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Psychoactive Drugs - Tolerance and Sensitization (Hardcover, 1989 ed.)
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Psychoactive Drugs - Tolerance and Sensitization (Hardcover, 1989 ed.)
Series: Contemporary Neuroscience
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Research into the processes of tolerance and sensitization has
escalated at a substantial rate in recent years, presumably because
of the fundamental importance of understanding the long-term, as
opposed simply to the initial, acute effects of drugs. The rapid of
such research in recent years is documented c1early by growth the
editors in the introductory chapter to this text. However, despite
the fact that there is a very large amount of literature concemed
with the effects of long-term drug treatment, there is, to the best
of our knowledge, no published text that has ever attempted to
integrate some of the many diverse findings that have been made in
this area. Basic research has uncovered a num ber of different
mechanisms by which tolerance and sensitization to drugs can
develop. Such mechanisms are of very different types, involving
psychological behavioral, metabolic, neuronal, and subcellular
processes. Because of the complexity of each of these different
types of mechanisms, with few exceptions, individual re searchers
usually tend, understandably, to concentrate on their own specific
areas of expertise, paying relatively little attention to rele vant
research occurring in other areas. Consequently, they neglect or
simply ignore the important question of the relative importance of
the specific mechanism that they are studying, and the related
question of the possible interrelationships that may exist between
different mechanisms for the production of tolerance and sensitiza
tion."
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