Microbial Biofilms: Omics Biology, Antimicrobials and Clinical Implications is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals. The chapters cover bacterial and fungal microbiomes, and the latest omics techniques organized in a clear and up-to-date manner. One of the highlights of this book is the comprehensive information on "omics of microbial biofilms". The chapters dedicated to metagenomics, proteomics and metabolomics are designed to provide a simple and holistic review of the current knowledge and, the applications of these techniques in the field of microbial biofilms. In addition to introductory chapters on microbial biofilms and their clinical implications, subsequent chapters delve into oral biofilms, their composition, and metagenomic diversity. Thereafter, mechanisms of drug resistance in microbial biofilms are reviewed, as well as the proteomic and metabolomic characterization of this resistance. The book includes a comprehensive discussion of persister cells and host-microbial interactions on mucosal surfaces. Finally, the book concludes with a summary of novel therapeutic approaches for biofilms such as synbiotics and biogenics.

The Patella provides a comprehensive, practical approach to the management of disorders of the patella and extensor mechanism of the knee. Discussions of the basic sciences, physical exam and imaging of the patellofemoral joint are followed by treatment options, including arthroscopy, osteotomy, surgical management of patellar malalignment, patellofemoral arthritis, conservative care, and complications of surgery. Additional chapters include problems in the young patient and rehabilitation. With over 300 illustrations, this book is a must for all orthopaedic surgeons and residents.

This is the first textbook devoted entirely to understanding and treating necrotizing enterocolitis (NEC), one of the leading causes of death and disability in premature infants. NEC continues to occur in neonatal units across the world, and the overall mortality has remained stubbornly high since its first description decades ago. Despite significant research into NEC, and a greater understanding of its underlying causes, there is no single source of information to which the care team can turn for guidance. This book fills that important gap in clinical care. In selecting the topics for this inaugural textbook, three guiding principles have been followed. First, to include chapters that provide detailed information for the medical team - the doctors and nurses, the therapists and pharmacists, the chaplains and the child life workers - so that each team member can optimally recognize, prevent and treat patients with this disease. Second, to ensure that chapters cover the depth and breadth of the latest clinical and scientific research into NEC, each selected to identify specific preventative strategies or therapies for this disease. Third, and perhaps most importantly, to focus not only on the child with NEC, but also on the child's family, in order to provide comprehensive information about a disease that families have barely heard about, until the jarring day when their precious infant is affected by it. This book therefore: serves as a "how-to guide" for the care of the infant with NEC summarises critical new research and offers guidelines for future key research areas addresses the complex and difficult issues surrounding care of the critically ill infant suffering from NEC Written for the entire health care team including paediatric surgeons, neonatologists, developmental paediatricians, epidemiologists, ethicists, child life professionals, therapists and specialist nurses, each team member will find this book of value. This book was written to demystify this cruel disease, and to unlock its closely held secrets of pathogenesis, diagnosis, treatment and prevention.

Review Questions for Dentistry is an essential exam practice tool designed for undergraduate dentistry students, postgraduate MJDF candidates, and overseas candidates sitting their OREs. Using the questions as a platform for learning consolidation, this exam preparation guide provides feedback to students to enable them to assess their knowledge and understanding of the subject. * Features multiple question formats including MCQs, EMQs, SAQs and find the missing word questions * Answers include detailed explanations to help expand and consolidate learning * The text is divided into two sections; introductory questions and questions exploring the subjects in more detail * The book is accompanied by a companion website offering further interactive self-assessment tools

Bariatric surgery plays an important role in the treatment of obesity; in this comprehensive resource the worldwide leaders of the field provide the most up-to-date information on the psychosocial issues that affect their patients. Included is an overview and history of surgical procedures, complete with illustrations, practical advice on topics such as physical activity and nutritional care after surgery, and essential information that allows clinicians to assist their clients as much as possible; for example, how pre-weight loss surgery psychosocial evaluations can serve as clinical interventions in their own right, and how structured interviews and questionnaires can be used in multiple contexts such as screening, treatment planning, and prognostic assessment. A distinctive chapter includes an overview of the special issues present in treating adolescents, who increasingly are the target of bariatric surgery procedures. This book is an essential reference for clinicians from the evaluation through the follow-up and aftercare of bariatric surgery patients.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

'Gripping ... so powerfully emotional that at times I had to put it down to wipe my eyes' Mail on Sunday 'How do you say thank you to someone for giving you their heart? It is the greatest gift a person can ever give.' Marc is a promising young footballers of 15, growing up in Scotland. A few hundred miles away in England, Martin is a fun-loving 16-year-old. Both are enjoying their summers when they are suddenly struck down by debilitating illnesses. Within days, the boys are close to death. Although their paths have never crossed, their fortunes are about to be bound in the most extraordinary, intimate way. One of them will die and in doing so, he will save the other's life. This is a deeply powerful and dramatic story. It is extremely rare for the family of a donor to have any personal contact with the recipient of their loved one's organ. Yet remarkably, the mothers of these two boys meet and become friends, enabling the extraordinary, bittersweet moment in which a mother who has lost her son meets the boy he saved. Reaching out and placing her palm flat against his chest, she feels the heart of her son beating away inside another. Her boy, the boy who gave his heart away.

This pocket handbook is geared towards surgical endocrinologists in training but will also be useful as a quick reference to the practicing endocrine surgeon or the resident in training during their surgical endocrinology rotation. It provides the essential information physicians need to aid them in the evaluation and management of patients with both straightforward and complex endocrine problems. This book contains practical information about how to order, perform, and interpret laboratory assessments, diagnostic tests and imaging tests, as well as useful treatment algorithms to aid in the care of patients with endocrine disorders.

This volume is the third in the series Recent Advances in Orthopedics, bringing orthopaedic surgeons, musculoskeletal research scientists and trainees fully up to date with the latest advances in the field. Divided into seven sections, each chapter discusses new techniques and technologies for the management of disorders in the different musculoskeletal subspecialties, explaining the basic science and its clinical applications. Topics include biofilm-related infections, skeletal adaptation to load, biomarkers for musculoskeletal disease, degenerative disk disease, hip disease, fibrosis and post-traumatic joint stiffness, and microenvironmental cues in tendon injury and repair. Each chapter highlights the latest developments in the relevant musculoskeletal research. Edited by renowned, US-based experts, this resource is further enhanced by clinical photographs and figures. The previous volume (9789352702879) published in 2018.

International illicit trade in human organs is on the increase, fueled by growing demand and unscrupulous traffickers. In order to truly understand the problem of organ trafficking, an analysis should take into account the various perspectives that come into play in this multifaceted issue. With contributions from international scholars and experts, The International Trafficking of Human Organs: A Multidisciplinary Perspective provides a broad-based exploration of this controversial phenomenon. Divided into four parts, the book examines the issue of human organ trafficking from the perspectives of criminal justice, business, medicine, ethics, philosophy, and theology. The book begins by presenting case studies of the trafficking of body parts occurring in the U.S. and Mexico. It examines the increase in organ harvesting from Chinese prisoners and describes widespread instances of trafficking in Europe. Diverse perspectives Next, it examines the economic ramifications of possible legislation of the sale of body parts and discusses other proposals for increasing the supply of kidneys and other organs. It explores ethical issues surrounding the kidney shortage and incentives to promote donation. It also offers arguments for and against compensation for transplant organs from Kantian, Dworkinian, and other perspectives. Lastly, theologians discuss opposing Catholic and Protestant perspectives on the sale of human organs. Learning tools Each chapter provides discussion questions to provoke vigorous debate and references to facilitate further study. The wide-ranging analysis provided by this volume is certain to enhance further inquiry into a disturbing and increasingly prevalent issue.

Now in its Second Edition with an updated design, this popular chart shows: the spinal column (lateral aspect) a typical vertebra (superior aspect) structural features and functions of intervertebral disks spinal nerve irritation due to exostosis herniated disk kyphosis scoliosis lordosis osteoporosis causes of pain in the lower back or leg

Many surgical revolutions distinguish the history and evolution of surgery. Some are small, others more dominant, but each revolution improves the art and science of surgery. Surgical revolutionaries are indispensable in the conception and completion of any surgical revolution, initiating scientific and technological advances that propel surgical practice forward. Surgical revolutionaries can come in the guises of Lister (antisepsis), Halsted (surgical residency and safe surgery), Cushing (safe brain surgery), Wangensteen (gastrointestinal physiological surgery), Blalock (relief of cyanotic heart disease), Lillehei (open heart surgery), and many others. With the hindsight of history, we can recognize patterns of progress, evaluate means of advancing new ideas, and solidify details of innovative behavior that could lead to new surgical revolutions. This volume examines the following vital questions in detail: What is a surgical revolution and how do we recognize one? Are surgical revolutionaries different? Is there a way to educate new surgical revolutionaries? Can history provide enduring examples of surgical revolutions? Are there different kinds of surgical revolutions? What characterizes a surgical revolution in the context of science and technology? What surgical revolutions are on the horizon?

Organ transplantation is one of the most dramatic interventions in modern medicine. Since the 1950s thousands of people have lived with 'new' hearts, kidneys, lungs, corneas, and other organs and tissues transplanted into their bodies. From the beginning, though, there was simply a problem: surgeons often encountered shortages of people willing and able to give their organs and tissues. To overcome this problem, they often brokered financial arrangements. Yet an ethic of gift exchange coexisted with the 'commodification of the body'. The same duality characterized the field of blood transfusion, which was essential to the development of modern surgery.
This book will be the first to bring together the histories of blood transfusion and organ transplantation. It will show how these two fields redrew the lines between self and non-self, the living and the dead, and humans and animals. Drawing on newspapers, magazines, legal cases, films and the papers and correspondence of physicians and surgeons, Lederer will challenge the assumptions of some bioethicists and policymakers that popular fears about organ transplantation necessarily reflect timeless human concerns and preoccupations with the body. She will show how notions of the body- intact, in parts, living and dead- are shaped by the particular culture in which they are embedded.

The volume contains essential information on elective (non-emergency) hand surgery practice. The author, M Merle, a world authority in surgery of the rheumatoid hand, synthesizes the depth of his experience into the book, and presents the management of these conditions in a clear manner. All the elective procedures are described in great detail and depth. The quality of illustrations is outstanding and is superior to any other hand textbooks on the market.

There are very few textbooks on elective hand surgery and this will be an essential resource for orthopedic surgeons, rheumatologists, and physiotherapists.

Over the last two decades, obesity has reached epidemic proportions in the world, resulting in suffering and premature death. Morbid obesity is a chronic medical illness that has long-reaching consequences and is caused by multiple factors. Bariatric surgery and other non-invasive procedures in carefully selected patients are effective treatments for obesity. It is the only tool for sustained and effective long-term weight loss.The field of surgery is developing rapidly - offering innovative options for patients who have failed to lose weight by diet, exercise and pharmacological methods. The editors review problems that the patients face in the perioperative period and in the long term, as well as their adjustments in lifestyle and healthcare management.The text is authored by authorities who participate in the multidisciplinary care of bariatric patients. It will address the assessment and selection of patients' treatment before surgery, options for surgical intervention and postoperative medical management.

Problem Based Neurosurgery is a remarkable fusion of recent advances in neuro-imaging and neurosurgery with modern teaching of integrated system based curricula. It approaches each problem systematically from history, and physical examination to differential diagnosis, investigations and management options. The book captures four decades of advances and experiences in diagnosis and management of patients. The problems upon which the book is based are real patients and cover all aspects of neurosurgical practice with up to date modern images. The blend of new scientific discoveries, modern imaging and the art of smart history and physical examinations underpins the book to improve diagnosis, investigation and the care of neurosurgical patients.The main thrust of this book is that it is based on clinical problems faced by fellows, residents and students, rather than traditional topic based. Problem based learning and management is the modern method of teaching in the new curriculum of teaching neurosurgery. It is a practical handbook that will help students, residents and community doctors alike. There is no similar book on the market that fulfills the objectives of this handbook.

This book provides a useful guide for the management of complex abdominal wall problems from the perspective of a general surgeon, with sensible, practical clinical advice for the management of problems as they arise. Starting from managing the open abdomen and optimising the chances of achieving later definitive fascial closure, through to dealing with incisional and parastomal hernias throughout the abdomen. Expert guidance supported by an evidence-based review of the literature aids higher surgical trainees and consultant general surgeons who wish to expand their practice in this area. Focuses on the needs of the general surgeon Offers practical tips and advice for handling difficult cases Based on current best evidence Complemented by high quality images

The exponential growth in the number of research papers published in recent decades can make it difficult to identify the key papers that have truly made a difference in the practice of oral and maxillofacial surgery. This book provides readers with a concise reference source for the key papers that underpin contemporary surgical practice in oral and maxillofacial surgery. Covering all aspects of the specialty, the content will help both trainees and specialists to understand the scientific developments and pioneering surgeries that allow us to practice as we currently do. It is essential revision material for those sitting for specialist examinations in oral and maxillofacial surgery. + Presents 50 key research studies on surgery along with full analysis + Additional commentaries from the original authors, experts or editors - providing a valuable perspective on why the study is important + Constitutes essential reading for trainees, residents and fellows, and surgeons studying for professional examinations + Distills all the literature into a compact guide on the must-know scientific articles About the Editors Niall MH McLeod FRCS (OMFS), FDS, MRCS Consultant Oral & Maxillofacial Surgeon, The Royal London and Whipps Cross Hospitals, London, UK Peter A Brennan MD, PhD, FRCS, FRCSI, FDS Consultant Maxillofacial Surgeon and Professor of Surgery, Queen Alexandra Hospital, Portsmouth, UK

Minimally invasive procedures are increasingly utilized and are replacing open surgery to reduce scarring and pain, enhance patient recovery, and minimize cost. Minimally Invasive Spine Surgery provides step-by-step guidance, expert instruction, and detailed illustration of current minimally invasive orthopedic spine procedures. With a variety of chapters covering critical developments in the field-including the utilization of biologic materials, image-guided surgery, and bone fusion-this guide delves into discussions of indications, methods for preoperative planning, complication avoidance strategies, and patient outcomes. Covering emerging technologies and biological advances that will result in smaller incisions, less trauma, and enhanced patient rehabilitation, this book: Helps surgeons identify key anatomical structures for minimally invasive access Considers preoperative planning, complications, and outcomes for all operative methods Updates surgeons on significant advances in bone graft substitutes for spine fusion Details decompression and mini-open surgical techniques-all intended to achieve less traumatic surgical treatments and improve patient outcomes Includes a section on needle-based procedures for chronic pain relief

Recognizing the increasing importance of ultrasonography in the evaluation and management of patients across a range of medical disciplines, this guide provides illustrative instruction on the performance and interpretation of ultrasound examinations in emergency, critical care, hospital, and outpatient settings.

This book follows a context-based approach to management of early-onset scoliosis (EOS) in countries with limited resources in education, finance, and research. Due to the great variety in etiology, onset age, progression rate, and severity associated with EOS, it calls for a unique treatment plan. This book enumerates the optimal provision of surgical and non-surgical services, from education/training of local surgeons, to effective teamwork, to implementing an effective data collection system; helping the surgeon to gain a hands-on experience. It also illustrates the successful execution of deformity correction using real life experiences from countries in Asia, Africa, and Latin America. Key Features Discusses biomedical principles that will help to get universally standard implants that are credible and affordable for countries with limited resources. Specific surgical Guidelines and the ability to develop evidence-based practice for this service would be an interesting read for surgeons working in global organizations as well as to local surgeons. First book to focus on countries with limited resources for the management of early onset scoliosis.

Written by internationally acclaimed specialists, Breast, Endocrine and Surgical Oncology provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated throughout by photographs that depict anatomic or technical principles. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Breast, Endocrine and Surgical Oncology provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.

Practical Ultrasound in Anesthesia for Critical Care and Pain Management is a stand-alone comprehensive reference that covers important aspects of ultrasound for the practicing anesthesiologist. Beginning with a background on the physics of equipment and practical applications, this text takes the specialist through subjects like needle visualization, teaching, training, accreditation, and getting the best out of your ultrasound equipment. With high-resolution ultrasound photographs Practical Ultrasound in Anesthesia for Critical Care and Pain Management covers topics that explore: vascular access nerve blockade echocardiography transesophageal echocardiography - evaluation of the valves basic echo Doppler transesophageal Doppler transcranial Doppler the respiratory system Also included is a fully developed CD, that includes high-resolution video clips of actual ultrasound examples, organized in an easy cross-referenced fashion for the busy clinician.

Revised, updated and expanded, Operative Orthopaedics: The Stanmore Guide, Second Edition, is a definitive and comprehensive guide to elective orthopaedic surgery. It is suitable for junior trainees during their various orthopaedic rotations and senior trainees preparing for the Fellowship of the Royal College of Surgeons (FRCS Tr and Orth) examination. With the emphasis on surgical techniques employed, and the reasoning and evidence base behind them, this book is both a practical instruction manual and a revision tool for the examination. The procedures identified by the Specialist Advisory Committee, including areas such as tumour surgery, paediatrics and limb reconstruction, are included. Each chapter follows a simple and consistent format explaining the surgery from preoperative planning and consent, through to approaches, techniques and postoperative care. The chapters also include key references and sample Viva Questions to extend and reinforce learning. Key Features New updated surgical techniques Highly illustrated to help explain surgical concepts easily Key point boxes to facilitate learning Recommended references for FRCS (Tr and Orth) examination success Editors Timothy WR Briggs MD MBBS (Hons), MCH (Orth), FRCS (Eng), FRCS (Ed), MD (Res) Royal National Orthopaedic Hospital Trust, Stanmore, United Kingdom Jonathan Miles MBChB, FRCS (Tr & Orth) Royal National Orthopaedic Hospital Trust, Stanmore, United Kingdom William Aston BSc, MBBS, FRCS (Tr & Orth) (Edinb) Royal National Orthopaedic Hospital Trust, Stanmore, United Kingdom Heledd Havard BSc, MBBCh, MSc, FRCS (Tr & Orth) Royal National Orthopaedic Hospital Trust, Stanmore, United Kingdom Daud Chou MBBS, BSc, MSc, FRCS (Tr & Orth) Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

Musculoskeletal applications of tissue engineering will be among the first to achieve widespread clinical use, and the resulting shift in clinical and surgical paradigms will highlight the need for an authoritative text on tissue engineering for musculoskeletal tissues including nerve, bone, tendon, skin, vessels, and cartilage. This book will serve the needs of a large readership including plastic surgeons, orthopedic surgeons, medical residents and medical students, researchers and academic faculty in regenerative medicine and biomedical engineering, and medical device experts. This textbook will serve as the curriculum for undergraduate and graduate courses in biomedical engineering and surgery.

Notable contributors to this volume include Antonios G Mikos, PhD; Wei Liu, MD; Yilin Cao, MD; Mark Randolph, MAS; Jennifer Elisseeff, PhD; Geoffrey C Gurtner, MD; Michael T Longaker, MD; and James Chang, MD, all of whom are leaders in tissue engineering research and applications.