This volume reviews the current understanding of the taxonomy, disease syndromes, genetics, biology, and pathogenic factors of Histophilus somni, as well as the host immune response to this pathogen. H. somni is one of the most important bacterial pathogens in cattle and other ruminants, and its virulence factors are highly conserved with Haemophilus influenzae and other members of the Pasteurellaceae. H. somni has been recognized as a major cause of thrombotic meningoencephalitis, respiratory disease syndromes, myocarditis, reproductive disease syndromes, polyarthritis, mastitis, ocular disease, and septicemia. The only known habitats of H. somni are the mucosal surfaces of ruminants, making this bacterium an opportunistic pathogen. Although it is capable of causing inflammation at systemic sites and is toxic to epithelial and phagocytic cells, the bacterium's wide array of virulence factors act primarily as a defense against, or to escape recognition from, host innate and adaptive immunity.

This vibrant collection delivers a laboratory roadmap of testing cognition in the rodent. While rodents and mazes are the main center and focus of this book, many aspects in the field of learning and memory are discussed and detailed, spanning from the molecular to the human, with every chapter delivering a comprehensive review of historical milestones in order to provide context for past discoveries, new findings, and future studies. Didactic foundations, operational definitions, and theory, as well as practical experimental and apparatus set-up, data analysis, and interpretation instructions are included in the first part of the book, while part two contains step-by-step protocols, troubleshooting, and tips from experts in the field. Authoritative and inspirational, The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition serves as a detailed and practical manual for scientists wishing to implement these tools in their laboratories and for scholars interested in this powerful field.

Therapeutic regimens for visceral leishmaniasis (also Kala-azar, Dum-dum fever or black fever), caused by parasitic protozoa of the Leishmania genus, evolve at a pace never seen before. Spread by tiny and abundant sand flies, the parasite infects internal organs and bone marrow and if left untreated will almost always result in the death of the host. In developing countries successful diagnosis and treatment are complicated by asymptomatic cases, undernutrition and Kala-azar/HIV co-infections.

This book brings together world-renown experts writing state-of-arts review on the progress in diagnosis and treatment of visceral leishmaniasis, ultimately leading to the complete elimination of this fatal disease from South Asia. The chapters provide valuable information for disease control as well as therapy and the diagnostic improvements necessary for early treatment, subclinical detection and drug-resistant cases. The presented methods allow for points-of-care testing in the endemic area, enabling rapid detection in resource-poor settings with easy handling and low costs.

This book provides essential information for scientists, medical practitioners and policy makers involved in the diagnosis, treatment and elimination of Kala-azar.

An essential resource for both students and practitioners, this comprehensive text provides practical, up-to-date information about normal reproduction and reproductive disorders in horses, cattle, small ruminants, swine, llamas, and other livestock. Featuring contributions from experts in the field, each section is devoted to a different large animal species and begins with a review of the clinically relevant aspects of the reproductive anatomy and physiology of both males and females. Key topics include the evaluation of breeding soundness, pregnancy diagnosis, diagnosis and treatment of infertility, abortion, obstetrics, surgery of the reproductive tract, care of neonates, and the latest reproductive technology. Includes coverage of all large animal species. All sections provide a review of clinically pertinent reproductive physiology and anatomy of males and females of each species. Complete coverage of the most current reproductive technology, including embryo transfer, estrous synchronization, and artificial insemination. A new section on alternative farming that addresses reproduction in bison, elk, and deer. New to the equine section: stallion management, infertility, and breeding soundness evaluation. New to the bovine section: estrous cycle synchronization, reproductive biotechnology, ultrasonographic determination of fetal gender, heifer development, and diagnosis of abortion. New to the porcine section: artificial insemination, boar/stud management, diseases of postpartum period, and infectious disease control. New to the llama section: infectious disease and nutrition.

Today, veterinary science experiences major development in all its fields as a consequence of continuous technological advances in diagnostic tools and breakthrough in applied genomics and biology. This book contains 33 proceedings that were selected among those presented at the 64th Italian Veterinary Science Congress held at ASTI in 2010. It provides a timely overview of the current progress made by Italian researchers and would be of great value to anyone interested in the field of veterinary science, from animal health and care to food hygiene, and from basic to applied disciplines.

Learn to heal your cattle by treating the cause and not the symptoms. Holistic veterinarian Richard "Doc" Holiday shares the secrets he's learned from more than fifty years of experience in animal nutrition and health.

Volume 22 of the Fish Physiology Series is entirely devoted to fishes of high latitudes (Arctic and Antarctic). Three central themes comprise the book:
The uniqueness of the physiology of fishes that live in cold polar environments, a comparative analysis of physiological patterns exemplified by fishes that live poles apart and, how fishes differ from fishes living in more temperate and tropical habitats.
This book highlights the physiological adaptations that evolved to allow certain fish to exploit the frigid, yet productive, Arctic and Antarctic Oceans. The reader will explore what is known, as well as what remains undiscovered, concerning the fish indigenous to both polar regions. This will be of great interest to physiologists, ichthyologists, and comparative biologists researching low temperature biology, fishery scientists, faculty, graduate students
* Offers an comparative analysis of the arctic and antarctic polar marine environments
* Authors answer the question: What is special about the physiology of fish from the stenothermal Arctic and Antarctic environments?
* Includes nine descriptive chapters, 40 tables and over 80 figures

This book examines how relationships between guardians and companion animals were challenged during a large-scale disaster: the tsunami of March 2011 and the following nuclear disaster in Fukushima. The author interrogates: 1) How did guardians and their companion animals survive the large disaster?; 2) Why was the relationship between guardians and their companion animals ignored during and after a disaster?; and 3) What structures and/or mechanisms shaped the outcomes for animals and their guardians? Through a critical realist framework, combined with a theoretical perspective developed by Roy Bhaskar and his colleagues, the author argues that despite the trivialization of companion animals by government officials, relationships between animals and guardians were often able to be maintained, in some cases through great pains by the guardians. While the notion of human-animal relationships in Japan has thus far been dominated by economic logic, the author reveals dynamics between guardians and companion animal transcend such structures, forging the concept of "bonding rights."

A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.
* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Cultured cells have combined accessibility and the ability to expand a homogeneous cell population from a relatively limited source, thus opening up a wealth of possibilities for researchers. In Mouse Cell Culture: Methods and Protocols, expert researchers provide a number of methods for the culture of a wide range of specific cells and tissues isolated from the key genetic model of the fetal or adult mouse. Including protocols for the explant of fetal tissues and stem cells that allow developmental processes to be followed ex vivo as well as protocols for the culture of isolated cell types that allow for the study of relatively homogeneous cell populations, this volume brings together a selection of the most current methods in order to make them available in one convenient source. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Practical and authoritative, Mouse Cell Culture: Methods and Protocols serves as an immediately applicable springboard for the development of new tissue culture methods in order to advance the study and treatment of human disorders.

P. Doherty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VB Introduction D. Dobbelaere and D. McKeever. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX Theileria Development and Host Cell Invasion Michael K. Shaw. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Genomic Polymorphism, Sexual Recombination and Molecular Epidemiology af Theileria Parva R. Bishop, D. Geysen, R. Skilton, D. Odongo, V. Nene, B. Allsopp, S. Mbogo, P. Spooner and S. Morzaria. . . . . . . . . . . . . . . . 23 Epidemiological Significance of Strain-Specific Immunity to Theileria Parva D. J. McKeever and W. I. Morrison. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Virulence and Attenuation in Theileria Annulata R. Adamson and R. Hall. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Theileria Survival Strategies and Host Cell Transformation V. T. Heussler. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Genomics of Theileria Parva V. Nene, R. Bishop, J. Quackenbush, M. Pertea, S. L. Salzberg, E. Taracha, S. Morzaria, C. M. Fraser and M. Gardner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Non-Transforming Theileria Parasites of Ruminants C. Sugimoto and K. Fujisaki 93 Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 FOREWORD The apicomplexan protozoal parasites continue to provide major challenges for human and animal health. While most of us have some familiarity with the ravages of malaria, there is relatively little awareness of diseases caused by parasites of the Theileria species. The reason is that these tick-borne organisms are problematic only in cattle and small ruminants. This does not mean, however, that the various manifestations of Theileriosis are of little interest to those concerned principally with human health. The economic loss and diminished food production associated with East Coast Fever (ECF, caused by T. parva) continues to be a major problem in East Africa.

This practical guide synthesizes the types of treatment available for specific diseases. It is a handy reference that provides readers with an understanding of complementary and alternative treatment options for more than 130 common disease states and describes a variety of possible approaches to small animal disorders. Concentrating on nutrition, herbs, traditional Chinese medicines, and physical therapies, the authors present both tradition- and evidence-based therapies for disorders not always responsive to conventional therapies. Presents new and alternative therapies with scientific support, encouraging veterinarians explore new therapies with confidence. Helps veterinarians develop treatment plans - a vast improvement over large texts that simply introduce the therapies. Clearly explains esoteric concepts of traditional Chinese medicine in updated language. Practical, user-friendly pocket manual format allows for quick access in the clinical setting. Chapters are organized logically by body system and disorders are alphabetized within each chapter. Each body system chapter includes a case report that describes the history, physical examination, assessment, treatment, and outcome of a specific patient to further illustrate how to develop a treatment plan. Each appendix offers practical backup for designing treatment plans, from homemade diets and Chinese food therapy to oral herb doses and a valuable herb cross-reference table.

This study examines James Herriot's five major books as carefully crafted volumes of autobiography based on the building block of the short story. In each of these works Herriot explores the fundamental choice of values underlying a happy and successful life. In his vision the bonds of affection and mutual dependence between all creatures, human and animal, form an enduring theme that lies at the heart of the choices he makes in his personal and professional life. This study will help the reader to understand the relationship between Herriot's stories and each book as a whole and to appreciate Herriot's work in the context of twentieth-century anxieties about identity and meaning.

Following a biographical chapter that describes the relationship between Herriot's life and literary work, Rossi discusses the genre of autobiography, the relationship between truth and fiction in modern autobiography, and Herriot's use of the genre. A separate chapter is then devoted to each of Herriot's works in turn: "All Creatures Great and Small," "All Things Bright and Beautiful," "All Things Wise and Wonderful," "The Lord God Made Them All," and DEGREES"Every Living Thing." The discussion of each work includes sections on plot development and narrative structure, character development, thematic issues, and alternative critical approaches that may be fruitfully applied to the book. Helpful appendices contain identifications of minor characters in the works. A complete bibliography of all of James Herriot's works, critical sources, and a listing of reviews of all of his works completes the volume. Because of the popularity of Herriot's work among adults and young adults this companion will be a key purchase for school and public libraries.

'300 Questions and Answers in Diagnostic Aids' has been published in response to repeated requests for self-test material in this subject - one of the areas that cause most difficulty in examination. This collection of multiple choice questions gives students the opportunity to concentrate on specific areas of weakness with a focussed and comprehensive review programme in the subject of their choice. Compiled by a leading training centre, these questions are representative of the type of question likely to appear in the examination paper. By using this revision guide you will not only increase your understanding of the subject but also increase your chances of achieving success in the examination. * Another new Butterworth-Heinemann study aid specifically tailored to the needs of the Veterinary Nurse student * '300 Questions and Answers in.....' provides the student with a collection of new questions and answers in individual subject areas so thatthe student can concentrate on specific areas of weakness * This new Series of Multiple Choice Questions provides the veterinary nurse student with additional opportunities for both self-assessment and examination practice

The ability to perform a good clinical examination is an essential tool that the practicingveterinarian must possess. Written by leading experts in small and large animal medicine and edited by cattle, equine and small animal experts, this new book provides all the information required to perform a thorough clinical examination of all small and large species, and of all organ systems. Initial chapters on restraint and handling and information gathering set the scene for the chapters on assessment of individual organ systems, giving the reader all they need to know to reach an accurate diagnosisof all clinical conditions. Handy clinical pointer boxes highlight key clinical information, and many tables and text boxes list important information in an easily-accessible format. Liberally illustrated with over 240 black and white prints, 38 colour prints and 150 line illustrations, Veterinary Clinical Examination and Diagnosisgives you all the tools you need to examine your patients and reach an accurate diagnosis.useful for students and practicing veterinarians full of clear, informative text on all aspects of examinationover 430 illustrations enhance the text and clearly demonstrate the techniques of examination handy clinical pointers give guidelines on key points written and edited by small and large animal experts worldwide - edited by cattle, equine and small animal experts large number of tables and text boxes summarise key information in an easy-to-read styleSubstantially revised and expanded chapter on toxins All chapters fully revisedNew quick review synopsis section for complex diseases in Section I of the book, so that key information is easy to find More didactic style of writing to make for quicker assimilation of key information Spanish version also available, ISBN: 84-8174-586-3