenatal family dynamics, including suggestions for methodological advances, exploration of prenatal risk factors, expansion of conceptual models to incorporate culturally-meaningful coparents besides mothers and fathers, and further focus on prenatal intervention programs. This book is an essential resource for researchers, clinicians and professionals, and graduate students in the fields of infant mental health/early child development, family studies, pediatrics, developmental psychology, public health, social work, and early childhood education.