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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, Vol. 93 (Hardcover, 2010 ed.)
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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, Vol. 93 (Hardcover, 2010 ed.)
Series: Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products, 93
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Lignans, by convention, are a group of natural products that are
formed by linking two phenylpropanoid units (C C units) by
oxidative coupling. Most importantly, in 6 3 a lignan, two (C C
units) are bound through the central carbon of their side chains, 6
3 0 i. e. the 8 and 8 positions (1, 2). The occurrence of C C
-dimers, linked at sites other 6 3 0 than the 8-8 positions, is
also known and these compounds have been termed neolignans (3, 4).
As these two groups of compounds have close structural as well as
biosynthetic relationships, they are often associated together and
incorporated under the general term "lignan" (5). The diverse
structural categorization of true lignans and of a few neolignans
is presented in Fig. 1. Through the years, several review articles
or books covering different facets of lignans, including their ch-
istry (6, 7), biogenesis (8), synthesis (9), and biological
activities (10) have been published. Enduring research for the
investigation of secondary metabolites of plants has evidenced some
compounds that are biogenetically related to true lignans or
neolignans but bear some features not discerned in conventional
lignans. These compounds or groups of compounds have been termed as
"non-conventional lignans", and include coumarinolignans,
?avonolignans, and stilbenolignans. The non-conventional lignans,
like the conventional ones, have two C C units linked 6 3 together
but have additional structural features to place them also under
the category of coumarins, ?avonoids, or stilbenes.
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