This issue of Veterinary Clinics of North America: Small Animal Practice, edited by Elizabeth Stelow, focuses on Behavior as an Illness Indicator, with topics including: Best Practices in Diagnosing Behavior Problems and Developing Plans to Treat Behavior Problems; Separation, Confinement, or Noises; Managing Canine Aggression in the Home; Diagnosing and Treating Cats Who Urinate Outside the Box; Desensitization and Counterconditioning; Diagnosing Behavior Problems in Older Pets; Behavioral Nutraceuticals and Diets; and Advances in Behavioral Psychopharmacology.

This issue of Veterinary Clinics of North America: Exotic Animal Practice focuses on Therapeutics, with topics including: Metabolic scaling and other methods used to extrapolate drug dosages for exotics; Update on antiviral therapies in birds; Multiresistant bacteria in exotic animal medicine: fact or faux?; Emergency drugs and fluid therapy in exotics; Guidelines for treatment of toxicities in exotic animals; Nutraceuticals in exotic animal medicine; Pharmacokinetic/pharmacodynamics modelling of analgesic drugs; Psychoactive drugs in avian medicine; Cardiovascular drugs in avian and small mammal medicine; Gastrointestinal drugs in small mammal medicine; Update on cancer treatment in exotics; Drug delivery methods with emphasis on low stress handling while medicating exotic animal; and Compounding and extra-label use of drugs in exotic animal medicine.

This issue of Veterinary Clinics of North America: Small Animal Practice focuses on Immunology and Vaccination, with topics including: Recent Advances In Vaccine Technologies; Immune System's Response to Vaccination; Current Vaccine Strategies for Dogs and Cats; Update on Therapeutic Vaccines; Common and Newly Recognized Autoimmune Diseases; Adverse Response to Vaccination; Vaccines in Shelters and Group Settings; Evidence vs Belief in Vaccine Recommendations; Effects of Aging on the Immune Response; and Use of Antibody Titer to Determine the Need for Vaccination.

This issue of Veterinary Clinics of North America: Equine Practice focuses on Equine Gastroenterology, and includes topics: Diagnostics and treatment of undifferentiated and infectious acute diarrhea in the adult horse; Foal diarrhea; established and postulated causes, prevention, diagnostics and treatments; Probiotic use in equine gastrointestinal disease; Understanding the intestinal microbiome in health and disease; Advances in diagnostics and treatments in horses with acute colic and postoperative ileus; Advances in diagnostics and treatments in horses and foals with gastric and or duodenal ulcers; Toxic causes of intestinal disease in horses; New perspectives in equine intestinal parasitic disease Diagnostics and Management new insight; Equine disautonomia; Diagnostics and treatments in chronic diarrhea and weight loss in horses; Enteral/parenteral nutrition in foals and adult horses practical guidelines for the practitioner; and Practical fluid therapy and treatment modalities for field conditions for horses and foals with gastro-intestinal problems.

Many controlled release veterinary drug delivery systems (CRVDDS) are presently in use, and recently there has been a host of new CRVDDS within veterinary medicine. The challenges of this area of drug delivery arise from the unique anatomy and physiology of the target animal, the cost constraints associated with the value of the animal being treated and the extended periods of time that delivery must be sustained for (often measured in months).

The purpose of this book is to introduce the reader to the unique opportunities and challenges of the field of CRVDDS and to explain and discuss the basic controlled release principles underlying the development of CRVDDS. Its aim is to provide an overview of many of the areas where CRVVDS have application, and to highlight the opportunities and prospects for controlled release technology in the veterinary field.

"Controlled Release Veterinary Drug Delivery" comprises chapters that provide workers in the field (and those interested in this area) with information on the design, development and assessment of a variety of CRVDDS. The book contains chapters that describe the relevant animal physiological and anatomical considerations alongside descriptions of current and emerging controlled release delivery systems for a variety of routes for drug delivery, and present overviews on the physical and chemical assessment of veterinary controlled release delivery systems.

The veterinary area is abound with opportunities for the development of controlled release drug delivery technologies. It is an area of medicine that is open to the acceptance of novel drug delivery devices, and which readily encompasses the use of novel routes of administration. It is an area of many unmet needs, most of which offer opportunities and unique challenges for the innovative formulation scientist to provide solutions. This book will provide an insight into the biological, clinical and pharmaceutical challenges that face the formulation scientist in this interesting and diverse area of research.

This issue, edited by Drs. Robert Callan and Meredyth Jones, focuses on Digestive Disorders in Ruminants. Article topics include: Rumen (Forestomach) Development and Function; Diagnostic Approach to Forestomach Diseases; Clinical Rumen Acidosis; Diagnosis and Herd Management of Subclinical Rumen Acidosis; Disorders of Rumen Distension and Dysmotility; Diagnosis and Treatment of Hardware Disease; Temporary Rumen Fistula for the Treatment of Forestomach Diseases and Enteral Nutrition; Rumen Microbiome, probiotics, and Fermentation Additives.

The ethical treatment of animals has become an issue of serious moral concern. Many people are challenging long-held assumptions about animals and raising questions about their status and treatment. What is the relationship between humans and animals? Do animals have moral standing? Do we have direct or indirect duties to animals? Does human benefit always outweigh animal suffering? The use of animals for experimentation raises all of these questions in a particularly insistent way. Donna Yarri gives an overview of the current state of the discussion, and presents an argument for significantly restricted animal experimentation. Pointing to the similarities between humans and animals, she argues that the actual differences are differences of degree rather than kind. Animal cognition and animal sentiency together are the basis for the claim that experimental animals do have rights. Examining arguments in the disciplines of ethology, philosophy, science, and theology, Yarri makes a case for placing substantial restrictions on animal experimentation. Grounding her examination in Christian theology, she formulates a more humane approach to animal experimentation. She concludes with a concrete burden-benefit analysis that can serve as the foundation for informed decision-making. The Ethics of Animal Experimentation serves as both a handbook of animal rights theory and a practical guide to navigating the complexities of animal experimentation. As animal experimentation features in an increasing number of scientific endeavors, it is an ethical issue that requires our immediate attention. Yarri's unique contribution forges a path toward an ethical practice of animal experimentation.

This issue of Veterinary Clinics of North America: Exotic Animal Practice on Exotic Animal Neurology, edited by Susan Orosz, includes: Pain and its control in Reptiles; The Neuroanatomical basis for pain and controlling pain in birds; Avian Bornavirus and its pathophysiology for Proventricular dilatation disease; Treatment of Proventricular dilatation disease and avian ganglioneuritis; Vaccination for Proventricular dilatation disease; Imaging the brain for exotic animal clinicians; EC in rabbits; Pain control in small mammals; Vaccination of ferrets for Rabies and Distemper; and Medication for Behavior Modification in Birds.

Selenium (Se) is an essential dietary trace element participating in the regulation of various physiological functions in both animals and humans through its incorporation into selenoproteins as the amino acid selenocysteine. Among many minerals Se has a special place being the most controversial trace element with a narrow gap between essentiality and toxicity. Indeed there are important environmental issues considering selenium as a pollutant from the one hand and global selenium deficiency on the other. In fact, Se deficiency is considered as a risk factor for the development of various diseases in human and animals. Decreased Se availability from soils as a result of low soil pH and usage of synthetic fertilizers is the major concern in European countries causing inadequate Se levels in food and feeds.Furthermore, it seems likely that sodium selenite used for the last 30 years as a feed supplement is not an optimal form of Se and the usage of organic selenium in animal diets could help to maintain optimal Se status as well as high immunocompetence, productive and reproductive performance. The aim of the present volume is to provide updated information on several important Se-related subjects, including Se status in Europe and ways of its improvement, advances in Se analysis and speciation in biological material, roles of selenium in poultry, pig and ruminant nutrition. In this title, production of functional Se-enriched food, the relationship between selenium and mycotoxins, polyunsaturated fatty acids as well as reoviruses are also addressed. This collection of articles will provide nutritionists, veterinarians, human doctors, researchers and any other readers with new insights into the exciting world of the goddess of the moon - Selenium.

This issue of Veterinary Clinics of North America: Small Animal Practice on Neurology, edited by Sharon Kerwin and Amanda Taylor, includes: Advances in High field MRI; Acupuncture for neurologic conditions; Head trauma; Pituitary hypophysectomy; Acute non-compressive disc extrusion and hydrated nucleus pulposus extrusion; Discospondylitis; Minimally Invasive Vertebral Column Surgery; Vascular events in the Brain; Fungal infections of the CNS; Feline Seizures; Clinical evaluation of the feline neurologic patient; Intervertebral disc disease, recent advances in therapy; Three-dimensional printing role in neurologic disease; and Diffusion tensor imaging in spinal cord injury.

This issue of PET Clinics focuses on Radiotracers, and is edited by Drs. Neil Vasdev and Abass Alavi. Articles will include: PET/CT detection of HER2-positive metastases in patients with 89Zr-DFO-trastuzumab; uPAR-PET with 68Ga-NOTA-AE105: first clinical experience with a novel PET ligand; 64Cu-FBP8: A fibrin-targeted probe for imaging of thrombus; Imaging of synaptic density in the brain via synaptic vesicle glycoprotein 2A (SV2A) with a novel biomarker [11C]UCB-J; Neuroimaging of stress sensitive and neuroinflammatory targets in mood disorders; Impact of MR-based PET motion correction on the quantification of PET kinetic parameters in simultaneous cardiac PET-MR; Multimodal studies of the contributions of amyloid and tau burden to neurodegeneration in AD, FTD and Non-AD tauopathies; Imaging of prostate-specific membrane antigen (PSMA) using [18F]DCFPyL; Ga-68 GRPR antagonist imaging; and more!

This issue of Veterinary Clinics of North America: Equine Practice is edited by Dr. Ashlee Watts and focuses on Orthopedic Disorders of Foals. Article topics include: Orthopedic conditions of the dysmature foal; Septic arthritis, osteomyelitis and physitis; Club foot; FLD - carpus and fetlock; ALD - growth augmentation; ALD - growth retardation; Foal Fractures - osteochondral fragmentation, sesamoiditis and coffin bone; Foal Fractures - physeal fractures; OCD development; OCD - surgical options and when to utilize them.

This issue of Veterinary Clinics of North America: Equine Practice is edited by Dr. Mary Lassaline and focuses on Equine Ophthalmology. Article topics include: Anatomy and Examination; Imaging; Eyelid; Cornea; Uveitis; Lens; Retina with emphasis on electrodiagnostics; Medications Update; Neuro-oph; Ocular neoplasia; Genetic ocular disease, and OMSD with emphasis on borreliosis.

This issue, edited by Dr. Jan Shearer, focuses on Lameness in Cattle. Article topics include: Economic Impact of Lameness in Cattle; Pathogenesis of Sole Ulcers and White Line Disease; Current Concepts on the Pathogenesis and Treatment of Digital Dermatitis; Pathogenesis and Treatment of Foot rot; A Brief Review of Effective Footbath Compounds, Design and Management; Pathogenesis and Treatment of Toe Lesions in Cattle (including Non-Healing Toe Lesions); A Comparison of Foot Trimming Methods for Use in Cattle; Pathogenesis and Management of Corkscrew Claw in Cattle; Diagnosis and Prognosis of Common Disorders Involving the Proximal Limb; Scoring Locomotion and Mobility in Cattle (to include Fatigue Cattle Syndrome); The Relationship of Cow Comfort and Flooring to Lameness Disorders in Dairy Cattle; Treatment Options for Lameness Disorders in Organic Dairies; Welfare Implications of Lameness in Dairy Cattle; Pain Management for Lameness Disorders in Cattle, and Training On-Farm Employees in Foot Care.

This issue of Veterinary Clinics of North America: Food Animal Practice focuses on Bovine Surgery. Article topics include: Local, regional, and spinal anesthesia in ruminants; Field sedation and anesthesia of ruminants; Respiratory Surgery; Surgery of the sinuses and eyes; Surgical procedures of the forestomachs; Surgical Management of Abomasal disease; Intestinal surgery; Surgery of the Umbilicus and Related Structures; Female reproductive surgery; Male reproductive surgery; Surgical management of the teats and udder; and more!