In this timely and expansive book, Wakefield-Rann investigates how emerging disease ecologies are undermining definitions of health and immunity that have persisted since the 19th century, and had a formative influence over the design of not only homes, but entire cities. This wide-ranging account traces the links between the history of medicine, modernist design and architecture, the rise of inflammatory disease, the microbiomes of buildings and humans, antimicrobial resistance, and novel chemical pollutants, to show how indoor environments have made us as we have made them. In highlighting the processes that have been missed in designing perfectly controlled interior habitats, Life Indoors shows the limitations of dominant practices, classifications and philosophies to apprehend current indoor pathogen ecologies.

This book provides a compact introduction to the bootstrap method. In addition to classical results on point estimation and test theory, multivariate linear regression models and generalized linear models are covered in detail. Special attention is given to the use of bootstrap procedures to perform goodness-of-fit tests to validate model or distributional assumptions. In some cases, new methods are presented here for the first time. The text is motivated by practical examples and the implementations of the corresponding algorithms are always given directly in R in a comprehensible form. Overall, R is given great importance throughout. Each chapter includes a section of exercises and, for the more mathematically inclined readers, concludes with rigorous proofs. The intended audience is graduate students who already have a prior knowledge of probability theory and mathematical statistics.

From the early days of humankind to today, steady technological advances have greatly changed the landscape of farming. In the United States in particular, these changes have in turn impacted the scope of food production-and often not in a positive way. In The Poisoning of Americans, author Jacob Silver presents an in-depth, investigative expose into the production of Americans' food and how it is responsible for the failing health of US citizens.

The Poisoning of Americans gives an overview of the fundamentals of humans and the food they consume, as well as the essential nutrients they need and how those relate to health. It discusses the production of beef, poultry, and pork and the effects of the use of antibiotics and hormones. It addresses the consequences of the ubiquitous presence of corn in many areas of food and food production and the harmful results of this practice.

Though the essays address the flaws in the food production system, they also provide recommendations and ideas to help restore the natural state of American agriculture and help to produce healthier citizens.

This interdisciplinary volume examines the relationship between community resilience and family resilience, identifying contributing factors on the micro-, meso-, and macro-level. Scholars and practitioners focus on how community-level policies and programs facilitate the distribution of resources, assets, and opportunities that provide valuable assistance to families who are struggling or in crisis due to economic hardship, mental illness, and the effects of natural and human made disasters. Additionally, representatives of local government and community agencies on the "front lines" of developing policies and programs to assist families provide valuable context for understanding the ways communities provide environments that encourage and nurture family resilience. Among the topics covered: How cities promote resilience from a public health perspective Family resilience following the Deepwater Horizon oil spill Resilience in women from trauma and addiction Trauma-sensitive schooling for elementary-age students Developing family resilience through community based missions Resilience and the Community will be of interest to policy-makers, researchers, and practitioners seeking to facilitate the development of evidence-based resilience practices, programs, and/or policies for those working with families at risk.

This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.

This book introduces the field of Responsible Innovation in Health (RIH) by clarifying its theoretical foundations and the practical approaches that enable the design and production of responsible medical devices, health and social care interventions, digital tools and solutions based on artificial intelligence. It brings a lasting impact on the ways innovation stakeholders think about and develop solutions to twenty-first century challenges, including the Sustainable Development Goals (SDGs).