Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels.
The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

The current concept of dystonic movement connects the abnormal function of somatosensory pathways and somatosensory analyzers with the dystonic performance of motor action, which is based on the abnormality of sensorimotor integration. This concept is reflected not only in idiopathic dystonia, but also in secondary and symptomatic dystonias. This bookwill give a comprehensive account ofthe history of the terms dystonia and dystonic, the physiology of dystonic movement, and the genetics and clinical appearance of primary and secondary dystonias. Taking into considerationlatest research findings, Dystonia and Dystonic Syndromes offers an in-depth discussion of current treatment options available for dystonia, including pharmacotherapy, surgery, and neurorehabilitation. Therefore, it serves as a valuable reference for practitioners in the fields of neurology, neurosurgery, psychiatry, and neuroradiology as well as for neuroscientists.

Destined to be the definitive reference in this complex surgical area, Endoscopic Craniosynostosis Surgery is the first single resource to offer complete coverage of techniques, outcomes, complications, and results when treating patients with craniosynostosis endoscopically. Dr. David F. Jimenez, a pioneer in the field who has developed minimally invasive endoscopic surgeries to treat very young infants with this condition, provides all appropriate data and detailed guidance on every aspect of the management of craniosynostosis using endoscopic techniques. Covers the surgical management of every type of single suture synostosis as well as multiple and complex synostosis. Presents surgical techniques in depth, with a complete review of short- and long-term outcomes and results. Provides detailed information on patient anesthesia and how to set up the operating room for surgery. Includes detailed descriptions of helmets and their management. Features hundreds of radiographs, clinical photos, and procedural illustrations, as well as procedural videos. Discusses complication avoidance, provides surgical pearls throughout, and supplies patient information online. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access bonus images plus all of the text, figures, and references from the book on a variety of devices.

Discover effective, outcome-oriented ways to help CFS patients who have endured useless or inappropriate treatments! From the author: For many years I have viewed brain function as a system of electrochemical impulses continually flashing through the brain. These neural networks can often be modulated fairly simply by 'tuning' them. The point I have been trying to make for many years is that this process may be pharmacologically regulated extremely rapidly in a manner which does not yet seem to be recognized by the medical profession. In this remarkable volume, Dr. Jay A. Goldstein clearly presents both the theoretical and the practical aspects of his revolutionary approach to treating CFS and other conditions that have often been termed psychosomatic. Dr. Goldstein (author of Chronic Fatigue Syndromes: The Limbic Hypothesis and Betrayal by the Brain: The Neurologic Basis of Chronic Fatigue Syndrome, Fibromyalgia Syndrome, and Related Neural Network Disorders) shows how he achieves results for patients with CFS and a variety of other syndromes in days, rather than months or years. This well-referenced book answers questions, from the most basic to the most complex, including: What is neurosomatic medicine? How did Dr. Goldstein come to pioneer and practice this specialty? What abnormalities in brain function produce neurosomatic disorders? How can an understanding of these abnormalities help you provide effective treatment? Why do these treatments sometimes work so rapidly? What is receptor profiling, and how does it indicate the type of receptor dysregulation in an individual patient? In Part I: Inventing Neurosomatic Medicine, Dr. Goldstein describes the remarkable how and why of his life and his development of this new field of medicine, including his clashes with the medical/psychoanalytic establishment. One of the greatest medical innovators of the modern era, Dr. Goldstein has seen over 20,000 CFS patients and has experienced most of the pitfalls that having such a large number of patients entails. He shares his insight on legal issues, such as how to deal with the law and court systems, how to best provide expert testimony, and how to defend against spurious legal actions. In addition, Dr. Goldstein describes how he learned to work effectively outside of the managed care system. In Part II: Society for Neuroscience Conference Proceedings, the author shares his expertise to bring you experimental results and pearls of wisdom relating to neurosomatic medicine from the 28th and 29th Annual Meetings of the Society for Neurosciencethe largest and most important neuroscience conference in the world. Dr. Goldstein sorted through thousands of experiments presented at the conferences to bring you the most relevant findings. Part III: Pathophysiology and Treatment is essential reading for anyone planning to practice neurosomatic medicine. In this section, richly illustrated with over 70 pages of color figures and diagrams that make complicated concepts clear, Dr. Goldstein shares his knowledge about dozens of the agents he uses to help CFS sufferers and others manage their pain, fatigue, and other symptoms. This is information that simply cannot be found anywhere else, and will prove invaluable to all fledgling neurosomatic practitioners. This one-of-a-kind volume is thoughtfully put togetherfrom the extensive list of abbreviations near the beginning to the exhaustive references and an appendix with diagnostic criteria, a treatment algorithm, a medication list of treatment options available now or in the near future, and a checklist of CFS symptoms.

The treatment of end-stage heart failure with advanced surgical therapies has evolved significantly over the last several years and is a dynamic subspecialty within cardiac surgery. "Surgical Treatmentfor Advanced Heart Failure "describes the surgical management of advanced heart failure, including coronary artery revascularization, mitral valve repair, aortic valve replacement, ventricular remodeling, cardiac resynchronization, mechanical circulatory support with short-term devices for acute stabilization, long-term mechanical support as a bridge to transplant and for destination therapy, left ventricular assist devices, complete cardiac replacement with the total artificial heart, and cardiac transplantation. With contributions from a distinguished group of heart failure cardiologists and transplant surgeons, it is an authoritative resource for cardiac surgeons, cardiologists, and surgeons.

In this issue of Foot and Ankle Clinics, guest editor Dr. Scott Ellis brings his considerable expertise to the topic of Managing Complications of Foot and Ankle Surgery. Top experts in the field cover key topics such as ankle and TTC fusion, complications from lesser toe surgery, ORIF ankle, navicular fracture, ankle instability, Achilles failed repair, and more. Contains 16 relevant, practice-oriented topics including hallux valgus and hallux rigidus; failed Lisfranc/midfoot arthritis/arthrodesis; flatfoot; persistent pain after hindfoot fusion; and more. Provides in-depth clinical reviews on managing complications of foot and ankle surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Clinical Research Methods for Surgeons is a comprehensive guide for the surgical scientist, and serves as both a critical review of existing literature and a reference guide for clinical research methodologies as they apply to surgery. The text addresses the clinical research questions facing 21st century surgeons, and provides clear direction on how to incorporate sophisticated research techniques into practice. In addition to the surgical generalist, this practical volume is specifically oriented to surgeons who treat unique diseases, yet have no single resource to facilitate clinical research in these specific areas.
This comprehensive and easy-to-use guide encompasses the entire process of clinical study design, application, and assessment. Part One is aimed at the young surgeon about to engage in new studies, and gives a general overview of the infrastructure of clinical research. Parts Two and Three are geared towards experienced investigators interested in pursuing clinical research and surgeons reviewing the literature for practical application. Part Two focuses on study design and related statistical issues, while Part Three is concerned with measuring and assessing the outcome of clinical studies. Part Four presents topics of interest to the active investigator, such as quality of care and cost-effectiveness analyses. Clinical Research Methods for Surgeons is relevant to both beginning investigators and established researchers, and addresses the unique concerns of surgical diseases and acknowledges that they require special approaches to deal with clinical questions.

This book covers the basics of evoked spinal cord potentials

(SCPs) with reference to studies in animals. Many illustrations help the reader grasp the neurophysiological and neuropharmacological background of spinal cord functions. Case studies offer insight into monitoring and diagnosing spinal cord dysfunctions and spinal cord diseases. The book is intended for students in clinical neurophysiology, neurosurgery, neurology, orthopedics and neuroanesthesia.

The third edition of Cardiopulmonary Bypass offers a comprehensive, and up-to-date reference text to extracorporeal cardiopulmonary support. This book provides a clinically-focused tutorial with chapters spanning the technical aspects, patient related considerations, and human factors essential to contemporary practice of cardiopulmonary bypass. Written concisely to allow the reader to gain and apply critical knowledge to the clinical setting and featuring artwork that has been extensively updated to include numerous figures and color plates imbedded into each chapter. A remarkable collection of international experts in the fields of perfusion, anesthesiology, and cardiac surgery were recruited to co-author chapters, providing a multidisciplinary approach to case management. This completely updated edition includes expanded content on developments in minimally invasive extracorporeal circulation, anticoagulation, organ injury, and human factors. The comprehensive coverage of perfusion practice in a concise, highly illustrated format makes it the go-to, portable reference manual for perfusionists, cardiac surgeons, and anesthesiologists.

In 2005, surgeons in France removed part of the face from a cadaver and grafted it onto the head of a 38-year-old woman grossly disfigured by a dog attack. Three years later, in December, 2008, surgeons at the Cleveland Clinic announced they had performed the first U.S. face transplant. Although modern culture is accustomed to pushing medicine and the human body beyond all limits, the world's first partial face transplant and the seven that have followed have caused a stir that still reverberates globally.

This book begins with the story of Isabelle Dinoire, the recipient of the first face transplant, and chronicles her surgery and battles with tissue rejection. Its scope widens with a look at how surgical teams, including three U.S. transplant teams, are in a global race to perform the first full face transplant, and at how medical history has led up to this point--with prior successful transplants ranging from body parts as simple as cornea to those as neurologically complicated as the heart, a hand, and a penis.

The most novel among these surgeries--the face transplant--conjures up particular and expansive psychological issues. Authors Bluhm and Clendenin show how transplant recipients struggle with functional issues including a lifetime of anti-rejection drugs, a danger highlighted by the recent death of the second face transplant patient, in China. But just as challenging in the case of face transplant is the psychological effect on--and potential threat to--identity. Who are you, if suddenly your face--or a significant portion of it--is not what you were born with? What is it like to look in the mirror, and see a face that is not the one you have always had? Dinoire lamented, "It will never be me." That statement is an absolute simplification of the identity issues a face transplant can create, explain the authors. Bluhm and Clendenin show how, across history and media, humankind--via medicine, literature, film, and other media--has dreamed of a day when face transplants would be possible.

With so many disfigurements occurring among the military in Iraq, and experimental face transplants too expensive for implementation in the private sector, it is likely that the U.S. military will take the reins and further face transplant techniques as quickly as possible to serve injured personnel.

This book is written as a reference and guidebook for practicing surgeons, gastroenterologists, and interventional radiologists with an interest in hepatobiliary diseases. It presents a strategy to enhance surgeons practice and the care of patients.

In this issue of Thoracic Surgery Clinics, Guest Editor Cherie Erkmen brings considerable expertise to the topic of social disparities in thoracic surgery. Top experts in the field cover key topics such as social disparities in lung cancer, population health, esophageal cancer, benign lung diseases, and more. Provides in-depth, clinical reviews on social disparities in thoracic surgery, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 12 relevant, practice-oriented topics including Social Disparities Database and Big Data; Health Disparities in Recruitment and Enrollment in Research; Social Disparities in Lung Cancer Risk and Screening; and more.

Epilepsy surgery is defined as any neurosurgical intervention whose pri- mary objective is to relieve medically intractable epilepsy (European Fed- eration of Neurological Societies Task Force 2000). The aim of epilepsy surgery is to reduce the number and intensity of seizures, minimise neuro- logical morbidity and antiepileptic drug (AED) toxicity, and improve quality of life. By definition, epilepsy surgery does not include normal surgical treatment of intracranial lesions where the primary goal is to di- agnose and possibly remove the pathological target, often an advancing tumour. In these patients, epileptic seizures are only one symptom of the lesion and will be treated concomitantly as part of the procedure. Temporal lobe epilepsy (TLE) is recognised as the most common type of refractory, focal epilepsy. In one third of all cases the neuronal systems responsible for the seizures that characterise this form of epilepsy fail to respond to currently available AEDs (Andermann F 2002). New imaging methods, especially magnetic resonance imaging (MRI), identify localising abnormalities in an increasing proportion of patients with intractable focal epilepsy. Consequently, the accuracy of the preoperative diagnostic pro- cedures has been significantly improved during the last decade; and suit- able candidates for surgery can be selected more reliably. Currently the main resources in most epilepsy surgery centres have been used to evaluate candidates for TLE surgery.

"Orthotics: A Comprehensive Clinical Approach" is an innovative and comprehensive new text that provides essential information about contemporary orthoses to guide the student and clinician in prescribing and utilizing these appliances in neuromuscular, musculoskeletal, and integumentary rehabilitation.

Written by recognized authorities in the field, Joan Edelstein, MA, PT, FISPO and Jan Bruckner, PhD, PT, this is a prime resource for practitioners and clinicians.

Individual chapters cover orthoses for the foot, ankle, knee, hip, trunk, neck, shoulder, elbow, wrist, and hand. Orthoses for patients with paraplegia, burns, and soft tissue contractures are detailed and illustrated. Prescription guidelines, evaluation techniques, goal setting, and training procedures are presented.

Each chapter has interesting "thought" questions and case studies to promote clinical reasoning and problem-solving skills. A unique feature of this text is the inclusion of a point-counterpoint discussion to demonstrate how clinicians can manage the same patient in different ways. This approach inspires broader thinking about clinical management.

This publication is intended as a guide to common diagnostic, operative and percutaneous techniques used in creating and maintaining vascular access for hemodialysis. When writing the text, the authors have focused on surgeons in training, fellows, interventional radiologists and clinically active nephrologists. Dialysis nurses and other clinicians involved in the care of end stage renal disease and dialysis patients will also greatly benefit from this handbook. This 2nd edition of the text contains expanded sections on ESRD, access surveillance and surgical and diagnostic devices, as well as new sections on peritoneal and dual lumen catheter placement, commonly used drugs and dialysis, hemo- and peritoneal dialysis techniques and CPT and ICD coding for statistical and billing purposes. These changes reflect the highly technical nature of clinical management in this evolving specialty.

Ophthalmic Anaesthesia is a new textbook written by an international group of authors who are recognized experts in the fields of anaesthesia and ophthalmology. Covering the entire subspecialty of anaesthesia for surgery of the eye, the book offers chapters on a variety of subjects including: the history of ophthalmic anaesthesia, physiology and pharmacology, anatomy, pre-operative assessment, paediatric anaesthesia, orbital regional anaesthesia, general anaesthesia, complications, high-volume cataract surgery, and future developments. Written by both academicians and experienced clinicians, this is a well-referenced and illustrated text describing the techniques used in the anaesthetic management of patients undergoing the most commonly performed surgical procedures in the world.

From a background in ethnography, Israeli teacher Ben-David aims to understand the meaning of organ donation and transplantation from the perspectives of the three major partners involved: donors, recipients, and the medical teams. The participation of all partners, each with specific interests, enables human organs to become an exchangeable commodity with social significance. Applying the resulting information from her comprehensive study, Ben-David assesses the roles played by life and death in organ donation within the Israeli Jewish community. She also examines issues of social legitimacy connected to organ donation in the Israeli society, institutionalization of transplantations, and transplantation as a trigger for transformation to hero status.

In this issue of Atlas of the Oral and Maxillofacial Surgery Clinics, guest editors Drs. Mark A. Miller and David M. Yates bring their considerable expertise to the topic of Common Procedures in Cleft and Craniofacial Surgery. Articles from top experts in the field include coverage of cleft lip surgery, different surgical approaches to craniosynostosis, and other craniofacial syndromes, as well as reconstruction and bone grafting. Contains 12 relevant, practice-oriented topics including primary cleft lip deformity; cleft nasal deformity; endoscopic approaches to craniosynostosis; open approaches to craniosynostosis; cranial deformities; and more. Provides in-depth clinical reviews on common procedures in cleft and craniofacial surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Endoscopic orbital procedures are at the forefront of today's multidisciplinary patient care and team approach to problem-solving. Endoscopic Surgery of the Orbit offers state-of-the-art, expert guidance on minimally invasive orbit techniques that promise a more streamlined approach to comprehensive patient care, improved patient satisfaction, and superior outcomes. This unique resource reflects the contemporary, unparalleled partnership between otolaryngology, neurosurgery, and ophthalmology that often also includes a cohesive team of clinicians from many other specialties. Provides expert perspectives from thought leaders in various specialties, including otolaryngologists, ophthalmologists, neurosurgeons, endocrinologists, medical and radiation oncologists, radiologists, and pathologists. Details the two-surgeon, multi-handed surgical techniques that have revolutionized the management of complex pathologies involving the orbit and skull base. Covers the full breadth of endoscopic orbital procedures-from advanced intraconal tumor removal and intracranial techniques involving the optic nerve and optic chiasm to more routine endoscopic procedures such as orbital decompressions, E-DCR, fracture repair, and subperiosteal abscess drainage. Reviews key topics such as neuromonitoring in orbital and skull base surgery, endoscopic surgery of the intraconal space for tumor resection, Transorbital NeuroEnodscopic Surgery (TONES), and reconstruction of the orbit. Includes tips and pearls on safe and effective procedures as well as novel approaches and innovations in the equipment used to perform these popular procedures. Provides superb visual reinforcement with more than 400 high-definition images of anatomy, imaging, and surgical techniques, as well as procedural videos. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Despite the significant decline in heart disease mortaht>' rates over the last 25 years, heart failure has remained a significant problem. We are now confronted with large numbers of terminally ill patients for whom conventional therapies for heart failure have been exhausted and for whom repeated hospital visits are necessary. There now is a major thrust towards a management strategy which embraces a comprehensive approach including vigorous preventive measures and earlier surgical interventions. This book outlines the major surgical options for the treatment of heart failure and brings together a very broad base of opinions with contributions from several outstanding individuals. With the improved knowledge and techniques to control rejection, transplantation has become the central pillar in the surgical management of this group of patients. Unfortunately, because of limited donor supply the teclmique cannot be applied to large numbers of patients. A great deal of excitement, however, exists in the potential for xenotransplantation as a supplement to homotransplantation. The use of cardiac assist devices has become a reality with several hundred LVADS and BiVADS implanted throughout the world and cardiac replacement with total artificial hearts continues to be used successfully as a bridge to transplantation. We are on the thieshold of the broad application of assist devices to provide prolonged relief of heart failure and restore patients to an ambulatoiy home environment and hopefully return to the work force in significant numbers.

Work related musculoskeletal disorders (WRMSDs) are the leading cause of worker impairment, disability, compensation costs and loss of productivity in industrialized countries. The aging of the workforce and the increased diffusion of physically demanding jobs contribute to the widespread concern about musculoskeletal disorders.
The effective prevention of work related musculoskeletal disorders needs a multidisciplinary approach, drawing together experience from backgrounds in engineering, mechanics, physiology, occupational medicine and psychology; all considered in the context of ergonomics.
This book is a collection of lectures on both back and upper limb musculoskeletal disorders presented at an International Course sponsored by the Nordic Institute for Advanced Training in Occupational Health (NIVA), and the University of Bologna in September 1999. The lectures were given by renowned international researchers on the subject and therefore the book provides a comprehensive overview of all critical issues related to musculoskeletal disorders at work. The book forms an update to the latest research in the field and will interest a wide range of professionals and researchers in ergonomics as well as in the fields from which the material is drawn.
The book covers the main topics addressed in dealing with occupational ergonomics including:
* occupational biomechanics
* physiology
* epidemiology
* psychosocial issues
* medical diagnosis and management
* ergonomic solutions


eBook available with sample pages: 0203484916