In addition to hypercholesterolaemia and smoking, hypertension, a
chronic disease with many cardiovascular complications, is one of
the major risk factors for cardiac ischemia, and the main risk
factor for cerebrovascular disease. To elucidate the role of
oxidative stress and lipid peroxidation in hypertension and the
effect of different medical therapies on these parameters.The
present study included measurement of serum lipid profile, total
lipid peroxidation and oxidized HDL ( Ox-HDL)in 69 patients aged
30-70 years . They were three groups according to the type of
therapy: atenelol, captopril & no pharmacological
antihypertensives NPAHT. The results were compared with those of 45
apparently healthy controls(age range=30-66 years). The results
showed a significant elevation in serum MDA and the OX.non-HDL %
with a significant reduction in the reduction in the OX.HDL % as
compared to the controls. The disturbance in the oxidant /
antioxidant balance happened despite the treatment and blood
pressure control showing different pictures with different
modalities of treatment, being the best with the captopril.
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