We examine how interacting genetic traits can affect the
interpretation of case-control studies. Our model of personality
reposes on three genetic traits: sanguinity (N), perfectionism (P)
and aggression (A). The "complementary genes" for traits N and A
are entangled: if one of the traits is absent, then the other must
be present. This entanglement is the cause of infertility in
certain combinations of NPA types. We examined hypothetical
case-control studies with the use of Hardy-Weinberg methodology.
Six different case-control studies were replicated in seven
different representative populations. The computed results of each
case-control study were highly dependent on the genetic composition
of the representative population. When the condition present in the
"case group" was genetically related to either trait N or A, there
was a reciprocal difference induced in the other trait due to their
entanglement, leading to possible confusion in interpretation of
the results. Synopsis, Glossary, 25 ill., 80 pp.
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