Faced with the BRCA mutation--the so-called "breast cancer gene"--one woman must answer the question: When genetics can predict how we may die, how then do we decide to live?
Eleven months after her mother succumbs to cancer, Jessica Queller has herself tested for the BRCA gene mutation. The results come back positive, putting her at a terrifyingly elevated risk of developing breast cancer before the age of fifty and ovarian cancer in her lifetime. Thirty-four, unattached, and yearning for marriage and a family of her own, Queller faces an agonizing choice: a lifetime of vigilant screenings and a commitment to fight the disease when caught, or its radical alternative--a prophylactic double mastectomy that would effectively restore life to her, even as it would challenge her most closely held beliefs about body image, identity, and sexuality.
Superbly informed and armed with surprising wit and style, Queller takes us on an odyssey from the frontiers of science to the private interiors of a woman's life. "Pretty Is What Changes" is an absorbing account of how she reaches her courageous decision and its physical, emotional, and philosophical consequences. It is also an incredibly moving story of what we inherit from our parents and how we fashion it into the stuff of our own lives, of mothers and daughters and sisters, and of the sisterhood that forms when women are united in battle against a common enemy.
Without flinching, Jessica Queller answers a question we may one day face for ourselves: If genes can map our fates and their dark knowledge is offered to us, will we willingly trade innocence for the information that could save our lives?
Praise for "Pretty Is What Changes"
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"By turns inspiring, sorrowful and profoundly moving. Queller's sense of humor and grace transform the most harrowing of situations into a riveting and heartfelt memoir."--"Kirkus Reviews"
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"Seamless and gripping. Readers will be rooting for Queller and her heroic decision to confront her genetic destiny."--"Publishers Weekly"
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"Jessica Queller gives us a warm, chilling, unflinching look at her personal journey of survival with style. The ending will surprise you. Her prescience is astounding. Her courage is inspirational. Brava Jessica "--Marisa Acocella Marchetto, author of "Cancer Vixen"

Leonardo da Vinci's scientific explorations were virtually unknown during his lifetime, despite their extraordinarily wide range. He studied the flight patterns of birds to create some of the first human flying machines; designed military weapons and defenses; studied optics, hydraulics, and the workings of the human circulatory system; and created designs for rebuilding Milan, employing principles still used by city planners today. Perhaps most importantly, Leonardo pioneered an empirical, systematic approach to the observation of nature-what is known today as the scientific method.
Drawing on over 6,000 pages of Leonardo's surviving notebooks, acclaimed scientist and bestselling author Fritjof Capra reveals Leonardo's artistic approach to scientific knowledge and his organic and ecological worldview. In this fascinating portrait of a thinker centuries ahead of his time, Leonardo singularly emerges as the unacknowledged "father of modern science."

Quantum Leap uses key events in the life of Polkinghorne to introduce the central ideas that make science and religion such a fascinating field of investigation. Sir John Polkinghorne is a British particle physicist who, after 25 years of research and discovery in academia, resigned his post to become an Anglican priest and theologian. He was a professor of mathematical physics at Cambridge University, and was elected to the Royal Society in 1974. As a physicist he participated in the research that led to the discovery of the quark, the smallest known particle. This cheerful biography-cum-appraisal of his life and work uses Polkinghorne's story to approach some of the most important questions: a scientist's view of God; why we pray, and what we expect; does the universe have a point?; moral and scientific laws; what happens next?

Marylebone has been home to its fair share of rogues, villains and eccentrics, and their stories are told here. The authors also want to remind the reader that alongside the glamour of Society, there has also been hardship and squalor in the parish, as was graphically illustrated in Charles Booth's poverty maps of London in 1889. Over the past 10 years the Marylebone Journal has printed historical essays on the people, places, and events that have helped shape the character of the area. Some are commemorated with a blue plaque, but many are not. This is not a check-list of the grandees of Marylebone, though plenty appear in these pages. The essays have been grouped into themes of: history, politicians and warriors, culture and sport (from pop music and television to high art), love and marriage (stories from romance to acrimonious divorce), criminals, science and medicine, buildings and places, and the mad bad and dangerous to know - those whose stories don't fit a convenient box but are too good not to tell.

The Next Pandemic is a gripping book that confronts the most urgent question facing our species: when, where, and how will the next major outbreak arrive? Some of history's biggest killers have been infectious diseases: The Black Death killed around 20 million in the 14th century; Spanish Flu killed 50 million in 1918; the AIDS pandemic has killed almost 40 million since 1981. There is no guarantee that we can prevent another such disaster, but whenever a new scare emerges, Dr. Ali Khan is sent to try. This book is Dr. Khan's story of 25 years of containing these near misses, in his long career at the Center for Disease Control. During the 1995 Ebola outbreak in Zaire, Khan worked among Red Cross workers digging mass graves, rescuing struggling patients from near-abandoned hospitals and ultimately finding Patient Zero. In 2001, he traveled to Washington, DC, summoned by a midnight phone call, to prevent anthrax spores from spreading through the Senate Office building's ventilation system. In 2002, he was called to Hong Kong to quarantine victims of SARS, a contagious disease with no cure and no vaccine. In each of these stories, Khan reconstructs the chaos of those first moments on the ground, making life-and-death decisions on limited and conflicting information, with local, federal, and international authorities fighting to contain both the virus and the panic. Through these and other stories, Khan breaks down the sources of the next pandemic: mutation; spillover from other species; lab accidents; bioterrorism; and natural disasters. He shows that the danger of an outbreak is more real than ever in a world of climate change and global commerce, but that we need not only live in fear. His career is a testament to the power of good information, habits, and poise under pressure, as we work to fight whatever exotic contagion comes next. The Next Pandemic is a vivid and necessary book about rampant and violent diseases, and disasters narrowly averted; and the tools we have to keep them at bay.

When Page Dickey moved away from her celebrated garden at Duck Hill, she left a landscape she had spent thirty-four years making, nurturing, and loving. She found her next chapter in southern Connecticut, on 17 acres of rolling fields and woodland around a former Methodist church. In Uprooted, celebrated garden writer Page Dickey reflects on this transition and on what it means for a gardener to start again. In these pages, fol low her journey: searching for a new home, discovering the ins and outs of the landscape surround ing her new garden, establishing the garden, and learning how to be a different kind of gardener. The sur prise at the heart of the book? Although Dickey was sad to leave her beloved garden, she found herself thrilled to begin a new garden in a wilder, larger landscape. Written with humour and elegance, Uprooted is an endearing story about transitions - and the satisfaction and joy that new horizons can bring.

This relatively nontechnical book is the first account of the history of statistics from the Fisher revolution to the computer revolution. It sketches the careers, and highlights some of the work, of 65 people, most of them statisticians. What gives the book its special character is its emphasis on the author's interaction with these people and the inclusion of many personal anecdotes. Combined, these portraits provide an amazing fly-on-the-wall view of statistics during the period in question. The stress is on ideas and technical material is held to a minimum. Thus the book is accessible to anyone with at least an elementary background in statistics.

Silas Burroughs arrived in London from America in 1878 and proved himself an exceptional entrepreneur, taking the pharmaceutical business by storm. He was the brains and energy behind Burroughs Wellcome & Co. With his business partner Henry Wellcome he created an internationally successful firm, the legacy of which can be found in the charity the Wellcome Trust, yet few now remember him and the impact he made in his short lifetime. A consummate salesman, Burroughs was also an astute businessman, with new ideas for marketing, advertising and manufacturing: his writings describe sales trips around the world and the people he met. He was also a visionary employer who supported the eight-hour working day, profit-sharing, and numerous social and radical political movements, including the single tax movement, free travel, Irish Home Rule and world peace. In this first biography of Burroughs, Julia Sheppard explores his American origins, his religion and marriage, and his philanthropic work, as well as re-evaluating the dramatic deterioration of his relationship with his partner Wellcome.

Forrest Galante, host of Extinct or Alive and the world's #1 rare species expert, takes readers along with him through the deepest wilderness and most remote and dangerous parts of the world to find all the animals we thought were extinct. In the course of his travels, Galante has been attacked by lions, stung by jellyfish, bitten by snakes and had run-ins with pissed off hippos. Still Alive offers a travelogue of Galante's most harrowing adventures, introducing readers to some of the most unique rare species he's encountered--while also adding the unpredictable drama and human element of traveling to some of the world's most isolated locations. Part memoir, part biological adventure, Still Alive is a calling card for conservation, highlighting not just Galante's toughness as he finds animals thought to be lost, but also the resiliency of the animals themselves, as they keep their species alive in spite of the odds.

This book explains how the Apollo crews learned to work on the lunar surface. Its lively and informative text draws heavily on transcripts and photographs to illustrate points. It puts the reader on the lunar surface with the astronauts, sharing their observations, excitement, and frustrations. The book describes the challenging yet exhilarating lunar environment facing the Apollo astronauts, and reveals their courageous, sometimes creative and occasionally humorous adaptation to the field conditions on another planet. Recent interviews with the astronauts are included in which they recall their thoughts after more than 25 years of reflection.

The definitive, internationally bestselling biography of Albert Einstein from the author of The Innovators, Steve Jobs and Benjamin Franklin. **Now the basis of Genius, the ten-part National Geographic series on the life of Albert Einstein, starring the Oscar, Emmy, and Tony Award-winning actor Geoffrey Rush** How did Einstein's mind work? What made him a genius? Isaacson's biography shows how Einstein's scientific imagination sprang from the rebellious nature of his personality. His fascinating story is a testament to the connection between creativity and freedom. Isaacson explores how an imaginative, impertinent patent clerk - a struggling father in a difficult marriage who couldn't get a teaching job or a doctorate - became the locksmith of the mysteries of the atom, and the universe. His success came from questioning conventional wisdom and marvelling at mysteries that struck others as mundane. This led him to embrace a morality and politics based on respect for free minds, free spirits and free individuals. Einstein, the classic No.1 New York Times bestseller, is a brilliantly acclaimed account of the most influential scientist of the twentieth century, 'An illuminating delight' New York Times 'Dramatic and revelatory' Sunday Times 'Beautifully written' Sunday Telegraph 'Astonishing' Mail on Sunday

Francis James Browne is remembered as the foremost obstetrician of his day. He is widely recognised as the founder of modern antenatal care. His book, Antenatal and Postnatal Care, became the best of its kind and a bible to many generations of medical students and junior obstetricians. In this biography, Herbert Reiss presents a fascinating glimpse into the life of a great man in a deft and vivid portrait..

This revised and greatly expanded second edition of the Russian text contains a wealth of new information about the lives and accomplishments of more than a dozen scientists throughout five centuries of history: from the first steps in algebra up to new achievements in geometry in connection with physics. The heroes of the book are renowned figures from early eras, as well some scientists of last century. A unique mixture of mathematics, physics, and history, this volume provides biographical glimpses of scientists and their contributions in the context of the social and political background of their times.

James T. Costa takes readers on a journey from Charles Darwin's youth and travels on the HMS Beagle to Down House, his bustling home of forty years. To test his insights into evolution, Darwin devised experiments using his garden and greenhouse, the surrounding land and his home-turned-field-station. His experiments yielded universal truths about nature and evidence for his revolutionary arguments in On the Origin of Species and other watershed works. We accompany Darwin in his myriad pursuits against the backdrop of his enduring marriage, chronic illness, grief at the loss of three children and joy in scientific revelation. At each chapter's end, Costa shows how we can investigate the wonders of nature, with directions on how to re-create Darwin's experiments.

An entertaining history of mathematics as chronicled through fifty short biographies. Mathematics today is the fruit of centuries of brilliant insights by men and women whose personalities and life experiences were often as extraordinary as their mathematical achievements. This entertaining history of mathematics chronicles those achievements through fifty short biographies that bring these great thinkers to life while making their contributions understandable to readers with little math background. Among the fascinating characters profiled are Isaac Newton (1642-1727), the founder of classical physics and infinitesimal calculus--he frequently quarreled with fellow scientists and was obsessed by alchemy and arcane Bible interpretation; Sophie Germain (1776 - 1831), who studied secretly at the Ecole Polytechnique in Paris, using the name of a previously enrolled male student--she is remembered for her work on Fermat's Last Theorem and on elasticity theory; Emmy Noether (1882 - 1935), whom Albert Einstein described as the most important woman in the history of mathematics--she made important contributions to abstract algebra and in physics she clarified the connection between conservation laws and symmetry; and Srinivasa Ramanujan (1887-1920), who came from humble origins in India and had almost no formal training, yet made substantial contributions to mathematical analysis, number theory, infinite series, and continued fractions. The unusual behavior and life circumstances of these and many other intriguing personalities make for fascinating reading and a highly enjoyable introduction to mathematics.

Many people know that Tesla was a scientific genius, instrumental in developing modern electricity and communications. What, perhaps, they don't know is that he was born during a lightning storm; spoke eight languages; and claimed to have invented a death ray that could destroy 10,000 planes from 250 miles away. This book presents an electrifying exploration of his life, work and fame, with 50 irresistible facts converted into infographics to reveal the scientist behind the science.

Many people know that Albert Einstein was a brilliant theoretical physicist who revolutionised modern science. What they may not know is that he only learnt to speak at four years old; that he was asked to become the President of Israel in 1952, but refused; or that he was under FBI surveillance for 22 years. This book presents an instant impression of his life with 50 irresistible facts converted into infographics to reveal the scientist behind the science.

This book recounts the life and achievements of Clarence King, widely recognized as one of America's most gifted intellectuals of the nineteenth century, and a legendary figure in the American West. King's genius, singular accomplishments, and near-death adventures unfold in a narrative centered on his personal relationship with his lifelong friend and colleague, James Gardner. The two, upon completing their studies at Yale, traveled by wagon train across the continent and worked with the California Geological Survey. King went on to establish the Geological Exploration of the 40th Parallel, a government mapping program that stretched across the western mountain chains from California to Wyoming. This was the precursor to the U.S. Geological Survey (USGS). Founded in 1879, with Clarence King as its architect and first director, the USGS became the most important and influential science agency in the nation. The adventurous aspects of conducting geological fieldwork in the West, much of them documented by letters written by King and Gardner, punctuate a book copiously illustrated with historic maps and photographs showing localities and people important to the story.

When Michael Collins decides to become a surgeon, he is totally unprepared for the chaotic life of a resident at a major hospital. A natural overachiever, Collins' success, in college and medical school led to a surgical residency at one of the most respected medical centers in the world, the famed Mayo Clinic. But compared to his fellow residents Collins feels inadequate and unprepared. All too soon, the euphoria of beginning his career as an orthopedic resident gives way to the feeling he is a counterfeit, an imposter who has infiltrated a society of brilliant surgeons.
This story of Collins' four-year surgical residency traces his rise from an eager but clueless first-year resident to accomplished Chief Resident in his final year. With unparalleled humor, he recounts the disparity between people's perceptions of a doctor's glamorous life and the real thing: a succession of run down cars that are towed to the junk yard, long weekends moonlighting at rural hospitals, a family that grows larger every year, and a laughable income.
Collins' good nature helps him over some of the rough spots but cannot spare him the harsh reality of a doctor's life. Every day he is confronted with decisions that will change people's lives-or end them-forever. A young boy's leg is mangled by a tractor: risk the boy's life to save his leg, or amputate immediately? A woman diagnosed with bone cancer injures her hip: go through a painful hip operation even though she has only months to live? Like a jolt to the system, he is faced with the reality of suffering and death as he struggles to reconcile his idealism and aspiration to heal with the recognition of his own limitations and imperfections.
Unflinching and deeply engaging, "Hot Lights, Cold Steel" is a humane and passionate reminder that doctors are people too. This is a gripping memoir, at times devastating, others triumphant, but always compulsively readable.

In May 1961, President Kennedy announced that the United States would attempt to land a man on the moon and return him safely to the earth before the end of that decade. Yet NASA did not have a specific plan for how to accomplish that goal. Over the next fourteen months, NASA vigorously debated several options. At first the consensus was to send one big rocket with several astronauts to the moon, land and explore, and then take off and return the astronauts to earth in the same vehicle. Another idea involved launching several smaller Saturn V rockets into the earth orbit, where a lander would be assembled and fueled before sending the crew to the moon. But it was a small group of engineers led by John C. Houbolt who came up with the plan that propelled human beings to the moon and back-not only safely, but faster, cheaper, and more reliably. Houbolt and his colleagues called it "lunar orbit rendezvous," or "LOR." At first the LOR idea was ignored, then it was criticized, and then finally dismissed by many senior NASA officials. Nevertheless, the group, under Houbolt's leadership, continued to press the LOR idea, arguing that it was the only way to get men to the moon and back by President Kennedy's deadline. Houbolt persisted, risking his career in the face of overwhelming opposition. This is the story of how John Houbolt convinced NASA to adopt the plan that made history.

Families are riddled with untold secrets. But Stephen Hinshaw never imagined that a profound secret was kept under lock and key for 18 years within his family - that his father's mysterious absences, for months at a time, resulted from serious mental illness and involuntary hospitalisations. From the moment his father revealed the truth, during Hinshaw's first spring break from college, he knew his life would change forever. Hinshaw calls this revelation his 'psychological birth.' After years of experiencing the ups and downs of his father's illness without knowing it existed, Hinshaw began to piece together the silent, often terrifying history of his father's life - in great contrast to his father's presence and love during periods of wellness. This exploration led to larger discoveries about the family saga, to Hinshaw's correctly diagnosing his father with bipolar disorder, and to his full-fledged career as a clinical and developmental psychologist and professor. In Another Kind of Madness, Hinshaw explores the burden of living in a family 'loaded' with mental illness and debunks the stigma behind it. He explains that in today's society, mental health problems still receive utter castigation - too often resulting in the loss of fundamental rights, including the inability to vote or run for office or automatic relinquishment of child custody. Through a poignant and moving family narrative, interlaced with shocking facts about how America and the world still view mental health conditions well into in the 21st century, Another Kind of Madness is a passionate call to arms regarding the importance of destigmatising mental illness.