Myelodysplastic syndrome comprises a group of clonal hematologic
disorders characterized clinically and morphologically by
ineffective hematopoiesis. It is viewed by most hematologists as
encompassing stages of neoplastic hematopoiesis associated with
cytopenias and as excluding nonneoplastic conditions. Neoplastic
transformation of hematopoietic cells can occur at various levels
of stem-cell development. The initial hematopoietic stem cell
injury can result from cytotoxic chemotherapy, radiation exposure,
viral infection, chemical exposure, or genetic predisposition. A
clonal mutation predominates over bone marrow suppressing healthy
stem cells. The decision about how to deal with the morbidity of
the disease versus the potential benefits and toxicities from
treatment will ultimately be made by the individual patient. This
decision is based on age, personal preferences, and available
information about disease biology and prognostic factors. The aim
of the present work is to review recent advances in myelodysplastic
syndrome as regard molecular pathogenesis, diagnosis,
classification and treatment.
General
Imprint: |
VDM Verlag
|
Country of origin: |
Germany |
Release date: |
October 2010 |
First published: |
October 2010 |
Authors: |
Ahmed Abdellatif
|
Dimensions: |
229 x 152 x 8mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
128 |
ISBN-13: |
978-3-639-30429-9 |
Categories: |
Books >
Medicine >
Clinical & internal medicine >
General
|
LSN: |
3-639-30429-2 |
Barcode: |
9783639304299 |
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