This volume provides readers with a comprehensive description of
phospholipid metabolism in brain, activities of phospholipases A2,
and their involvement in neurological disorders. The purpose of
this book is to present readers with cutting edge information in a
lively manner that is useful not only to student and teachers but
also to researchers and physicians. This book has 14 chapters that
will describe (1) the metabolism in brain of glycerophospholipids,
including those containing a vinyl ether group (plasmalogens); (2)
cutting edge information on the properties and roles of
phospholipases A2 in the central nervous system; (3) the release by
phospholipases A2 of second messengers (arachidonic acid,
docosahexaenoic acid, and lysophospholipid) from neural membrane
phospholipids and their neurochemical effects on brain metabolism
and functions; (4) the involvement of phospholipases A2 in
neurological and neuropsychiatric disorders, and the use of
phospholipase A2 inhibitors for the treatment of diseases
associated with altered phospholipid metabolism; and (5) methods
for the assays of phospholipases A2 and their clinical
significance.
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