Modern Management of Cancer of the Rectum is intended to provide a comprehensive overview of all aspects of rectal neoplasms. It addresses epidemiology, biology, screening and chemoprevention, the role of imaging in diagnosis, staging and prognosis, radiation therapy, medical and surgical treatment, as well as new modalities of therapy, including laparoscopy, and transanal endoscopic surgery. A greater understanding of prognostic factors, patterns of spread and natural history has occurred during the past decade; together with new diagnostic modalities this has led to significant changes in the management of patients with rectal cancer. This book will be invaluable for all those who treat rectal cancer.

Peyronie's Disease: A Guide to Clinical Management is the first comprehensive book on this prevalent disorder in adult men (estimated range from 5-9 per cent) designed to clarify misconceptions and myths, provide an update on the etiology, pathophysiology and current research, provide useful information for clinical practice and hopefully stimulate further research into understanding the pathophysiology of this devastating problem. There will also be extensive attention to the current medical and surgical treatments with detail on surgical technique.

Sharmila Majumdar In the area of osteoporosis and skeletal changes, it is currently accepted that bone mineral density (BMD), widely used for screening, monitoring and assessing therapeutic efficacy, does not adequately explain the pathogenesis of osteoporosis, the process of aging, or the therapeutic efficacy of various treatments. In this context, trabecular micro- architecture has enormous potential to contribute to understanding the pathophysiology of osteopor.osis and therapy assessment. The use and value of noninvasive imaging and quantitative image analysis and processing of trabecular bone micro-architecture have increased dramatically due to recent advances in instrumentation and software. This emerging field is diverse, interdisciplinary, and encompasses many different imaging modalities. Interested researchers include those involved in technique development, basic science and animal studies, as well as clinical researchers and practicing physicians. With the growth of this area of research, a group of investigators at the 11th Interna- tional Workshop of Bone Densitometry, 1 concluded that a forum dedicated to this matter was urgently needed. With this agenda, Dr. Peter Ruegsegger organized the first sympo- 2 sium on conjunction with the 10th Conference of the European Society of Biomechanics. The symposium on Bone Architecture and Competence was a two-hourlong event which resulted in five chapters in Bone Research and Biomechanics, edited by G. Lowet, P. Ruegsegger, H. Weinans, and A. Meunier, published by lOS Press, 1997. The second symposium was held as a pre-symposium to the 12th Workshop on Bone Denistometry,3 and flourished as a daylong event.

When doctors first look at sutureless anastomosis devices created by new technologies, the most frequent comment is how amazingly easy it is to create a vascular anastomosis and, as a direct consequence, they believe anybody could play the role of the cardiovascular surgeon. Pessimistic c- diovascular surgeons, on their side, think that creating a machine capable of perfectly reproducing their core activity, which consists in making an- tomosis, will kill their profession. Actually, no medical specialty's demise has been more often predicted and, at the same time, more greatly ex- gerated than that of cardiovascular surgery. According to its detractors, - ginning in the late 1980s with the angioplasty boom, continuing in the mid-1990s with the introduction of bare metal stents, and then more - cently with the introduction of drug-eluting stents, cardiovascular surgery has been on life support for nearly 15 years. This specialty's claimed collapse has generally been attributed to recent advantages in percutaneous procedures and devices that give the oppor- nity to non-surgeon doctors to accomplish the surgeon's work. The reality is different. Data suggest that cardiac surgery continues to survive and has not suffered the precipitous decline that was predicted. From the economical standpoint, CABG is much more of a mature market and the size of the opportunity remains impressive and relatively stable, with around 1,500,000 procedures performed annually worldwide, at a total cost approaching 2. 5 billion US$.

Pediatric Urology: Evidence for Optimal Patient Management provides pediatric urologists the information needed for state-of-the-art patient care. Chapters are organized around pertinent clinical questions within major areas of pediatric urology, answered using the best available data while also reporting areas for which there is poor evidence. The text includes randomized controlled trials and prospective observational studies, tables that summarize important studies, and figures that illustrate algorithms with best options for management and their expected results. With an easy to use format not found in other volumes, Pediatric Urology: Evidence for Optimal Patient Management is an indispensible and unique resource for experienced pediatric urologists, pediatric surgeons, general urologists with an interest in pediatric urology, as well as fellows and residents in training.

Challenging Concepts in Oral and Maxillofacial Surgery details over 25 challenging and complex scenarios matched to the OMFS syllabus including frontal sinus fractures, reconstructive challenges following blast injuries to the facial soft tissue and skeleton, and reratocystic odontogenic tumours. This case-based learning book is designed to be used by trainees and speciality registrars. Each case is supported by the commentary of a renowned expert in the field, allowing readers to improve their own management of these patients. As the reader works through each case there are 'Clinical Tips', 'Learning Points' and 'Evidence Base' boxes to enhance the learning process along with the 'Expert Commentary', providing an inside track on how the experts approach challenging cases. The range of topics discussed including three complex battlefield cases will be essential reading for trainees in oral and maxillofacial surgery and related specialties, such as otolaryngology, oral surgery, orthodontics, and dentistry.

This book illuminates how crucial transformations in medical politics and organization were linked to wider changes in society, economy and ideology. Paying particular attention to developments in medical welfare for physically handicapped children, wounded soldiers and injured workers, this documented study challenges conventional accounts of medical specialization, provides Anglo-American comparisons and demonstrates the importance for medical modernity of changing interactions between philanthropy, war, labour, capital and the state.

This book addresses instruments, methodologies and diagnostic methods used to evaluate and diagnose human movement, locomotion and physical status in general. Starting from historical perspective, the idea of understanding human locomotion by applying technical measurement devices and incorporating measurement data into physical representation of gross body movement is presented and explained, an approach known as inverse dynamics. With this approach as a kind of umbrella concept, components of measurement systems including relevant signal and data processing methods are described. Modern instruments to capture body movement by measuring its kinematics, kinetics and surface electromyography (sEMG) are thus described; all systems being used dominantly-if not exclusively-in a movement analysis laboratory setting. Focusing mainly on human posture and gait, but including also examples of movement patterns from selected kinesiological and sports activities, the book attempts to present essentials of biomechanics and biomedical engineering approach to this subject matter. It illustrates how data collected and elaborated by modern engineering technology can complement traditional expert knowledge of a kinesiologist or a medical doctor. The book is applicable in the fields of sports, physical activities, as well as in medical diagnostics and rehabilitation. The examples of this book's practical application might be in evaluation of efficiency of human gait, in evaluation of skeletal muscle fatigue in physical exercise, in biomechanical diagnostics of traumatological conditions requiring orthopaedic treatment and the like. This book can also be used in planning and executing research endeavours, particularly in a clinical context as a reference for various diagnostics procedures. It presents the lecture notes of a course carrying the same name within Medical Studies in English at the University of Zagreb for more than a decade.

Part of the Challenging Concepts in series, this book is a case-based guide to challenging clinical scenarios in neurosurgery covering the major sub-speciality areas of oncology, vascular neurosurgery, brain and spine trauma, paediatrics, spinal degenerative disease, peripheral and cranial nerves, functional neurosurgery and infection. Specific cases are examined with consideration of clinical presentation, diagnostics, and surgical principles, with a summary of evidence from the neurosurgical literature highlighting areas of interest and controversy. This book serves as a useful and engaging resource for consultants and trainees in neurosurgery as well as in the disciplines of neurology, maxillofacial surgery, spinal surgery and neuro-oncology.

This book provides a comprehensive analysis of the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of a wide variety of pathologies. Sonography reliably identifies a wide range of diseases, and the efficacy of modern ultrasound has dramatically improved with contrast enhancement. This book covers almost all aspects of CEUS starting from basic principles and ending with features of its application in individual organs. In particular, it explores the diseases of abdominal, retroperitoneal, and pelvic organs as well as superficial structures, highlighting the characteristic features of typical findings. Focal lesions are discussed in depth, with attention to their early detection and differential diagnosis. Besides, a practical approach to the stratification of the risk of malignancies is provided. The authors summarized their own experience with CEUS in oncology, hepatology, gynecology, urology, endocrinology, and other fields of medicine. The role of CEUS in differential diagnosis of various disorders of the female reproductive system is comprehensively discussed as well. The presentation is clear and concise, and richly illustrated. The book will be a helpful tool for both residents and practitioners approaching ultrasound diagnostics, as well for more experienced radiologists and other professionals.

Transplantation is a medically successful and cost-effective way to treat people whose organs have failed-but not enough organs are available to meet demand. Ethics and the Acquisition of Organs is concerned with the major ethical problems raised by policies for acquiring organs. The main topics are the rights of the dead, the role of the family, opt in and opt out systems, the conscription of organs, living organ donation from adults and children, directed donation and priority for donors, and the sale of organs. In this ground-breaking work, T. M. Wilkinson uses concepts from moral and political theory such as autonomy, rights, posthumous interests, justice, and well-being, in a context informed by the clinical, legal, and policy aspects of transplantation. The result is a rigorous philosophical exploration of real problems and options. He argues that the ethics of acquiring organs for transplantation is not only of great intellectual interest, but also of practical importance. As such, this book will be of profit not only to students and academics who work in applied ethics and bioethics, but also to the lawyers, policy-makers, clinicians, and lobby groups interested in transplantation.

Critical care medicine comprises the observation, diagnosis, treatment, and rehabilitation of patients with overt or potential failure of vital functions. Unlike other, bulkier reference texts, Handbook of Acute Critical Care Neurology focuses on one topic for quick and easy use on the job. Written by a highly respected expert in the field, this book will be extremely helpful for the practioner.

This volume introduces engineers and healthcare professionals to the latest in neurosurgical robotic technology. The chapters in this book are organized into two parts and cover basic engineering concepts that underpin surgical robotics; various robotic platforms and how these systems make their way to the clinic; popular applications of surgical robots in neurosurgery within subspecialties; and a discussion on the future development of neurosurgical robotic systems. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your clinic. Cutting-edge and thorough, Neurosurgical Robotics is a valuable resources for scientists and engineers interested in learning more about this fascinating and developing field.

50 Studies every Vascular Surgeon Should Know presents key studies that have shaped the practice of Vascular Surgery. Selected using a rigorous methodology, the studies cover topics including carotid artery disease, aortic aneurysm, peripheral artery disease, trauma, venous disease and vascular access. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implication for practice. An illustrative clinical case concludes each review to highlight the impact of the study on clinical practice. This book is a must read for vascular surgeons, especially those in training and preparing for board exams, as well as anyone who wants to learn more about the data behind clinical practice.

All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine, furnishing the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

"Merkel Cell Carcinoma" is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world.

Features:

. Comprehensive single-source clinical reference

. Treatment focus

. Written for practitioners, with emphasis on clinical relevance and quick retrieval of information

. Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology

. International in perspective, with contributors from US and abroad

.Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters

Sole reference in the field of orthopedic surgery

Now in vibrant full color, Manual of Splinting and Casting, 2nd Edition, provides highly visual, step-by-step instructions on the most common, need-to-know techniques for initial orthopaedic injury management. This practical point-of-care reference uses a highly templated format with hundreds of illustrations and photographs so you can quickly grasp exactly how to perform each technique. It's an ideal resource for orthopaedic and sports medicine residents, nurses, medical students, emergency physicians, and orthopaedic technologists-anyone who needs a concise, easy-to-follow guide to splinting and casting at the point of care. Presents each technique in a highly templated format using bulleted steps and illustrations that show each crucial step.  Features "how-to” clinical photographs and decision-making and treatment algorithms throughout.  Contains fully updated content and new techniques in sections covering Orthopaedic Analgesia, Reduction Maneuvers, Splints and Casts, and Traction Maneuvers.  An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 

Stone's Plastic Surgery Facts 4e provides a complete revision tool for the FRCS exit examination in plastic surgery. Written in the form of notes and lists, the full range of plastic surgery topics is covered as follows, wound care, burns, head & neck, cleft lip and palate and craniofacial anomalies, breast, hand and upper limb, lower limb, skin and soft tissue tumours, genitourinary and trunk, aesthetic and general plastic surgery. Updated article summaries and a review section in each chapter highlight important points and explain common misconceptions. A vital resource for the surgical trainee.

Atlas of Selective Lymphadenectomy for Melanoma, Breast Cancer and Colon Cancer emphasizes a multidisciplinary approach combining the experiences of a nuclear medicine physician, surgeon, and pathologist. This is an important reference also for researchers and clinicians who want to become familiar with sentinel lymph node mapping. The underlying thesis in solid tumor biology is that metastasis in general starts in an orderly progression with lymphatic spread first to the sentinel lymph node (SLN) in the nearest lymph node basin. Therefore, the logical approach is to harvest that specific SLN for thorough analysis.

Bone Resorption, the second volume of the series Topics in Bone Biology, is centered on the osteoclast, the bone-resorbing cell. The volume thus c- plements the ?rst volume of the series, Bone Formation, which discussed origin, function, and pathology of the bone-forming cell, the osteoblast.Both volumes are addressed to scientists and clinicians who are active in or wish to enter the ?eld of skeletal function; this group encompasses a wide variety of specialties, including orthopaedics, rheumatology, endocrinology, nephrology, oncology, dentistry, nursing, and chiropractic medicine. Rubin and Green?eld, in the ?rst chapter, discuss the origin and differ- tiation of the osteoclast. Recognized as a multinuclear cell about 150 years ago, its origin was not uncovered until a century later when, as a result of an experiment in which quail and chicken cells were co-cultured, it became clear that osteoclasts arose from hematopoietic stem cells.The authors then discuss the osteoclastogenic factor, now known as RANKL; the inhibitory binding protein, osteoprotegerin (OPG); and the complex signaling pathway that leads to differentiation and late differentiation of this complicated cell. A section of the chapter is devoted to a concise discussion of regulators and repressors of osteoclast differentiation, including sex steroids, calcitonin, nitric oxide, and mechanical factors. The chapter concludes that the ost- clast modulates bone development, bone growth, and

This detailed second edition provides key updates on well-established methods as well as coverage of recently emerging sophisticated techniques and methods that are essential for an in-depth and state-of-the-art understanding of skeletal development and homeostasis and the pathological mechanisms that cause skeletal degeneration. The first half of the book examines cell and molecular biological aspects of osteoarthritis and osteoporosis, while the remainder of the collection focuses on in vivo models of skeletal tissue injury, degeneration, and repair. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Osteoporosis and Osteoarthritis, Second Edition aims to assist investigators concerned with research topics broadly related to osteoporosis, osteoarthritis, intervertebral disc degeneration, as well as other musculoskeletal disorders.