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Mechanisms of Gastrointestinal Motility and Secretion (Paperback, Softcover reprint of the original 1st ed. 1984)
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Mechanisms of Gastrointestinal Motility and Secretion (Paperback, Softcover reprint of the original 1st ed. 1984)
Series: NATO ASI Subseries A:, 80
Expected to ship within 10 - 15 working days
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The physiological role of histamine in gastric secretion has been
controversial since Popielski demonstrated that histamine sti-
mulates this secretion. The results using H2-receptor antagonists,
together with the findings that histamine is produced and stored in
the fundic mucosa and released upon vagal or hormonal stimulation,
indicate that this amine is the major physiological stimulant of
the parietal cells. The concepts of histamine as a 'final common
chemo- stimulator' of parietal cells, and as part of a
'multi-messenger' potentiating interaction of various hormonal
secretagogues on parietal cells, have both been proposed to explain
the involvement of hista- mine in gastric secretory mechanisms.
Histamine may also be an im- portant factor in the pathogenesis of
gastric hypersecretion and peptic ulcer disease since its
mobilization from gastric mucosal stores is accelerated in peptic
ulcer disease, and since treatment with vagotomy or H2-receptor
antagonists decreases histamine release and increases its
degradation in the gastric mucosa. REFERENCES Angus, J. A. , 1982,
Histamine receptors - their classification and role in gastric acid
secretion, in: Receptor Update; Proceedings. Excerpta Medica,
Geneva, 29. Angus, J. A. , and Black, J. W. , 1978, Production of
acid secretion in the isolated stomach by electrical field
stimulation, Br. J. Pharmacal. 62: 460P. Angus, J. A. , and Black,
J. W. , 1982, The interaction of choline esters, vagal stimulation
and H2-receptor blockade on acid secretion in vitro, Eur. J.
Pharmacal. 80: 217. Ash, A. S. F. , and Schild, H. O.
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Series: |
NATO ASI Subseries A:, 80 |
Release date: |
November 2012 |
First published: |
1984 |
Editors: |
A. Bennett
|
Dimensions: |
244 x 170 x 19mm (L x W x T) |
Format: |
Paperback
|
Pages: |
359 |
Edition: |
Softcover reprint of the original 1st ed. 1984 |
ISBN-13: |
978-1-4684-4855-9 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
Gastroenterology
|
LSN: |
1-4684-4855-2 |
Barcode: |
9781468448559 |
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