Cloning has the potential to be an extremely valuable tool across
many fields. In agriculture, the reproductive cloning of farm
animals could prove to be advantageous. In clinical medicine, the
employment of therapeutic cloning for cell, tissue, and organ
replacement appears to be imminent. However, as with any
advancement that is poised to touch human lives, the process of
cloning must be looked at through the lens of the medical
community's obligation to "do no harm,"
Epigenetic Risks of Cloning includes contributions from 32
leading researchers who are intimately involved with various
aspects of cloning. At the frontlines of this science, they are
best positioned to explain what is really occurring. With chapters
dedicated to each of the animal models being employed for
experimentation, the text presents a detailed accounting of cloning
methods, an objective review of current findings, and an
even-handed discussion of potential concerns.
While procedures utilizing a variety of somatic cell types to
create cloned animals have proven to be repeatable, efficient
consistency has proven to be elusive at best. Less than four
percent of reconstructed embryos typically develop to adulthood.
This low success rate is the cumulative result of inefficiencies
occurring at every stage of development.
Epigenetic Risks of Cloning considers the very real consequences
of those inefficiencies. In addition to embryonic loss, cloning
experiments have experienced very high rates of fetal, perinatal,
and neonatal loss, as well as the production of abnormal offspring.
At present, there is a legitimate concern that the propensity for
epigenetic errors could be paralleled in human embryos. This
bookoffers an excellent opportunity to become acquainted with the
current state of cloning, both the methods being utilized, as well
as the risks being realized.
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