A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.
* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interepreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

Exotics and Wildlife: a manual of veterinary nursing care provides a hands-on approach to nursing exotic pets and wildlife common to the UK. The increasing popularity of exotic pets sees a wide variety of species pass through practices on a daily basis of which the care and management is the responsibility of the veterinary nurse. This change in pet ownership has been recognised and reflected in the updated curriculum of the veterinary nurse. Exotics and Wildlife: a manual of veterinary nursing links with the current S/NVQ syllabus, informing, preparing and teaching the veterinary nurse to deal with the variety of species they are likely to see in practice. Species covered include: rabbits, rodents, snakes, lizards, chelonia, cage and wild birds, birds of prey, bats, foxes, hedgehogs, squirrels, deer and badgers. This one-stop reference tool is perfect for use in the daily clinical management of exotic species. Comprehensive information is presented on the day-to-day management of the more unusual patient. Practical advice is given on providing effective nursing care for the exotic pet. Unique Tips of the Trade are offered by VNs with experience working with this type of patient.

Cultured cells have combined accessibility and the ability to expand a homogeneous cell population from a relatively limited source, thus opening up a wealth of possibilities for researchers. In Mouse Cell Culture: Methods and Protocols, expert researchers provide a number of methods for the culture of a wide range of specific cells and tissues isolated from the key genetic model of the fetal or adult mouse. Including protocols for the explant of fetal tissues and stem cells that allow developmental processes to be followed ex vivo as well as protocols for the culture of isolated cell types that allow for the study of relatively homogeneous cell populations, this volume brings together a selection of the most current methods in order to make them available in one convenient source. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Practical and authoritative, Mouse Cell Culture: Methods and Protocols serves as an immediately applicable springboard for the development of new tissue culture methods in order to advance the study and treatment of human disorders.

P. Doherty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VB Introduction D. Dobbelaere and D. McKeever. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX Theileria Development and Host Cell Invasion Michael K. Shaw. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Genomic Polymorphism, Sexual Recombination and Molecular Epidemiology af Theileria Parva R. Bishop, D. Geysen, R. Skilton, D. Odongo, V. Nene, B. Allsopp, S. Mbogo, P. Spooner and S. Morzaria. . . . . . . . . . . . . . . . 23 Epidemiological Significance of Strain-Specific Immunity to Theileria Parva D. J. McKeever and W. I. Morrison. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Virulence and Attenuation in Theileria Annulata R. Adamson and R. Hall. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Theileria Survival Strategies and Host Cell Transformation V. T. Heussler. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Genomics of Theileria Parva V. Nene, R. Bishop, J. Quackenbush, M. Pertea, S. L. Salzberg, E. Taracha, S. Morzaria, C. M. Fraser and M. Gardner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Non-Transforming Theileria Parasites of Ruminants C. Sugimoto and K. Fujisaki 93 Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 FOREWORD The apicomplexan protozoal parasites continue to provide major challenges for human and animal health. While most of us have some familiarity with the ravages of malaria, there is relatively little awareness of diseases caused by parasites of the Theileria species. The reason is that these tick-borne organisms are problematic only in cattle and small ruminants. This does not mean, however, that the various manifestations of Theileriosis are of little interest to those concerned principally with human health. The economic loss and diminished food production associated with East Coast Fever (ECF, caused by T. parva) continues to be a major problem in East Africa.

The keeping of exotic animals is becoming an increasingly popular aspect of pet ownership. Reptile owners are becoming more and more inexperienced as the popularity of these animals becomes more widespread. Vets and veterinary nurses are having to familiarise themselves with reptilian illnesses and husbandry issues without being experts themselves. Access to the answers for these complaints is an ongoing problem for the busy vet. This guide plus FREE CD-ROM, provide you with a quick, readily available and detailed answers to the increasing number of reptilian illnesses that are entering the veterinary practice waiting room. Features a problem-based approach to the diagnosis and treatment of common husbandry-related problems in reptile species. Unique checklists ensure accurate assessment of both problem and solution. An easy-to-use reference for the non-specialist - appropriate for all levels of veterinary practice. Offers downloadable assessment forms on a free disk.

The portfolio must be submitted as evidence of competence and knowledge, and this practical manual has been specifically written to help both students and assessors achieve success in this area. Both levels S/NVQ 2 and 3 are covered, and this excellent guide is required reading for all professionals involved with veterinary nurse training. * the complete guide to understanding and completing the S/NVQ veterinary nursing portfolio * this practical manual will ensure that your portfolio achieves the standard required by the RCVS * explains the role of the verifier and assessor, as well as the differences between assessment and verification

This manual is designed for those who care for working horses but who may have little or no access to professional veterinary help. By guiding readers to the appropriate action to take when caring for a sick animal, this book will help alleviate the suffering of horses, donkeys and mules and thereby minimize the lost livelihood opportunities that can result.Horse Healthcare" is designed to be accessible to both the owners of working equids themselves and the people who can help them. Simple language is used and the text is clearly laid out with illustrations throughout. This makes the book useful to people who cannot understand standard texts on horse health care.The book is not intended to replace the role of the veterinary profession where an adequate animal health service exists. In poorer countries, however, in situations where horse owners have no alternative but to treat their own sick animals, this manual gives guidance on how to do this properly and provides advice on how to prevent many common illnesses in equids.Published in association with the Brooke Hospital for Animals.

This practical guide synthesizes the types of treatment available for specific diseases. It is a handy reference that provides readers with an understanding of complementary and alternative treatment options for more than 130 common disease states and describes a variety of possible approaches to small animal disorders. Concentrating on nutrition, herbs, traditional Chinese medicines, and physical therapies, the authors present both tradition- and evidence-based therapies for disorders not always responsive to conventional therapies. Presents new and alternative therapies with scientific support, encouraging veterinarians explore new therapies with confidence. Helps veterinarians develop treatment plans - a vast improvement over large texts that simply introduce the therapies. Clearly explains esoteric concepts of traditional Chinese medicine in updated language. Practical, user-friendly pocket manual format allows for quick access in the clinical setting. Chapters are organized logically by body system and disorders are alphabetized within each chapter. Each body system chapter includes a case report that describes the history, physical examination, assessment, treatment, and outcome of a specific patient to further illustrate how to develop a treatment plan. Each appendix offers practical backup for designing treatment plans, from homemade diets and Chinese food therapy to oral herb doses and a valuable herb cross-reference table.

Learn to heal your cattle by treating the cause and not the symptoms. Holistic veterinarian Richard "Doc" Holiday shares the secrets he's learned from more than fifty years of experience in animal nutrition and health.

This study examines James Herriot's five major books as carefully crafted volumes of autobiography based on the building block of the short story. In each of these works Herriot explores the fundamental choice of values underlying a happy and successful life. In his vision the bonds of affection and mutual dependence between all creatures, human and animal, form an enduring theme that lies at the heart of the choices he makes in his personal and professional life. This study will help the reader to understand the relationship between Herriot's stories and each book as a whole and to appreciate Herriot's work in the context of twentieth-century anxieties about identity and meaning.

Following a biographical chapter that describes the relationship between Herriot's life and literary work, Rossi discusses the genre of autobiography, the relationship between truth and fiction in modern autobiography, and Herriot's use of the genre. A separate chapter is then devoted to each of Herriot's works in turn: "All Creatures Great and Small," "All Things Bright and Beautiful," "All Things Wise and Wonderful," "The Lord God Made Them All," and DEGREES"Every Living Thing." The discussion of each work includes sections on plot development and narrative structure, character development, thematic issues, and alternative critical approaches that may be fruitfully applied to the book. Helpful appendices contain identifications of minor characters in the works. A complete bibliography of all of James Herriot's works, critical sources, and a listing of reviews of all of his works completes the volume. Because of the popularity of Herriot's work among adults and young adults this companion will be a key purchase for school and public libraries.

An ever-increasing number of drugs are available to veterinarians for use in the control of pain. This new, concise guide gives vets with all the information they need to choose the most appropriate pain medication for any clinical situation. Introductory chapters explain the physiology of pain and pharmacology of analgesics, and are followed by detailed chapters on management of acute and post-operative pain and chronic pain, the problems of pain management and pain assessment. Written by an international team of veterinary pain management experts, Pain Management in Animals provides vets with all the information they need to provide good pain control in all their patients.All species, large and small, covered in detail Comprehensive tables on recommended doses of all analgesics in all speciesExtensive chapters on chronic and acute pain All the problems vets are likely to encounter in pain management discussed in full Fully referenced throughout to key journal articles Lots of practical advice on all aspects of pain management

This volume covers the fields of origin, evolution and phylogenesis from prokaryotic to eukaryotic cells. The eminent authors, experts in their fields, review the three kingdoms of life (Archea, Eubacteria and Eukarya) from molecular evolutionary levels to ecological aspects in enigmatic habitats, including general reviews of puzzling pro-and eukaryotic organisms and their domains. We discuss dry habitats, thermophilic (cells in hot springs and undersea thermal vents up to 110AC), psychrophilic (cryophiles) and halophilic (high salt concentrations) niches which among the harshest conditions found on Earth where microbial life is frequently detected. Some chapters deal with the organisms which grow in extreme pH conditions (acidity vs. alkalinity), and under hydrostatic pressure in the deep sea, and microbial growth on petroleum. Other contributors present their research on aerobiology and microbes growing in various gases and various levels of radiation, including cellular morphological modification in these extremophilic microbes. This volume also includes the symbiotic association between two or more organisms on the endocellular and exocellular levels. Finally one paper identifies the extremophiles as candidates for exobiology. This is a valuable comprehensive volume in English that covers most of the extremophiles in a new light with current research data. Audience: Students, lecturers and researchers; scholars in the fields of biology, evolutionary biology and chemistry, and other evolutionary fields, and the intelligent layman.