Cardiology of the Horse is a multi-author, contemporary reference on equine cardiology. The first section reviews the physiology, pathophysiology and pharmacology of the equine cardiovascular system. The second section describes diagnostic methods from basic to specialist examination skills and the third section addresses the investigation and management of common clinical problems using a problem-orientated approach. Suitable for students, general and specialist practitioners and teachers. An up-to-date account of current clinical practice in equine cardiology covering: recent developments in research and practice problem-orientated approaches helpful to both general and specialist practitioners clinical management of specific groups from foals and racehorses to geriatric patients cardiac problems related to exercise, anaesthesia and intensive care A superb companion DVD of clinical cases with extensive footage combining theory and clinical practice: echocardiograms heart sounds and murmurs ECGs radiography pathology Extensive linking of text to DVD, integrating fundamental principles and diagnostic data with information on clinical management of specific problems.

The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies’ differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.

This volume contains 81 chapters that relate to veterinary and bacterial virology. The first section describes general features of farm and other animals of agricultural importance. The following three sections detail other animal viruses, avian viruses, and viruses affecting aquatic species such as fish and crustaceans. The Section five deals with viruses which infect bacteria.
The most comprehensive single-volume source providing an overview of virology issues related to animal and bateria
Bridges the gap between basic undergraduate texts and specialized reviews
Concise and general overviews of important topics within the field will help in preparation of lectures, writing reports, or drafting grant applications

Horse Pasture Management, Second Edition provides updated coverage on strategies for managing behavior, grouping, environments and feeding needs of grazing horses. Sections cover the structure, function and identification of forages, continuing into nutritional value of pasture plants. Management of soil, the function of a pasture ecosystem and management of plants in a pasture is covered next, followed by forage yield determination, horse grazing behavior, feed choices of horses, management of grazing horses, and how to calculate how many horses should be grazing relative to land size. Advantages of grazing more than one species of animal are described. Management of hay and silage are included since year-round grazing is not possible on many horse farms. Several chapters deal with interactions of a horse farm with the environment, including climate and weather and other living things. The book also covers strategies for managing manure, erosion, and water quality. It is ideal for researchers, scientists and students involved in animal science, specifically equine studies. Agriculturists, equine managers and veterinarians will also find this book useful.

This vibrant collection delivers a laboratory roadmap of testing cognition in the rodent. While rodents and mazes are the main center and focus of this book, many aspects in the field of learning and memory are discussed and detailed, spanning from the molecular to the human, with every chapter delivering a comprehensive review of historical milestones in order to provide context for past discoveries, new findings, and future studies. Didactic foundations, operational definitions, and theory, as well as practical experimental and apparatus set-up, data analysis, and interpretation instructions are included in the first part of the book, while part two contains step-by-step protocols, troubleshooting, and tips from experts in the field. Authoritative and inspirational, The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition serves as a detailed and practical manual for scientists wishing to implement these tools in their laboratories and for scholars interested in this powerful field.

The most effective, practical approach to the recognition and management of cardiovascular and cardiopulmonary medicine, MANUAL OF CANINE AND FELINE CARDIOLOGY, 4th Edition takes a user-friendly approach to the challenges and conditions you encounter in everyday practice. This completely revised and updated edition includes vital information on diagnostic modalities and techniques, therapeutic options, surgical procedures, and pharmaceutical management of the dog and cat cardiac patient. This invaluable, practical reference covers the full breadth of canine and feline cardiology diagnosis and management in a straightforward and clinically focused format. The latest coverage on common cardiovascular disorders and practical treatment methods addresses topics, such as: cardiac failure, cardiac arrhythmias, conduction disturbances, cardiopulmonary arrest, and more. Easy-to-follow organization separates content into three sections that build on each other - Section 1: Diagnosis of Heart Disease; Section 2: Cardiovascular Disease; Section 3: Treatment of Cardiovascular Disease. Extensive art program contains vivid illustrations, clinical photographs, and color Doppler images. Drug formulary appendix features a list of commonly used cardiopulmonary drugs, along with formulations, indications, and dosages (for both dogs and cats). Streamlined text, bullet points, and helpful boxes help to highlight the most important clinical content. Highlighted key points spotlight key information, diagnosis considerations, clinical tips and more. NEW! Genetic and Biomarker Testing of Cardiovascular Diseases chapter covers genetic testing for mutations associated with specific cardiac diseases and testing for circulating substances indicative of heart disease or injury. NEW! Nutrition and Cardiovascular Disease chapter focuses on the significant role nutrition can play in preventing or treating cardiac disease. NEW! Significantly revised Echocardiography chapter features the latest information on indications and the role of the electrocardiogram in clinical practice. NEW! All new doppler echocardiogram images in the Feline Cardiomyopathy chapter show the primary cardiomyopathies, including: severe hypertrophic cardiomyopathy, severe hypertrophic obstructive cardiomyopathy, severe dilated cardiomyopathy, severe endomyocardial fibrosis and restrictive cardiomyopathy, severe unclassified cardiomyopathy, and severe arrhythmogenic right ventricular cardiomyopathy. NEW! Section on hybrid cardiac procedures in the Cardiac Surgery chapter include image-guided catheter-based interventions with direct transcardiac (transatrial, transventricular, transapical) surgical approaches to the heart.

An essential resource for both students and practitioners, this comprehensive text provides practical, up-to-date information about normal reproduction and reproductive disorders in horses, cattle, small ruminants, swine, llamas, and other livestock. Featuring contributions from experts in the field, each section is devoted to a different large animal species and begins with a review of the clinically relevant aspects of the reproductive anatomy and physiology of both males and females. Key topics include the evaluation of breeding soundness, pregnancy diagnosis, diagnosis and treatment of infertility, abortion, obstetrics, surgery of the reproductive tract, care of neonates, and the latest reproductive technology. Includes coverage of all large animal species. All sections provide a review of clinically pertinent reproductive physiology and anatomy of males and females of each species. Complete coverage of the most current reproductive technology, including embryo transfer, estrous synchronization, and artificial insemination. A new section on alternative farming that addresses reproduction in bison, elk, and deer. New to the equine section: stallion management, infertility, and breeding soundness evaluation. New to the bovine section: estrous cycle synchronization, reproductive biotechnology, ultrasonographic determination of fetal gender, heifer development, and diagnosis of abortion. New to the porcine section: artificial insemination, boar/stud management, diseases of postpartum period, and infectious disease control. New to the llama section: infectious disease and nutrition.

Today, veterinary science experiences major development in all its fields as a consequence of continuous technological advances in diagnostic tools and breakthrough in applied genomics and biology. This book contains 33 proceedings that were selected among those presented at the 64th Italian Veterinary Science Congress held at ASTI in 2010. It provides a timely overview of the current progress made by Italian researchers and would be of great value to anyone interested in the field of veterinary science, from animal health and care to food hygiene, and from basic to applied disciplines.

This volume reviews the current understanding of the taxonomy, disease syndromes, genetics, biology, and pathogenic factors of Histophilus somni, as well as the host immune response to this pathogen. H. somni is one of the most important bacterial pathogens in cattle and other ruminants, and its virulence factors are highly conserved with Haemophilus influenzae and other members of the Pasteurellaceae. H. somni has been recognized as a major cause of thrombotic meningoencephalitis, respiratory disease syndromes, myocarditis, reproductive disease syndromes, polyarthritis, mastitis, ocular disease, and septicemia. The only known habitats of H. somni are the mucosal surfaces of ruminants, making this bacterium an opportunistic pathogen. Although it is capable of causing inflammation at systemic sites and is toxic to epithelial and phagocytic cells, the bacterium's wide array of virulence factors act primarily as a defense against, or to escape recognition from, host innate and adaptive immunity.

A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included.
* Two-color, user-friendly format, with copious illustrations and color plates
* Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

This book provides a practical, comprehensive and up-to-date overview of the use of spatial statistics in epidemiology - the study of the incidence and distribution of diseases. Used appropriately, spatial analytical methods in conjunction with GIS and remotely sensed data can provide significant insights into the biological patterns and processes that underlie disease transmission. In turn, these can be used to understand and predict disease prevalence. This user-friendly text brings together the specialised and widely-dispersed literature on spatial analysis to make these methodological tools accessible to epidemiologists for the first time.
With its focus is on application rather than theory, Spatial Analysis in Epidemiology includes a wide range of examples taken from both medical (human) and veterinary (animal) disciplines, and describes both infectious diseases and non-infectious conditions. Furthermore, it provides worked examples of methodologies using a single data set from the same disease example throughout, and is structured to follow the logical sequence of description of spatial data, visualisation, exploration, modelling and decision support. This accessible text is aimed at graduate students and researchers dealing with spatial data in the fields of epidemiology (both medical and veterinary), ecology, zoology and parasitology, environmental science, geography and statistics.

This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interepreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.

P. Doherty. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VB Introduction D. Dobbelaere and D. McKeever. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX Theileria Development and Host Cell Invasion Michael K. Shaw. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Genomic Polymorphism, Sexual Recombination and Molecular Epidemiology af Theileria Parva R. Bishop, D. Geysen, R. Skilton, D. Odongo, V. Nene, B. Allsopp, S. Mbogo, P. Spooner and S. Morzaria. . . . . . . . . . . . . . . . 23 Epidemiological Significance of Strain-Specific Immunity to Theileria Parva D. J. McKeever and W. I. Morrison. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Virulence and Attenuation in Theileria Annulata R. Adamson and R. Hall. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Theileria Survival Strategies and Host Cell Transformation V. T. Heussler. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Genomics of Theileria Parva V. Nene, R. Bishop, J. Quackenbush, M. Pertea, S. L. Salzberg, E. Taracha, S. Morzaria, C. M. Fraser and M. Gardner. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Non-Transforming Theileria Parasites of Ruminants C. Sugimoto and K. Fujisaki 93 Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 FOREWORD The apicomplexan protozoal parasites continue to provide major challenges for human and animal health. While most of us have some familiarity with the ravages of malaria, there is relatively little awareness of diseases caused by parasites of the Theileria species. The reason is that these tick-borne organisms are problematic only in cattle and small ruminants. This does not mean, however, that the various manifestations of Theileriosis are of little interest to those concerned principally with human health. The economic loss and diminished food production associated with East Coast Fever (ECF, caused by T. parva) continues to be a major problem in East Africa.